Incidental Mutation 'R6085:Taar7e'
| ID |
482434 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Taar7e
|
| Ensembl Gene |
ENSMUSG00000100689 |
| Gene Name |
trace amine-associated receptor 7E |
| Synonyms |
LOC276742 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.136)
|
| Stock # |
R6085 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
10 |
| Chromosomal Location |
23913512-23914588 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 23913761 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Phenylalanine to Leucine
at position 84
(F84L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000090326
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000092656]
|
| AlphaFold |
Q5QD09 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000092656
AA Change: F84L
PolyPhen 2
Score 0.027 (Sensitivity: 0.95; Specificity: 0.81)
|
| SMART Domains |
Protein: ENSMUSP00000090326
Gene: ENSMUSG00000100689
AA Change: F84L
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7TM_GPCR_Srx
|
56 |
261 |
5.4e-8 |
PFAM |
|
Pfam:7TM_GPCR_Srsx
|
58 |
341 |
4.3e-10 |
PFAM |
|
Pfam:7tm_1
|
64 |
326 |
9.4e-59 |
PFAM |
|
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.6%
- 10x: 98.1%
- 20x: 94.5%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 22 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Boc |
G |
T |
16: 44,308,970 (GRCm39) |
D847E |
probably damaging |
Het |
| Bora |
A |
T |
14: 99,299,730 (GRCm39) |
Q234L |
possibly damaging |
Het |
| Cdk12 |
T |
C |
11: 98,134,255 (GRCm39) |
I1051T |
unknown |
Het |
| Ciita |
A |
G |
16: 10,330,029 (GRCm39) |
E771G |
probably benign |
Het |
| Cul2 |
T |
C |
18: 3,431,508 (GRCm39) |
F638L |
probably benign |
Het |
| Ddx21 |
A |
G |
10: 62,429,866 (GRCm39) |
Y293H |
probably damaging |
Het |
| Dhx8 |
C |
T |
11: 101,655,139 (GRCm39) |
R1050W |
probably damaging |
Het |
| Etv1 |
G |
A |
12: 38,904,194 (GRCm39) |
D285N |
probably damaging |
Het |
| Hs3st3a1 |
G |
A |
11: 64,327,004 (GRCm39) |
V38I |
possibly damaging |
Het |
| Ifit1bl2 |
A |
C |
19: 34,597,217 (GRCm39) |
F133C |
possibly damaging |
Het |
| Lama3 |
C |
T |
18: 12,615,156 (GRCm39) |
T1360I |
probably benign |
Het |
| Mgrn1 |
A |
G |
16: 4,738,240 (GRCm39) |
T265A |
probably benign |
Het |
| Nup155 |
T |
C |
15: 8,177,842 (GRCm39) |
V1075A |
probably damaging |
Het |
| Or1ad6 |
A |
G |
11: 50,859,950 (GRCm39) |
Y35C |
|
Het |
| Pld4 |
A |
G |
12: 112,733,320 (GRCm39) |
T299A |
probably benign |
Het |
| Prr5 |
T |
A |
15: 84,572,106 (GRCm39) |
I38N |
probably damaging |
Het |
| Slc25a47 |
A |
G |
12: 108,820,254 (GRCm39) |
Y86C |
probably benign |
Het |
| Spata31e5 |
T |
C |
1: 28,817,308 (GRCm39) |
I241M |
possibly damaging |
Het |
| Synrg |
A |
T |
11: 83,930,487 (GRCm39) |
E1276D |
possibly damaging |
Het |
| Tssk1 |
G |
A |
16: 17,712,848 (GRCm39) |
C211Y |
possibly damaging |
Het |
| Tymp |
GC |
GCC |
15: 89,258,567 (GRCm39) |
|
probably null |
Het |
| Xpo7 |
A |
T |
14: 70,934,051 (GRCm39) |
S236T |
probably benign |
Het |
|
| Other mutations in Taar7e |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00494:Taar7e
|
APN |
10 |
23,914,038 (GRCm39) |
missense |
probably benign |
|
|
IGL03150:Taar7e
|
APN |
10 |
23,913,528 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL03366:Taar7e
|
APN |
10 |
23,913,813 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2013:Taar7e
|
UTSW |
10 |
23,913,732 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R2095:Taar7e
|
UTSW |
10 |
23,913,949 (GRCm39) |
nonsense |
probably null |
|
|
R4210:Taar7e
|
UTSW |
10 |
23,913,932 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4211:Taar7e
|
UTSW |
10 |
23,913,932 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4766:Taar7e
|
UTSW |
10 |
23,914,464 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6117:Taar7e
|
UTSW |
10 |
23,914,427 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6918:Taar7e
|
UTSW |
10 |
23,913,513 (GRCm39) |
start codon destroyed |
probably null |
0.15 |
|
R7410:Taar7e
|
UTSW |
10 |
23,914,424 (GRCm39) |
missense |
probably benign |
|
|
R7913:Taar7e
|
UTSW |
10 |
23,913,902 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R9008:Taar7e
|
UTSW |
10 |
23,913,810 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9081:Taar7e
|
UTSW |
10 |
23,913,893 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9205:Taar7e
|
UTSW |
10 |
23,913,972 (GRCm39) |
missense |
probably benign |
|
|
R9360:Taar7e
|
UTSW |
10 |
23,913,949 (GRCm39) |
nonsense |
probably null |
|
|
R9465:Taar7e
|
UTSW |
10 |
23,914,310 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R9790:Taar7e
|
UTSW |
10 |
23,913,554 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9791:Taar7e
|
UTSW |
10 |
23,913,554 (GRCm39) |
missense |
probably benign |
0.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GAGCTGTGCTATGAGAACCTG -3'
(R):5'- CAGTAAACCTGGTGGGGTAGATC -3'
Sequencing Primer
(F):5'- CCTGAACAGGTCCTGTGTCAGAAG -3'
(R):5'- GGGGTCACTGACTGCAATATATC -3'
|
| Posted On |
2017-07-14 |
Incidental Mutation