Incidental Mutation 'R5983:Morn3'
| ID |
481517 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Morn3
|
| Ensembl Gene |
ENSMUSG00000029477 |
| Gene Name |
MORN repeat containing 3 |
| Synonyms |
4930438O03Rik |
| MMRRC Submission |
044164-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.118)
|
| Stock # |
R5983 (G1)
|
| Quality Score |
211.009 |
|
Status
|
Validated
|
| Chromosome |
5 |
| Chromosomal Location |
123173832-123185079 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 123175851 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Glycine
at position 179
(D179G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000031437
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000031437]
[ENSMUST00000045843]
[ENSMUST00000132775]
[ENSMUST00000145257]
|
| AlphaFold |
Q8C5T4 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000031437
AA Change: D179G
PolyPhen 2
Score 0.797 (Sensitivity: 0.84; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000031437
Gene: ENSMUSG00000029477
AA Change: D179G
| Domain | Start | End | E-Value | Type |
|---|
|
MORN
|
36 |
57 |
3.24e-4 |
SMART |
|
MORN
|
60 |
81 |
5.18e-3 |
SMART |
|
MORN
|
89 |
110 |
3.51e0 |
SMART |
|
MORN
|
112 |
133 |
3.09e-1 |
SMART |
|
MORN
|
135 |
156 |
1.15e-4 |
SMART |
|
MORN
|
158 |
179 |
2.57e-1 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000045843
|
| SMART Domains |
Protein: ENSMUSP00000041714
Gene: ENSMUSG00000029477
| Domain | Start | End | E-Value | Type |
|---|
|
MORN
|
36 |
57 |
3.24e-4 |
SMART |
|
MORN
|
60 |
81 |
5.18e-3 |
SMART |
|
MORN
|
89 |
110 |
3.51e0 |
SMART |
|
MORN
|
112 |
133 |
3.09e-1 |
SMART |
|
MORN
|
135 |
156 |
2.26e-3 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000129934
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000132775
|
| SMART Domains |
Protein: ENSMUSP00000120199
Gene: ENSMUSG00000029477
| Domain | Start | End | E-Value | Type |
|---|
|
MORN
|
36 |
57 |
3.24e-4 |
SMART |
|
MORN
|
60 |
81 |
5.18e-3 |
SMART |
|
MORN
|
89 |
110 |
3.51e0 |
SMART |
|
MORN
|
112 |
133 |
3.09e-1 |
SMART |
|
MORN
|
135 |
156 |
2.26e-3 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000137490
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000145257
|
| SMART Domains |
Protein: ENSMUSP00000122306
Gene: ENSMUSG00000029477
| Domain | Start | End | E-Value | Type |
|---|
|
MORN
|
36 |
57 |
3.24e-4 |
SMART |
|
MORN
|
60 |
81 |
5.18e-3 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000197455
|
| Meta Mutation Damage Score |
0.1001 |
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.5%
- 10x: 97.6%
- 20x: 92.6%
|
| Validation Efficiency |
100% (29/29) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 28 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcc2 |
T |
A |
19: 43,807,942 (GRCm39) |
M861K |
probably benign |
Het |
| Abhd18 |
T |
A |
3: 40,864,979 (GRCm39) |
F73L |
probably damaging |
Het |
| Abraxas1 |
A |
G |
5: 100,955,777 (GRCm39) |
V237A |
probably benign |
Het |
| Adam26b |
T |
C |
8: 43,974,378 (GRCm39) |
Y208C |
probably damaging |
Het |
| Aire |
A |
G |
10: 77,878,903 (GRCm39) |
L48P |
probably damaging |
Het |
| Bach2 |
A |
T |
4: 32,563,324 (GRCm39) |
E597V |
probably damaging |
Het |
| Ccdc170 |
A |
T |
10: 4,470,851 (GRCm39) |
R232* |
probably null |
Het |
| Cfap100 |
A |
C |
6: 90,396,373 (GRCm39) |
|
probably benign |
Het |
| Dppa2 |
G |
A |
16: 48,136,204 (GRCm39) |
M185I |
probably benign |
Het |
| Ecsit |
C |
T |
9: 21,989,443 (GRCm39) |
|
probably null |
Het |
| Fbxw26 |
A |
G |
9: 109,547,033 (GRCm39) |
I464T |
possibly damaging |
Het |
| Grm8 |
T |
C |
6: 27,760,220 (GRCm39) |
K370R |
probably benign |
Het |
| Ide |
C |
T |
19: 37,249,549 (GRCm39) |
|
probably null |
Het |
| Katnip |
T |
A |
7: 125,449,545 (GRCm39) |
W870R |
probably damaging |
Het |
| Nkapd1 |
A |
G |
9: 50,519,142 (GRCm39) |
S157P |
probably damaging |
Het |
| Nvl |
A |
T |
1: 180,964,471 (GRCm39) |
D102E |
probably benign |
Het |
| Or5an10 |
T |
A |
19: 12,276,467 (GRCm39) |
I10F |
probably benign |
Het |
| Rbm5 |
G |
A |
9: 107,622,141 (GRCm39) |
P611L |
probably damaging |
Het |
| Rsph9 |
A |
G |
17: 46,440,406 (GRCm39) |
M230T |
probably benign |
Het |
| Sacs |
G |
A |
14: 61,442,648 (GRCm39) |
V1565M |
probably damaging |
Het |
| Serpina3n |
T |
C |
12: 104,375,288 (GRCm39) |
L120P |
probably damaging |
Het |
| Spsb2 |
A |
C |
6: 124,786,711 (GRCm39) |
E148A |
probably benign |
Het |
| Tmc2 |
T |
A |
2: 130,089,896 (GRCm39) |
M627K |
probably damaging |
Het |
| Tmem147 |
T |
C |
7: 30,427,484 (GRCm39) |
D111G |
probably damaging |
Het |
| Ttn |
A |
G |
2: 76,572,725 (GRCm39) |
V17729A |
possibly damaging |
Het |
| Vmn2r104 |
G |
A |
17: 20,261,970 (GRCm39) |
P387S |
probably damaging |
Het |
| Zfp940 |
C |
T |
7: 29,544,477 (GRCm39) |
V477M |
possibly damaging |
Het |
| Zw10 |
A |
G |
9: 48,988,745 (GRCm39) |
|
probably null |
Het |
|
| Other mutations in Morn3 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01925:Morn3
|
APN |
5 |
123,184,825 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02257:Morn3
|
APN |
5 |
123,175,788 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02516:Morn3
|
APN |
5 |
123,175,363 (GRCm39) |
nonsense |
probably null |
|
|
R0052:Morn3
|
UTSW |
5 |
123,184,726 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0052:Morn3
|
UTSW |
5 |
123,184,726 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0433:Morn3
|
UTSW |
5 |
123,177,396 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1854:Morn3
|
UTSW |
5 |
123,184,692 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4893:Morn3
|
UTSW |
5 |
123,175,745 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5854:Morn3
|
UTSW |
5 |
123,179,178 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5899:Morn3
|
UTSW |
5 |
123,179,166 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6106:Morn3
|
UTSW |
5 |
123,184,823 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R6766:Morn3
|
UTSW |
5 |
123,179,270 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7512:Morn3
|
UTSW |
5 |
123,175,343 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8722:Morn3
|
UTSW |
5 |
123,179,177 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8780:Morn3
|
UTSW |
5 |
123,175,825 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9782:Morn3
|
UTSW |
5 |
123,175,822 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Morn3
|
UTSW |
5 |
123,184,783 (GRCm39) |
frame shift |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- GCTGGTTGGTTGCTAGAAAAC -3'
(R):5'- AGAGCTAGCACACACTGGTC -3'
Sequencing Primer
(F):5'- GATTTAAACGCGTGTGCCAC -3'
(R):5'- ACACACTGGTCAGCAGCTG -3'
|
| Posted On |
2017-06-26 |
Incidental Mutation