Incidental Mutation 'R6077:Ube2g2'
ID 482801
Institutional Source Beutler Lab
Gene Symbol Ube2g2
Ensembl Gene ENSMUSG00000009293
Gene Name ubiquitin-conjugating enzyme E2G 2
Synonyms UBC7, D10Xrf369, 1110003O05Rik, Ubc7p
MMRRC Submission 044238-MU
Accession Numbers
Essential gene? Possibly essential (E-score: 0.741) question?
Stock # R6077 (G1)
Quality Score 108.008
Status Not validated
Chromosome 10
Chromosomal Location 77458155-77481824 bp(+) (GRCm39)
Type of Mutation unclassified
DNA Base Change (assembly) G to T at 77458139 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000134208 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000020501] [ENSMUST00000099538] [ENSMUST00000172813] [ENSMUST00000174113] [ENSMUST00000174510] [ENSMUST00000174546]
AlphaFold P60605
Predicted Effect probably benign
Transcript: ENSMUST00000020501
SMART Domains Protein: ENSMUSP00000020501
Gene: ENSMUSG00000020265

DomainStartEndE-ValueType
UBQ 17 88 1.07e-13 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000099538
SMART Domains Protein: ENSMUSP00000097136
Gene: ENSMUSG00000020265

DomainStartEndE-ValueType
UBQ 17 88 1.07e-13 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000172772
SMART Domains Protein: ENSMUSP00000134397
Gene: ENSMUSG00000009293

DomainStartEndE-ValueType
SCOP:d2ucz__ 2 41 7e-12 SMART
PDB:3H8K|A 2 96 3e-24 PDB
Blast:UBCc 6 96 3e-20 BLAST
Predicted Effect probably benign
Transcript: ENSMUST00000172813
SMART Domains Protein: ENSMUSP00000134670
Gene: ENSMUSG00000009293

DomainStartEndE-ValueType
UBCc 1 70 1.2e-2 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000174113
SMART Domains Protein: ENSMUSP00000134357
Gene: ENSMUSG00000112241

DomainStartEndE-ValueType
UBQ 17 74 4.07e-1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000174510
SMART Domains Protein: ENSMUSP00000133515
Gene: ENSMUSG00000009293

DomainStartEndE-ValueType
UBCc 7 164 1.33e-64 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000174546
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.2%
  • 20x: 95.0%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein shares 100% sequence identity with the mouse counterpart. This gene is ubiquitously expressed, with high expression seen in adult muscle. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acly C T 11: 100,410,583 (GRCm39) V132I probably benign Het
Adgrb3 A T 1: 25,133,081 (GRCm39) L1335* probably null Het
Adgre5 A G 8: 84,454,595 (GRCm39) S301P probably benign Het
Afg3l2 G T 18: 67,554,329 (GRCm39) L458M probably damaging Het
Aldh1b1 A G 4: 45,802,525 (GRCm39) Y21C possibly damaging Het
Ank3 G A 10: 69,838,395 (GRCm39) R1566K possibly damaging Het
Ankrd7 T A 6: 18,868,071 (GRCm39) S112R probably benign Het
Arhgap23 T A 11: 97,382,058 (GRCm39) probably null Het
Atp4a G A 7: 30,415,344 (GRCm39) M321I probably benign Het
C2cd4d A T 3: 94,271,615 (GRCm39) R294W probably damaging Het
Carns1 T C 19: 4,220,875 (GRCm39) I352V probably benign Het
Cdh17 T A 4: 11,803,969 (GRCm39) S547R probably benign Het
Cdyl2 G T 8: 117,316,129 (GRCm39) N286K probably damaging Het
Fam186a C A 15: 99,840,584 (GRCm39) V1887L possibly damaging Het
Fat4 C T 3: 39,056,951 (GRCm39) R4216C probably damaging Het
Fcamr T C 1: 130,740,663 (GRCm39) W361R probably damaging Het
Helz2 G A 2: 180,874,831 (GRCm39) P1888S probably benign Het
Itih1 A T 14: 30,651,833 (GRCm39) F840L possibly damaging Het
Kansl2 T C 15: 98,429,312 (GRCm39) D146G probably benign Het
Kcnk18 T C 19: 59,223,746 (GRCm39) V297A probably damaging Het
Kif1a T C 1: 92,982,618 (GRCm39) T720A possibly damaging Het
Kl C G 5: 150,876,466 (GRCm39) F95L probably damaging Het
Large2 C T 2: 92,196,915 (GRCm39) R423K probably benign Het
Lgals3bp A G 11: 118,290,568 (GRCm39) V13A probably damaging Het
Lrrd1 A G 5: 3,900,837 (GRCm39) I381V probably benign Het
Mastl A T 2: 23,045,806 (GRCm39) I23N probably damaging Het
Mettl23 T C 11: 116,739,728 (GRCm39) V1A possibly damaging Het
Mindy2 A G 9: 70,538,363 (GRCm39) V324A probably damaging Het
Mtmr4 T A 11: 87,501,845 (GRCm39) L633Q probably damaging Het
Myh1 G A 11: 67,102,273 (GRCm39) E855K probably damaging Het
Nin C T 12: 70,066,006 (GRCm39) A2026T probably damaging Het
Nova2 G A 7: 18,691,794 (GRCm39) A244T unknown Het
Or2w1 A T 13: 21,317,463 (GRCm39) I173F probably benign Het
Otulin T C 15: 27,611,696 (GRCm39) T166A probably benign Het
P2ry14 T A 3: 59,022,798 (GRCm39) R230W probably damaging Het
Pcsk4 T C 10: 80,162,073 (GRCm39) E83G probably damaging Het
Raet1e C A 10: 22,057,887 (GRCm39) T218N possibly damaging Het
Rsf1 GCGGCGGC GCGGCGGCGTCGGCGGC 7: 97,229,135 (GRCm39) probably benign Het
Safb G A 17: 56,909,956 (GRCm39) probably benign Het
Scn7a T A 2: 66,527,940 (GRCm39) N850I probably damaging Het
Slc16a4 A G 3: 107,208,381 (GRCm39) D297G possibly damaging Het
Tcf7l2 A T 19: 55,905,868 (GRCm39) K278* probably null Het
Tesmin T C 19: 3,439,260 (GRCm39) V104A possibly damaging Het
Tiam1 A G 16: 89,594,918 (GRCm39) probably null Het
Tmc4 T C 7: 3,670,526 (GRCm39) T522A probably damaging Het
Tmprss3 T A 17: 31,408,141 (GRCm39) I274F possibly damaging Het
Topbp1 A G 9: 103,210,189 (GRCm39) K916E probably damaging Het
Trdv1 A G 14: 54,119,513 (GRCm39) D58G probably benign Het
Unc5d G T 8: 29,165,335 (GRCm39) Q747K possibly damaging Het
Xpo6 A G 7: 125,709,124 (GRCm39) V819A possibly damaging Het
Zan T A 5: 137,412,559 (GRCm39) probably benign Het
Zfp317 T A 9: 19,558,184 (GRCm39) W133R probably benign Het
Other mutations in Ube2g2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03348:Ube2g2 APN 10 77,466,711 (GRCm39) missense probably benign 0.05
R0180:Ube2g2 UTSW 10 77,466,573 (GRCm39) missense possibly damaging 0.87
R5299:Ube2g2 UTSW 10 77,480,379 (GRCm39) missense possibly damaging 0.92
R6454:Ube2g2 UTSW 10 77,470,580 (GRCm39) intron probably benign
R7831:Ube2g2 UTSW 10 77,470,576 (GRCm39) missense
R9004:Ube2g2 UTSW 10 77,479,434 (GRCm39) missense probably benign 0.04
R9751:Ube2g2 UTSW 10 77,480,307 (GRCm39) missense probably benign 0.00
Predicted Primers
Posted On 2017-07-14