Incidental Mutation 'R0514:Lmo7'
| ID |
48144 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Lmo7
|
| Ensembl Gene |
ENSMUSG00000033060 |
| Gene Name |
LIM domain only 7 |
| Synonyms |
FBXO20, LOC380928 |
| MMRRC Submission |
038708-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.133)
|
| Stock # |
R0514 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
14 |
| Chromosomal Location |
101967393-102172146 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 102124609 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Leucine to Proline
at position 356
(L356P)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000123706
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000100337]
[ENSMUST00000159026]
[ENSMUST00000159258]
[ENSMUST00000159314]
[ENSMUST00000159597]
|
| AlphaFold |
E9PYF4 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000100337
AA Change: L478P
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000097910
Gene: ENSMUSG00000033060
AA Change: L478P
| Domain | Start | End | E-Value | Type |
|---|
|
CH
|
14 |
124 |
2.57e-13 |
SMART |
|
low complexity region
|
200 |
211 |
N/A |
INTRINSIC |
|
Pfam:DUF4757
|
242 |
348 |
2.2e-14 |
PFAM |
|
low complexity region
|
448 |
462 |
N/A |
INTRINSIC |
|
Pfam:DUF4757
|
568 |
735 |
1.8e-46 |
PFAM |
|
low complexity region
|
861 |
879 |
N/A |
INTRINSIC |
|
low complexity region
|
979 |
991 |
N/A |
INTRINSIC |
|
low complexity region
|
1003 |
1015 |
N/A |
INTRINSIC |
|
PDZ
|
1047 |
1119 |
1.05e-8 |
SMART |
|
coiled coil region
|
1222 |
1275 |
N/A |
INTRINSIC |
|
coiled coil region
|
1319 |
1411 |
N/A |
INTRINSIC |
|
low complexity region
|
1585 |
1596 |
N/A |
INTRINSIC |
|
low complexity region
|
1599 |
1617 |
N/A |
INTRINSIC |
|
LIM
|
1629 |
1687 |
6.54e-10 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000159026
AA Change: L245P
PolyPhen 2
Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
|
| SMART Domains |
Protein: ENSMUSP00000124605
Gene: ENSMUSG00000033060
AA Change: L245P
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
215 |
229 |
N/A |
INTRINSIC |
|
coiled coil region
|
435 |
471 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000159258
AA Change: L245P
PolyPhen 2
Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
|
| SMART Domains |
Protein: ENSMUSP00000125465
Gene: ENSMUSG00000033060
AA Change: L245P
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
215 |
229 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000159314
AA Change: L245P
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000124349
Gene: ENSMUSG00000033060
AA Change: L245P
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
215 |
229 |
N/A |
INTRINSIC |
|
coiled coil region
|
435 |
492 |
N/A |
INTRINSIC |
|
low complexity region
|
628 |
646 |
N/A |
INTRINSIC |
|
low complexity region
|
746 |
758 |
N/A |
INTRINSIC |
|
low complexity region
|
770 |
782 |
N/A |
INTRINSIC |
|
PDZ
|
814 |
886 |
1.05e-8 |
SMART |
|
coiled coil region
|
989 |
1042 |
N/A |
INTRINSIC |
|
coiled coil region
|
1086 |
1178 |
N/A |
INTRINSIC |
|
low complexity region
|
1352 |
1363 |
N/A |
INTRINSIC |
|
low complexity region
|
1366 |
1384 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000159597
AA Change: L356P
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000123706
Gene: ENSMUSG00000033060
AA Change: L356P
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
78 |
89 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
111 |
141 |
6.96e-5 |
PROSPERO |
|
internal_repeat_1
|
218 |
248 |
6.96e-5 |
PROSPERO |
|
low complexity region
|
326 |
340 |
N/A |
INTRINSIC |
|
coiled coil region
|
546 |
603 |
N/A |
INTRINSIC |
|
low complexity region
|
739 |
757 |
N/A |
INTRINSIC |
|
low complexity region
|
857 |
869 |
N/A |
INTRINSIC |
|
low complexity region
|
881 |
893 |
N/A |
INTRINSIC |
|
PDZ
|
925 |
997 |
1.05e-8 |
SMART |
|
coiled coil region
|
1127 |
1180 |
N/A |
INTRINSIC |
|
coiled coil region
|
1224 |
1316 |
N/A |
INTRINSIC |
|
low complexity region
|
1490 |
1501 |
N/A |
INTRINSIC |
|
low complexity region
|
1504 |
1522 |
N/A |
INTRINSIC |
|
LIM
|
1534 |
1592 |
6.54e-10 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000159797
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000159806
|
| SMART Domains |
Protein: ENSMUSP00000124300
Gene: ENSMUSG00000033060
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
34 |
45 |
N/A |
INTRINSIC |
|
Pfam:DUF4757
|
76 |
225 |
4.5e-53 |
PFAM |
|
low complexity region
|
351 |
369 |
N/A |
INTRINSIC |
|
low complexity region
|
469 |
481 |
N/A |
INTRINSIC |
|
low complexity region
|
493 |
505 |
N/A |
INTRINSIC |
|
PDZ
|
537 |
609 |
1.05e-8 |
SMART |
|
internal_repeat_1
|
620 |
691 |
9.31e-5 |
PROSPERO |
|
coiled coil region
|
711 |
764 |
N/A |
INTRINSIC |
|
coiled coil region
|
808 |
900 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
921 |
976 |
9.31e-5 |
PROSPERO |
|
low complexity region
|
1075 |
1086 |
N/A |
INTRINSIC |
|
low complexity region
|
1089 |
1107 |
N/A |
INTRINSIC |
|
LIM
|
1119 |
1177 |
6.54e-10 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000159812
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000161668
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000162091
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000159948
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000160876
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 96.8%
- 20x: 94.1%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein containing a calponin homology (CH) domain, a PDZ domain, and a LIM domain, and may be involved in protein-protein interactions. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene, however, the full-length nature of some variants is not known. [provided by RefSeq, Jan 2009]
PHENOTYPE: Targeted mutations in this gene result in postnatal lethality, growth defects, skeletal muscle abnormalities and retinal defects reflective of retinal degeneration. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 90 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acp3 |
T |
A |
9: 104,197,177 (GRCm39) |
Y154F |
probably damaging |
Het |
| Acsl6 |
A |
T |
11: 54,241,406 (GRCm39) |
D579V |
probably damaging |
Het |
| Adamts18 |
C |
T |
8: 114,465,401 (GRCm39) |
|
probably null |
Het |
| Adamts20 |
A |
T |
15: 94,168,257 (GRCm39) |
V1882D |
probably damaging |
Het |
| Add3 |
A |
T |
19: 53,225,274 (GRCm39) |
K465* |
probably null |
Het |
| Ago1 |
T |
G |
4: 126,333,388 (GRCm39) |
I524L |
probably benign |
Het |
| Akr1c18 |
A |
G |
13: 4,187,190 (GRCm39) |
M208T |
probably benign |
Het |
| Anapc1 |
C |
A |
2: 128,474,575 (GRCm39) |
L1413F |
probably damaging |
Het |
| Arid4b |
A |
T |
13: 14,358,902 (GRCm39) |
D646V |
probably damaging |
Het |
| Arnt2 |
T |
C |
7: 83,954,067 (GRCm39) |
E261G |
probably benign |
Het |
| Bccip |
C |
T |
7: 133,320,859 (GRCm39) |
T211I |
possibly damaging |
Het |
| Bsn |
T |
C |
9: 108,002,981 (GRCm39) |
S475G |
probably benign |
Het |
| Cdh26 |
G |
A |
2: 178,108,621 (GRCm39) |
|
probably null |
Het |
| Ceacam2 |
A |
G |
7: 25,220,356 (GRCm39) |
F414S |
probably benign |
Het |
| Cep43 |
A |
G |
17: 8,410,266 (GRCm39) |
N342S |
possibly damaging |
Het |
| Cfb |
T |
C |
17: 35,079,874 (GRCm39) |
R172G |
probably damaging |
Het |
| Cntnap5b |
A |
C |
1: 99,700,511 (GRCm39) |
T8P |
probably benign |
Het |
| Cpne9 |
A |
T |
6: 113,266,974 (GRCm39) |
I136L |
probably damaging |
Het |
| Crtc1 |
A |
T |
8: 70,855,079 (GRCm39) |
|
probably null |
Het |
| Dcdc2a |
A |
T |
13: 25,303,369 (GRCm39) |
H300L |
probably benign |
Het |
| Dhdh |
C |
T |
7: 45,138,130 (GRCm39) |
V20M |
probably benign |
Het |
| Dhx34 |
T |
C |
7: 15,944,462 (GRCm39) |
Q584R |
probably benign |
Het |
| Dis3l2 |
A |
G |
1: 86,974,814 (GRCm39) |
Y701C |
probably damaging |
Het |
| Dmrt2 |
T |
C |
19: 25,653,019 (GRCm39) |
|
probably null |
Het |
| Dnah5 |
A |
G |
15: 28,366,467 (GRCm39) |
T2727A |
probably damaging |
Het |
| Dop1a |
A |
G |
9: 86,402,787 (GRCm39) |
E1329G |
probably damaging |
Het |
| Evpl |
A |
G |
11: 116,114,117 (GRCm39) |
V1191A |
probably damaging |
Het |
| Fhl4 |
T |
C |
10: 84,934,250 (GRCm39) |
D177G |
probably damaging |
Het |
| Gask1a |
A |
G |
9: 121,807,418 (GRCm39) |
T521A |
possibly damaging |
Het |
| Heg1 |
A |
G |
16: 33,547,126 (GRCm39) |
T662A |
possibly damaging |
Het |
| Ifih1 |
A |
G |
2: 62,453,735 (GRCm39) |
|
probably null |
Het |
| Il13 |
T |
C |
11: 53,523,345 (GRCm39) |
R87G |
possibly damaging |
Het |
| Kcnc3 |
T |
A |
7: 44,245,352 (GRCm39) |
Y547* |
probably null |
Het |
| Krt81 |
C |
A |
15: 101,361,508 (GRCm39) |
R24L |
possibly damaging |
Het |
| Lama1 |
G |
A |
17: 68,071,693 (GRCm39) |
G860D |
probably benign |
Het |
| Lrp2bp |
A |
G |
8: 46,464,995 (GRCm39) |
H38R |
probably damaging |
Het |
| Magi3 |
G |
A |
3: 103,922,338 (GRCm39) |
P1460S |
probably damaging |
Het |
| Megf8 |
T |
A |
7: 25,063,728 (GRCm39) |
C2695S |
possibly damaging |
Het |
| Mrgprb2 |
T |
G |
7: 48,201,718 (GRCm39) |
S336R |
probably benign |
Het |
| Mrgprx2 |
C |
T |
7: 48,132,712 (GRCm39) |
M1I |
probably null |
Het |
| Mug2 |
T |
C |
6: 122,058,558 (GRCm39) |
L1320P |
probably damaging |
Het |
| Noxred1 |
A |
G |
12: 87,273,838 (GRCm39) |
S68P |
probably benign |
Het |
| Or51f5 |
T |
A |
7: 102,424,539 (GRCm39) |
H269Q |
probably benign |
Het |
| Or56b1b |
T |
A |
7: 108,164,879 (GRCm39) |
Y41F |
probably damaging |
Het |
| Os9 |
C |
T |
10: 126,955,508 (GRCm39) |
C123Y |
probably damaging |
Het |
| Ostf1 |
T |
A |
19: 18,573,723 (GRCm39) |
T42S |
probably benign |
Het |
| Parg |
C |
A |
14: 31,976,517 (GRCm39) |
T186K |
possibly damaging |
Het |
| Pcnx1 |
T |
A |
12: 82,041,884 (GRCm39) |
M2172K |
probably benign |
Het |
| Pip4k2a |
A |
G |
2: 18,850,747 (GRCm39) |
I360T |
probably damaging |
Het |
| Pkn2 |
T |
C |
3: 142,516,219 (GRCm39) |
D568G |
possibly damaging |
Het |
| Plch2 |
A |
G |
4: 155,083,343 (GRCm39) |
S431P |
probably damaging |
Het |
| Prl8a6 |
A |
T |
13: 27,616,990 (GRCm39) |
C233* |
probably null |
Het |
| Prox1 |
G |
A |
1: 189,893,653 (GRCm39) |
T264I |
probably damaging |
Het |
| Prr5 |
A |
G |
15: 84,586,967 (GRCm39) |
N248S |
probably benign |
Het |
| Psip1 |
A |
C |
4: 83,378,274 (GRCm39) |
S407R |
probably damaging |
Het |
| Rab32 |
A |
T |
10: 10,426,640 (GRCm39) |
V102E |
probably damaging |
Het |
| Rap1gap2 |
T |
G |
11: 74,279,680 (GRCm39) |
K687Q |
possibly damaging |
Het |
| Rbak |
A |
T |
5: 143,159,169 (GRCm39) |
V628E |
probably damaging |
Het |
| Rnf148 |
T |
C |
6: 23,654,792 (GRCm39) |
E68G |
possibly damaging |
Het |
| Rnf212 |
A |
T |
5: 108,897,308 (GRCm39) |
S3T |
probably damaging |
Het |
| Rrad |
T |
G |
8: 105,355,259 (GRCm39) |
I250L |
probably benign |
Het |
| Sall4 |
T |
C |
2: 168,597,625 (GRCm39) |
H405R |
probably damaging |
Het |
| Scn9a |
T |
C |
2: 66,314,022 (GRCm39) |
R1888G |
probably damaging |
Het |
| Setd5 |
G |
T |
6: 113,096,398 (GRCm39) |
E535* |
probably null |
Het |
| Slc20a1 |
C |
T |
2: 129,041,811 (GRCm39) |
S58L |
probably damaging |
Het |
| Slc31a1 |
A |
G |
4: 62,303,841 (GRCm39) |
|
probably benign |
Het |
| Slc38a11 |
G |
T |
2: 65,147,209 (GRCm39) |
Q423K |
probably benign |
Het |
| Snrpd1 |
A |
T |
18: 10,626,846 (GRCm39) |
T38S |
possibly damaging |
Het |
| Taar4 |
A |
G |
10: 23,836,780 (GRCm39) |
D130G |
probably damaging |
Het |
| Tfb2m |
C |
T |
1: 179,358,869 (GRCm39) |
R338H |
probably benign |
Het |
| Tm2d2 |
A |
G |
8: 25,512,742 (GRCm39) |
I197V |
possibly damaging |
Het |
| Tmem132a |
C |
T |
19: 10,836,355 (GRCm39) |
G725D |
probably damaging |
Het |
| Tmem67 |
T |
C |
4: 12,089,317 (GRCm39) |
T38A |
probably benign |
Het |
| Tmprss15 |
A |
T |
16: 78,765,155 (GRCm39) |
S816T |
probably benign |
Het |
| Tnfrsf11a |
A |
G |
1: 105,754,717 (GRCm39) |
E263G |
probably damaging |
Het |
| Tnfrsf17 |
C |
T |
16: 11,133,191 (GRCm39) |
L90F |
probably benign |
Het |
| Tpr |
A |
G |
1: 150,278,024 (GRCm39) |
K117E |
possibly damaging |
Het |
| Trim43a |
C |
T |
9: 88,466,389 (GRCm39) |
Q5* |
probably null |
Het |
| Ubn1 |
A |
T |
16: 4,890,935 (GRCm39) |
D498V |
probably damaging |
Het |
| Vipr1 |
T |
A |
9: 121,487,115 (GRCm39) |
C63S |
probably damaging |
Het |
| Vmn1r237 |
T |
A |
17: 21,534,932 (GRCm39) |
H218Q |
possibly damaging |
Het |
| Vmn2r100 |
C |
A |
17: 19,742,382 (GRCm39) |
P252Q |
possibly damaging |
Het |
| Vmn2r95 |
T |
C |
17: 18,671,844 (GRCm39) |
V527A |
probably benign |
Het |
| Vmn2r97 |
A |
T |
17: 19,134,734 (GRCm39) |
T51S |
probably benign |
Het |
| Vwa8 |
G |
A |
14: 79,184,629 (GRCm39) |
V376I |
probably benign |
Het |
| Wdfy4 |
T |
A |
14: 32,802,732 (GRCm39) |
T1838S |
probably benign |
Het |
| Zcwpw1 |
A |
T |
5: 137,794,945 (GRCm39) |
E47V |
probably benign |
Het |
| Zeb2 |
T |
C |
2: 44,892,659 (GRCm39) |
E130G |
possibly damaging |
Het |
| Zfp111 |
A |
G |
7: 23,898,568 (GRCm39) |
Y348H |
probably damaging |
Het |
| Zfp53 |
T |
C |
17: 21,729,271 (GRCm39) |
S435P |
probably damaging |
Het |
|
| Other mutations in Lmo7 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00569:Lmo7
|
APN |
14 |
102,124,487 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL00733:Lmo7
|
APN |
14 |
102,153,138 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00778:Lmo7
|
APN |
14 |
102,148,321 (GRCm39) |
splice site |
probably benign |
|
|
IGL01014:Lmo7
|
APN |
14 |
102,157,993 (GRCm39) |
splice site |
probably benign |
|
|
IGL01401:Lmo7
|
APN |
14 |
102,031,713 (GRCm39) |
nonsense |
probably null |
|
|
IGL01550:Lmo7
|
APN |
14 |
102,163,576 (GRCm39) |
utr 3 prime |
probably benign |
|
|
IGL01570:Lmo7
|
APN |
14 |
102,139,807 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01602:Lmo7
|
APN |
14 |
102,148,192 (GRCm39) |
splice site |
probably benign |
|
|
IGL01605:Lmo7
|
APN |
14 |
102,148,192 (GRCm39) |
splice site |
probably benign |
|
|
IGL02012:Lmo7
|
APN |
14 |
102,126,152 (GRCm39) |
intron |
probably benign |
|
|
IGL02145:Lmo7
|
APN |
14 |
102,139,659 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02236:Lmo7
|
APN |
14 |
102,163,524 (GRCm39) |
splice site |
probably benign |
|
|
IGL02318:Lmo7
|
APN |
14 |
102,137,502 (GRCm39) |
splice site |
probably benign |
|
|
IGL02345:Lmo7
|
APN |
14 |
102,124,909 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02498:Lmo7
|
APN |
14 |
102,044,918 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02583:Lmo7
|
APN |
14 |
102,171,360 (GRCm39) |
utr 3 prime |
probably benign |
|
|
IGL02670:Lmo7
|
APN |
14 |
102,118,416 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02694:Lmo7
|
APN |
14 |
102,124,606 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03026:Lmo7
|
APN |
14 |
102,166,769 (GRCm39) |
utr 3 prime |
probably benign |
|
|
IGL03062:Lmo7
|
APN |
14 |
102,149,515 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
IGL03068:Lmo7
|
APN |
14 |
102,112,928 (GRCm39) |
unclassified |
probably benign |
|
|
IGL03178:Lmo7
|
APN |
14 |
102,166,696 (GRCm39) |
nonsense |
probably null |
|
|
IGL03279:Lmo7
|
APN |
14 |
102,137,944 (GRCm39) |
missense |
probably benign |
0.30 |
|
PIT4458001:Lmo7
|
UTSW |
14 |
102,124,923 (GRCm39) |
nonsense |
probably null |
|
|
R0029:Lmo7
|
UTSW |
14 |
102,171,357 (GRCm39) |
utr 3 prime |
probably benign |
|
|
R0112:Lmo7
|
UTSW |
14 |
102,124,629 (GRCm39) |
nonsense |
probably null |
|
|
R0345:Lmo7
|
UTSW |
14 |
102,114,313 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0372:Lmo7
|
UTSW |
14 |
102,155,489 (GRCm39) |
splice site |
probably benign |
|
|
R0393:Lmo7
|
UTSW |
14 |
102,137,892 (GRCm39) |
missense |
probably benign |
|
|
R0514:Lmo7
|
UTSW |
14 |
102,133,995 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0526:Lmo7
|
UTSW |
14 |
102,137,996 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0615:Lmo7
|
UTSW |
14 |
102,114,295 (GRCm39) |
nonsense |
probably null |
|
|
R0900:Lmo7
|
UTSW |
14 |
102,124,624 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0961:Lmo7
|
UTSW |
14 |
102,031,705 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0964:Lmo7
|
UTSW |
14 |
102,158,003 (GRCm39) |
splice site |
probably benign |
|
|
R1078:Lmo7
|
UTSW |
14 |
102,157,910 (GRCm39) |
splice site |
probably benign |
|
|
R1252:Lmo7
|
UTSW |
14 |
102,138,019 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1527:Lmo7
|
UTSW |
14 |
102,114,264 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1537:Lmo7
|
UTSW |
14 |
102,166,700 (GRCm39) |
utr 3 prime |
probably benign |
|
|
R1565:Lmo7
|
UTSW |
14 |
102,124,957 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1637:Lmo7
|
UTSW |
14 |
102,118,268 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1943:Lmo7
|
UTSW |
14 |
102,139,738 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1967:Lmo7
|
UTSW |
14 |
102,137,651 (GRCm39) |
missense |
probably benign |
0.36 |
|
R2002:Lmo7
|
UTSW |
14 |
102,124,497 (GRCm39) |
missense |
probably benign |
0.13 |
|
R2057:Lmo7
|
UTSW |
14 |
102,124,614 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2131:Lmo7
|
UTSW |
14 |
102,137,674 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2153:Lmo7
|
UTSW |
14 |
102,157,951 (GRCm39) |
utr 3 prime |
probably benign |
|
|
R2257:Lmo7
|
UTSW |
14 |
102,137,566 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2355:Lmo7
|
UTSW |
14 |
102,126,121 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2356:Lmo7
|
UTSW |
14 |
102,124,381 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2898:Lmo7
|
UTSW |
14 |
102,114,350 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R3847:Lmo7
|
UTSW |
14 |
102,159,531 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R3848:Lmo7
|
UTSW |
14 |
102,159,531 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R3849:Lmo7
|
UTSW |
14 |
102,159,531 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R3916:Lmo7
|
UTSW |
14 |
102,166,778 (GRCm39) |
utr 3 prime |
probably benign |
|
|
R4050:Lmo7
|
UTSW |
14 |
102,139,713 (GRCm39) |
nonsense |
probably null |
|
|
R4326:Lmo7
|
UTSW |
14 |
102,137,510 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R4357:Lmo7
|
UTSW |
14 |
102,125,091 (GRCm39) |
missense |
probably null |
1.00 |
|
R4571:Lmo7
|
UTSW |
14 |
102,125,030 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4658:Lmo7
|
UTSW |
14 |
102,124,393 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4857:Lmo7
|
UTSW |
14 |
102,124,784 (GRCm39) |
splice site |
probably null |
|
|
R5006:Lmo7
|
UTSW |
14 |
102,163,673 (GRCm39) |
utr 3 prime |
probably benign |
|
|
R5528:Lmo7
|
UTSW |
14 |
102,139,522 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5588:Lmo7
|
UTSW |
14 |
102,134,026 (GRCm39) |
splice site |
probably null |
|
|
R5643:Lmo7
|
UTSW |
14 |
102,166,772 (GRCm39) |
utr 3 prime |
probably benign |
|
|
R5644:Lmo7
|
UTSW |
14 |
102,166,772 (GRCm39) |
utr 3 prime |
probably benign |
|
|
R5650:Lmo7
|
UTSW |
14 |
102,136,110 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5737:Lmo7
|
UTSW |
14 |
102,124,672 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5832:Lmo7
|
UTSW |
14 |
102,121,649 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5966:Lmo7
|
UTSW |
14 |
102,137,938 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R6026:Lmo7
|
UTSW |
14 |
102,118,426 (GRCm39) |
missense |
probably benign |
0.04 |
|
R6072:Lmo7
|
UTSW |
14 |
102,166,772 (GRCm39) |
utr 3 prime |
probably benign |
|
|
R6158:Lmo7
|
UTSW |
14 |
102,137,573 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6246:Lmo7
|
UTSW |
14 |
102,156,136 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6335:Lmo7
|
UTSW |
14 |
102,138,072 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6620:Lmo7
|
UTSW |
14 |
102,112,888 (GRCm39) |
missense |
probably benign |
0.29 |
|
R6658:Lmo7
|
UTSW |
14 |
102,148,281 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R6917:Lmo7
|
UTSW |
14 |
102,155,446 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7064:Lmo7
|
UTSW |
14 |
102,121,615 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7072:Lmo7
|
UTSW |
14 |
102,136,136 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7121:Lmo7
|
UTSW |
14 |
102,124,471 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7136:Lmo7
|
UTSW |
14 |
102,157,975 (GRCm39) |
missense |
unknown |
|
|
R7196:Lmo7
|
UTSW |
14 |
102,133,936 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R7228:Lmo7
|
UTSW |
14 |
102,133,971 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7337:Lmo7
|
UTSW |
14 |
102,121,640 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7341:Lmo7
|
UTSW |
14 |
102,122,948 (GRCm39) |
missense |
probably benign |
0.30 |
|
R7408:Lmo7
|
UTSW |
14 |
102,118,389 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7432:Lmo7
|
UTSW |
14 |
102,139,551 (GRCm39) |
missense |
probably benign |
0.42 |
|
R7470:Lmo7
|
UTSW |
14 |
102,138,040 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R7506:Lmo7
|
UTSW |
14 |
102,157,045 (GRCm39) |
missense |
unknown |
|
|
R7559:Lmo7
|
UTSW |
14 |
102,124,662 (GRCm39) |
nonsense |
probably null |
|
|
R7565:Lmo7
|
UTSW |
14 |
102,122,737 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7788:Lmo7
|
UTSW |
14 |
102,136,012 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R8095:Lmo7
|
UTSW |
14 |
102,124,855 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R8100:Lmo7
|
UTSW |
14 |
102,137,899 (GRCm39) |
missense |
probably benign |
0.33 |
|
R8121:Lmo7
|
UTSW |
14 |
102,163,736 (GRCm39) |
missense |
unknown |
|
|
R8308:Lmo7
|
UTSW |
14 |
102,139,807 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8371:Lmo7
|
UTSW |
14 |
102,124,444 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8403:Lmo7
|
UTSW |
14 |
102,139,800 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8690:Lmo7
|
UTSW |
14 |
102,168,644 (GRCm39) |
missense |
unknown |
|
|
R8778:Lmo7
|
UTSW |
14 |
102,156,655 (GRCm39) |
missense |
probably benign |
0.24 |
|
R8778:Lmo7
|
UTSW |
14 |
102,149,503 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8822:Lmo7
|
UTSW |
14 |
102,121,610 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8849:Lmo7
|
UTSW |
14 |
102,163,543 (GRCm39) |
missense |
unknown |
|
|
R8923:Lmo7
|
UTSW |
14 |
102,137,679 (GRCm39) |
missense |
probably benign |
0.31 |
|
R9006:Lmo7
|
UTSW |
14 |
102,155,072 (GRCm39) |
small deletion |
probably benign |
|
|
R9135:Lmo7
|
UTSW |
14 |
102,118,297 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9154:Lmo7
|
UTSW |
14 |
102,122,743 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9178:Lmo7
|
UTSW |
14 |
102,044,906 (GRCm39) |
nonsense |
probably null |
|
|
R9375:Lmo7
|
UTSW |
14 |
102,136,123 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9428:Lmo7
|
UTSW |
14 |
102,155,076 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9488:Lmo7
|
UTSW |
14 |
102,122,783 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R9493:Lmo7
|
UTSW |
14 |
102,137,907 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9594:Lmo7
|
UTSW |
14 |
102,156,136 (GRCm39) |
missense |
probably null |
0.98 |
|
R9674:Lmo7
|
UTSW |
14 |
102,078,340 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9736:Lmo7
|
UTSW |
14 |
102,157,929 (GRCm39) |
missense |
unknown |
|
|
X0066:Lmo7
|
UTSW |
14 |
102,124,897 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0067:Lmo7
|
UTSW |
14 |
102,124,369 (GRCm39) |
splice site |
probably null |
|
|
Z1176:Lmo7
|
UTSW |
14 |
102,156,717 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1176:Lmo7
|
UTSW |
14 |
102,121,742 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1176:Lmo7
|
UTSW |
14 |
102,166,664 (GRCm39) |
missense |
unknown |
|
|
Z1176:Lmo7
|
UTSW |
14 |
102,156,879 (GRCm39) |
missense |
unknown |
|
|
Z1177:Lmo7
|
UTSW |
14 |
102,135,993 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Lmo7
|
UTSW |
14 |
102,133,954 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
| Predicted Primers |
PCR Primer
(F):5'- ATTGCTTCAGGCCCTCCAAACC -3'
(R):5'- TGTCCTTTCGAGCACAGAGAGAAAC -3'
Sequencing Primer
(F):5'- TGTCCTCGGAAACAAGTGTC -3'
(R):5'- CACAGAGAGAAACTTCGCTTG -3'
|
| Posted On |
2013-06-12 |
Incidental Mutation