Incidental Mutation 'R6116:Or11a4'
ID 485135
Institutional Source Beutler Lab
Gene Symbol Or11a4
Ensembl Gene ENSMUSG00000064121
Gene Name olfactory receptor family 11 subfamily A member 4
Synonyms MOR121-1, Olfr96, GA_x6K02T2PSCP-1665046-1665987
MMRRC Submission 044265-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.164) question?
Stock # R6116 (G1)
Quality Score 225.009
Status Not validated
Chromosome 17
Chromosomal Location 37535982-37537032 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 37536459 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 148 (T148A)
Ref Sequence ENSEMBL: ENSMUSP00000151151 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000078209] [ENSMUST00000213475] [ENSMUST00000214482]
AlphaFold Q8VFE3
Predicted Effect probably benign
Transcript: ENSMUST00000078209
AA Change: T148A

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000077338
Gene: ENSMUSG00000064121
AA Change: T148A

DomainStartEndE-ValueType
Pfam:7tm_4 33 309 6.6e-53 PFAM
Pfam:7tm_1 43 291 6.2e-22 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213475
AA Change: T148A

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Predicted Effect probably benign
Transcript: ENSMUST00000214482
AA Change: T148A

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.2%
  • 20x: 95.1%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ahnak T A 19: 8,990,327 (GRCm39) probably benign Het
Apc A T 18: 34,449,508 (GRCm39) I2101F probably damaging Het
Bpifa3 G A 2: 153,975,633 (GRCm39) V68I possibly damaging Het
Csmd1 T A 8: 16,261,864 (GRCm39) I878F probably damaging Het
Cyp2c67 A T 19: 39,605,879 (GRCm39) M339K probably damaging Het
Dock3 A G 9: 106,809,161 (GRCm39) Y1321H probably damaging Het
Dsc1 G T 18: 20,230,356 (GRCm39) D316E probably benign Het
Eno3 C T 11: 70,552,401 (GRCm39) T351M possibly damaging Het
Erbb2 T A 11: 98,318,225 (GRCm39) F487Y probably damaging Het
Exosc10 T C 4: 148,657,810 (GRCm39) L652P probably benign Het
Glmn A T 5: 107,705,206 (GRCm39) M470K probably damaging Het
Gm15446 T A 5: 110,090,902 (GRCm39) C385S probably damaging Het
Hspa8 A G 9: 40,716,271 (GRCm39) E581G probably damaging Het
Igfn1 T C 1: 135,898,205 (GRCm39) D787G probably benign Het
Igkv12-44 T C 6: 69,791,838 (GRCm39) T42A possibly damaging Het
Itsn2 T C 12: 4,679,939 (GRCm39) probably benign Het
Jade2 T C 11: 51,726,460 (GRCm39) E84G probably damaging Het
Lpar3 T A 3: 145,946,352 (GRCm39) M10K possibly damaging Het
Lpin2 A G 17: 71,550,925 (GRCm39) D695G probably damaging Het
Mosmo T A 7: 120,325,418 (GRCm39) L7H probably damaging Het
Ms4a8a C T 19: 11,058,436 (GRCm39) A9T unknown Het
Myb T C 10: 21,030,653 (GRCm39) D48G probably damaging Het
Neurod6 T C 6: 55,655,776 (GRCm39) Y287C probably damaging Het
Olr1 T A 6: 129,476,947 (GRCm39) D106V probably damaging Het
Or8b4 A G 9: 37,829,955 (GRCm39) M1V probably null Het
Peg10 C CCCATCAGGA 6: 4,756,351 (GRCm39) probably benign Het
Plch1 C T 3: 63,609,444 (GRCm39) R912H probably damaging Het
Ppfia3 T C 7: 45,004,127 (GRCm39) Y505C probably damaging Het
Sdk2 T A 11: 113,745,190 (GRCm39) I702F probably damaging Het
Slc16a11 T C 11: 70,106,262 (GRCm39) F119L probably benign Het
Slc2a10 A C 2: 165,359,623 (GRCm39) T496P probably damaging Het
Slc7a2 T C 8: 41,353,206 (GRCm39) Y181H probably damaging Het
Spata31e5 G A 1: 28,817,780 (GRCm39) A84V probably benign Het
Stab2 G T 10: 86,743,054 (GRCm39) P1185Q probably damaging Het
Tcf7l2 T A 19: 55,907,446 (GRCm39) S335R probably damaging Het
Ttc41 G A 10: 86,594,952 (GRCm39) probably null Het
Vmn2r32 A T 7: 7,467,092 (GRCm39) I812N probably damaging Het
Wdr24 C T 17: 26,043,579 (GRCm39) H134Y probably benign Het
Other mutations in Or11a4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01868:Or11a4 APN 17 37,536,043 (GRCm39) missense probably benign 0.05
IGL02151:Or11a4 APN 17 37,536,057 (GRCm39) missense probably damaging 1.00
IGL02335:Or11a4 APN 17 37,536,217 (GRCm39) missense probably damaging 0.97
R0360:Or11a4 UTSW 17 37,536,934 (GRCm39) missense possibly damaging 0.49
R0364:Or11a4 UTSW 17 37,536,934 (GRCm39) missense possibly damaging 0.49
R1763:Or11a4 UTSW 17 37,536,321 (GRCm39) missense probably benign 0.02
R3977:Or11a4 UTSW 17 37,536,049 (GRCm39) missense probably benign 0.24
R6248:Or11a4 UTSW 17 37,536,451 (GRCm39) nonsense probably null
R6378:Or11a4 UTSW 17 37,536,688 (GRCm39) missense probably benign 0.21
R6518:Or11a4 UTSW 17 37,536,159 (GRCm39) missense probably benign 0.05
R6614:Or11a4 UTSW 17 37,536,790 (GRCm39) missense probably benign 0.01
R6798:Or11a4 UTSW 17 37,536,697 (GRCm39) missense probably damaging 1.00
R6874:Or11a4 UTSW 17 37,536,238 (GRCm39) missense probably benign 0.00
R7468:Or11a4 UTSW 17 37,536,276 (GRCm39) missense probably benign 0.01
R7820:Or11a4 UTSW 17 37,536,786 (GRCm39) missense probably benign 0.00
R7852:Or11a4 UTSW 17 37,536,163 (GRCm39) missense probably benign 0.01
R8322:Or11a4 UTSW 17 37,536,241 (GRCm39) missense probably damaging 0.99
R8481:Or11a4 UTSW 17 37,536,295 (GRCm39) missense probably damaging 1.00
R8933:Or11a4 UTSW 17 37,536,346 (GRCm39) missense possibly damaging 0.96
X0027:Or11a4 UTSW 17 37,536,634 (GRCm39) missense possibly damaging 0.93
Predicted Primers PCR Primer
(F):5'- ACCATATCTGTGGCTGGCTG -3'
(R):5'- GCACAGTCACTACAATCTGAGC -3'

Sequencing Primer
(F):5'- CTGGCTGCTTGCTCCAG -3'
(R):5'- AGTCACTACAATCTGAGCATAGG -3'
Posted On 2017-08-16