Incidental Mutation 'IGL00557:Gsta2'
ID 4841
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gsta2
Ensembl Gene ENSMUSG00000057933
Gene Name glutathione S-transferase, alpha 2 (Yc2)
Synonyms Gstc2, Gstc-2, Gst2-2
Accession Numbers
Essential gene? Probably non essential (E-score: 0.112) question?
Stock # IGL00557
Quality Score
Status
Chromosome 9
Chromosomal Location 78238300-78254474 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) T to A at 78238525 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Stop codon at position 185 (K185*)
Ref Sequence ENSEMBL: ENSMUSP00000034902 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000034902] [ENSMUST00000043734] [ENSMUST00000125479] [ENSMUST00000129247] [ENSMUST00000186336] [ENSMUST00000187667]
AlphaFold P10648
PDB Structure Crystal Structure of mGSTA2-2 in Complex with the Glutathione Conjugate of Benzo[a]pyrene-7(R),8(S)-Diol-9(S),10(R)-Epoxide [X-RAY DIFFRACTION]
Predicted Effect probably null
Transcript: ENSMUST00000034902
AA Change: K185*
SMART Domains Protein: ENSMUSP00000034902
Gene: ENSMUSG00000057933
AA Change: K185*

DomainStartEndE-ValueType
Pfam:GST_N 5 77 5.1e-23 PFAM
Pfam:GST_C 99 192 8.9e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000043734
SMART Domains Protein: ENSMUSP00000036132
Gene: ENSMUSG00000038750

DomainStartEndE-ValueType
transmembrane domain 69 91 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000125479
SMART Domains Protein: ENSMUSP00000115517
Gene: ENSMUSG00000057933

DomainStartEndE-ValueType
Pfam:GST_N 5 77 1.1e-21 PFAM
Pfam:GST_C 78 182 1.1e-14 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000129247
SMART Domains Protein: ENSMUSP00000117101
Gene: ENSMUSG00000057933

DomainStartEndE-ValueType
Pfam:GST_N 5 77 1.1e-21 PFAM
Pfam:GST_C 78 179 1.2e-13 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000140498
Predicted Effect probably benign
Transcript: ENSMUST00000186336
Predicted Effect probably benign
Transcript: ENSMUST00000187667
SMART Domains Protein: ENSMUSP00000139767
Gene: ENSMUSG00000038750

DomainStartEndE-ValueType
transmembrane domain 69 91 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000187890
Predicted Effect probably benign
Transcript: ENSMUST00000189243
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 25 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Agpat3 A T 10: 78,109,516 (GRCm39) probably benign Het
Arhgap35 T C 7: 16,298,340 (GRCm39) T242A probably benign Het
Asb15 C A 6: 24,558,649 (GRCm39) R55S probably benign Het
Brca2 C T 5: 150,484,003 (GRCm39) R2941W probably benign Het
Chrng T C 1: 87,134,469 (GRCm39) V135A probably damaging Het
Corin G T 5: 72,462,231 (GRCm39) H859Q probably damaging Het
Cul7 A G 17: 46,963,434 (GRCm39) E208G probably damaging Het
Dnah6 T C 6: 73,172,603 (GRCm39) N285S possibly damaging Het
Ell2 T A 13: 75,904,409 (GRCm39) I166N probably damaging Het
Fsip2 A G 2: 82,821,657 (GRCm39) R5797G possibly damaging Het
Galntl6 T C 8: 59,364,451 (GRCm39) I20V possibly damaging Het
Glra2 A G X: 164,072,633 (GRCm39) F78L possibly damaging Het
Gm12258 A G 11: 58,746,896 (GRCm39) D51G probably benign Het
Hmgcr C T 13: 96,795,786 (GRCm39) D294N probably benign Het
Iglv2 A G 16: 19,079,547 (GRCm39) probably benign Het
Myo10 T A 15: 25,776,466 (GRCm39) L63H probably damaging Het
P2ry10b T C X: 106,215,243 (GRCm39) V201A probably benign Het
Psmb2 A G 4: 126,571,642 (GRCm39) probably null Het
Samd4 T A 14: 47,290,355 (GRCm39) L154H probably damaging Het
Sult2a4 A T 7: 13,718,870 (GRCm39) D124E probably damaging Het
Trav9-1 A T 14: 53,725,815 (GRCm39) Y43F probably damaging Het
Trpv2 A G 11: 62,483,681 (GRCm39) N506S probably damaging Het
Ube3c T C 5: 29,824,227 (GRCm39) S474P probably damaging Het
Wdr87-ps A G 7: 29,235,227 (GRCm39) noncoding transcript Het
Zfp942 A T 17: 22,148,042 (GRCm39) C196S probably benign Het
Other mutations in Gsta2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02240:Gsta2 APN 9 78,238,441 (GRCm39) missense probably benign 0.01
IGL03057:Gsta2 APN 9 78,241,192 (GRCm39) unclassified probably benign
R1476:Gsta2 UTSW 9 78,249,147 (GRCm39) missense probably benign 0.02
R4972:Gsta2 UTSW 9 78,244,961 (GRCm39) missense probably damaging 0.98
R7269:Gsta2 UTSW 9 78,239,419 (GRCm39) missense probably benign 0.07
R8855:Gsta2 UTSW 9 78,244,880 (GRCm39) missense probably damaging 0.98
R9766:Gsta2 UTSW 9 78,244,876 (GRCm39) nonsense probably null
Posted On 2012-04-20