Incidental Mutation 'R6058:Or5h23'
ID 483085
Institutional Source Beutler Lab
Gene Symbol Or5h23
Ensembl Gene ENSMUSG00000094539
Gene Name olfactory receptor family 5 subfamily H member 23
Synonyms Olfr191, MOR183-5P, GA_x54KRFPKG5P-55314632-55313703
MMRRC Submission 044224-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.077) question?
Stock # R6058 (G1)
Quality Score 225.009
Status Not validated
Chromosome 16
Chromosomal Location 58905915-58906844 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 58906273 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 191 (D191G)
Ref Sequence ENSEMBL: ENSMUSP00000150473 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000078517] [ENSMUST00000205471] [ENSMUST00000215647]
AlphaFold L7N1Z8
Predicted Effect probably damaging
Transcript: ENSMUST00000078517
AA Change: D191G

PolyPhen 2 Score 0.987 (Sensitivity: 0.73; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000077604
Gene: ENSMUSG00000094539
AA Change: D191G

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 4e-47 PFAM
Pfam:7tm_1 41 290 6.2e-16 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000205471
AA Change: D191G
Predicted Effect probably damaging
Transcript: ENSMUST00000215647
AA Change: D191G

PolyPhen 2 Score 0.987 (Sensitivity: 0.73; Specificity: 0.96)
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 97.9%
  • 20x: 93.6%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 71 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930505A04Rik C T 11: 30,376,349 (GRCm39) V173M probably damaging Het
Adamts20 G A 15: 94,227,928 (GRCm39) R1040* probably null Het
Akt1 A G 12: 112,628,634 (GRCm39) L52P probably damaging Het
Alk T A 17: 72,176,742 (GRCm39) T1521S probably benign Het
Armt1 A G 10: 4,403,488 (GRCm39) N191S probably damaging Het
Ascl1 T G 10: 87,328,562 (GRCm39) N130T probably damaging Het
Bahcc1 T G 11: 120,178,211 (GRCm39) S2257A probably damaging Het
Cd86 T C 16: 36,449,377 (GRCm39) M7V possibly damaging Het
Cep57 A T 9: 13,722,057 (GRCm39) S304R possibly damaging Het
Cep57l1 A T 10: 41,616,918 (GRCm39) I123N possibly damaging Het
Cers6 A G 2: 68,692,008 (GRCm39) N10S probably benign Het
Chrng A G 1: 87,139,074 (GRCm39) D475G probably damaging Het
Crabp1 T A 9: 54,680,129 (GRCm39) V128E probably damaging Het
Csnk2a1-ps3 T C 1: 156,352,425 (GRCm39) Y209H probably damaging Het
Dcdc2a T C 13: 25,240,354 (GRCm39) V34A possibly damaging Het
Eeig1 G A 2: 32,450,102 (GRCm39) V117I probably benign Het
Fbn1 A G 2: 125,308,532 (GRCm39) C177R possibly damaging Het
Fras1 A G 5: 96,857,844 (GRCm39) D2046G probably benign Het
Glul T C 1: 153,783,087 (GRCm39) I220T probably benign Het
Gpc6 C T 14: 118,202,182 (GRCm39) T464M probably damaging Het
Gpm6a T C 8: 55,511,833 (GRCm39) S236P probably damaging Het
H2-K2 G T 17: 34,218,304 (GRCm39) T204K probably benign Het
H2-K2 T C 17: 34,218,305 (GRCm39) T204A probably benign Het
Hecw2 T C 1: 53,963,135 (GRCm39) H792R possibly damaging Het
Herc4 T A 10: 63,110,821 (GRCm39) I244K possibly damaging Het
Hsd11b2 G T 8: 106,249,966 (GRCm39) R359L possibly damaging Het
Igsf9 G A 1: 172,312,456 (GRCm39) E56K probably damaging Het
Il9 T C 13: 56,628,495 (GRCm39) T65A possibly damaging Het
Kcnip1 T C 11: 33,592,478 (GRCm39) T102A probably damaging Het
L3mbtl2 T C 15: 81,551,555 (GRCm39) S74P probably benign Het
Lamc2 C T 1: 153,012,575 (GRCm39) D700N probably benign Het
Ldb2 T C 5: 44,633,905 (GRCm39) T322A possibly damaging Het
Lix1 A T 17: 17,664,012 (GRCm39) I117F probably damaging Het
Map2 T A 1: 66,454,573 (GRCm39) D1154E probably benign Het
Marco A T 1: 120,404,435 (GRCm39) I425N probably damaging Het
Mark4 T C 7: 19,160,310 (GRCm39) E650G probably benign Het
Mink1 A G 11: 70,502,546 (GRCm39) T1086A possibly damaging Het
Nxf1 G A 19: 8,745,186 (GRCm39) V479M probably damaging Het
Or10v1 T A 19: 11,873,388 (GRCm39) M1K probably null Het
Or11g2 T C 14: 50,856,158 (GRCm39) F160L probably benign Het
Or2n1e A G 17: 38,586,150 (GRCm39) T163A probably damaging Het
Or6c5 T C 10: 129,074,329 (GRCm39) S104P probably damaging Het
Otx2 T C 14: 48,896,215 (GRCm39) D281G probably damaging Het
Pcdhga3 A T 18: 37,808,141 (GRCm39) D198V probably damaging Het
Ppp1r13l T C 7: 19,104,500 (GRCm39) V273A probably benign Het
Ppp6r2 T C 15: 89,137,455 (GRCm39) probably null Het
Pramel51 T A 12: 88,143,995 (GRCm39) I273F possibly damaging Het
Prg4 C T 1: 150,327,197 (GRCm39) G873D probably damaging Het
Ptprq T C 10: 107,471,135 (GRCm39) N1422S probably benign Het
Rbm27 A T 18: 42,460,570 (GRCm39) K839M probably damaging Het
Rere A T 4: 150,553,255 (GRCm39) N149I probably damaging Het
Ret A G 6: 118,156,280 (GRCm39) L340S probably benign Het
Sel1l2 T A 2: 140,082,889 (GRCm39) D583V possibly damaging Het
Shroom1 A T 11: 53,354,308 (GRCm39) D76V possibly damaging Het
Slc5a3 C A 16: 91,875,963 (GRCm39) S673R probably benign Het
Spink1 A T 18: 43,861,247 (GRCm39) I74N probably damaging Het
Tbc1d1 T A 5: 64,435,352 (GRCm39) S497T probably damaging Het
Trim3 C T 7: 105,260,278 (GRCm39) R741Q probably damaging Het
Ttn A G 2: 76,747,022 (GRCm39) C4676R probably benign Het
Ubqlnl G A 7: 103,797,959 (GRCm39) P513S probably benign Het
Unc13d C T 11: 115,964,394 (GRCm39) probably null Het
Vmn1r125 TGG TG 7: 21,006,144 (GRCm39) probably null Het
Vmn2r7 A T 3: 64,632,436 (GRCm39) C9S probably benign Het
Xdh T A 17: 74,213,264 (GRCm39) M829L probably damaging Het
Zcrb1 A G 15: 93,285,463 (GRCm39) F173L probably benign Het
Zfp41 T C 15: 75,490,372 (GRCm39) V108A probably damaging Het
Zfp438 T C 18: 5,213,209 (GRCm39) E583G probably damaging Het
Zfp628 T C 7: 4,923,917 (GRCm39) L713P probably damaging Het
Zfp664 T A 5: 124,963,042 (GRCm39) C145* probably null Het
Zfp683 T C 4: 133,786,042 (GRCm39) C390R probably damaging Het
Zfp941 G A 7: 140,392,010 (GRCm39) P450S probably damaging Het
Other mutations in Or5h23
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00951:Or5h23 APN 16 58,906,756 (GRCm39) missense possibly damaging 0.86
IGL01553:Or5h23 APN 16 58,906,685 (GRCm39) missense probably benign 0.35
R0233:Or5h23 UTSW 16 58,906,038 (GRCm39) missense probably benign 0.01
R0233:Or5h23 UTSW 16 58,906,038 (GRCm39) missense probably benign 0.01
R1367:Or5h23 UTSW 16 58,906,706 (GRCm39) missense probably benign 0.00
R1631:Or5h23 UTSW 16 58,906,408 (GRCm39) missense probably benign
R1660:Or5h23 UTSW 16 58,906,706 (GRCm39) missense probably benign 0.00
R2166:Or5h23 UTSW 16 58,905,949 (GRCm39) missense probably benign 0.07
R2167:Or5h23 UTSW 16 58,905,949 (GRCm39) missense probably benign 0.07
R2168:Or5h23 UTSW 16 58,905,949 (GRCm39) missense probably benign 0.07
R2191:Or5h23 UTSW 16 58,906,038 (GRCm39) missense probably benign 0.01
R3836:Or5h23 UTSW 16 58,906,586 (GRCm39) missense possibly damaging 0.61
R4999:Or5h23 UTSW 16 58,906,765 (GRCm39) missense probably damaging 1.00
R5386:Or5h23 UTSW 16 58,906,253 (GRCm39) missense probably benign
R5589:Or5h23 UTSW 16 58,906,334 (GRCm39) missense probably benign 0.03
R5590:Or5h23 UTSW 16 58,906,360 (GRCm39) missense probably benign 0.06
R5609:Or5h23 UTSW 16 58,906,439 (GRCm39) missense possibly damaging 0.96
R5965:Or5h23 UTSW 16 58,906,666 (GRCm39) missense probably damaging 1.00
R5989:Or5h23 UTSW 16 58,906,697 (GRCm39) missense probably benign 0.00
R6049:Or5h23 UTSW 16 58,906,509 (GRCm39) nonsense probably null
R6058:Or5h23 UTSW 16 58,906,792 (GRCm39) missense probably benign
R6250:Or5h23 UTSW 16 58,906,195 (GRCm39) missense probably damaging 1.00
R6319:Or5h23 UTSW 16 58,906,384 (GRCm39) missense probably benign 0.08
R6473:Or5h23 UTSW 16 58,906,406 (GRCm39) missense probably benign 0.09
R6524:Or5h23 UTSW 16 58,906,640 (GRCm39) missense possibly damaging 0.76
R6748:Or5h23 UTSW 16 58,906,253 (GRCm39) missense probably benign
R6874:Or5h23 UTSW 16 58,906,312 (GRCm39) missense probably benign 0.02
R9303:Or5h23 UTSW 16 58,906,802 (GRCm39) missense probably benign 0.11
Predicted Primers PCR Primer
(F):5'- GGCGCACATACATGAAGAGC -3'
(R):5'- CGCTATGTAGCCATATGCAAACC -3'

Sequencing Primer
(F):5'- CATGAAGAGCAGAGGGCCATAGTAC -3'
(R):5'- GTAGCCATATGCAAACCTTTACTC -3'
Posted On 2017-07-14