Incidental Mutation 'R5418:Ncoa7'
ID 484516
Institutional Source Beutler Lab
Gene Symbol Ncoa7
Ensembl Gene ENSMUSG00000039697
Gene Name nuclear receptor coactivator 7
Synonyms 9030406N13Rik
MMRRC Submission 042986-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R5418 (G1)
Quality Score 225
Status Validated
Chromosome 10
Chromosomal Location 30521578-30683401 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 30524035 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 153 (V153A)
Ref Sequence ENSEMBL: ENSMUSP00000150671 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000068567] [ENSMUST00000092610] [ENSMUST00000213836] [ENSMUST00000213897] [ENSMUST00000215740] [ENSMUST00000217644] [ENSMUST00000215926] [ENSMUST00000216172] [ENSMUST00000217138]
AlphaFold Q6DFV7
Predicted Effect possibly damaging
Transcript: ENSMUST00000068567
AA Change: V875A

PolyPhen 2 Score 0.662 (Sensitivity: 0.86; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000066741
Gene: ENSMUSG00000039697
AA Change: V875A

DomainStartEndE-ValueType
coiled coil region 1 32 N/A INTRINSIC
LysM 118 161 2.24e-7 SMART
low complexity region 165 176 N/A INTRINSIC
TLDc 781 943 2.86e-64 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000092610
SMART Domains Protein: ENSMUSP00000090273
Gene: ENSMUSG00000039697

DomainStartEndE-ValueType
TLDc 59 221 2.86e-64 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000213836
AA Change: V864A

PolyPhen 2 Score 0.439 (Sensitivity: 0.89; Specificity: 0.90)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000213889
Predicted Effect probably benign
Transcript: ENSMUST00000213897
Predicted Effect possibly damaging
Transcript: ENSMUST00000215740
AA Change: V875A

PolyPhen 2 Score 0.662 (Sensitivity: 0.86; Specificity: 0.91)
Predicted Effect probably damaging
Transcript: ENSMUST00000217644
AA Change: V153A

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
Predicted Effect probably damaging
Transcript: ENSMUST00000215926
AA Change: V826A

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
Predicted Effect probably damaging
Transcript: ENSMUST00000216172
AA Change: V153A

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
Predicted Effect probably benign
Transcript: ENSMUST00000217138
Meta Mutation Damage Score 0.4483 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.4%
Validation Efficiency 99% (81/82)
Allele List at MGI

All alleles(108) : Gene trapped(108)

Other mutations in this stock
Total: 75 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930568D16Rik A G 2: 35,244,738 (GRCm39) S205P probably damaging Het
Abcc1 T C 16: 14,278,996 (GRCm39) V1102A probably benign Het
Acad8 A T 9: 26,896,853 (GRCm39) M202K probably damaging Het
Acoxl T A 2: 127,719,722 (GRCm39) M161K probably benign Het
Adamts4 T A 1: 171,080,143 (GRCm39) V35E probably damaging Het
Add2 A G 6: 86,087,894 (GRCm39) S614G probably benign Het
Adgrv1 T A 13: 81,567,427 (GRCm39) I5249L probably benign Het
Agps A G 2: 75,689,248 (GRCm39) T252A probably damaging Het
Alms1-ps1 G A 6: 85,732,584 (GRCm39) noncoding transcript Het
Ankrd24 T A 10: 81,480,776 (GRCm39) probably benign Het
Bcl9l A G 9: 44,416,733 (GRCm39) Q218R possibly damaging Het
Bin2 T C 15: 100,547,027 (GRCm39) Y232C probably damaging Het
Bptf A G 11: 107,002,120 (GRCm39) Y331H probably damaging Het
Ccr10 C T 11: 101,064,904 (GRCm39) V209M probably benign Het
Cflar A T 1: 58,791,810 (GRCm39) D371V possibly damaging Het
Col1a2 A G 6: 4,516,931 (GRCm39) probably benign Het
Crlf2 A G 5: 109,704,899 (GRCm39) V104A probably benign Het
Dennd1c CCGCCCCTCGCTGACAGC CC 17: 57,373,755 (GRCm39) probably null Het
Dmxl2 A G 9: 54,281,935 (GRCm39) probably null Het
Dnah17 C A 11: 117,985,810 (GRCm39) E1422D probably benign Het
Dnase1l1 C T X: 73,320,644 (GRCm39) probably null Het
Efcab11 A G 12: 99,821,877 (GRCm39) L80S possibly damaging Het
Emc8 G A 8: 121,385,342 (GRCm39) T130M probably damaging Het
Epha6 C A 16: 60,245,198 (GRCm39) A334S possibly damaging Het
Erc2 A G 14: 27,688,467 (GRCm39) M196V probably benign Het
Etnk2 T C 1: 133,300,995 (GRCm39) I254T probably damaging Het
Fam120b C T 17: 15,622,061 (GRCm39) T13M probably damaging Het
Fam234b A G 6: 135,203,966 (GRCm39) K423E probably benign Het
Fcgbp G A 7: 27,784,738 (GRCm39) G266D probably damaging Het
Fndc4 A T 5: 31,451,978 (GRCm39) S146R probably benign Het
Frmd3 G A 4: 74,079,935 (GRCm39) probably null Het
Glrx2 C A 1: 143,615,446 (GRCm39) S16R possibly damaging Het
Gm26526 T G 7: 39,238,358 (GRCm39) noncoding transcript Het
Hc C T 2: 34,898,195 (GRCm39) probably null Het
Herc2 T C 7: 55,787,313 (GRCm39) C1695R probably damaging Het
Hic1 A G 11: 75,057,425 (GRCm39) probably null Het
Igkv4-92 A T 6: 68,732,564 (GRCm39) V5E possibly damaging Het
Irs1 G A 1: 82,266,491 (GRCm39) T575I probably damaging Het
Kcp A T 6: 29,504,283 (GRCm39) Y143* probably null Het
Klb A G 5: 65,540,813 (GRCm39) N969D probably benign Het
Klra6 T A 6: 129,990,393 (GRCm39) L239F probably damaging Het
Lhx6 A G 2: 35,977,378 (GRCm39) probably null Het
Lrrc34 G A 3: 30,696,923 (GRCm39) P116S possibly damaging Het
Map3k9 T A 12: 81,790,591 (GRCm39) K321* probably null Het
Mapk14 T C 17: 28,960,817 (GRCm39) V196A possibly damaging Het
Matcap2 G T 9: 22,343,066 (GRCm39) R187L probably damaging Het
Mmp1b T C 9: 7,384,897 (GRCm39) I251V possibly damaging Het
Mtmr12 T C 15: 12,270,045 (GRCm39) L711P probably damaging Het
Mylk T C 16: 34,732,600 (GRCm39) S627P probably benign Het
Nbea A T 3: 55,553,410 (GRCm39) Y2631N possibly damaging Het
Or4a79 T C 2: 89,552,343 (GRCm39) I37M probably benign Het
Pax6 A T 2: 105,521,910 (GRCm39) D175V probably benign Het
Piezo1 A G 8: 123,213,519 (GRCm39) L1793P probably damaging Het
Pkp4 T C 2: 59,140,506 (GRCm39) V404A probably benign Het
Plxnb2 A G 15: 89,050,694 (GRCm39) Y421H probably benign Het
Prkdc T G 16: 15,612,961 (GRCm39) V3173G probably benign Het
Prss40 A T 1: 34,599,840 (GRCm39) I49N probably benign Het
Prx T A 7: 27,216,699 (GRCm39) V400E probably damaging Het
Rbm11 A C 16: 75,393,423 (GRCm39) T40P probably damaging Het
Resf1 T C 6: 149,227,634 (GRCm39) Y227H probably damaging Het
Scara5 CG C 14: 65,997,111 (GRCm39) probably null Het
Sema3f A G 9: 107,569,820 (GRCm39) Y70H probably damaging Het
Senp6 G A 9: 80,029,151 (GRCm39) E505K possibly damaging Het
Slc25a3 T C 10: 90,955,398 (GRCm39) I147M probably benign Het
Slc4a7 T A 14: 14,760,280 (GRCm38) S572T probably benign Het
Smarcal1 C T 1: 72,638,068 (GRCm39) P501S probably benign Het
Sox7 C T 14: 64,185,396 (GRCm39) T144M probably benign Het
Taar1 T C 10: 23,797,214 (GRCm39) F304S possibly damaging Het
Tcf3 A G 10: 80,263,517 (GRCm39) F46L probably damaging Het
Tmem184c A G 8: 78,324,449 (GRCm39) V347A probably damaging Het
Tpcn2 C T 7: 144,832,518 (GRCm39) E113K probably damaging Het
Vmn1r232 T A 17: 21,134,378 (GRCm39) Y74F possibly damaging Het
Vmn2r102 C T 17: 19,914,415 (GRCm39) T660I probably damaging Het
Zdhhc3 A G 9: 122,909,456 (GRCm39) M234T probably damaging Het
Zfp960 T A 17: 17,307,805 (GRCm39) L173H probably damaging Het
Other mutations in Ncoa7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01406:Ncoa7 APN 10 30,566,836 (GRCm39) missense probably damaging 1.00
IGL01716:Ncoa7 APN 10 30,538,330 (GRCm39) missense probably damaging 0.96
IGL02114:Ncoa7 APN 10 30,538,360 (GRCm39) missense probably damaging 1.00
IGL02170:Ncoa7 APN 10 30,565,849 (GRCm39) missense possibly damaging 0.94
IGL02436:Ncoa7 APN 10 30,570,143 (GRCm39) missense probably damaging 1.00
IGL02499:Ncoa7 APN 10 30,566,885 (GRCm39) missense probably benign 0.04
IGL02533:Ncoa7 APN 10 30,598,781 (GRCm39) missense probably damaging 1.00
IGL02533:Ncoa7 APN 10 30,566,895 (GRCm39) missense possibly damaging 0.87
IGL02590:Ncoa7 APN 10 30,570,159 (GRCm39) missense probably damaging 1.00
IGL02657:Ncoa7 APN 10 30,528,972 (GRCm39) missense probably damaging 1.00
IGL03065:Ncoa7 APN 10 30,523,993 (GRCm39) missense probably damaging 1.00
IGL03088:Ncoa7 APN 10 30,574,121 (GRCm39) splice site probably null
IGL03090:Ncoa7 APN 10 30,538,396 (GRCm39) missense probably damaging 0.96
IGL03196:Ncoa7 APN 10 30,523,510 (GRCm39) utr 3 prime probably benign
D6062:Ncoa7 UTSW 10 30,598,651 (GRCm39) missense probably damaging 1.00
R0058:Ncoa7 UTSW 10 30,523,537 (GRCm39) missense probably damaging 1.00
R0058:Ncoa7 UTSW 10 30,523,537 (GRCm39) missense probably damaging 1.00
R0578:Ncoa7 UTSW 10 30,577,913 (GRCm39) critical splice donor site probably null
R0729:Ncoa7 UTSW 10 30,567,575 (GRCm39) missense probably benign 0.00
R1538:Ncoa7 UTSW 10 30,570,207 (GRCm39) missense probably damaging 0.99
R1539:Ncoa7 UTSW 10 30,647,725 (GRCm39) missense probably damaging 1.00
R1574:Ncoa7 UTSW 10 30,570,097 (GRCm39) missense probably damaging 1.00
R1574:Ncoa7 UTSW 10 30,570,097 (GRCm39) missense probably damaging 1.00
R1624:Ncoa7 UTSW 10 30,580,655 (GRCm39) missense possibly damaging 0.87
R1639:Ncoa7 UTSW 10 30,577,988 (GRCm39) missense probably damaging 1.00
R1655:Ncoa7 UTSW 10 30,574,241 (GRCm39) critical splice acceptor site probably null
R1876:Ncoa7 UTSW 10 30,574,122 (GRCm39) intron probably benign
R1885:Ncoa7 UTSW 10 30,524,448 (GRCm39) missense possibly damaging 0.81
R1886:Ncoa7 UTSW 10 30,524,448 (GRCm39) missense possibly damaging 0.81
R1887:Ncoa7 UTSW 10 30,524,448 (GRCm39) missense possibly damaging 0.81
R1909:Ncoa7 UTSW 10 30,565,796 (GRCm39) missense probably damaging 1.00
R1938:Ncoa7 UTSW 10 30,574,166 (GRCm39) missense probably benign 0.02
R1965:Ncoa7 UTSW 10 30,530,426 (GRCm39) nonsense probably null
R1978:Ncoa7 UTSW 10 30,567,295 (GRCm39) missense probably benign
R2303:Ncoa7 UTSW 10 30,530,431 (GRCm39) missense probably damaging 1.00
R3777:Ncoa7 UTSW 10 30,565,752 (GRCm39) missense probably damaging 1.00
R3778:Ncoa7 UTSW 10 30,565,752 (GRCm39) missense probably damaging 1.00
R4026:Ncoa7 UTSW 10 30,598,720 (GRCm39) missense probably benign 0.02
R4230:Ncoa7 UTSW 10 30,574,253 (GRCm39) splice site probably null
R4667:Ncoa7 UTSW 10 30,566,786 (GRCm39) missense probably damaging 1.00
R4786:Ncoa7 UTSW 10 30,531,638 (GRCm39) missense probably benign 0.28
R4809:Ncoa7 UTSW 10 30,647,758 (GRCm39) missense possibly damaging 0.92
R4820:Ncoa7 UTSW 10 30,524,472 (GRCm39) missense probably damaging 1.00
R4839:Ncoa7 UTSW 10 30,598,655 (GRCm39) missense possibly damaging 0.93
R4861:Ncoa7 UTSW 10 30,580,608 (GRCm39) missense probably benign
R4861:Ncoa7 UTSW 10 30,580,608 (GRCm39) missense probably benign
R5271:Ncoa7 UTSW 10 30,598,725 (GRCm39) missense probably benign 0.02
R5384:Ncoa7 UTSW 10 30,598,813 (GRCm39) missense probably benign 0.00
R5964:Ncoa7 UTSW 10 30,580,632 (GRCm39) missense probably damaging 1.00
R6257:Ncoa7 UTSW 10 30,570,173 (GRCm39) missense probably damaging 1.00
R6683:Ncoa7 UTSW 10 30,647,717 (GRCm39) missense probably damaging 0.99
R6813:Ncoa7 UTSW 10 30,572,188 (GRCm39) missense probably damaging 1.00
R6910:Ncoa7 UTSW 10 30,570,117 (GRCm39) missense possibly damaging 0.89
R7123:Ncoa7 UTSW 10 30,530,435 (GRCm39) missense probably benign 0.28
R7327:Ncoa7 UTSW 10 30,565,796 (GRCm39) missense probably damaging 1.00
R7412:Ncoa7 UTSW 10 30,598,847 (GRCm39) missense possibly damaging 0.94
R7638:Ncoa7 UTSW 10 30,598,794 (GRCm39) missense probably benign 0.35
R7653:Ncoa7 UTSW 10 30,570,239 (GRCm39) missense probably damaging 1.00
R7848:Ncoa7 UTSW 10 30,524,414 (GRCm39) missense possibly damaging 0.82
R7861:Ncoa7 UTSW 10 30,567,056 (GRCm39) missense probably benign 0.38
R8125:Ncoa7 UTSW 10 30,570,087 (GRCm39) missense possibly damaging 0.80
R8198:Ncoa7 UTSW 10 30,580,664 (GRCm39) missense probably benign 0.00
R8240:Ncoa7 UTSW 10 30,567,725 (GRCm39) missense probably benign 0.45
R8353:Ncoa7 UTSW 10 30,570,155 (GRCm39) missense probably damaging 1.00
R8509:Ncoa7 UTSW 10 30,572,048 (GRCm39) missense probably benign 0.00
R8861:Ncoa7 UTSW 10 30,567,364 (GRCm39) missense probably benign 0.02
R9040:Ncoa7 UTSW 10 30,530,389 (GRCm39) missense probably benign 0.00
R9136:Ncoa7 UTSW 10 30,567,628 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- AAATGGTTGCAGTCTCTCAGG -3'
(R):5'- GCCAGCACATTATCGAATGG -3'

Sequencing Primer
(F):5'- TGCAGTCTCTCAGGCACATTAATAC -3'
(R):5'- CCAGCACATTATCGAATGGTCTTTAC -3'
Posted On 2017-08-08