Incidental Mutation 'R5980:Vmn2r95'
ID 481403
Institutional Source Beutler Lab
Gene Symbol Vmn2r95
Ensembl Gene ENSMUSG00000091631
Gene Name vomeronasal 2, receptor 95
Synonyms
MMRRC Submission 044162-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.067) question?
Stock # R5980 (G1)
Quality Score 225.009
Status Validated
Chromosome 17
Chromosomal Location 18644366-18672586 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 18661624 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Valine at position 457 (I457V)
Ref Sequence ENSEMBL: ENSMUSP00000156117 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000166327] [ENSMUST00000232090] [ENSMUST00000232464]
AlphaFold A0A338P6T0
Predicted Effect probably benign
Transcript: ENSMUST00000166327
AA Change: I457V

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000126106
Gene: ENSMUSG00000091631
AA Change: I457V

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
Pfam:ANF_receptor 82 462 1.8e-35 PFAM
Pfam:NCD3G 509 562 3.2e-20 PFAM
Pfam:7tm_3 594 830 3.2e-51 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000232090
AA Change: I457V

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Predicted Effect probably benign
Transcript: ENSMUST00000232464
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.6%
  • 20x: 96.2%
Validation Efficiency 96% (50/52)
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A2ml1 T C 6: 128,544,018 (GRCm39) N508D possibly damaging Het
Ago1 C T 4: 126,354,362 (GRCm39) probably benign Het
Apol6 A T 15: 76,935,219 (GRCm39) T163S possibly damaging Het
Arhgap27 T C 11: 103,247,095 (GRCm39) T33A probably benign Het
Atg7 C A 6: 114,657,197 (GRCm39) F132L possibly damaging Het
Cep104 C A 4: 154,072,930 (GRCm39) A396E probably benign Het
Cers4 T A 8: 4,568,269 (GRCm39) C107* probably null Het
Cntn6 T C 6: 104,825,093 (GRCm39) S878P probably damaging Het
Dnah6 T C 6: 73,158,705 (GRCm39) K633E probably benign Het
Dst T A 1: 34,221,972 (GRCm39) I2592K probably benign Het
Ep400 G A 5: 110,881,595 (GRCm39) probably benign Het
Fbn1 A G 2: 125,157,324 (GRCm39) C2320R probably damaging Het
Gpi1 A G 7: 33,928,351 (GRCm39) probably null Het
Gse1 T G 8: 120,956,376 (GRCm39) probably benign Het
Hid1 G A 11: 115,241,774 (GRCm39) T612I possibly damaging Het
Ighmbp2 G T 19: 3,315,295 (GRCm39) H708Q probably benign Het
Igkv10-95 T C 6: 68,657,573 (GRCm39) S10P probably damaging Het
Igkv14-100 T C 6: 68,496,009 (GRCm39) V5A probably benign Het
Irgq G A 7: 24,232,770 (GRCm39) G204S probably damaging Het
Kansl1 T C 11: 104,234,463 (GRCm39) K681R possibly damaging Het
Kcnv1 C A 15: 44,972,810 (GRCm39) V358L probably damaging Het
Lrp2 A T 2: 69,365,349 (GRCm39) S275T probably damaging Het
Lysmd1 A T 3: 95,045,219 (GRCm39) D155V probably damaging Het
Magel2 A T 7: 62,030,344 (GRCm39) I1083F unknown Het
Mta3 T A 17: 84,015,834 (GRCm39) V12D probably damaging Het
Mtmr4 T C 11: 87,494,977 (GRCm39) I423T probably damaging Het
Mup11 A G 4: 60,616,887 (GRCm39) Y16H possibly damaging Het
Mycbp G A 4: 123,804,889 (GRCm39) V91I probably benign Het
Ngly1 A C 14: 16,270,509 (GRCm38) Q72P possibly damaging Het
Nol4 T A 18: 23,085,258 (GRCm39) Q52L probably damaging Het
Nrcam T C 12: 44,618,416 (GRCm39) V808A probably damaging Het
Or10p22 A G 10: 128,826,309 (GRCm39) H176R probably damaging Het
Or5ak23 A T 2: 85,244,509 (GRCm39) F238Y probably damaging Het
Or8k24 A T 2: 86,216,141 (GRCm39) L207* probably null Het
Pate10 A C 9: 35,652,911 (GRCm39) D51A probably damaging Het
Pik3c2b C A 1: 133,016,046 (GRCm39) D869E probably benign Het
Pom121l2 T C 13: 22,167,546 (GRCm39) S606P probably damaging Het
Prdm15 G A 16: 97,613,770 (GRCm39) R517* probably null Het
Ralgapa1 T A 12: 55,817,401 (GRCm39) probably null Het
Saraf T A 8: 34,632,541 (GRCm39) F207I probably benign Het
Sema6d A G 2: 124,506,628 (GRCm39) D874G probably damaging Het
Sfrp5 A T 19: 42,190,411 (GRCm39) L14M unknown Het
Sidt1 A T 16: 44,083,675 (GRCm39) C485* probably null Het
Sptbn4 A G 7: 27,071,596 (GRCm39) Y1618H probably damaging Het
Syt14 T C 1: 192,662,716 (GRCm39) Q127R possibly damaging Het
Tbc1d2 C T 4: 46,629,912 (GRCm39) G252R probably benign Het
Ticrr G A 7: 79,310,703 (GRCm39) A206T probably damaging Het
Tmem132d T A 5: 127,861,662 (GRCm39) I820F probably benign Het
Trafd1 A G 5: 121,511,520 (GRCm39) Y433H probably damaging Het
Trim68 A G 7: 102,328,038 (GRCm39) V305A probably damaging Het
Vmn2r58 T A 7: 41,514,480 (GRCm39) Y163F possibly damaging Het
Vmn2r83 T A 10: 79,314,626 (GRCm39) H291Q probably benign Het
Other mutations in Vmn2r95
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01024:Vmn2r95 APN 17 18,672,590 (GRCm39) utr 3 prime probably benign
IGL01479:Vmn2r95 APN 17 18,664,124 (GRCm39) missense probably damaging 1.00
IGL01890:Vmn2r95 APN 17 18,671,737 (GRCm39) missense probably damaging 1.00
IGL01986:Vmn2r95 APN 17 18,660,473 (GRCm39) missense probably benign 0.06
IGL02113:Vmn2r95 APN 17 18,660,169 (GRCm39) missense possibly damaging 0.47
IGL02154:Vmn2r95 APN 17 18,672,248 (GRCm39) missense probably benign 0.16
IGL02190:Vmn2r95 APN 17 18,672,038 (GRCm39) missense probably benign 0.00
IGL02412:Vmn2r95 APN 17 18,660,218 (GRCm39) missense probably damaging 1.00
IGL02550:Vmn2r95 APN 17 18,671,994 (GRCm39) missense probably damaging 1.00
IGL02679:Vmn2r95 APN 17 18,664,116 (GRCm39) missense probably damaging 1.00
IGL02691:Vmn2r95 APN 17 18,672,120 (GRCm39) missense probably benign 0.07
IGL02990:Vmn2r95 APN 17 18,672,298 (GRCm39) nonsense probably null
IGL03032:Vmn2r95 APN 17 18,672,575 (GRCm39) missense probably benign 0.00
R0416:Vmn2r95 UTSW 17 18,661,664 (GRCm39) missense probably damaging 1.00
R0448:Vmn2r95 UTSW 17 18,672,005 (GRCm39) missense possibly damaging 0.92
R0514:Vmn2r95 UTSW 17 18,671,844 (GRCm39) missense probably benign
R0519:Vmn2r95 UTSW 17 18,659,765 (GRCm39) missense probably damaging 1.00
R0539:Vmn2r95 UTSW 17 18,672,362 (GRCm39) missense probably damaging 1.00
R1501:Vmn2r95 UTSW 17 18,660,118 (GRCm39) missense probably damaging 0.99
R1598:Vmn2r95 UTSW 17 18,672,575 (GRCm39) missense probably benign 0.03
R1613:Vmn2r95 UTSW 17 18,660,901 (GRCm39) splice site probably benign
R1861:Vmn2r95 UTSW 17 18,672,530 (GRCm39) missense probably damaging 1.00
R1921:Vmn2r95 UTSW 17 18,644,575 (GRCm39) missense probably benign 0.11
R1986:Vmn2r95 UTSW 17 18,671,805 (GRCm39) missense probably benign
R2031:Vmn2r95 UTSW 17 18,659,717 (GRCm39) missense possibly damaging 0.94
R2040:Vmn2r95 UTSW 17 18,661,561 (GRCm39) missense probably damaging 1.00
R3608:Vmn2r95 UTSW 17 18,660,235 (GRCm39) missense possibly damaging 0.47
R3727:Vmn2r95 UTSW 17 18,661,744 (GRCm39) nonsense probably null
R3953:Vmn2r95 UTSW 17 18,660,358 (GRCm39) missense possibly damaging 0.79
R3955:Vmn2r95 UTSW 17 18,660,358 (GRCm39) missense possibly damaging 0.79
R3957:Vmn2r95 UTSW 17 18,660,358 (GRCm39) missense possibly damaging 0.79
R4474:Vmn2r95 UTSW 17 18,672,507 (GRCm39) missense probably damaging 1.00
R4672:Vmn2r95 UTSW 17 18,672,413 (GRCm39) missense probably damaging 1.00
R4850:Vmn2r95 UTSW 17 18,671,915 (GRCm39) missense probably damaging 1.00
R5054:Vmn2r95 UTSW 17 18,671,708 (GRCm39) missense possibly damaging 0.63
R5178:Vmn2r95 UTSW 17 18,660,337 (GRCm39) missense probably benign 0.01
R6183:Vmn2r95 UTSW 17 18,664,192 (GRCm39) missense probably damaging 0.99
R6276:Vmn2r95 UTSW 17 18,671,732 (GRCm39) missense possibly damaging 0.96
R6651:Vmn2r95 UTSW 17 18,660,622 (GRCm39) missense probably damaging 1.00
R6682:Vmn2r95 UTSW 17 18,660,489 (GRCm39) missense probably damaging 1.00
R6797:Vmn2r95 UTSW 17 18,672,551 (GRCm39) utr 3 prime probably benign
R6799:Vmn2r95 UTSW 17 18,659,555 (GRCm39) missense probably damaging 1.00
R6849:Vmn2r95 UTSW 17 18,664,182 (GRCm39) missense probably damaging 1.00
R6849:Vmn2r95 UTSW 17 18,664,181 (GRCm39) missense probably damaging 1.00
R6982:Vmn2r95 UTSW 17 18,672,323 (GRCm39) missense probably damaging 1.00
R7203:Vmn2r95 UTSW 17 18,661,577 (GRCm39) missense probably benign 0.01
R7226:Vmn2r95 UTSW 17 18,672,245 (GRCm39) missense possibly damaging 0.90
R7240:Vmn2r95 UTSW 17 18,672,225 (GRCm39) missense probably benign 0.15
R7383:Vmn2r95 UTSW 17 18,660,734 (GRCm39) missense probably benign 0.06
R7614:Vmn2r95 UTSW 17 18,660,352 (GRCm39) missense probably benign
R7755:Vmn2r95 UTSW 17 18,644,367 (GRCm39) start codon destroyed probably null 0.99
R7942:Vmn2r95 UTSW 17 18,660,529 (GRCm39) missense possibly damaging 0.74
R8355:Vmn2r95 UTSW 17 18,660,352 (GRCm39) missense probably benign
R8455:Vmn2r95 UTSW 17 18,660,352 (GRCm39) missense probably benign
R8478:Vmn2r95 UTSW 17 18,672,544 (GRCm39) missense probably damaging 1.00
R8547:Vmn2r95 UTSW 17 18,664,161 (GRCm39) missense probably damaging 1.00
R8752:Vmn2r95 UTSW 17 18,661,738 (GRCm39) missense probably damaging 0.98
R8788:Vmn2r95 UTSW 17 18,671,790 (GRCm39) missense probably benign 0.09
R8852:Vmn2r95 UTSW 17 18,664,113 (GRCm39) missense possibly damaging 0.95
R9098:Vmn2r95 UTSW 17 18,660,167 (GRCm39) missense possibly damaging 0.88
R9202:Vmn2r95 UTSW 17 18,644,394 (GRCm39) missense probably benign 0.00
R9244:Vmn2r95 UTSW 17 18,672,189 (GRCm39) missense possibly damaging 0.91
R9546:Vmn2r95 UTSW 17 18,661,721 (GRCm39) missense probably benign 0.01
R9665:Vmn2r95 UTSW 17 18,660,607 (GRCm39) missense probably damaging 0.99
Z1088:Vmn2r95 UTSW 17 18,660,663 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- CTTGAGCTTGGTTCTAAGTTTTCAC -3'
(R):5'- TAGGTAATACATAACCCACCTCTG -3'

Sequencing Primer
(F):5'- TGGTATTCTGAACATCCTTTCAAC -3'
(R):5'- ACCTCTGAAAATATTGCTGGCC -3'
Posted On 2017-06-26