Incidental Mutation 'R6113:Trib1'
ID 484978
Institutional Source Beutler Lab
Gene Symbol Trib1
Ensembl Gene ENSMUSG00000032501
Gene Name tribbles pseudokinase 1
Synonyms A530090O15Rik, Trb1
MMRRC Submission 044262-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R6113 (G1)
Quality Score 225.009
Status Validated
Chromosome 15
Chromosomal Location 59520503-59528948 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) C to T at 59523487 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Stop codon at position 174 (R174*)
Ref Sequence ENSEMBL: ENSMUSP00000112828 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000067543] [ENSMUST00000118228]
AlphaFold Q8K4K4
Predicted Effect probably null
Transcript: ENSMUST00000067543
AA Change: R174*
SMART Domains Protein: ENSMUSP00000068834
Gene: ENSMUSG00000032501
AA Change: R174*

DomainStartEndE-ValueType
low complexity region 61 82 N/A INTRINSIC
Pfam:Pkinase 105 338 1.1e-33 PFAM
Pfam:Pkinase_Tyr 120 335 2.1e-15 PFAM
Pfam:Kinase-like 124 326 1.4e-8 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000118228
AA Change: R174*
SMART Domains Protein: ENSMUSP00000112828
Gene: ENSMUSG00000032501
AA Change: R174*

DomainStartEndE-ValueType
low complexity region 61 82 N/A INTRINSIC
Pfam:Pkinase 104 218 7.9e-12 PFAM
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 97.9%
  • 20x: 94.1%
Validation Efficiency 100% (58/58)
MGI Phenotype PHENOTYPE: Macrophages from mice homozygous for a knock-out allele exhibit impaired IL12 response to LPS, MALP-1, or CpG DNA. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abat C A 16: 8,390,764 (GRCm39) T7N probably benign Het
Aldh1l2 G T 10: 83,343,998 (GRCm39) C359* probably null Het
Atpsckmt T C 15: 31,608,308 (GRCm39) Y120H probably damaging Het
Bpifb6 G A 2: 153,752,651 (GRCm39) E384K probably benign Het
Chtf18 G A 17: 25,941,841 (GRCm39) R544C probably damaging Het
Cilp2 T C 8: 70,335,009 (GRCm39) D663G probably benign Het
Cplx3 T A 9: 57,509,723 (GRCm39) I92F probably damaging Het
Cr1l T C 1: 194,813,719 (GRCm39) probably benign Het
Cyp1a1 T A 9: 57,609,174 (GRCm39) F323I probably damaging Het
Dclk1 T C 3: 55,397,240 (GRCm39) Y186H probably benign Het
Dclre1c T C 2: 3,453,900 (GRCm39) L261P probably damaging Het
Dcst2 T C 3: 89,275,192 (GRCm39) S312P possibly damaging Het
Dnah17 A G 11: 118,017,101 (GRCm39) L213P probably damaging Het
Dnd1 T A 18: 36,898,448 (GRCm39) Y102F probably damaging Het
Dnm1l T C 16: 16,158,867 (GRCm39) N121S probably benign Het
Dsp T A 13: 38,376,023 (GRCm39) N1269K probably damaging Het
Dync1h1 T C 12: 110,586,848 (GRCm39) V943A probably benign Het
Eml5 T A 12: 98,790,933 (GRCm39) K1322* probably null Het
Fgf23 A G 6: 127,055,117 (GRCm39) T76A probably benign Het
Fgf6 T C 6: 126,992,900 (GRCm39) probably null Het
Fkbp15 G A 4: 62,258,884 (GRCm39) T124I probably benign Het
Gm12185 A T 11: 48,806,167 (GRCm39) H341Q possibly damaging Het
Gm20647 A G 5: 72,487,143 (GRCm39) probably benign Het
Lrp2 G C 2: 69,313,901 (GRCm39) R2277G possibly damaging Het
Lrrc69 T C 4: 14,708,673 (GRCm39) T224A probably benign Het
Ly75 T G 2: 60,199,217 (GRCm39) I175L probably benign Het
Morc2b G T 17: 33,357,042 (GRCm39) Y243* probably null Het
Myo18b C G 5: 113,014,251 (GRCm39) D764H probably damaging Het
Naip6 T C 13: 100,435,794 (GRCm39) S910G possibly damaging Het
Nbeal1 T A 1: 60,261,422 (GRCm39) I21N possibly damaging Het
P3h2 A T 16: 25,799,903 (GRCm39) I430K probably benign Het
Pcdh9 A G 14: 94,124,544 (GRCm39) V542A probably damaging Het
Pkp3 T A 7: 140,662,569 (GRCm39) N60K probably damaging Het
Pold1 C A 7: 44,187,124 (GRCm39) G686C probably damaging Het
Prdm6 T A 18: 53,606,673 (GRCm39) L58Q probably damaging Het
Rab13 C A 3: 90,132,173 (GRCm39) R86S probably benign Het
Rad21l A C 2: 151,499,398 (GRCm39) L265V probably damaging Het
Rec8 G A 14: 55,859,935 (GRCm39) A228T probably damaging Het
Rgs12 C A 5: 35,177,667 (GRCm39) R76S probably damaging Het
Sfmbt1 A G 14: 30,537,141 (GRCm39) N670D possibly damaging Het
Slc17a7 A G 7: 44,824,175 (GRCm39) T464A possibly damaging Het
Srcap C A 7: 127,159,453 (GRCm39) probably benign Het
Srgap2 A T 1: 131,283,243 (GRCm39) probably null Het
Tenm1 C T X: 41,916,072 (GRCm39) G404E probably damaging Het
Thpo C A 16: 20,547,597 (GRCm39) probably benign Het
Tle4 A T 19: 14,572,952 (GRCm39) probably null Het
Tnfrsf14 T C 4: 155,008,949 (GRCm39) Q74R possibly damaging Het
Trav15-2-dv6-2 T G 14: 53,887,182 (GRCm39) V34G probably benign Het
Trbv13-1 C T 6: 41,093,313 (GRCm39) A82V probably benign Het
Trpv3 G A 11: 73,176,844 (GRCm39) V408I probably benign Het
Tyk2 A T 9: 21,019,218 (GRCm39) V1068E probably damaging Het
Usp35 A G 7: 96,973,533 (GRCm39) S230P probably damaging Het
Utp25 T C 1: 192,811,810 (GRCm39) I46V probably null Het
Vav1 T A 17: 57,608,884 (GRCm39) D349E probably benign Het
Vcan T A 13: 89,805,655 (GRCm39) R114* probably null Het
Vmn1r25 T C 6: 57,955,557 (GRCm39) E244G probably benign Het
Vmn2r5 T C 3: 64,398,820 (GRCm39) T720A probably benign Het
Wdr72 T A 9: 74,059,923 (GRCm39) D444E probably benign Het
Zfhx3 T A 8: 109,674,053 (GRCm39) M1701K probably benign Het
Other mutations in Trib1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01140:Trib1 APN 15 59,523,476 (GRCm39) missense probably damaging 1.00
IGL01648:Trib1 APN 15 59,526,350 (GRCm39) missense probably benign 0.38
IGL02267:Trib1 APN 15 59,523,449 (GRCm39) missense probably damaging 0.98
IGL03018:Trib1 APN 15 59,526,333 (GRCm39) missense probably damaging 1.00
Dibble UTSW 15 59,526,324 (GRCm39) missense probably damaging 1.00
lawrence UTSW 15 59,521,264 (GRCm39) missense probably benign
Topcat UTSW 15 59,523,487 (GRCm39) nonsense probably null
R1994:Trib1 UTSW 15 59,521,192 (GRCm39) missense possibly damaging 0.70
R2073:Trib1 UTSW 15 59,526,189 (GRCm39) missense probably damaging 1.00
R2407:Trib1 UTSW 15 59,526,449 (GRCm39) missense probably benign 0.00
R3709:Trib1 UTSW 15 59,526,210 (GRCm39) missense probably damaging 1.00
R5759:Trib1 UTSW 15 59,526,350 (GRCm39) missense probably benign
R5986:Trib1 UTSW 15 59,526,451 (GRCm39) splice site probably null
R6083:Trib1 UTSW 15 59,526,324 (GRCm39) missense probably damaging 1.00
R6084:Trib1 UTSW 15 59,526,324 (GRCm39) missense probably damaging 1.00
R6086:Trib1 UTSW 15 59,526,324 (GRCm39) missense probably damaging 1.00
R6112:Trib1 UTSW 15 59,523,487 (GRCm39) nonsense probably null
R6316:Trib1 UTSW 15 59,521,264 (GRCm39) missense probably benign
R7288:Trib1 UTSW 15 59,526,471 (GRCm39) missense probably benign
R7663:Trib1 UTSW 15 59,523,562 (GRCm39) missense probably damaging 1.00
R7744:Trib1 UTSW 15 59,526,512 (GRCm39) missense probably benign 0.04
R8061:Trib1 UTSW 15 59,523,404 (GRCm39) missense probably damaging 0.97
Predicted Primers PCR Primer
(F):5'- TCAGATAGGACCTTGGAGGC -3'
(R):5'- GTTGTTCCAAAAGGCCACCAG -3'

Sequencing Primer
(F):5'- TAAACAGGTCACTTTTCTCCCCACAG -3'
(R):5'- CACCAGAAGTGCTGTGTCAG -3'
Posted On 2017-08-16