Incidental Mutation 'R6060:Fam47e'
ID |
483183 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Fam47e
|
Ensembl Gene |
ENSMUSG00000057068 |
Gene Name |
family with sequence similarity 47, member E |
Synonyms |
LOC384198, Gm1381 |
MMRRC Submission |
044426-MU
|
Accession Numbers |
|
Essential gene? |
Non essential
(E-score: 0.000)
|
Stock # |
R6060 (G1)
|
Quality Score |
225.009 |
Status
|
Validated
|
Chromosome |
5 |
Chromosomal Location |
92702928-92739138 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to A
at 92727472 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Phenylalanine to Isoleucine
at position 127
(F127I)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000118033
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000082382]
[ENSMUST00000131166]
[ENSMUST00000146417]
[ENSMUST00000175974]
[ENSMUST00000176448]
[ENSMUST00000176621]
|
AlphaFold |
D3YWC7 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000082382
|
SMART Domains |
Protein: ENSMUSP00000080987 Gene: ENSMUSG00000057068
Domain | Start | End | E-Value | Type |
low complexity region
|
136 |
150 |
N/A |
INTRINSIC |
|
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000131166
AA Change: F127I
PolyPhen 2
Score 0.881 (Sensitivity: 0.82; Specificity: 0.94)
|
SMART Domains |
Protein: ENSMUSP00000118033 Gene: ENSMUSG00000057068 AA Change: F127I
Domain | Start | End | E-Value | Type |
low complexity region
|
197 |
211 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000146417
AA Change: F269I
PolyPhen 2
Score 0.253 (Sensitivity: 0.91; Specificity: 0.88)
|
SMART Domains |
Protein: ENSMUSP00000115229 Gene: ENSMUSG00000057068 AA Change: F269I
Domain | Start | End | E-Value | Type |
Pfam:FAM47
|
17 |
191 |
1.7e-31 |
PFAM |
low complexity region
|
339 |
353 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000149617
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000175974
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000176448
AA Change: F93I
PolyPhen 2
Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000176621
|
Meta Mutation Damage Score |
0.1795 |
Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.6%
- 10x: 97.9%
- 20x: 93.6%
|
Validation Efficiency |
100% (56/56) |
Allele List at MGI |
|
Other mutations in this stock |
Total: 41 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
1110057P08Rik |
A |
G |
16: 88,966,630 (GRCm39) |
|
probably null |
Het |
Adh1 |
T |
C |
3: 137,992,544 (GRCm39) |
I220T |
probably damaging |
Het |
Ajap1 |
G |
A |
4: 153,516,699 (GRCm39) |
T214I |
probably damaging |
Het |
Ank2 |
A |
G |
3: 126,749,601 (GRCm39) |
F476S |
probably damaging |
Het |
Atp6v1g3 |
A |
G |
1: 138,201,582 (GRCm39) |
K27E |
possibly damaging |
Het |
BC034090 |
A |
G |
1: 155,117,245 (GRCm39) |
I291T |
probably benign |
Het |
Cnot9 |
T |
A |
1: 74,556,285 (GRCm39) |
N27K |
probably benign |
Het |
Cyp2c70 |
A |
T |
19: 40,153,857 (GRCm39) |
L244* |
probably null |
Het |
Cyp2d22 |
T |
C |
15: 82,260,086 (GRCm39) |
T6A |
probably benign |
Het |
D630045J12Rik |
T |
C |
6: 38,107,799 (GRCm39) |
E1829G |
probably damaging |
Het |
Dnajc4 |
G |
T |
19: 6,968,093 (GRCm39) |
S61* |
probably null |
Het |
Dpysl4 |
A |
G |
7: 138,669,324 (GRCm39) |
M1V |
probably null |
Het |
Fam149a |
T |
A |
8: 45,811,799 (GRCm39) |
|
probably benign |
Het |
Fam184b |
T |
C |
5: 45,710,489 (GRCm39) |
E547G |
probably damaging |
Het |
Ifi207 |
G |
A |
1: 173,558,093 (GRCm39) |
T215I |
unknown |
Het |
Iftap |
T |
C |
2: 101,440,950 (GRCm39) |
K18E |
probably benign |
Het |
Lpxn |
T |
C |
19: 12,810,489 (GRCm39) |
L311P |
probably damaging |
Het |
Lrp1b |
A |
T |
2: 40,640,946 (GRCm39) |
N3499K |
|
Het |
Mknk2 |
A |
T |
10: 80,507,468 (GRCm39) |
D76E |
probably benign |
Het |
Nectin2 |
A |
T |
7: 19,451,700 (GRCm39) |
Y445N |
probably damaging |
Het |
Ngb |
A |
C |
12: 87,146,963 (GRCm39) |
S85A |
probably benign |
Het |
Nrp1 |
C |
A |
8: 129,224,419 (GRCm39) |
H727Q |
probably damaging |
Het |
Or5b112 |
C |
T |
19: 13,319,497 (GRCm39) |
A125V |
probably benign |
Het |
Or6k2 |
C |
A |
1: 173,986,907 (GRCm39) |
C189* |
probably null |
Het |
Pold3 |
A |
C |
7: 99,749,819 (GRCm39) |
Y115* |
probably null |
Het |
Ppp1r12b |
C |
G |
1: 134,883,262 (GRCm39) |
V87L |
probably benign |
Het |
Ppp1r26 |
A |
G |
2: 28,341,042 (GRCm39) |
N224S |
probably benign |
Het |
Prl7a1 |
G |
A |
13: 27,821,571 (GRCm39) |
P122S |
probably damaging |
Het |
Rc3h2 |
T |
C |
2: 37,289,612 (GRCm39) |
H400R |
possibly damaging |
Het |
Rnf32 |
A |
T |
5: 29,411,752 (GRCm39) |
I214L |
probably benign |
Het |
Safb2 |
A |
T |
17: 56,870,246 (GRCm39) |
|
probably null |
Het |
Serpinb6e |
A |
G |
13: 34,025,256 (GRCm39) |
C12R |
possibly damaging |
Het |
Sh2b2 |
A |
T |
5: 136,261,209 (GRCm39) |
N2K |
possibly damaging |
Het |
Slc12a4 |
G |
A |
8: 106,672,338 (GRCm39) |
A821V |
probably damaging |
Het |
Slc41a1 |
A |
G |
1: 131,767,972 (GRCm39) |
M179V |
probably benign |
Het |
Slc9a3 |
A |
G |
13: 74,299,004 (GRCm39) |
Y141C |
probably damaging |
Het |
Tenm4 |
G |
A |
7: 96,522,918 (GRCm39) |
V1450I |
probably damaging |
Het |
Trmt1l |
A |
G |
1: 151,333,331 (GRCm39) |
N642S |
possibly damaging |
Het |
Ttll13 |
G |
A |
7: 79,908,491 (GRCm39) |
R576H |
probably damaging |
Het |
Zar1 |
T |
A |
5: 72,738,272 (GRCm39) |
R43S |
probably benign |
Het |
Zfp455 |
A |
G |
13: 67,355,257 (GRCm39) |
Y175C |
probably damaging |
Het |
|
Other mutations in Fam47e |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00391:Fam47e
|
APN |
5 |
92,727,522 (GRCm39) |
missense |
probably damaging |
1.00 |
R0646:Fam47e
|
UTSW |
5 |
92,726,317 (GRCm39) |
intron |
probably benign |
|
R1170:Fam47e
|
UTSW |
5 |
92,713,781 (GRCm39) |
splice site |
probably benign |
|
R1216:Fam47e
|
UTSW |
5 |
92,710,343 (GRCm39) |
missense |
probably damaging |
0.99 |
R1926:Fam47e
|
UTSW |
5 |
92,733,244 (GRCm39) |
missense |
possibly damaging |
0.61 |
R3434:Fam47e
|
UTSW |
5 |
92,733,221 (GRCm39) |
missense |
probably damaging |
0.99 |
R3435:Fam47e
|
UTSW |
5 |
92,733,221 (GRCm39) |
missense |
probably damaging |
0.99 |
R4899:Fam47e
|
UTSW |
5 |
92,722,528 (GRCm39) |
missense |
probably benign |
0.23 |
R4925:Fam47e
|
UTSW |
5 |
92,733,149 (GRCm39) |
missense |
probably damaging |
1.00 |
R5885:Fam47e
|
UTSW |
5 |
92,713,827 (GRCm39) |
missense |
probably damaging |
0.97 |
R6278:Fam47e
|
UTSW |
5 |
92,710,376 (GRCm39) |
missense |
probably damaging |
1.00 |
R6964:Fam47e
|
UTSW |
5 |
92,713,911 (GRCm39) |
missense |
probably damaging |
1.00 |
R7661:Fam47e
|
UTSW |
5 |
92,735,384 (GRCm39) |
missense |
probably damaging |
0.97 |
R7992:Fam47e
|
UTSW |
5 |
92,722,541 (GRCm39) |
missense |
probably damaging |
1.00 |
R8349:Fam47e
|
UTSW |
5 |
92,702,990 (GRCm39) |
missense |
probably benign |
0.27 |
R8449:Fam47e
|
UTSW |
5 |
92,702,990 (GRCm39) |
missense |
probably benign |
0.27 |
R9058:Fam47e
|
UTSW |
5 |
92,719,367 (GRCm39) |
start gained |
probably benign |
|
R9260:Fam47e
|
UTSW |
5 |
92,735,384 (GRCm39) |
missense |
probably damaging |
0.97 |
R9595:Fam47e
|
UTSW |
5 |
92,726,395 (GRCm39) |
missense |
probably benign |
0.00 |
R9596:Fam47e
|
UTSW |
5 |
92,726,395 (GRCm39) |
missense |
probably benign |
0.00 |
R9624:Fam47e
|
UTSW |
5 |
92,726,395 (GRCm39) |
missense |
probably benign |
0.00 |
Z1176:Fam47e
|
UTSW |
5 |
92,727,527 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
Predicted Primers |
PCR Primer
(F):5'- GTTAATCTCATGCCCAAGGAATTC -3'
(R):5'- ACGCTGATGCAACTCTTCC -3'
Sequencing Primer
(F):5'- CCTGGTCTACAAAGTGAGTTCCAG -3'
(R):5'- GCTGATGCAACTCTTCCTTCTTCTG -3'
|
Posted On |
2017-07-14 |