Incidental Mutation 'R6058:Or6c5'
ID 483064
Institutional Source Beutler Lab
Gene Symbol Or6c5
Ensembl Gene ENSMUSG00000096229
Gene Name olfactory receptor family 6 subfamily C member 5
Synonyms Olfr774, MOR111-2, GA_x6K02T2PULF-10924432-10925370, MOR111-11
MMRRC Submission 044224-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.064) question?
Stock # R6058 (G1)
Quality Score 225.009
Status Not validated
Chromosome 10
Chromosomal Location 129074020-129074958 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 129074329 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 104 (S104P)
Ref Sequence ENSEMBL: ENSMUSP00000145042 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000097164] [ENSMUST00000203248]
AlphaFold Q7TRI5
Predicted Effect probably damaging
Transcript: ENSMUST00000097164
AA Change: S104P

PolyPhen 2 Score 0.972 (Sensitivity: 0.77; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000131609
Gene: ENSMUSG00000096229
AA Change: S104P

DomainStartEndE-ValueType
Pfam:7tm_4 28 307 6e-49 PFAM
Pfam:7tm_1 39 288 2.2e-18 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000203248
AA Change: S104P

PolyPhen 2 Score 0.972 (Sensitivity: 0.77; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000145042
Gene: ENSMUSG00000096229
AA Change: S104P

DomainStartEndE-ValueType
Pfam:7tm_4 28 307 6e-49 PFAM
Pfam:7tm_1 39 288 2.2e-18 PFAM
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 97.9%
  • 20x: 93.6%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 72 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930505A04Rik C T 11: 30,376,349 (GRCm39) V173M probably damaging Het
Adamts20 G A 15: 94,227,928 (GRCm39) R1040* probably null Het
Akt1 A G 12: 112,628,634 (GRCm39) L52P probably damaging Het
Alk T A 17: 72,176,742 (GRCm39) T1521S probably benign Het
Armt1 A G 10: 4,403,488 (GRCm39) N191S probably damaging Het
Ascl1 T G 10: 87,328,562 (GRCm39) N130T probably damaging Het
Bahcc1 T G 11: 120,178,211 (GRCm39) S2257A probably damaging Het
Cd86 T C 16: 36,449,377 (GRCm39) M7V possibly damaging Het
Cep57 A T 9: 13,722,057 (GRCm39) S304R possibly damaging Het
Cep57l1 A T 10: 41,616,918 (GRCm39) I123N possibly damaging Het
Cers6 A G 2: 68,692,008 (GRCm39) N10S probably benign Het
Chrng A G 1: 87,139,074 (GRCm39) D475G probably damaging Het
Crabp1 T A 9: 54,680,129 (GRCm39) V128E probably damaging Het
Csnk2a1-ps3 T C 1: 156,352,425 (GRCm39) Y209H probably damaging Het
Dcdc2a T C 13: 25,240,354 (GRCm39) V34A possibly damaging Het
Eeig1 G A 2: 32,450,102 (GRCm39) V117I probably benign Het
Fbn1 A G 2: 125,308,532 (GRCm39) C177R possibly damaging Het
Fras1 A G 5: 96,857,844 (GRCm39) D2046G probably benign Het
Glul T C 1: 153,783,087 (GRCm39) I220T probably benign Het
Gpc6 C T 14: 118,202,182 (GRCm39) T464M probably damaging Het
Gpm6a T C 8: 55,511,833 (GRCm39) S236P probably damaging Het
H2-K2 G T 17: 34,218,304 (GRCm39) T204K probably benign Het
H2-K2 T C 17: 34,218,305 (GRCm39) T204A probably benign Het
Hecw2 T C 1: 53,963,135 (GRCm39) H792R possibly damaging Het
Herc4 T A 10: 63,110,821 (GRCm39) I244K possibly damaging Het
Hsd11b2 G T 8: 106,249,966 (GRCm39) R359L possibly damaging Het
Igsf9 G A 1: 172,312,456 (GRCm39) E56K probably damaging Het
Il9 T C 13: 56,628,495 (GRCm39) T65A possibly damaging Het
Kcnip1 T C 11: 33,592,478 (GRCm39) T102A probably damaging Het
L3mbtl2 T C 15: 81,551,555 (GRCm39) S74P probably benign Het
Lamc2 C T 1: 153,012,575 (GRCm39) D700N probably benign Het
Ldb2 T C 5: 44,633,905 (GRCm39) T322A possibly damaging Het
Lix1 A T 17: 17,664,012 (GRCm39) I117F probably damaging Het
Map2 T A 1: 66,454,573 (GRCm39) D1154E probably benign Het
Marco A T 1: 120,404,435 (GRCm39) I425N probably damaging Het
Mark4 T C 7: 19,160,310 (GRCm39) E650G probably benign Het
Mink1 A G 11: 70,502,546 (GRCm39) T1086A possibly damaging Het
Nxf1 G A 19: 8,745,186 (GRCm39) V479M probably damaging Het
Or10v1 T A 19: 11,873,388 (GRCm39) M1K probably null Het
Or11g2 T C 14: 50,856,158 (GRCm39) F160L probably benign Het
Or2n1e A G 17: 38,586,150 (GRCm39) T163A probably damaging Het
Or5h23 T C 16: 58,906,273 (GRCm39) D191G probably damaging Het
Or5h23 A G 16: 58,906,792 (GRCm39) V18A probably benign Het
Otx2 T C 14: 48,896,215 (GRCm39) D281G probably damaging Het
Pcdhga3 A T 18: 37,808,141 (GRCm39) D198V probably damaging Het
Ppp1r13l T C 7: 19,104,500 (GRCm39) V273A probably benign Het
Ppp6r2 T C 15: 89,137,455 (GRCm39) probably null Het
Pramel51 T A 12: 88,143,995 (GRCm39) I273F possibly damaging Het
Prg4 C T 1: 150,327,197 (GRCm39) G873D probably damaging Het
Ptprq T C 10: 107,471,135 (GRCm39) N1422S probably benign Het
Rbm27 A T 18: 42,460,570 (GRCm39) K839M probably damaging Het
Rere A T 4: 150,553,255 (GRCm39) N149I probably damaging Het
Ret A G 6: 118,156,280 (GRCm39) L340S probably benign Het
Sel1l2 T A 2: 140,082,889 (GRCm39) D583V possibly damaging Het
Shroom1 A T 11: 53,354,308 (GRCm39) D76V possibly damaging Het
Slc5a3 C A 16: 91,875,963 (GRCm39) S673R probably benign Het
Spink1 A T 18: 43,861,247 (GRCm39) I74N probably damaging Het
Tbc1d1 T A 5: 64,435,352 (GRCm39) S497T probably damaging Het
Trim3 C T 7: 105,260,278 (GRCm39) R741Q probably damaging Het
Ttn A G 2: 76,747,022 (GRCm39) C4676R probably benign Het
Ubqlnl G A 7: 103,797,959 (GRCm39) P513S probably benign Het
Unc13d C T 11: 115,964,394 (GRCm39) probably null Het
Vmn1r125 TGG TG 7: 21,006,144 (GRCm39) probably null Het
Vmn2r7 A T 3: 64,632,436 (GRCm39) C9S probably benign Het
Xdh T A 17: 74,213,264 (GRCm39) M829L probably damaging Het
Zcrb1 A G 15: 93,285,463 (GRCm39) F173L probably benign Het
Zfp41 T C 15: 75,490,372 (GRCm39) V108A probably damaging Het
Zfp438 T C 18: 5,213,209 (GRCm39) E583G probably damaging Het
Zfp628 T C 7: 4,923,917 (GRCm39) L713P probably damaging Het
Zfp664 T A 5: 124,963,042 (GRCm39) C145* probably null Het
Zfp683 T C 4: 133,786,042 (GRCm39) C390R probably damaging Het
Zfp941 G A 7: 140,392,010 (GRCm39) P450S probably damaging Het
Other mutations in Or6c5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01308:Or6c5 APN 10 129,074,476 (GRCm39) missense probably benign 0.00
IGL01627:Or6c5 APN 10 129,074,138 (GRCm39) missense probably damaging 1.00
IGL01678:Or6c5 APN 10 129,074,537 (GRCm39) missense possibly damaging 0.94
IGL01759:Or6c5 APN 10 129,074,941 (GRCm39) missense probably benign 0.13
IGL03261:Or6c5 APN 10 129,074,272 (GRCm39) missense possibly damaging 0.72
R1996:Or6c5 UTSW 10 129,074,298 (GRCm39) missense possibly damaging 0.89
R2103:Or6c5 UTSW 10 129,074,368 (GRCm39) missense probably damaging 0.99
R2104:Or6c5 UTSW 10 129,074,368 (GRCm39) missense probably damaging 0.99
R2330:Or6c5 UTSW 10 129,074,908 (GRCm39) nonsense probably null
R3977:Or6c5 UTSW 10 129,074,377 (GRCm39) missense probably damaging 1.00
R4544:Or6c5 UTSW 10 129,074,027 (GRCm39) missense probably damaging 0.96
R8176:Or6c5 UTSW 10 129,074,747 (GRCm39) missense probably benign 0.39
R8708:Or6c5 UTSW 10 129,074,678 (GRCm39) missense possibly damaging 0.92
R9476:Or6c5 UTSW 10 129,074,656 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CCTCACATTGCTAGACTCTCAG -3'
(R):5'- ATGTATCTGAGCAGGAGAGCTG -3'

Sequencing Primer
(F):5'- TGCTAGACTCTCAGTTAAAGACTCC -3'
(R):5'- TCTAACTTGAGAAACAGCATGAGC -3'
Posted On 2017-07-14