Mutagenetix > Incidental Mutation

Incidental Mutation 'R6079:Vmn2r79'

482854

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r79

Ensembl Gene

ENSMUSG00000090362

Gene Name

vomeronasal 2, receptor 79

Synonyms

EG621430

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.092) question?

Stock #

R6079 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

86645673-86687176 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 86653319 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Aspartic acid at position 528 (V528D)

Ref Sequence

ENSEMBL: ENSMUSP00000132478 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000164462]

AlphaFold

E9Q067

Predicted Effect

possibly damaging
Transcript: ENSMUST00000164462
AA Change: V528D

PolyPhen 2 Score 0.864 (Sensitivity: 0.83; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000132478
Gene: ENSMUSG00000090362
AA Change: V528D

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	75	464	1.9e-31	PFAM
Pfam:NCD3G	506	559	3.1e-21	PFAM
Pfam:7tm_3	592	827	2.8e-53	PFAM

Meta Mutation Damage Score

0.1795

Coding Region Coverage

1x: 99.9%
3x: 99.6%
10x: 98.2%
20x: 95.2%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 28 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700012B07Rik	G	T	11: 109,684,980 (GRCm39)	C172*	probably null	Het
Abcc8	T	C	7: 45,755,268 (GRCm39)	M1511V	probably benign	Het
Adamts2	T	A	11: 50,647,533 (GRCm39)	I302N	probably damaging	Het
Adgra2	G	A	8: 27,604,457 (GRCm39)	A511T	probably damaging	Het
Anxa10	C	A	8: 62,530,960 (GRCm39)	M83I	probably benign	Het
Atp2b4	TTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTT	TTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTTCTT	1: 133,629,440 (GRCm39)		probably benign	Het
Cdc20b	T	C	13: 113,220,576 (GRCm39)	F485S	probably damaging	Het
Edc4	C	T	8: 106,614,180 (GRCm39)	R19C	probably benign	Het
Fam90a1b	T	C	X: 93,400,191 (GRCm39)	N213S	probably benign	Het
Gkn3	C	T	6: 87,360,507 (GRCm39)	A163T	probably damaging	Het
Itgae	A	G	11: 73,006,400 (GRCm39)	E356G	possibly damaging	Het
Lgr6	C	T	1: 134,921,748 (GRCm39)	A199T	probably damaging	Het
Lrrc19	A	T	4: 94,531,580 (GRCm39)	F11I	probably benign	Het
Msl1	G	T	11: 98,689,519 (GRCm39)	G9C	probably benign	Het
Muc4	T	A	16: 32,575,621 (GRCm39)		probably benign	Het
Myo7a	C	T	7: 97,714,997 (GRCm39)	W1558*	probably null	Het
Or5p81	T	A	7: 108,267,412 (GRCm39)	V263E	probably damaging	Het
Pgk1	C	A	X: 105,238,098 (GRCm39)	L85I	possibly damaging	Het
Ppp4r1	G	A	17: 66,121,343 (GRCm39)	V268I	possibly damaging	Het
Rad23b	C	T	4: 55,370,400 (GRCm39)	A142V	probably damaging	Het
Satl1	T	C	X: 111,315,613 (GRCm39)	T281A	probably benign	Het
Shroom3	G	T	5: 93,090,945 (GRCm39)	V1151F	probably damaging	Het
Synrg	A	G	11: 83,915,126 (GRCm39)	E1044G	probably damaging	Het
Syt12	T	C	19: 4,506,896 (GRCm39)	D83G	probably benign	Het
Taf4b	T	C	18: 14,955,255 (GRCm39)	C603R	possibly damaging	Het
Tbx5	T	C	5: 120,021,211 (GRCm39)	S406P	probably benign	Het
Tfe3	T	C	X: 7,637,288 (GRCm39)	L231P	probably damaging	Het
Tns2	C	T	15: 102,017,369 (GRCm39)	R281C	probably damaging	Het

Other mutations in Vmn2r79

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01401:Vmn2r79	APN	7	86,686,481 (GRCm39)	missense	probably benign	0.01
IGL01675:Vmn2r79	APN	7	86,645,856 (GRCm39)	missense	probably benign	0.01
IGL01760:Vmn2r79	APN	7	86,651,366 (GRCm39)	missense	probably benign
IGL01834:Vmn2r79	APN	7	86,686,354 (GRCm39)	missense	probably benign	0.01
IGL01843:Vmn2r79	APN	7	86,686,485 (GRCm39)	missense	probably damaging	1.00
IGL01914:Vmn2r79	APN	7	86,686,571 (GRCm39)	missense	probably benign	0.14
IGL01980:Vmn2r79	APN	7	86,686,290 (GRCm39)	missense	possibly damaging	0.49
IGL02438:Vmn2r79	APN	7	86,651,744 (GRCm39)	missense	probably damaging	0.98
IGL02740:Vmn2r79	APN	7	86,653,366 (GRCm39)	missense	probably benign	0.00
IGL03052:Vmn2r79	UTSW	7	86,652,799 (GRCm39)	missense	probably benign	0.00
PIT4445001:Vmn2r79	UTSW	7	86,651,408 (GRCm39)	missense	possibly damaging	0.46
R0096:Vmn2r79	UTSW	7	86,686,527 (GRCm39)	missense	probably damaging	1.00
R0096:Vmn2r79	UTSW	7	86,686,527 (GRCm39)	missense	probably damaging	1.00
R0270:Vmn2r79	UTSW	7	86,652,594 (GRCm39)	missense	probably benign	0.00
R0336:Vmn2r79	UTSW	7	86,651,287 (GRCm39)	missense	probably benign	0.15
R0418:Vmn2r79	UTSW	7	86,651,611 (GRCm39)	missense	probably benign	0.18
R1070:Vmn2r79	UTSW	7	86,652,681 (GRCm39)	missense	probably damaging	1.00
R1234:Vmn2r79	UTSW	7	86,653,307 (GRCm39)	missense	possibly damaging	0.71
R1459:Vmn2r79	UTSW	7	86,687,002 (GRCm39)	missense	probably benign	0.01
R1513:Vmn2r79	UTSW	7	86,686,652 (GRCm39)	missense	probably benign	0.01
R1624:Vmn2r79	UTSW	7	86,653,247 (GRCm39)	critical splice acceptor site	probably null
R1633:Vmn2r79	UTSW	7	86,687,042 (GRCm39)	missense	possibly damaging	0.52
R1676:Vmn2r79	UTSW	7	86,651,839 (GRCm39)	missense	probably benign
R1781:Vmn2r79	UTSW	7	86,651,555 (GRCm39)	missense	probably benign	0.00
R1794:Vmn2r79	UTSW	7	86,650,621 (GRCm39)	missense	probably benign	0.37
R1823:Vmn2r79	UTSW	7	86,687,080 (GRCm39)	missense	probably damaging	1.00
R2013:Vmn2r79	UTSW	7	86,653,289 (GRCm39)	missense	possibly damaging	0.50
R2018:Vmn2r79	UTSW	7	86,651,634 (GRCm39)	missense	probably benign	0.07
R2019:Vmn2r79	UTSW	7	86,651,634 (GRCm39)	missense	probably benign	0.07
R2177:Vmn2r79	UTSW	7	86,645,839 (GRCm39)	missense	possibly damaging	0.94
R2984:Vmn2r79	UTSW	7	86,651,099 (GRCm39)	missense	possibly damaging	0.85
R3719:Vmn2r79	UTSW	7	86,651,245 (GRCm39)	missense	probably benign	0.05
R3798:Vmn2r79	UTSW	7	86,651,402 (GRCm39)	missense	possibly damaging	0.88
R3969:Vmn2r79	UTSW	7	86,652,801 (GRCm39)	missense	probably damaging	1.00
R4182:Vmn2r79	UTSW	7	86,651,099 (GRCm39)	missense	possibly damaging	0.85
R4183:Vmn2r79	UTSW	7	86,651,099 (GRCm39)	missense	possibly damaging	0.85
R4245:Vmn2r79	UTSW	7	86,651,624 (GRCm39)	missense	possibly damaging	0.73
R4301:Vmn2r79	UTSW	7	86,651,099 (GRCm39)	missense	possibly damaging	0.85
R4391:Vmn2r79	UTSW	7	86,651,099 (GRCm39)	missense	possibly damaging	0.85
R4393:Vmn2r79	UTSW	7	86,651,099 (GRCm39)	missense	possibly damaging	0.85
R4394:Vmn2r79	UTSW	7	86,651,099 (GRCm39)	missense	possibly damaging	0.85
R4396:Vmn2r79	UTSW	7	86,651,099 (GRCm39)	missense	possibly damaging	0.85
R4397:Vmn2r79	UTSW	7	86,651,099 (GRCm39)	missense	possibly damaging	0.85
R4592:Vmn2r79	UTSW	7	86,653,319 (GRCm39)	missense	possibly damaging	0.86
R4697:Vmn2r79	UTSW	7	86,687,168 (GRCm39)	missense	probably damaging	0.98
R4897:Vmn2r79	UTSW	7	86,650,675 (GRCm39)	missense	probably benign
R5016:Vmn2r79	UTSW	7	86,686,548 (GRCm39)	missense	probably benign	0.00
R5058:Vmn2r79	UTSW	7	86,651,423 (GRCm39)	missense	probably damaging	0.98
R5177:Vmn2r79	UTSW	7	86,651,177 (GRCm39)	missense	probably damaging	0.97
R6078:Vmn2r79	UTSW	7	86,653,319 (GRCm39)	missense	possibly damaging	0.86
R6138:Vmn2r79	UTSW	7	86,653,319 (GRCm39)	missense	possibly damaging	0.86
R6257:Vmn2r79	UTSW	7	86,651,778 (GRCm39)	missense	probably benign	0.27
R6260:Vmn2r79	UTSW	7	86,686,365 (GRCm39)	missense	probably benign	0.00
R6307:Vmn2r79	UTSW	7	86,686,976 (GRCm39)	missense	probably damaging	1.00
R6323:Vmn2r79	UTSW	7	86,650,522 (GRCm39)	missense	probably benign	0.05
R6374:Vmn2r79	UTSW	7	86,651,498 (GRCm39)	missense	probably benign	0.02
R6530:Vmn2r79	UTSW	7	86,651,252 (GRCm39)	missense	possibly damaging	0.91
R6546:Vmn2r79	UTSW	7	86,652,741 (GRCm39)	missense	probably benign	0.01
R6682:Vmn2r79	UTSW	7	86,653,370 (GRCm39)	missense	possibly damaging	0.69
R6858:Vmn2r79	UTSW	7	86,686,580 (GRCm39)	missense	probably benign
R6965:Vmn2r79	UTSW	7	86,651,100 (GRCm39)	missense	probably benign	0.10
R7130:Vmn2r79	UTSW	7	86,651,474 (GRCm39)	missense	probably damaging	0.99
R7156:Vmn2r79	UTSW	7	86,686,851 (GRCm39)	missense	probably damaging	0.98
R7604:Vmn2r79	UTSW	7	86,652,592 (GRCm39)	critical splice acceptor site	probably null
R7691:Vmn2r79	UTSW	7	86,687,111 (GRCm39)	missense	probably damaging	0.96
R8055:Vmn2r79	UTSW	7	86,686,541 (GRCm39)	missense	possibly damaging	0.94
R8070:Vmn2r79	UTSW	7	86,651,336 (GRCm39)	missense	probably benign
R8073:Vmn2r79	UTSW	7	86,651,462 (GRCm39)	missense	probably benign	0.00
R8145:Vmn2r79	UTSW	7	86,686,862 (GRCm39)	missense	probably benign	0.02
R8263:Vmn2r79	UTSW	7	86,686,726 (GRCm39)	missense	possibly damaging	0.89
R8350:Vmn2r79	UTSW	7	86,686,741 (GRCm39)	nonsense	probably null
R8400:Vmn2r79	UTSW	7	86,651,308 (GRCm39)	missense	probably benign	0.00
R8814:Vmn2r79	UTSW	7	86,651,714 (GRCm39)	missense	probably benign	0.00
R8862:Vmn2r79	UTSW	7	86,645,712 (GRCm39)	missense	probably benign	0.23
R9146:Vmn2r79	UTSW	7	86,650,681 (GRCm39)	nonsense	probably null
R9276:Vmn2r79	UTSW	7	86,687,045 (GRCm39)	missense	probably damaging	1.00
R9361:Vmn2r79	UTSW	7	86,652,822 (GRCm39)	critical splice donor site	probably null
R9676:Vmn2r79	UTSW	7	86,686,452 (GRCm39)	missense	probably damaging	1.00
U15987:Vmn2r79	UTSW	7	86,653,319 (GRCm39)	missense	possibly damaging	0.86
X0054:Vmn2r79	UTSW	7	86,653,270 (GRCm39)	missense	probably benign	0.01
Z1088:Vmn2r79	UTSW	7	86,651,549 (GRCm39)	missense	probably damaging	1.00
Z1176:Vmn2r79	UTSW	7	86,686,377 (GRCm39)	missense	probably benign
Z1176:Vmn2r79	UTSW	7	86,651,526 (GRCm39)	missense	probably benign	0.00

Predicted Primers

PCR Primer
(F):5'- GTAAAAGGAGATCTTTCGATGGC -3'
(R):5'- AGCATGCAACCATAAGAAATGTGTG -3'

Sequencing Primer
(F):5'- AAAGGAGATCTTTCGATGGCTTTCTC -3'
(R):5'- CCTCACCTGTCATGTTGG -3'

Posted On

2017-07-14