Incidental Mutation 'R6021:Akr1b10'
ID 482055
Institutional Source Beutler Lab
Gene Symbol Akr1b10
Ensembl Gene ENSMUSG00000061758
Gene Name aldo-keto reductase family 1, member B10
Synonyms 2310005E10Rik
MMRRC Submission 044194-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.066) question?
Stock # R6021 (G1)
Quality Score 225.009
Status Validated
Chromosome 6
Chromosomal Location 34361182-34373884 bp(+) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) T to A at 34369309 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000110703 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000038383] [ENSMUST00000115051] [ENSMUST00000115051] [ENSMUST00000139156]
AlphaFold G5E895
Predicted Effect probably null
Transcript: ENSMUST00000038383
SMART Domains Protein: ENSMUSP00000039114
Gene: ENSMUSG00000061758

DomainStartEndE-ValueType
Pfam:Aldo_ket_red 15 294 2.1e-61 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000115051
SMART Domains Protein: ENSMUSP00000110703
Gene: ENSMUSG00000061758

DomainStartEndE-ValueType
Pfam:Aldo_ket_red 18 266 2e-53 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000115051
SMART Domains Protein: ENSMUSP00000110703
Gene: ENSMUSG00000061758

DomainStartEndE-ValueType
Pfam:Aldo_ket_red 18 266 2e-53 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000139156
SMART Domains Protein: ENSMUSP00000138639
Gene: ENSMUSG00000061758

DomainStartEndE-ValueType
Pfam:Aldo_ket_red 15 128 2.3e-27 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000144072
Predicted Effect noncoding transcript
Transcript: ENSMUST00000144384
Predicted Effect noncoding transcript
Transcript: ENSMUST00000182055
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.5%
  • 10x: 97.5%
  • 20x: 92.2%
Validation Efficiency 94% (61/65)
Allele List at MGI
Other mutations in this stock
Total: 64 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933427I04Rik A G 4: 123,754,509 (GRCm39) D141G possibly damaging Het
A1bg T C 15: 60,791,713 (GRCm39) E241G possibly damaging Het
Abca13 G A 11: 9,240,465 (GRCm39) W776* probably null Het
Aopep A G 13: 63,208,896 (GRCm39) T338A probably damaging Het
Atf7 T C 15: 102,465,908 (GRCm39) D84G probably benign Het
AW209491 C T 13: 14,812,365 (GRCm39) A406V probably benign Het
Azi2 T A 9: 117,876,487 (GRCm39) M1K probably null Het
Boc T A 16: 44,309,017 (GRCm39) M832L probably benign Het
Brix1 C T 15: 10,476,675 (GRCm39) R267H probably benign Het
Cacna1s T C 1: 136,034,225 (GRCm39) L1050P probably benign Het
Celsr2 G T 3: 108,308,561 (GRCm39) P1789T probably benign Het
Crebbp G A 16: 3,903,282 (GRCm39) R1986C probably damaging Het
Crtam T A 9: 40,901,477 (GRCm39) I150F probably damaging Het
Crybg1 G T 10: 43,873,534 (GRCm39) S1191R probably damaging Het
D630045J12Rik T C 6: 38,167,552 (GRCm39) T1017A probably benign Het
Dnah10 A G 5: 124,814,048 (GRCm39) E396G probably damaging Het
Enpp5 A T 17: 44,396,210 (GRCm39) Y374F probably benign Het
Fzd4 G A 7: 89,056,942 (GRCm39) A330T probably benign Het
Gabra5 A G 7: 57,157,740 (GRCm39) S25P probably benign Het
Get1 T C 16: 95,946,878 (GRCm39) probably benign Het
Ggps1 T C 13: 14,228,589 (GRCm39) Y198C probably damaging Het
Gm3173 A C 14: 15,728,458 (GRCm39) D39A probably damaging Het
Grm2 T C 9: 106,527,999 (GRCm39) D295G probably damaging Het
H2-T13 T G 17: 36,392,166 (GRCm39) E182A probably damaging Het
Igfbp5 A G 1: 72,902,363 (GRCm39) M208T possibly damaging Het
Ildr2 T A 1: 166,131,173 (GRCm39) M343K possibly damaging Het
Kif19b A T 5: 140,455,434 (GRCm39) M347L probably damaging Het
Loxhd1 A T 18: 77,499,946 (GRCm39) D120V probably damaging Het
Lrp1 T C 10: 127,413,883 (GRCm39) D1175G probably damaging Het
Lrp1b C A 2: 41,234,439 (GRCm39) D1171Y probably benign Het
Lrrc9 A T 12: 72,516,005 (GRCm39) I563F probably damaging Het
Ltbp3 A T 19: 5,803,708 (GRCm39) T798S probably benign Het
Msantd4 T A 9: 4,384,063 (GRCm39) V128E probably benign Het
Mtf2 A G 5: 108,229,003 (GRCm39) I69V possibly damaging Het
Myh10 T A 11: 68,699,688 (GRCm39) S1712T possibly damaging Het
Mylk3 A G 8: 86,091,442 (GRCm39) V121A possibly damaging Het
Ndufaf4 A G 4: 24,901,760 (GRCm39) N100D probably benign Het
Notch2 T C 3: 98,029,288 (GRCm39) F1017S probably damaging Het
Or4a27 G T 2: 88,559,294 (GRCm39) Y216* probably null Het
Or4a80 A C 2: 89,582,465 (GRCm39) S236A probably benign Het
Or4c108 G T 2: 88,803,376 (GRCm39) Y286* probably null Het
P2ry2 T C 7: 100,647,607 (GRCm39) T233A probably benign Het
Paip1 T "TTA,TT" 13: 119,593,671 (GRCm39) probably null Het
Pak1 T C 7: 97,503,670 (GRCm39) S2P probably damaging Het
Pde8b A T 13: 95,162,670 (GRCm39) D817E possibly damaging Het
Pfdn2 C A 1: 171,173,338 (GRCm39) probably benign Het
Pramel28 A T 4: 143,692,336 (GRCm39) C222S probably benign Het
Raver1 A G 9: 20,987,918 (GRCm39) L606P probably damaging Het
Robo3 C T 9: 37,333,829 (GRCm39) W668* probably null Het
Rsf1 G GACGGCGGCT 7: 97,229,116 (GRCm39) probably benign Het
Rxfp2 A G 5: 149,987,202 (GRCm39) N337S possibly damaging Het
Samhd1 T C 2: 156,962,474 (GRCm39) probably null Het
Sardh A G 2: 27,079,655 (GRCm39) V879A probably benign Het
Slc4a4 A T 5: 89,188,261 (GRCm39) probably benign Het
Slc6a11 T C 6: 114,207,012 (GRCm39) L332P probably damaging Het
Tas2r135 T C 6: 42,383,321 (GRCm39) Y287H probably damaging Het
Tlr4 T A 4: 66,759,103 (GRCm39) I632N probably damaging Het
Tmem145 C T 7: 25,008,270 (GRCm39) probably null Het
Trmt61a C A 12: 111,647,411 (GRCm39) F169L probably damaging Het
Trp53tg5 T A 2: 164,313,391 (GRCm39) I95L probably benign Het
Vmn1r85 T C 7: 12,818,616 (GRCm39) E176G probably benign Het
Vmn2r75 T C 7: 85,820,820 (GRCm39) D38G probably benign Het
Vmn2r99 A G 17: 19,598,210 (GRCm39) Y78C probably damaging Het
Zfp964 G T 8: 70,115,742 (GRCm39) S114I unknown Het
Other mutations in Akr1b10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00482:Akr1b10 APN 6 34,365,837 (GRCm39) splice site probably benign
IGL00840:Akr1b10 APN 6 34,371,041 (GRCm39) missense possibly damaging 0.61
IGL01906:Akr1b10 APN 6 34,364,746 (GRCm39) missense probably benign
R0552:Akr1b10 UTSW 6 34,369,920 (GRCm39) missense possibly damaging 0.52
R0732:Akr1b10 UTSW 6 34,367,044 (GRCm39) missense probably benign
R1371:Akr1b10 UTSW 6 34,369,394 (GRCm39) missense probably benign 0.28
R1895:Akr1b10 UTSW 6 34,365,805 (GRCm39) missense probably damaging 1.00
R3704:Akr1b10 UTSW 6 34,371,690 (GRCm39) missense probably benign 0.00
R3704:Akr1b10 UTSW 6 34,371,689 (GRCm39) missense probably damaging 0.98
R3975:Akr1b10 UTSW 6 34,369,431 (GRCm39) critical splice donor site probably null
R4020:Akr1b10 UTSW 6 34,369,388 (GRCm39) missense probably benign 0.42
R4573:Akr1b10 UTSW 6 34,369,064 (GRCm39) missense probably damaging 1.00
R5062:Akr1b10 UTSW 6 34,369,041 (GRCm39) missense probably damaging 1.00
R5540:Akr1b10 UTSW 6 34,371,047 (GRCm39) missense probably damaging 1.00
R6012:Akr1b10 UTSW 6 34,364,715 (GRCm39) missense probably damaging 1.00
R6256:Akr1b10 UTSW 6 34,364,623 (GRCm39) missense probably damaging 1.00
R7963:Akr1b10 UTSW 6 34,364,643 (GRCm39) missense possibly damaging 0.93
R8696:Akr1b10 UTSW 6 34,369,067 (GRCm39) missense possibly damaging 0.49
R9049:Akr1b10 UTSW 6 34,373,561 (GRCm39) missense possibly damaging 0.89
R9417:Akr1b10 UTSW 6 34,371,027 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- TGCTTCAACACCAGGAGTTC -3'
(R):5'- TTCTTGTGCCTTGGAAAGTACATAC -3'

Sequencing Primer
(F):5'- ACCAGGAGTTCAATACTGTCTGC -3'
(R):5'- ACAAACTATGAAATGCCAGTTTTAAG -3'
Posted On 2017-06-27