Incidental Mutation 'R6101:Or8d2b'
ID 485262
Institutional Source Beutler Lab
Gene Symbol Or8d2b
Ensembl Gene ENSMUSG00000064333
Gene Name olfactory receptor family 8 subfamily D member 2D
Synonyms MOR171-8, Olfr926, GA_x6K02T2PVTD-32573036-32573962
MMRRC Submission 044251-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.085) question?
Stock # R6101 (G1)
Quality Score 225.009
Status Not validated
Chromosome 9
Chromosomal Location 38788474-38789400 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 38788604 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Proline at position 44 (L44P)
Ref Sequence ENSEMBL: ENSMUSP00000077405 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000078289]
AlphaFold Q9EQ98
Predicted Effect possibly damaging
Transcript: ENSMUST00000078289
AA Change: L44P

PolyPhen 2 Score 0.947 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000077405
Gene: ENSMUSG00000064333
AA Change: L44P

DomainStartEndE-ValueType
Pfam:7tm_4 28 305 2.9e-53 PFAM
Pfam:7TM_GPCR_Srsx 32 282 8.6e-7 PFAM
Pfam:7tm_1 38 287 1.6e-20 PFAM
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.2%
  • 20x: 95.0%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam9 A T 8: 25,460,775 (GRCm39) C570S probably damaging Het
Adh6b T A 3: 138,063,471 (GRCm39) I350K possibly damaging Het
Ahnak G A 19: 8,981,463 (GRCm39) V916I probably benign Het
Aldh4a1 C T 4: 139,365,806 (GRCm39) P266S possibly damaging Het
Arhgap11a G A 2: 113,665,219 (GRCm39) R460* probably null Het
Chl1 A T 6: 103,669,993 (GRCm39) D477V probably damaging Het
Clstn3 A T 6: 124,438,629 (GRCm39) L45Q probably damaging Het
Cnot7 C T 8: 40,963,078 (GRCm39) R32Q probably benign Het
Csrnp1 T C 9: 119,802,551 (GRCm39) D220G probably damaging Het
Cyb5a G A 18: 84,889,718 (GRCm39) R49Q possibly damaging Het
Fblim1 G A 4: 141,312,033 (GRCm39) R231C probably damaging Het
Glul T A 1: 153,782,177 (GRCm39) Y137* probably null Het
Gm10549 C A 18: 33,597,358 (GRCm39) probably benign Het
Igha T A 12: 113,220,017 (GRCm39) probably benign Het
Kif2b A G 11: 91,466,814 (GRCm39) S490P probably benign Het
Kxd1 A T 8: 70,972,589 (GRCm39) N33K probably benign Het
Lrrk2 T C 15: 91,607,338 (GRCm39) I567T probably benign Het
Man2a2 T C 7: 80,016,749 (GRCm39) D355G probably damaging Het
Map6 T C 7: 98,917,314 (GRCm39) V29A probably damaging Het
Mical3 A T 6: 121,010,671 (GRCm39) V437D probably damaging Het
Mief1 T C 15: 80,133,941 (GRCm39) Y333H probably benign Het
Or12j4 T A 7: 140,046,432 (GRCm39) V106D probably benign Het
Or4f7 A G 2: 111,644,598 (GRCm39) F158L probably benign Het
Or8b52 A G 9: 38,576,916 (GRCm39) S75P probably damaging Het
Pak1ip1 T A 13: 41,158,361 (GRCm39) L78Q probably damaging Het
Pikfyve A G 1: 65,303,504 (GRCm39) probably null Het
Pinlyp C T 7: 24,245,405 (GRCm39) R5K possibly damaging Het
Pkd1l3 A G 8: 110,367,478 (GRCm39) D1225G probably damaging Het
Pnma8b T A 7: 16,680,493 (GRCm39) S492R probably benign Het
Postn A G 3: 54,279,641 (GRCm39) probably null Het
Ptprq A G 10: 107,416,127 (GRCm39) Y1724H possibly damaging Het
Rpn2 T A 2: 157,152,108 (GRCm39) probably null Het
Scn5a A G 9: 119,351,716 (GRCm39) V755A probably damaging Het
Slc22a30 T C 19: 8,315,232 (GRCm39) probably null Het
Specc1l T C 10: 75,084,466 (GRCm39) S730P probably damaging Het
Steap2 T A 5: 5,725,891 (GRCm39) I378F possibly damaging Het
Tdrd12 A T 7: 35,180,558 (GRCm39) Y818* probably null Het
Thbs4 G T 13: 92,911,993 (GRCm39) Q246K possibly damaging Het
Tnfsf10 A G 3: 27,389,698 (GRCm39) Y253C probably damaging Het
Tnpo3 G T 6: 29,588,042 (GRCm39) C125* probably null Het
Trim58 A G 11: 58,542,441 (GRCm39) N467S probably benign Het
Trpm6 C T 19: 18,831,112 (GRCm39) R1326* probably null Het
Zc3hav1l A G 6: 38,270,012 (GRCm39) V279A probably benign Het
Zfp618 A T 4: 63,051,478 (GRCm39) Q753L probably benign Het
Zfp647 G A 15: 76,796,285 (GRCm39) P125L probably damaging Het
Zkscan17 A T 11: 59,394,401 (GRCm39) C67S probably damaging Het
Other mutations in Or8d2b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01886:Or8d2b APN 9 38,788,844 (GRCm39) missense probably damaging 0.97
IGL02315:Or8d2b APN 9 38,789,353 (GRCm39) missense probably damaging 1.00
IGL02626:Or8d2b APN 9 38,788,784 (GRCm39) missense probably benign 0.05
IGL03001:Or8d2b APN 9 38,789,374 (GRCm39) missense probably benign
IGL03085:Or8d2b APN 9 38,788,959 (GRCm39) missense probably benign
R0365:Or8d2b UTSW 9 38,788,481 (GRCm39) missense probably benign 0.00
R0600:Or8d2b UTSW 9 38,789,111 (GRCm39) missense probably damaging 0.99
R0708:Or8d2b UTSW 9 38,788,571 (GRCm39) missense probably damaging 0.97
R1178:Or8d2b UTSW 9 38,789,051 (GRCm39) missense probably damaging 1.00
R1762:Or8d2b UTSW 9 38,789,081 (GRCm39) missense probably damaging 0.98
R1856:Or8d2b UTSW 9 38,788,892 (GRCm39) missense possibly damaging 0.58
R1924:Or8d2b UTSW 9 38,789,147 (GRCm39) missense probably damaging 1.00
R2267:Or8d2b UTSW 9 38,789,359 (GRCm39) missense probably benign 0.00
R3729:Or8d2b UTSW 9 38,788,547 (GRCm39) missense probably damaging 1.00
R4290:Or8d2b UTSW 9 38,788,609 (GRCm39) missense probably damaging 1.00
R4292:Or8d2b UTSW 9 38,788,609 (GRCm39) missense probably damaging 1.00
R4293:Or8d2b UTSW 9 38,788,609 (GRCm39) missense probably damaging 1.00
R4295:Or8d2b UTSW 9 38,788,609 (GRCm39) missense probably damaging 1.00
R4973:Or8d2b UTSW 9 38,789,400 (GRCm39) makesense probably null
R5026:Or8d2b UTSW 9 38,789,195 (GRCm39) missense possibly damaging 0.95
R5086:Or8d2b UTSW 9 38,789,087 (GRCm39) missense probably damaging 1.00
R5103:Or8d2b UTSW 9 38,788,872 (GRCm39) missense probably damaging 1.00
R5817:Or8d2b UTSW 9 38,788,673 (GRCm39) missense probably damaging 1.00
R5998:Or8d2b UTSW 9 38,789,165 (GRCm39) missense probably damaging 0.99
R6105:Or8d2b UTSW 9 38,788,604 (GRCm39) missense possibly damaging 0.95
R6176:Or8d2b UTSW 9 38,788,673 (GRCm39) missense probably damaging 1.00
R6403:Or8d2b UTSW 9 38,788,538 (GRCm39) missense probably damaging 0.97
R8116:Or8d2b UTSW 9 38,789,026 (GRCm39) missense probably damaging 0.98
R8144:Or8d2b UTSW 9 38,788,662 (GRCm39) missense probably damaging 1.00
R8972:Or8d2b UTSW 9 38,789,150 (GRCm39) missense probably benign 0.00
R9520:Or8d2b UTSW 9 38,789,039 (GRCm39) missense probably benign 0.22
R9550:Or8d2b UTSW 9 38,788,937 (GRCm39) missense probably benign 0.00
R9614:Or8d2b UTSW 9 38,789,281 (GRCm39) missense probably damaging 0.98
RF014:Or8d2b UTSW 9 38,789,196 (GRCm39) missense probably benign 0.14
X0022:Or8d2b UTSW 9 38,788,952 (GRCm39) missense possibly damaging 0.84
Predicted Primers PCR Primer
(F):5'- TGAATCCATCAATCACGATTCCAAG -3'
(R):5'- ATAGCGGTCATAGGCCATGG -3'

Sequencing Primer
(F):5'- AAAATAACCATTGCCCTCCCTTTTC -3'
(R):5'- GCAGGTAGCCTTCTGAAATAGC -3'
Posted On 2017-08-16