Incidental Mutation 'R6116:Lpar3'
ID 485109
Institutional Source Beutler Lab
Gene Symbol Lpar3
Ensembl Gene ENSMUSG00000036832
Gene Name lysophosphatidic acid receptor 3
Synonyms Edg7, LPA3
MMRRC Submission 044265-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R6116 (G1)
Quality Score 225.009
Status Not validated
Chromosome 3
Chromosomal Location 145926718-145991941 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 145946352 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Lysine at position 10 (M10K)
Ref Sequence ENSEMBL: ENSMUSP00000037712 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000039164]
AlphaFold Q9EQ31
Predicted Effect possibly damaging
Transcript: ENSMUST00000039164
AA Change: M10K

PolyPhen 2 Score 0.703 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000037712
Gene: ENSMUSG00000036832
AA Change: M10K

DomainStartEndE-ValueType
Pfam:7tm_1 47 293 2.4e-37 PFAM
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.2%
  • 20x: 95.1%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the G protein-coupled receptor family, as well as the EDG family of proteins. This protein functions as a cellular receptor for lysophosphatidic acid and mediates lysophosphatidic acid-evoked calcium mobilization. This receptor couples predominantly to G(q/11) alpha proteins. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous null females produce smaller litter sizes and exhibit delayed implantation and altered embryo spacing that leads to delayed development of embryos and hypertrophic placentas that were shared by multiple embryos. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ahnak T A 19: 8,990,327 (GRCm39) probably benign Het
Apc A T 18: 34,449,508 (GRCm39) I2101F probably damaging Het
Bpifa3 G A 2: 153,975,633 (GRCm39) V68I possibly damaging Het
Csmd1 T A 8: 16,261,864 (GRCm39) I878F probably damaging Het
Cyp2c67 A T 19: 39,605,879 (GRCm39) M339K probably damaging Het
Dock3 A G 9: 106,809,161 (GRCm39) Y1321H probably damaging Het
Dsc1 G T 18: 20,230,356 (GRCm39) D316E probably benign Het
Eno3 C T 11: 70,552,401 (GRCm39) T351M possibly damaging Het
Erbb2 T A 11: 98,318,225 (GRCm39) F487Y probably damaging Het
Exosc10 T C 4: 148,657,810 (GRCm39) L652P probably benign Het
Glmn A T 5: 107,705,206 (GRCm39) M470K probably damaging Het
Gm15446 T A 5: 110,090,902 (GRCm39) C385S probably damaging Het
Hspa8 A G 9: 40,716,271 (GRCm39) E581G probably damaging Het
Igfn1 T C 1: 135,898,205 (GRCm39) D787G probably benign Het
Igkv12-44 T C 6: 69,791,838 (GRCm39) T42A possibly damaging Het
Itsn2 T C 12: 4,679,939 (GRCm39) probably benign Het
Jade2 T C 11: 51,726,460 (GRCm39) E84G probably damaging Het
Lpin2 A G 17: 71,550,925 (GRCm39) D695G probably damaging Het
Mosmo T A 7: 120,325,418 (GRCm39) L7H probably damaging Het
Ms4a8a C T 19: 11,058,436 (GRCm39) A9T unknown Het
Myb T C 10: 21,030,653 (GRCm39) D48G probably damaging Het
Neurod6 T C 6: 55,655,776 (GRCm39) Y287C probably damaging Het
Olr1 T A 6: 129,476,947 (GRCm39) D106V probably damaging Het
Or11a4 A G 17: 37,536,459 (GRCm39) T148A probably benign Het
Or8b4 A G 9: 37,829,955 (GRCm39) M1V probably null Het
Peg10 C CCCATCAGGA 6: 4,756,351 (GRCm39) probably benign Het
Plch1 C T 3: 63,609,444 (GRCm39) R912H probably damaging Het
Ppfia3 T C 7: 45,004,127 (GRCm39) Y505C probably damaging Het
Sdk2 T A 11: 113,745,190 (GRCm39) I702F probably damaging Het
Slc16a11 T C 11: 70,106,262 (GRCm39) F119L probably benign Het
Slc2a10 A C 2: 165,359,623 (GRCm39) T496P probably damaging Het
Slc7a2 T C 8: 41,353,206 (GRCm39) Y181H probably damaging Het
Spata31e5 G A 1: 28,817,780 (GRCm39) A84V probably benign Het
Stab2 G T 10: 86,743,054 (GRCm39) P1185Q probably damaging Het
Tcf7l2 T A 19: 55,907,446 (GRCm39) S335R probably damaging Het
Ttc41 G A 10: 86,594,952 (GRCm39) probably null Het
Vmn2r32 A T 7: 7,467,092 (GRCm39) I812N probably damaging Het
Wdr24 C T 17: 26,043,579 (GRCm39) H134Y probably benign Het
Other mutations in Lpar3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02444:Lpar3 APN 3 145,946,949 (GRCm39) missense probably damaging 1.00
R0656:Lpar3 UTSW 3 145,946,426 (GRCm39) missense possibly damaging 0.54
R0893:Lpar3 UTSW 3 145,946,348 (GRCm39) missense possibly damaging 0.82
R1809:Lpar3 UTSW 3 145,946,303 (GRCm39) splice site probably benign
R4937:Lpar3 UTSW 3 145,990,506 (GRCm39) missense probably damaging 0.98
R6587:Lpar3 UTSW 3 145,946,918 (GRCm39) missense probably damaging 1.00
R7232:Lpar3 UTSW 3 145,947,061 (GRCm39) critical splice donor site probably null
R8029:Lpar3 UTSW 3 145,946,718 (GRCm39) missense probably benign 0.01
R8266:Lpar3 UTSW 3 145,946,385 (GRCm39) missense probably benign 0.02
R9676:Lpar3 UTSW 3 145,990,434 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- GAGGCCAGGAGTGAACTTACTG -3'
(R):5'- AGGAACACGTAAGCGATTCC -3'

Sequencing Primer
(F):5'- TGAACTTACTGAAAGGAGTCACC -3'
(R):5'- TCCGCAGCAGCTAAGTTAG -3'
Posted On 2017-08-16