Incidental Mutation 'R6077:Or2w1'
ID 482810
Institutional Source Beutler Lab
Gene Symbol Or2w1
Ensembl Gene ENSMUSG00000071522
Gene Name olfactory receptor family 2 subfamily W member 1
Synonyms GA_x6K02T2QHY8-12114828-12113875, MOR256-61, Olfr263, GA_x6K02T2N5E5-9379-8514, Olfr263-ps1, IA3, Olfr42, MOR256-37P, MOR256-31
MMRRC Submission 044238-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.101) question?
Stock # R6077 (G1)
Quality Score 225.009
Status Not validated
Chromosome 13
Chromosomal Location 21316947-21317900 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 21317463 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 173 (I173F)
Ref Sequence ENSEMBL: ENSMUSP00000149892 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000096006] [ENSMUST00000215804]
AlphaFold Q7TQT8
Predicted Effect probably benign
Transcript: ENSMUST00000096006
AA Change: I173F

PolyPhen 2 Score 0.019 (Sensitivity: 0.95; Specificity: 0.80)
SMART Domains Protein: ENSMUSP00000093705
Gene: ENSMUSG00000071522
AA Change: I173F

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 1.4e-46 PFAM
Pfam:7tm_1 41 290 4.2e-30 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000215804
AA Change: I173F

PolyPhen 2 Score 0.019 (Sensitivity: 0.95; Specificity: 0.80)
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.2%
  • 20x: 95.0%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acly C T 11: 100,410,583 (GRCm39) V132I probably benign Het
Adgrb3 A T 1: 25,133,081 (GRCm39) L1335* probably null Het
Adgre5 A G 8: 84,454,595 (GRCm39) S301P probably benign Het
Afg3l2 G T 18: 67,554,329 (GRCm39) L458M probably damaging Het
Aldh1b1 A G 4: 45,802,525 (GRCm39) Y21C possibly damaging Het
Ank3 G A 10: 69,838,395 (GRCm39) R1566K possibly damaging Het
Ankrd7 T A 6: 18,868,071 (GRCm39) S112R probably benign Het
Arhgap23 T A 11: 97,382,058 (GRCm39) probably null Het
Atp4a G A 7: 30,415,344 (GRCm39) M321I probably benign Het
C2cd4d A T 3: 94,271,615 (GRCm39) R294W probably damaging Het
Carns1 T C 19: 4,220,875 (GRCm39) I352V probably benign Het
Cdh17 T A 4: 11,803,969 (GRCm39) S547R probably benign Het
Cdyl2 G T 8: 117,316,129 (GRCm39) N286K probably damaging Het
Fam186a C A 15: 99,840,584 (GRCm39) V1887L possibly damaging Het
Fat4 C T 3: 39,056,951 (GRCm39) R4216C probably damaging Het
Fcamr T C 1: 130,740,663 (GRCm39) W361R probably damaging Het
Helz2 G A 2: 180,874,831 (GRCm39) P1888S probably benign Het
Itih1 A T 14: 30,651,833 (GRCm39) F840L possibly damaging Het
Kansl2 T C 15: 98,429,312 (GRCm39) D146G probably benign Het
Kcnk18 T C 19: 59,223,746 (GRCm39) V297A probably damaging Het
Kif1a T C 1: 92,982,618 (GRCm39) T720A possibly damaging Het
Kl C G 5: 150,876,466 (GRCm39) F95L probably damaging Het
Large2 C T 2: 92,196,915 (GRCm39) R423K probably benign Het
Lgals3bp A G 11: 118,290,568 (GRCm39) V13A probably damaging Het
Lrrd1 A G 5: 3,900,837 (GRCm39) I381V probably benign Het
Mastl A T 2: 23,045,806 (GRCm39) I23N probably damaging Het
Mettl23 T C 11: 116,739,728 (GRCm39) V1A possibly damaging Het
Mindy2 A G 9: 70,538,363 (GRCm39) V324A probably damaging Het
Mtmr4 T A 11: 87,501,845 (GRCm39) L633Q probably damaging Het
Myh1 G A 11: 67,102,273 (GRCm39) E855K probably damaging Het
Nin C T 12: 70,066,006 (GRCm39) A2026T probably damaging Het
Nova2 G A 7: 18,691,794 (GRCm39) A244T unknown Het
Otulin T C 15: 27,611,696 (GRCm39) T166A probably benign Het
P2ry14 T A 3: 59,022,798 (GRCm39) R230W probably damaging Het
Pcsk4 T C 10: 80,162,073 (GRCm39) E83G probably damaging Het
Raet1e C A 10: 22,057,887 (GRCm39) T218N possibly damaging Het
Rsf1 GCGGCGGC GCGGCGGCGTCGGCGGC 7: 97,229,135 (GRCm39) probably benign Het
Safb G A 17: 56,909,956 (GRCm39) probably benign Het
Scn7a T A 2: 66,527,940 (GRCm39) N850I probably damaging Het
Slc16a4 A G 3: 107,208,381 (GRCm39) D297G possibly damaging Het
Tcf7l2 A T 19: 55,905,868 (GRCm39) K278* probably null Het
Tesmin T C 19: 3,439,260 (GRCm39) V104A possibly damaging Het
Tiam1 A G 16: 89,594,918 (GRCm39) probably null Het
Tmc4 T C 7: 3,670,526 (GRCm39) T522A probably damaging Het
Tmprss3 T A 17: 31,408,141 (GRCm39) I274F possibly damaging Het
Topbp1 A G 9: 103,210,189 (GRCm39) K916E probably damaging Het
Trdv1 A G 14: 54,119,513 (GRCm39) D58G probably benign Het
Ube2g2 G T 10: 77,458,139 (GRCm39) probably benign Het
Unc5d G T 8: 29,165,335 (GRCm39) Q747K possibly damaging Het
Xpo6 A G 7: 125,709,124 (GRCm39) V819A possibly damaging Het
Zan T A 5: 137,412,559 (GRCm39) probably benign Het
Zfp317 T A 9: 19,558,184 (GRCm39) W133R probably benign Het
Other mutations in Or2w1
AlleleSourceChrCoordTypePredicted EffectPPH Score
R1880:Or2w1 UTSW 13 21,317,802 (GRCm39) missense probably damaging 1.00
R2012:Or2w1 UTSW 13 21,317,659 (GRCm39) missense probably benign 0.13
R3113:Or2w1 UTSW 13 21,317,299 (GRCm39) missense probably damaging 1.00
R4210:Or2w1 UTSW 13 21,317,607 (GRCm39) missense possibly damaging 0.78
R4934:Or2w1 UTSW 13 21,317,241 (GRCm39) missense probably benign
R4952:Or2w1 UTSW 13 21,317,514 (GRCm39) missense probably benign 0.00
R5755:Or2w1 UTSW 13 21,317,695 (GRCm39) missense probably damaging 0.98
R6012:Or2w1 UTSW 13 21,316,978 (GRCm39) missense probably benign 0.01
R6168:Or2w1 UTSW 13 21,317,399 (GRCm39) missense possibly damaging 0.53
R6325:Or2w1 UTSW 13 21,317,245 (GRCm39) missense probably damaging 0.97
R6829:Or2w1 UTSW 13 21,317,023 (GRCm39) missense possibly damaging 0.69
R7130:Or2w1 UTSW 13 21,317,416 (GRCm39) missense probably benign 0.41
R7257:Or2w1 UTSW 13 21,317,427 (GRCm39) missense probably benign 0.34
R8113:Or2w1 UTSW 13 21,317,371 (GRCm39) missense probably benign 0.00
R9348:Or2w1 UTSW 13 21,317,131 (GRCm39) missense possibly damaging 0.95
R9359:Or2w1 UTSW 13 21,317,865 (GRCm39) missense probably benign 0.00
R9403:Or2w1 UTSW 13 21,317,865 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- AGTGTCTGCTCCTAGCTGTC -3'
(R):5'- TGAGATGGGATCCACAGGTATTC -3'

Sequencing Primer
(F):5'- AGCTGTCATGTCCTATGATCG -3'
(R):5'- AGATGGGATCCACAGGTATTCATTGC -3'
Posted On 2017-07-14