Incidental Mutation 'R6086:Vmn2r26'
| ID |
482478 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r26
|
| Ensembl Gene |
ENSMUSG00000096630 |
| Gene Name |
vomeronasal 2, receptor 26 |
| Synonyms |
V2r1b |
| MMRRC Submission |
044427-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.094)
|
| Stock # |
R6086 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
6 |
| Chromosomal Location |
124001717-124038994 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 124016519 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Threonine
at position 328
(S328T)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000032238
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000032238]
|
| AlphaFold |
Q6TAC4 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000032238
AA Change: S328T
PolyPhen 2
Score 0.482 (Sensitivity: 0.89; Specificity: 0.90)
|
| SMART Domains |
Protein: ENSMUSP00000032238
Gene: ENSMUSG00000096630
AA Change: S328T
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
22 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
82 |
471 |
1.5e-31 |
PFAM |
|
Pfam:NCD3G
|
519 |
572 |
4.6e-25 |
PFAM |
|
Pfam:7tm_3
|
603 |
840 |
1.5e-55 |
PFAM |
|
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.6%
- 10x: 98.2%
- 20x: 94.9%
|
| Validation Efficiency |
96% (65/68) |
| MGI Phenotype |
PHENOTYPE: Mice homozygous for a knock-out allele exhibit abnormal vomeronasal sensory neuron physiology and avnosmia. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 65 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Apob |
G |
T |
12: 8,065,164 (GRCm39) |
K4044N |
probably benign |
Het |
| Asic4 |
G |
A |
1: 75,449,887 (GRCm39) |
V468I |
possibly damaging |
Het |
| Atf4 |
T |
A |
15: 80,141,654 (GRCm39) |
V348D |
probably benign |
Het |
| Bcl9 |
A |
G |
3: 97,112,840 (GRCm39) |
V1205A |
possibly damaging |
Het |
| Bora |
A |
T |
14: 99,299,730 (GRCm39) |
Q234L |
possibly damaging |
Het |
| Cap2 |
C |
A |
13: 46,789,188 (GRCm39) |
P131Q |
probably damaging |
Het |
| Cdyl2 |
A |
G |
8: 117,316,035 (GRCm39) |
S318P |
probably damaging |
Het |
| Ces1a |
T |
G |
8: 93,753,981 (GRCm39) |
N341H |
probably benign |
Het |
| Cimap2 |
T |
C |
4: 106,470,403 (GRCm39) |
E218G |
probably damaging |
Het |
| Crlf3 |
C |
T |
11: 79,939,436 (GRCm39) |
V352M |
possibly damaging |
Het |
| Cybb |
C |
G |
X: 9,316,989 (GRCm39) |
D246H |
probably benign |
Het |
| Cyren |
A |
G |
6: 34,851,555 (GRCm39) |
S127P |
probably damaging |
Het |
| Dnah2 |
T |
C |
11: 69,406,834 (GRCm39) |
T529A |
probably benign |
Het |
| Dnah9 |
C |
T |
11: 65,880,741 (GRCm39) |
D2619N |
probably damaging |
Het |
| Dnah9 |
A |
C |
11: 65,976,000 (GRCm39) |
S1350A |
probably benign |
Het |
| Dnajc6 |
C |
T |
4: 101,455,004 (GRCm39) |
S65L |
probably benign |
Het |
| Dnm3 |
C |
A |
1: 162,148,602 (GRCm39) |
R256S |
probably damaging |
Het |
| Enpp2 |
T |
C |
15: 54,709,230 (GRCm39) |
D795G |
probably damaging |
Het |
| Fah |
A |
T |
7: 84,238,120 (GRCm39) |
W367R |
probably damaging |
Het |
| Fam220a |
T |
A |
5: 143,548,796 (GRCm39) |
H69Q |
probably benign |
Het |
| Fgd3 |
T |
A |
13: 49,440,772 (GRCm39) |
T220S |
probably benign |
Het |
| Furin |
G |
T |
7: 80,045,179 (GRCm39) |
H248Q |
probably damaging |
Het |
| Gabrg1 |
A |
T |
5: 70,911,396 (GRCm39) |
L410Q |
probably damaging |
Het |
| Gm10801 |
AAGT |
AAGTAGT |
2: 98,494,148 (GRCm39) |
|
probably null |
Het |
| Gm9742 |
T |
C |
13: 8,080,069 (GRCm39) |
|
noncoding transcript |
Het |
| Gpcpd1 |
A |
G |
2: 132,380,034 (GRCm39) |
S252P |
probably damaging |
Het |
| Hnrnpdl |
C |
T |
5: 100,184,340 (GRCm39) |
G398S |
probably null |
Het |
| Hspa1l |
T |
C |
17: 35,197,131 (GRCm39) |
V390A |
possibly damaging |
Het |
| Htr3b |
T |
C |
9: 48,858,598 (GRCm39) |
S94G |
probably benign |
Het |
| Klf10 |
G |
T |
15: 38,297,181 (GRCm39) |
S271R |
probably benign |
Het |
| Klk1b3 |
T |
A |
7: 43,851,158 (GRCm39) |
L197Q |
probably damaging |
Het |
| Knl1 |
A |
G |
2: 118,924,549 (GRCm39) |
R1861G |
probably damaging |
Het |
| Myo9a |
C |
T |
9: 59,697,340 (GRCm39) |
Q374* |
probably null |
Het |
| Myt1l |
G |
A |
12: 29,882,331 (GRCm39) |
G509R |
unknown |
Het |
| Ncapg |
T |
C |
5: 45,850,578 (GRCm39) |
L728P |
probably damaging |
Het |
| Nfxl1 |
A |
C |
5: 72,698,362 (GRCm39) |
F228V |
probably benign |
Het |
| Ntaq1 |
C |
A |
15: 58,014,024 (GRCm39) |
A71E |
probably damaging |
Het |
| Oc90 |
A |
G |
15: 65,761,560 (GRCm39) |
S153P |
probably damaging |
Het |
| Or4c123 |
A |
G |
2: 89,127,198 (GRCm39) |
C139R |
probably damaging |
Het |
| Or5b105 |
A |
G |
19: 13,079,745 (GRCm39) |
*308Q |
probably null |
Het |
| Pbk |
A |
T |
14: 66,052,702 (GRCm39) |
K182* |
probably null |
Het |
| Piezo1 |
A |
G |
8: 123,228,396 (GRCm39) |
F296S |
possibly damaging |
Het |
| Psmg1 |
T |
A |
16: 95,781,244 (GRCm39) |
Y288F |
probably damaging |
Het |
| Rab11fip4 |
G |
A |
11: 79,574,306 (GRCm39) |
D132N |
probably damaging |
Het |
| Recql4 |
T |
C |
15: 76,588,787 (GRCm39) |
D1051G |
probably damaging |
Het |
| Reep5 |
A |
C |
18: 34,490,184 (GRCm39) |
D104E |
probably damaging |
Het |
| Rnpepl1 |
T |
C |
1: 92,845,403 (GRCm39) |
Y441H |
probably damaging |
Het |
| Scnm1 |
T |
C |
3: 95,037,596 (GRCm39) |
I157V |
probably benign |
Het |
| Sema3b |
T |
C |
9: 107,478,047 (GRCm39) |
D446G |
probably damaging |
Het |
| Sema4d |
C |
T |
13: 51,867,781 (GRCm39) |
R190Q |
probably damaging |
Het |
| Slco3a1 |
G |
A |
7: 73,968,338 (GRCm39) |
R461C |
possibly damaging |
Het |
| Spmap2l |
T |
A |
5: 77,209,152 (GRCm39) |
V458E |
probably benign |
Het |
| Tenm2 |
T |
A |
11: 35,899,473 (GRCm39) |
I2562F |
possibly damaging |
Het |
| Tmem40 |
G |
T |
6: 115,710,628 (GRCm39) |
N120K |
possibly damaging |
Het |
| Tmod3 |
T |
C |
9: 75,407,405 (GRCm39) |
H351R |
probably benign |
Het |
| Tnn |
C |
T |
1: 159,913,690 (GRCm39) |
V1268M |
probably damaging |
Het |
| Tpmt |
T |
A |
13: 47,188,506 (GRCm39) |
D132V |
probably damaging |
Het |
| Trgc3 |
T |
C |
13: 19,447,454 (GRCm39) |
S136P |
probably damaging |
Het |
| Trib1 |
G |
A |
15: 59,526,324 (GRCm39) |
R298H |
probably damaging |
Het |
| Tsen2 |
A |
G |
6: 115,537,036 (GRCm39) |
E264G |
probably benign |
Het |
| Urah |
A |
G |
7: 140,416,711 (GRCm39) |
I60M |
probably benign |
Het |
| Vmn2r27 |
G |
C |
6: 124,168,958 (GRCm39) |
T724R |
probably damaging |
Het |
| Washc2 |
A |
G |
6: 116,233,177 (GRCm39) |
|
probably null |
Het |
| Zfp955b |
T |
A |
17: 33,521,478 (GRCm39) |
W316R |
probably benign |
Het |
| Zranb2 |
T |
C |
3: 157,248,883 (GRCm39) |
|
probably null |
Het |
|
| Other mutations in Vmn2r26 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01070:Vmn2r26
|
APN |
6 |
124,038,566 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01370:Vmn2r26
|
APN |
6 |
124,038,715 (GRCm39) |
missense |
probably benign |
0.08 |
|
IGL01603:Vmn2r26
|
APN |
6 |
124,030,833 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01651:Vmn2r26
|
APN |
6 |
124,027,632 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02282:Vmn2r26
|
APN |
6 |
124,038,584 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02425:Vmn2r26
|
APN |
6 |
124,038,777 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02551:Vmn2r26
|
APN |
6 |
124,003,100 (GRCm39) |
missense |
probably benign |
0.11 |
|
IGL02690:Vmn2r26
|
APN |
6 |
124,003,091 (GRCm39) |
missense |
probably benign |
0.14 |
|
IGL03002:Vmn2r26
|
APN |
6 |
124,016,754 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
IGL03270:Vmn2r26
|
APN |
6 |
124,027,778 (GRCm39) |
missense |
probably benign |
0.16 |
|
R0032:Vmn2r26
|
UTSW |
6 |
124,016,858 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R0052:Vmn2r26
|
UTSW |
6 |
124,038,992 (GRCm39) |
makesense |
probably null |
|
|
R0083:Vmn2r26
|
UTSW |
6 |
124,030,940 (GRCm39) |
splice site |
probably null |
|
|
R0682:Vmn2r26
|
UTSW |
6 |
124,038,129 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1061:Vmn2r26
|
UTSW |
6 |
124,038,603 (GRCm39) |
missense |
probably benign |
0.12 |
|
R1077:Vmn2r26
|
UTSW |
6 |
124,030,872 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1263:Vmn2r26
|
UTSW |
6 |
124,027,667 (GRCm39) |
missense |
probably benign |
|
|
R1579:Vmn2r26
|
UTSW |
6 |
124,016,706 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1741:Vmn2r26
|
UTSW |
6 |
124,038,431 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1834:Vmn2r26
|
UTSW |
6 |
124,038,369 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R1838:Vmn2r26
|
UTSW |
6 |
124,001,730 (GRCm39) |
missense |
probably benign |
|
|
R1956:Vmn2r26
|
UTSW |
6 |
124,030,846 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1996:Vmn2r26
|
UTSW |
6 |
124,038,144 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2140:Vmn2r26
|
UTSW |
6 |
124,038,196 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2327:Vmn2r26
|
UTSW |
6 |
124,016,708 (GRCm39) |
missense |
probably benign |
0.07 |
|
R2417:Vmn2r26
|
UTSW |
6 |
124,038,309 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3930:Vmn2r26
|
UTSW |
6 |
124,002,938 (GRCm39) |
missense |
probably benign |
|
|
R4490:Vmn2r26
|
UTSW |
6 |
124,027,697 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R4629:Vmn2r26
|
UTSW |
6 |
124,038,150 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R4655:Vmn2r26
|
UTSW |
6 |
124,038,375 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4709:Vmn2r26
|
UTSW |
6 |
124,030,924 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4992:Vmn2r26
|
UTSW |
6 |
124,003,070 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5297:Vmn2r26
|
UTSW |
6 |
124,038,832 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5482:Vmn2r26
|
UTSW |
6 |
124,038,285 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R5517:Vmn2r26
|
UTSW |
6 |
124,027,676 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5737:Vmn2r26
|
UTSW |
6 |
124,016,408 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5739:Vmn2r26
|
UTSW |
6 |
124,002,925 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5873:Vmn2r26
|
UTSW |
6 |
124,038,633 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5907:Vmn2r26
|
UTSW |
6 |
124,016,830 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6134:Vmn2r26
|
UTSW |
6 |
124,038,444 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6391:Vmn2r26
|
UTSW |
6 |
124,038,348 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6428:Vmn2r26
|
UTSW |
6 |
124,003,039 (GRCm39) |
missense |
probably benign |
0.17 |
|
R6637:Vmn2r26
|
UTSW |
6 |
124,038,650 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6927:Vmn2r26
|
UTSW |
6 |
124,016,057 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R6953:Vmn2r26
|
UTSW |
6 |
124,016,741 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7173:Vmn2r26
|
UTSW |
6 |
124,038,255 (GRCm39) |
missense |
probably benign |
0.16 |
|
R7206:Vmn2r26
|
UTSW |
6 |
124,016,727 (GRCm39) |
missense |
probably benign |
0.17 |
|
R7208:Vmn2r26
|
UTSW |
6 |
124,038,948 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7283:Vmn2r26
|
UTSW |
6 |
124,002,914 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7506:Vmn2r26
|
UTSW |
6 |
124,016,700 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7672:Vmn2r26
|
UTSW |
6 |
124,016,606 (GRCm39) |
missense |
probably benign |
0.25 |
|
R7674:Vmn2r26
|
UTSW |
6 |
124,016,321 (GRCm39) |
missense |
probably benign |
|
|
R7696:Vmn2r26
|
UTSW |
6 |
124,038,494 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7716:Vmn2r26
|
UTSW |
6 |
124,038,704 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7831:Vmn2r26
|
UTSW |
6 |
124,016,758 (GRCm39) |
nonsense |
probably null |
|
|
R8063:Vmn2r26
|
UTSW |
6 |
124,001,914 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8331:Vmn2r26
|
UTSW |
6 |
124,038,887 (GRCm39) |
missense |
probably benign |
0.22 |
|
R8352:Vmn2r26
|
UTSW |
6 |
124,016,577 (GRCm39) |
missense |
probably benign |
0.09 |
|
R8445:Vmn2r26
|
UTSW |
6 |
124,002,995 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8452:Vmn2r26
|
UTSW |
6 |
124,016,577 (GRCm39) |
missense |
probably benign |
0.09 |
|
R8681:Vmn2r26
|
UTSW |
6 |
124,001,877 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8914:Vmn2r26
|
UTSW |
6 |
124,038,983 (GRCm39) |
missense |
probably benign |
|
|
R9333:Vmn2r26
|
UTSW |
6 |
124,003,009 (GRCm39) |
missense |
probably benign |
0.13 |
|
R9351:Vmn2r26
|
UTSW |
6 |
124,016,333 (GRCm39) |
missense |
probably benign |
|
|
R9436:Vmn2r26
|
UTSW |
6 |
124,002,826 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9515:Vmn2r26
|
UTSW |
6 |
124,038,137 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF010:Vmn2r26
|
UTSW |
6 |
124,016,448 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
| Predicted Primers |
PCR Primer
(F):5'- GGAACGACTTACCTTGACACCTG -3'
(R):5'- GGTATTCATATCCCAAGCATGCAG -3'
|
| Posted On |
2017-07-14 |
Incidental Mutation