Incidental Mutation 'R5987:Sin3a'
| ID |
481742 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Sin3a
|
| Ensembl Gene |
ENSMUSG00000042557 |
| Gene Name |
transcriptional regulator, SIN3A (yeast) |
| Synonyms |
Sin3, mSin3A |
| MMRRC Submission |
044167-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R5987 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
9 |
| Chromosomal Location |
56979324-57035650 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 57034484 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Glycine
at position 1219
(D1219G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000128956
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000034836]
[ENSMUST00000049169]
[ENSMUST00000159130]
[ENSMUST00000160147]
[ENSMUST00000168502]
[ENSMUST00000167715]
[ENSMUST00000168678]
[ENSMUST00000168177]
[ENSMUST00000161663]
[ENSMUST00000160584]
[ENSMUST00000161182]
[ENSMUST00000162915]
[ENSMUST00000161393]
|
| AlphaFold |
Q60520 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000034836
|
| SMART Domains |
Protein: ENSMUSP00000034836
Gene: ENSMUSG00000032295
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
187 |
195 |
N/A |
INTRINSIC |
|
Pfam:Glyco_hydro_38
|
251 |
510 |
4.3e-89 |
PFAM |
|
Alpha-mann_mid
|
516 |
593 |
1.37e-26 |
SMART |
|
low complexity region
|
603 |
613 |
N/A |
INTRINSIC |
|
Pfam:Glyco_hydro_38C
|
619 |
1029 |
1.3e-84 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000049169
AA Change: D1216G
PolyPhen 2
Score 0.405 (Sensitivity: 0.89; Specificity: 0.89)
|
| SMART Domains |
Protein: ENSMUSP00000045044
Gene: ENSMUSG00000042557
AA Change: D1216G
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
98 |
119 |
N/A |
INTRINSIC |
|
Pfam:PAH
|
141 |
187 |
1.4e-19 |
PFAM |
|
low complexity region
|
217 |
248 |
N/A |
INTRINSIC |
|
low complexity region
|
267 |
282 |
N/A |
INTRINSIC |
|
Pfam:PAH
|
322 |
381 |
1.8e-23 |
PFAM |
|
Pfam:PAH
|
478 |
524 |
4e-16 |
PFAM |
|
HDAC_interact
|
551 |
651 |
3.31e-61 |
SMART |
|
low complexity region
|
834 |
847 |
N/A |
INTRINSIC |
|
low complexity region
|
915 |
930 |
N/A |
INTRINSIC |
|
low complexity region
|
1135 |
1151 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000125333
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000142077
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000159130
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000160122
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000160147
|
| SMART Domains |
Protein: ENSMUSP00000125478
Gene: ENSMUSG00000032295
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
187 |
195 |
N/A |
INTRINSIC |
|
Pfam:Glyco_hydro_38
|
251 |
510 |
2.8e-86 |
PFAM |
|
Alpha-mann_mid
|
516 |
595 |
1.22e-32 |
SMART |
|
low complexity region
|
605 |
615 |
N/A |
INTRINSIC |
|
Pfam:Glyco_hydro_38C
|
621 |
1031 |
1.2e-84 |
PFAM |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000168502
AA Change: D1219G
PolyPhen 2
Score 0.745 (Sensitivity: 0.85; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000128956
Gene: ENSMUSG00000042557
AA Change: D1219G
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
98 |
119 |
N/A |
INTRINSIC |
|
Pfam:PAH
|
141 |
187 |
1.4e-19 |
PFAM |
|
low complexity region
|
217 |
248 |
N/A |
INTRINSIC |
|
low complexity region
|
267 |
282 |
N/A |
INTRINSIC |
|
Pfam:PAH
|
322 |
381 |
1.8e-23 |
PFAM |
|
Pfam:PAH
|
478 |
524 |
4e-16 |
PFAM |
|
HDAC_interact
|
551 |
651 |
3.31e-61 |
SMART |
|
low complexity region
|
834 |
847 |
N/A |
INTRINSIC |
|
low complexity region
|
915 |
930 |
N/A |
INTRINSIC |
|
low complexity region
|
1138 |
1154 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000167715
AA Change: D1216G
PolyPhen 2
Score 0.405 (Sensitivity: 0.89; Specificity: 0.89)
|
| SMART Domains |
Protein: ENSMUSP00000130641
Gene: ENSMUSG00000042557
AA Change: D1216G
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
98 |
119 |
N/A |
INTRINSIC |
|
Pfam:PAH
|
141 |
187 |
1.4e-19 |
PFAM |
|
low complexity region
|
217 |
248 |
N/A |
INTRINSIC |
|
low complexity region
|
267 |
282 |
N/A |
INTRINSIC |
|
Pfam:PAH
|
322 |
381 |
1.8e-23 |
PFAM |
|
Pfam:PAH
|
478 |
524 |
4e-16 |
PFAM |
|
HDAC_interact
|
551 |
651 |
3.31e-61 |
SMART |
|
low complexity region
|
834 |
847 |
N/A |
INTRINSIC |
|
low complexity region
|
915 |
930 |
N/A |
INTRINSIC |
|
low complexity region
|
1135 |
1151 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000168678
AA Change: D1216G
PolyPhen 2
Score 0.405 (Sensitivity: 0.89; Specificity: 0.89)
|
| SMART Domains |
Protein: ENSMUSP00000126601
Gene: ENSMUSG00000042557
AA Change: D1216G
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
98 |
119 |
N/A |
INTRINSIC |
|
Pfam:PAH
|
141 |
187 |
1.4e-19 |
PFAM |
|
low complexity region
|
217 |
248 |
N/A |
INTRINSIC |
|
low complexity region
|
267 |
282 |
N/A |
INTRINSIC |
|
Pfam:PAH
|
322 |
381 |
1.8e-23 |
PFAM |
|
Pfam:PAH
|
478 |
524 |
4e-16 |
PFAM |
|
HDAC_interact
|
551 |
651 |
3.31e-61 |
SMART |
|
low complexity region
|
834 |
847 |
N/A |
INTRINSIC |
|
low complexity region
|
915 |
930 |
N/A |
INTRINSIC |
|
low complexity region
|
1135 |
1151 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000168177
AA Change: D1219G
PolyPhen 2
Score 0.745 (Sensitivity: 0.85; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000130221
Gene: ENSMUSG00000042557
AA Change: D1219G
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
98 |
119 |
N/A |
INTRINSIC |
|
Pfam:PAH
|
142 |
186 |
5.3e-22 |
PFAM |
|
low complexity region
|
217 |
248 |
N/A |
INTRINSIC |
|
low complexity region
|
267 |
282 |
N/A |
INTRINSIC |
|
Pfam:PAH
|
323 |
380 |
9.6e-22 |
PFAM |
|
Pfam:PAH
|
479 |
523 |
8.1e-11 |
PFAM |
|
HDAC_interact
|
551 |
651 |
3.31e-61 |
SMART |
|
low complexity region
|
834 |
847 |
N/A |
INTRINSIC |
|
Pfam:Sin3a_C
|
887 |
1190 |
1.2e-93 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000162738
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000167963
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000161696
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000162340
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000161663
|
| SMART Domains |
Protein: ENSMUSP00000124124
Gene: ENSMUSG00000032295
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
187 |
195 |
N/A |
INTRINSIC |
|
Pfam:Glyco_hydro_38
|
302 |
551 |
1.8e-81 |
PFAM |
|
Alpha-mann_mid
|
557 |
636 |
1.22e-32 |
SMART |
|
low complexity region
|
646 |
656 |
N/A |
INTRINSIC |
|
Pfam:Glyco_hydro_38C
|
662 |
866 |
1.2e-25 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000160584
|
| SMART Domains |
Protein: ENSMUSP00000123840
Gene: ENSMUSG00000032295
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
187 |
195 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000161182
|
| SMART Domains |
Protein: ENSMUSP00000124020
Gene: ENSMUSG00000032295
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Glyco_hydro_38
|
175 |
411 |
9.4e-67 |
PFAM |
|
Alpha-mann_mid
|
417 |
496 |
1.22e-32 |
SMART |
|
low complexity region
|
506 |
516 |
N/A |
INTRINSIC |
|
Pfam:Glyco_hydro_38C
|
522 |
932 |
1.1e-84 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000162915
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000161393
|
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.4%
- 10x: 97.2%
- 20x: 91.2%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a transcriptional regulatory protein. It contains paired amphipathic helix (PAH) domains, which are important for protein-protein interactions and may mediate repression by the Mad-Max complex. [provided by RefSeq, Jul 2008]
PHENOTYPE: Targeted disruption of this gene results in early embryonic lethality. Homozygous null MEFs display poor cell proliferation, reduced S-phase and increased G2/M fractions, a block in DNA replication, and enhanced apoptosis; however, no increase in chromosomal instability is observed. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 93 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca12 |
A |
C |
1: 71,297,257 (GRCm39) |
L2411R |
probably damaging |
Het |
| Als2 |
A |
G |
1: 59,245,746 (GRCm39) |
W577R |
probably damaging |
Het |
| Aox1 |
C |
A |
1: 58,346,518 (GRCm39) |
R551S |
probably benign |
Het |
| Areg |
A |
T |
5: 91,294,577 (GRCm39) |
H245L |
possibly damaging |
Het |
| Arhgap35 |
T |
C |
7: 16,297,392 (GRCm39) |
T558A |
possibly damaging |
Het |
| Arhgef28 |
A |
T |
13: 98,073,368 (GRCm39) |
C1322* |
probably null |
Het |
| Arhgef38 |
T |
C |
3: 132,912,719 (GRCm39) |
R107G |
possibly damaging |
Het |
| Atf7ip |
T |
A |
6: 136,548,500 (GRCm39) |
F695L |
probably damaging |
Het |
| AW209491 |
C |
T |
13: 14,812,365 (GRCm39) |
A406V |
probably benign |
Het |
| Bche |
T |
G |
3: 73,556,011 (GRCm39) |
Q549P |
possibly damaging |
Het |
| Blnk |
A |
G |
19: 40,917,733 (GRCm39) |
F417L |
possibly damaging |
Het |
| Bloc1s1 |
T |
G |
10: 128,759,255 (GRCm39) |
K17T |
probably damaging |
Het |
| C330018D20Rik |
G |
T |
18: 57,090,968 (GRCm39) |
T65K |
probably damaging |
Het |
| Ccdc168 |
A |
T |
1: 44,096,417 (GRCm39) |
N1560K |
probably benign |
Het |
| Cers1 |
T |
A |
8: 70,774,228 (GRCm39) |
S162T |
possibly damaging |
Het |
| Cgn |
T |
C |
3: 94,686,832 (GRCm39) |
K157E |
probably benign |
Het |
| Cldn7 |
G |
A |
11: 69,858,494 (GRCm39) |
R196Q |
probably benign |
Het |
| Clrn2 |
C |
A |
5: 45,611,369 (GRCm39) |
Q73K |
probably benign |
Het |
| Cmss1 |
A |
G |
16: 57,122,608 (GRCm39) |
V262A |
probably benign |
Het |
| Cpb2 |
T |
A |
14: 75,498,128 (GRCm39) |
V97E |
probably damaging |
Het |
| Ctnnd2 |
G |
A |
15: 30,683,387 (GRCm39) |
V463I |
probably benign |
Het |
| Cyp7a1 |
A |
T |
4: 6,268,476 (GRCm39) |
S416R |
probably benign |
Het |
| Dip2b |
C |
T |
15: 100,087,960 (GRCm39) |
R965C |
probably damaging |
Het |
| Dkk3 |
T |
C |
7: 111,749,865 (GRCm39) |
T102A |
probably benign |
Het |
| Dmap1 |
C |
A |
4: 117,538,039 (GRCm39) |
|
probably null |
Het |
| Dnah12 |
C |
A |
14: 26,608,828 (GRCm39) |
D3872E |
possibly damaging |
Het |
| Dnah7b |
A |
G |
1: 46,158,558 (GRCm39) |
|
probably null |
Het |
| Dnai1 |
C |
T |
4: 41,632,391 (GRCm39) |
T575I |
probably benign |
Het |
| Dsg1a |
T |
A |
18: 20,464,599 (GRCm39) |
Y365N |
probably damaging |
Het |
| Dusp11 |
T |
A |
6: 85,936,215 (GRCm39) |
K18* |
probably null |
Het |
| E2f2 |
A |
T |
4: 135,900,245 (GRCm39) |
T52S |
probably benign |
Het |
| Elavl4 |
A |
G |
4: 110,147,841 (GRCm39) |
L13S |
probably benign |
Het |
| Epor |
T |
C |
9: 21,873,572 (GRCm39) |
D59G |
possibly damaging |
Het |
| Eral1 |
A |
G |
11: 77,971,059 (GRCm39) |
C43R |
possibly damaging |
Het |
| Fam135b |
A |
G |
15: 71,362,697 (GRCm39) |
V228A |
probably benign |
Het |
| Gba1 |
T |
C |
3: 89,113,129 (GRCm39) |
S187P |
probably damaging |
Het |
| Gcc2 |
G |
T |
10: 58,091,669 (GRCm39) |
|
probably benign |
Het |
| Gdap2 |
C |
A |
3: 100,109,572 (GRCm39) |
|
probably benign |
Het |
| Gm10271 |
A |
T |
10: 116,808,497 (GRCm39) |
F6L |
probably damaging |
Het |
| Gm10801 |
C |
CGTG |
2: 98,494,152 (GRCm39) |
|
probably null |
Het |
| Gpr160 |
T |
C |
3: 30,950,612 (GRCm39) |
L228P |
probably benign |
Het |
| Gsdmc2 |
A |
C |
15: 63,702,715 (GRCm39) |
V184G |
probably benign |
Het |
| Gtf2e2 |
A |
T |
8: 34,266,080 (GRCm39) |
K252M |
probably damaging |
Het |
| Gtf2e2 |
G |
T |
8: 34,266,081 (GRCm39) |
K252N |
probably benign |
Het |
| Gys1 |
T |
C |
7: 45,087,529 (GRCm39) |
Y102H |
probably benign |
Het |
| H4c2 |
A |
G |
13: 23,941,209 (GRCm39) |
D69G |
probably damaging |
Het |
| Ifit3b |
A |
C |
19: 34,589,598 (GRCm39) |
D258A |
probably damaging |
Het |
| Itpr3 |
T |
A |
17: 27,323,575 (GRCm39) |
M1200K |
probably damaging |
Het |
| Kcng4 |
A |
T |
8: 120,353,098 (GRCm39) |
F271I |
probably damaging |
Het |
| Klhdc2 |
C |
T |
12: 69,350,387 (GRCm39) |
S144L |
possibly damaging |
Het |
| Lhcgr |
A |
G |
17: 89,063,006 (GRCm39) |
F222S |
probably damaging |
Het |
| Lrp5 |
C |
G |
19: 3,678,299 (GRCm39) |
G519R |
probably damaging |
Het |
| Magel2 |
T |
C |
7: 62,028,515 (GRCm39) |
V473A |
probably benign |
Het |
| Map1a |
T |
C |
2: 121,134,776 (GRCm39) |
V1864A |
possibly damaging |
Het |
| Mast4 |
T |
A |
13: 102,895,242 (GRCm39) |
Q760H |
probably damaging |
Het |
| Mertk |
A |
G |
2: 128,613,294 (GRCm39) |
N437D |
probably benign |
Het |
| Mettl18 |
G |
A |
1: 163,824,344 (GRCm39) |
V222I |
probably benign |
Het |
| Mical2 |
C |
T |
7: 111,934,155 (GRCm39) |
T782M |
probably benign |
Het |
| Mocos |
T |
A |
18: 24,819,750 (GRCm39) |
V664E |
probably damaging |
Het |
| Neb |
G |
T |
2: 52,185,306 (GRCm39) |
N975K |
probably benign |
Het |
| Nectin3 |
A |
T |
16: 46,284,508 (GRCm39) |
S59T |
probably benign |
Het |
| Nelfb |
A |
T |
2: 25,093,900 (GRCm39) |
M11K |
probably damaging |
Het |
| Nrp1 |
A |
G |
8: 129,202,650 (GRCm39) |
N545S |
probably damaging |
Het |
| Or10ak11 |
T |
C |
4: 118,687,478 (GRCm39) |
D53G |
probably damaging |
Het |
| Or2g1 |
T |
A |
17: 38,107,248 (GRCm39) |
N304K |
probably benign |
Het |
| Or51b4 |
T |
A |
7: 103,530,907 (GRCm39) |
D181V |
probably damaging |
Het |
| Or5b117 |
A |
T |
19: 13,431,324 (GRCm39) |
S186T |
possibly damaging |
Het |
| Or5p67 |
T |
A |
7: 107,922,254 (GRCm39) |
T210S |
probably benign |
Het |
| Or6c70 |
A |
T |
10: 129,710,390 (GRCm39) |
F79I |
probably damaging |
Het |
| Or8g53 |
T |
C |
9: 39,683,836 (GRCm39) |
T87A |
probably benign |
Het |
| P3h1 |
A |
G |
4: 119,103,862 (GRCm39) |
H587R |
probably damaging |
Het |
| Paqr4 |
A |
G |
17: 23,958,832 (GRCm39) |
|
probably null |
Het |
| Pde12 |
A |
G |
14: 26,390,253 (GRCm39) |
V152A |
probably benign |
Het |
| Ppip5k1 |
C |
A |
2: 121,180,972 (GRCm39) |
E45* |
probably null |
Het |
| Ptch2 |
C |
T |
4: 116,967,254 (GRCm39) |
A677V |
probably benign |
Het |
| Rgs12 |
A |
G |
5: 35,177,689 (GRCm39) |
N93S |
probably damaging |
Het |
| Rif1 |
C |
G |
2: 51,985,856 (GRCm39) |
L614V |
probably damaging |
Het |
| Rnf32 |
T |
C |
5: 29,408,145 (GRCm39) |
S125P |
probably damaging |
Het |
| Robo4 |
A |
G |
9: 37,322,696 (GRCm39) |
I850V |
probably damaging |
Het |
| Scap |
T |
A |
9: 110,210,219 (GRCm39) |
I876N |
probably damaging |
Het |
| Skint5 |
T |
C |
4: 113,743,005 (GRCm39) |
E354G |
unknown |
Het |
| Spart |
A |
G |
3: 55,033,962 (GRCm39) |
D396G |
probably benign |
Het |
| Spindoc |
G |
A |
19: 7,351,024 (GRCm39) |
S311L |
probably benign |
Het |
| Spta1 |
G |
T |
1: 174,050,894 (GRCm39) |
R1791L |
probably damaging |
Het |
| Tbck |
T |
C |
3: 132,507,278 (GRCm39) |
I750T |
possibly damaging |
Het |
| Tmem191 |
T |
C |
16: 17,094,334 (GRCm39) |
|
probably null |
Het |
| Trgv1 |
A |
T |
13: 19,524,474 (GRCm39) |
Y66F |
probably benign |
Het |
| Vmn2r125 |
A |
G |
4: 156,702,292 (GRCm39) |
Y26C |
probably damaging |
Het |
| Zbtb17 |
T |
C |
4: 141,192,128 (GRCm39) |
C358R |
possibly damaging |
Het |
| Zfp180 |
G |
A |
7: 23,804,859 (GRCm39) |
G426E |
probably damaging |
Het |
| Zfp445 |
A |
G |
9: 122,682,951 (GRCm39) |
V330A |
probably benign |
Het |
| Zfp595 |
A |
G |
13: 67,465,688 (GRCm39) |
C192R |
probably damaging |
Het |
| Zkscan4 |
A |
G |
13: 21,668,623 (GRCm39) |
H387R |
probably damaging |
Het |
|
| Other mutations in Sin3a |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00433:Sin3a
|
APN |
9 |
57,005,185 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00836:Sin3a
|
APN |
9 |
57,014,629 (GRCm39) |
splice site |
probably null |
|
|
IGL00913:Sin3a
|
APN |
9 |
57,005,402 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01721:Sin3a
|
APN |
9 |
57,002,609 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01964:Sin3a
|
APN |
9 |
57,014,631 (GRCm39) |
splice site |
probably benign |
|
|
IGL02333:Sin3a
|
APN |
9 |
57,014,843 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
IGL02673:Sin3a
|
APN |
9 |
57,014,725 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Crumbled
|
UTSW |
9 |
57,017,938 (GRCm39) |
nonsense |
probably null |
|
|
Delicate
|
UTSW |
9 |
57,011,213 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03014:Sin3a
|
UTSW |
9 |
57,002,539 (GRCm39) |
intron |
probably benign |
|
|
PIT4519001:Sin3a
|
UTSW |
9 |
57,002,740 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R0024:Sin3a
|
UTSW |
9 |
57,025,537 (GRCm39) |
intron |
probably benign |
|
|
R0309:Sin3a
|
UTSW |
9 |
57,018,196 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0511:Sin3a
|
UTSW |
9 |
57,004,179 (GRCm39) |
nonsense |
probably null |
|
|
R1205:Sin3a
|
UTSW |
9 |
57,026,459 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1365:Sin3a
|
UTSW |
9 |
57,032,487 (GRCm39) |
nonsense |
probably null |
|
|
R1496:Sin3a
|
UTSW |
9 |
57,026,442 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R1544:Sin3a
|
UTSW |
9 |
57,011,281 (GRCm39) |
splice site |
probably benign |
|
|
R1958:Sin3a
|
UTSW |
9 |
57,012,893 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1993:Sin3a
|
UTSW |
9 |
57,008,483 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2037:Sin3a
|
UTSW |
9 |
57,004,109 (GRCm39) |
missense |
probably benign |
0.14 |
|
R2065:Sin3a
|
UTSW |
9 |
57,018,084 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R2079:Sin3a
|
UTSW |
9 |
56,996,807 (GRCm39) |
missense |
probably benign |
|
|
R2193:Sin3a
|
UTSW |
9 |
57,024,761 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R3004:Sin3a
|
UTSW |
9 |
57,004,118 (GRCm39) |
nonsense |
probably null |
|
|
R3929:Sin3a
|
UTSW |
9 |
57,025,421 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4326:Sin3a
|
UTSW |
9 |
57,002,642 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4327:Sin3a
|
UTSW |
9 |
57,002,642 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4329:Sin3a
|
UTSW |
9 |
57,002,642 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4765:Sin3a
|
UTSW |
9 |
57,004,087 (GRCm39) |
missense |
probably benign |
0.14 |
|
R4806:Sin3a
|
UTSW |
9 |
56,994,026 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4979:Sin3a
|
UTSW |
9 |
57,025,360 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5018:Sin3a
|
UTSW |
9 |
57,018,175 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5368:Sin3a
|
UTSW |
9 |
57,018,084 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R5379:Sin3a
|
UTSW |
9 |
57,018,272 (GRCm39) |
missense |
probably benign |
0.10 |
|
R5391:Sin3a
|
UTSW |
9 |
57,012,957 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5395:Sin3a
|
UTSW |
9 |
57,012,957 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5519:Sin3a
|
UTSW |
9 |
57,025,457 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5927:Sin3a
|
UTSW |
9 |
57,018,395 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6083:Sin3a
|
UTSW |
9 |
57,014,824 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6161:Sin3a
|
UTSW |
9 |
57,002,708 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R6196:Sin3a
|
UTSW |
9 |
57,011,213 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6374:Sin3a
|
UTSW |
9 |
57,024,765 (GRCm39) |
missense |
probably benign |
|
|
R6456:Sin3a
|
UTSW |
9 |
57,020,985 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R6815:Sin3a
|
UTSW |
9 |
57,024,824 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6900:Sin3a
|
UTSW |
9 |
57,014,858 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7051:Sin3a
|
UTSW |
9 |
57,011,218 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7081:Sin3a
|
UTSW |
9 |
57,001,755 (GRCm39) |
missense |
probably null |
1.00 |
|
R7285:Sin3a
|
UTSW |
9 |
57,034,583 (GRCm39) |
missense |
possibly damaging |
0.57 |
|
R7462:Sin3a
|
UTSW |
9 |
57,002,809 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7538:Sin3a
|
UTSW |
9 |
57,011,210 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R7699:Sin3a
|
UTSW |
9 |
57,017,938 (GRCm39) |
nonsense |
probably null |
|
|
R8150:Sin3a
|
UTSW |
9 |
57,034,568 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R8158:Sin3a
|
UTSW |
9 |
57,020,828 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R8717:Sin3a
|
UTSW |
9 |
57,034,510 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9048:Sin3a
|
UTSW |
9 |
57,032,620 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9283:Sin3a
|
UTSW |
9 |
57,002,717 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9300:Sin3a
|
UTSW |
9 |
57,014,744 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9330:Sin3a
|
UTSW |
9 |
57,032,481 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9396:Sin3a
|
UTSW |
9 |
57,008,445 (GRCm39) |
missense |
probably benign |
0.28 |
|
R9550:Sin3a
|
UTSW |
9 |
56,996,768 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9746:Sin3a
|
UTSW |
9 |
57,025,358 (GRCm39) |
missense |
probably benign |
0.11 |
|
RF017:Sin3a
|
UTSW |
9 |
57,034,610 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
X0026:Sin3a
|
UTSW |
9 |
57,032,476 (GRCm39) |
missense |
probably benign |
0.01 |
|
| Predicted Primers |
PCR Primer
(F):5'- CAGAATGACTGGTGTACAAATAAAGTA -3'
(R):5'- GGGGCTTTGAATACTGTGCCG -3'
Sequencing Primer
(F):5'- CAGGTGGCATATGTCTAATCCCAG -3'
(R):5'- GAATACTGTGCCGTATTTGACACG -3'
|
| Posted On |
2017-06-26 |
Incidental Mutation