Mutagenetix > Incidental Mutation

Incidental Mutation 'R6051:Or51m1'

484090

Institutional Source

Beutler Lab

Gene Symbol

Or51m1

Ensembl Gene

ENSMUSG00000042219

Gene Name

olfactory receptor family 51 subfamily M member 1

Synonyms

Olfr631, MOR3-1, GA_x6K02T2PBJ9-6662699-6663658

MMRRC Submission

044219-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.140) question?

Stock #

R6051 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

103578032-103578991 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 103578084 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Serine at position 18 (F18S)

Ref Sequence

ENSEMBL: ENSMUSP00000102476 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000106863]

AlphaFold

F8VPJ9

Predicted Effect

probably damaging
Transcript: ENSMUST00000106863
AA Change: F18S

PolyPhen 2 Score 0.980 (Sensitivity: 0.75; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000102476
Gene: ENSMUSG00000042219
AA Change: F18S

Domain	Start	End	E-Value	Type
Pfam:7tm_4	32	311	2e-114	PFAM
Pfam:7TM_GPCR_Srsx	36	308	6.6e-8	PFAM
Pfam:7tm_1	42	293	4.8e-25	PFAM

Coding Region Coverage

1x: 99.9%
3x: 99.6%
10x: 98.1%
20x: 94.3%

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 56 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2700049A03Rik	G	T	12: 71,231,304 (GRCm39)	A1021S	possibly damaging	Het
Abl2	A	G	1: 156,469,655 (GRCm39)	D869G	probably damaging	Het
Adamts9	G	A	6: 92,836,907 (GRCm39)	A615V	possibly damaging	Het
Adamts9	A	G	6: 92,867,099 (GRCm39)	Y96H	probably damaging	Het
Arhgef37	A	G	18: 61,640,345 (GRCm39)	I238T	probably damaging	Het
Atr	T	A	9: 95,790,422 (GRCm39)	H1587Q	possibly damaging	Het
BB014433	T	C	8: 15,092,179 (GRCm39)	T225A	possibly damaging	Het
Bcas2	T	C	3: 103,081,657 (GRCm39)	Y87H	possibly damaging	Het
Brca1	C	T	11: 101,415,072 (GRCm39)	E160K	probably damaging	Het
Cd2ap	T	C	17: 43,107,219 (GRCm39)	*638W	probably null	Het
Chd2	A	T	7: 73,085,590 (GRCm39)	D1681E	probably benign	Het
Cit	C	T	5: 115,984,464 (GRCm39)	P12L	probably benign	Het
Cracdl	G	T	1: 37,663,306 (GRCm39)	P864Q	probably damaging	Het
Crisp1	T	C	17: 40,616,017 (GRCm39)	Y120C	possibly damaging	Het
Cyp2c65	A	G	19: 39,049,610 (GRCm39)	D46G	probably benign	Het
Cyp2d34	A	T	15: 82,500,971 (GRCm39)	V387D	probably damaging	Het
E130311K13Rik	T	C	3: 63,823,062 (GRCm39)	H194R	probably benign	Het
Egfr	C	A	11: 16,833,607 (GRCm39)	T625N	possibly damaging	Het
Fat3	A	G	9: 16,286,751 (GRCm39)	V924A	possibly damaging	Het
Fgd6	T	C	10: 93,973,427 (GRCm39)		probably null	Het
Galnt6	A	T	15: 100,592,549 (GRCm39)	C553S	probably damaging	Het
Gm5617	T	C	9: 48,407,187 (GRCm39)	L107P	possibly damaging	Het
Hectd1	G	T	12: 51,800,887 (GRCm39)	T2035N	probably benign	Het
Hp1bp3	A	G	4: 137,961,615 (GRCm39)	T154A	possibly damaging	Het
Il10rb	A	G	16: 91,218,752 (GRCm39)	T262A	probably benign	Het
Kansl1l	A	T	1: 66,765,885 (GRCm39)	N704K	probably null	Het
Kbtbd12	T	C	6: 88,594,930 (GRCm39)	D300G	possibly damaging	Het
Lama4	G	A	10: 38,943,898 (GRCm39)	A734T	probably benign	Het
Mllt6	G	T	11: 97,571,569 (GRCm39)	G1069*	probably null	Het
Mns1	T	C	9: 72,356,735 (GRCm39)	L302P	probably damaging	Het
Muc5ac	T	A	7: 141,365,594 (GRCm39)	C2039S	possibly damaging	Het
Myof	A	G	19: 38,012,809 (GRCm39)	L42P	probably damaging	Het
Ncoa3	T	C	2: 165,900,685 (GRCm39)	L868S	probably damaging	Het
Ndc80	C	T	17: 71,824,573 (GRCm39)	G212E	probably benign	Het
Ntn4	A	G	10: 93,581,657 (GRCm39)	H610R	probably benign	Het
Nufip2	T	A	11: 77,582,742 (GRCm39)	Y219N	probably damaging	Het
Pbxip1	T	C	3: 89,350,477 (GRCm39)	S41P	probably benign	Het
Phactr2	A	T	10: 13,137,555 (GRCm39)	C196S	probably null	Het
Ppp3ca	T	A	3: 136,581,883 (GRCm39)	Y140N	probably damaging	Het
Ptprb	C	A	10: 116,176,995 (GRCm39)	Y1260*	probably null	Het
Rap1a	C	T	3: 105,657,613 (GRCm39)	R2H	possibly damaging	Het
Rbbp8	G	A	18: 11,871,664 (GRCm39)	V794I	probably benign	Het
Rbks	T	C	5: 31,809,163 (GRCm39)	N200S	probably damaging	Het
Relch	G	T	1: 105,648,997 (GRCm39)	G712V	probably damaging	Het
Rnf186	G	T	4: 138,695,277 (GRCm39)	K272N	probably damaging	Het
Rtl1	G	A	12: 109,559,458 (GRCm39)	P794S	probably damaging	Het
Tbc1d30	T	A	10: 121,132,750 (GRCm39)	I205F	probably damaging	Het
Tkt	C	T	14: 30,290,153 (GRCm39)	P261S	probably benign	Het
Trp53	G	A	11: 69,480,434 (GRCm39)	R267H	possibly damaging	Het
Ttc14	T	C	3: 33,863,073 (GRCm39)		probably benign	Het
Ttn	A	G	2: 76,737,805 (GRCm39)	S4245P	probably benign	Het
Vmn1r75	A	T	7: 11,614,978 (GRCm39)	I237F	probably damaging	Het
Vmn2r57	T	A	7: 41,097,896 (GRCm39)	H57L	probably benign	Het
Wdr62	T	C	7: 29,960,809 (GRCm39)	N40S	possibly damaging	Het
Xcr1	A	T	9: 123,685,181 (GRCm39)	F194I	probably benign	Het
Zmiz1	T	A	14: 25,572,494 (GRCm39)	M1K	probably null	Het

Other mutations in Or51m1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02632:Or51m1	APN	7	103,578,914 (GRCm39)	missense	possibly damaging	0.93
IGL02732:Or51m1	APN	7	103,578,336 (GRCm39)	missense	probably damaging	1.00
IGL02834:Or51m1	APN	7	103,578,601 (GRCm39)	nonsense	probably null
IGL03089:Or51m1	APN	7	103,578,329 (GRCm39)	missense	probably benign	0.01
IGL03137:Or51m1	APN	7	103,578,801 (GRCm39)	missense	probably benign
IGL03407:Or51m1	APN	7	103,578,158 (GRCm39)	missense	probably damaging	1.00
R0034:Or51m1	UTSW	7	103,578,708 (GRCm39)	missense	probably benign	0.04
R1768:Or51m1	UTSW	7	103,578,932 (GRCm39)	nonsense	probably null
R1779:Or51m1	UTSW	7	103,578,668 (GRCm39)	missense	probably benign	0.39
R1933:Or51m1	UTSW	7	103,578,337 (GRCm39)	missense	probably damaging	0.99
R4976:Or51m1	UTSW	7	103,578,944 (GRCm39)	missense	probably benign
R5783:Or51m1	UTSW	7	103,578,149 (GRCm39)	missense	probably damaging	1.00
R5888:Or51m1	UTSW	7	103,578,239 (GRCm39)	missense	possibly damaging	0.47
R7016:Or51m1	UTSW	7	103,578,737 (GRCm39)	missense	probably benign	0.01
R7605:Or51m1	UTSW	7	103,578,075 (GRCm39)	missense	probably damaging	1.00
R8247:Or51m1	UTSW	7	103,578,783 (GRCm39)	missense	possibly damaging	0.46
R9420:Or51m1	UTSW	7	103,578,980 (GRCm39)	missense	possibly damaging	0.93
Z1176:Or51m1	UTSW	7	103,578,984 (GRCm39)	nonsense	probably null

Predicted Primers

PCR Primer
(F):5'- TTGCAAAGTTCCTGACAGAGATG -3'
(R):5'- GGCTCCAAAATAAATGCCATGG -3'

Sequencing Primer
(F):5'- CAAAGTTCCTGACAGAGATGTGTTTG -3'
(R):5'- GCAAGGTAGACACTGACAGCC -3'

Posted On

2017-07-14