Incidental Mutation 'R6102:Vmn2r19'
ID 485304
Institutional Source Beutler Lab
Gene Symbol Vmn2r19
Ensembl Gene ENSMUSG00000091260
Gene Name vomeronasal 2, receptor 19
Synonyms EG232358
MMRRC Submission 044252-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.063) question?
Stock # R6102 (G1)
Quality Score 225.009
Status Validated
Chromosome 6
Chromosomal Location 123285292-123313496 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 123306907 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 472 (I472F)
Ref Sequence ENSEMBL: ENSMUSP00000073604 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000073948]
AlphaFold G5E8G4
Predicted Effect probably damaging
Transcript: ENSMUST00000073948
AA Change: I472F

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000073604
Gene: ENSMUSG00000091260
AA Change: I472F

DomainStartEndE-ValueType
signal peptide 1 17 N/A INTRINSIC
Pfam:ANF_receptor 81 476 2.9e-35 PFAM
Pfam:NCD3G 518 571 8.3e-23 PFAM
Pfam:7tm_3 603 839 7.2e-52 PFAM
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.4%
  • 20x: 95.6%
Validation Efficiency 97% (65/67)
Allele List at MGI
Other mutations in this stock
Total: 67 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Alox12e A G 11: 70,210,849 (GRCm39) I290T possibly damaging Het
Apeh T A 9: 107,963,638 (GRCm39) D559V probably damaging Het
Aspm T A 1: 139,405,197 (GRCm39) Y1361* probably null Het
Atad5 G T 11: 80,002,398 (GRCm39) probably null Het
Ccr4 C T 9: 114,325,561 (GRCm39) probably null Het
Clasrp G A 7: 19,320,393 (GRCm39) probably benign Het
Cldn23 A G 8: 36,292,705 (GRCm39) M261T probably benign Het
Cmya5 T C 13: 93,230,739 (GRCm39) M1450V probably benign Het
Cyp4v3 T A 8: 45,773,197 (GRCm39) E202V probably damaging Het
Dnah7a A T 1: 53,598,299 (GRCm39) V1412E probably benign Het
Dnah9 A G 11: 65,881,342 (GRCm39) S2578P probably damaging Het
Dsc2 T A 18: 20,180,165 (GRCm39) Y196F probably benign Het
Exoc1 T C 5: 76,685,626 (GRCm39) S113P probably damaging Het
Fbxo6 A T 4: 148,233,979 (GRCm39) I39N probably damaging Het
Frs3 C T 17: 48,013,596 (GRCm39) H173Y probably damaging Het
Ginm1 G T 10: 7,644,260 (GRCm39) T323K probably benign Het
Golgb1 T C 16: 36,733,227 (GRCm39) S825P probably damaging Het
Hs3st3b1 A T 11: 63,812,681 (GRCm39) C11* probably null Het
Ighv3-3 G C 12: 114,160,080 (GRCm39) A110G possibly damaging Het
Igkv6-20 G A 6: 70,312,853 (GRCm39) H107Y probably benign Het
Kcnj16 A G 11: 110,916,403 (GRCm39) E355G probably benign Het
Lig4 C T 8: 10,022,872 (GRCm39) G303S probably damaging Het
Map1b A C 13: 99,562,381 (GRCm39) V2443G unknown Het
Map3k6 T C 4: 132,974,442 (GRCm39) probably null Het
Mmp13 A G 9: 7,276,688 (GRCm39) Q261R probably benign Het
Mphosph9 T A 5: 124,435,772 (GRCm39) I554F possibly damaging Het
Mrgpra3 A T 7: 47,239,897 (GRCm39) F10I possibly damaging Het
Ms4a18 G A 19: 10,990,887 (GRCm39) T69I probably benign Het
Mtmr3 T C 11: 4,437,673 (GRCm39) N927S probably damaging Het
Necab1 T A 4: 14,989,211 (GRCm39) Q188L probably benign Het
Nfatc2 A G 2: 168,361,427 (GRCm39) probably benign Het
Or5i1 T C 2: 87,613,192 (GRCm39) F103L probably damaging Het
Or5p70 T C 7: 107,994,491 (GRCm39) S55P probably damaging Het
Or7g34 T C 9: 19,478,318 (GRCm39) M121V possibly damaging Het
Paip2b A C 6: 83,785,828 (GRCm39) V134G possibly damaging Het
Pax3 T C 1: 78,108,984 (GRCm39) T225A probably damaging Het
Pbx1 C A 1: 168,011,134 (GRCm39) A298S probably benign Het
Pcdhac2 A T 18: 37,279,335 (GRCm39) K772* probably null Het
Pcsk4 A T 10: 80,161,651 (GRCm39) Y163* probably null Het
Plcd3 A G 11: 102,971,470 (GRCm39) V58A probably damaging Het
Plek2 T A 12: 78,946,867 (GRCm39) T57S possibly damaging Het
Plscr2 C T 9: 92,169,721 (GRCm39) T57I probably benign Het
Ppp2r5b A G 19: 6,284,768 (GRCm39) S32P probably benign Het
Ppp3r2 C T 4: 49,682,022 (GRCm39) probably benign Het
Psme4 T A 11: 30,815,567 (GRCm39) L1693H probably damaging Het
Rrbp1 T A 2: 143,830,313 (GRCm39) Q618L probably damaging Het
Rsf1 ATGGCG ATGGCGACGGTGGCG 7: 97,229,111 (GRCm39) probably benign Het
Rsrc1 C T 3: 66,901,982 (GRCm39) P44L unknown Het
Serpina3b A T 12: 104,100,428 (GRCm39) T337S probably benign Het
Slc18a2 T C 19: 59,282,310 (GRCm39) Y506H probably benign Het
Slc9a9 A G 9: 94,818,482 (GRCm39) Y292C probably benign Het
Spta1 T C 1: 174,052,086 (GRCm39) V1840A probably benign Het
Ssb T C 2: 69,701,552 (GRCm39) *416Q probably null Het
Strada A G 11: 106,059,262 (GRCm39) V209A probably benign Het
Tbc1d31 A T 15: 57,799,489 (GRCm39) D225V probably damaging Het
Tgm4 T C 9: 122,885,600 (GRCm39) F381L probably benign Het
Tmem120b T A 5: 123,253,207 (GRCm39) Y203N probably damaging Het
Tmem176b A G 6: 48,812,868 (GRCm39) V109A probably benign Het
Tnfrsf11a C A 1: 105,747,671 (GRCm39) L201M possibly damaging Het
Ttn C A 2: 76,804,694 (GRCm39) probably null Het
Tubb2a T C 13: 34,259,326 (GRCm39) I155V probably benign Het
Vmn1r5 A G 6: 56,963,099 (GRCm39) D258G probably damaging Het
Vmn2r121 T C X: 123,043,272 (GRCm39) T120A probably benign Het
Vwa3a A G 7: 120,375,361 (GRCm39) probably null Het
Zfp273 A G 13: 67,970,466 (GRCm39) Y5C probably damaging Het
Zfp647 G A 15: 76,796,285 (GRCm39) P125L probably damaging Het
Zfp825 A G 13: 74,628,772 (GRCm39) L248P probably damaging Het
Other mutations in Vmn2r19
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01407:Vmn2r19 APN 6 123,306,826 (GRCm39) missense possibly damaging 0.92
IGL02294:Vmn2r19 APN 6 123,306,937 (GRCm39) missense probably benign 0.19
IGL02442:Vmn2r19 APN 6 123,286,621 (GRCm39) missense possibly damaging 0.94
IGL02871:Vmn2r19 APN 6 123,313,042 (GRCm39) missense probably damaging 1.00
H8562:Vmn2r19 UTSW 6 123,292,861 (GRCm39) missense possibly damaging 0.82
R0025:Vmn2r19 UTSW 6 123,308,506 (GRCm39) missense probably benign 0.01
R0389:Vmn2r19 UTSW 6 123,312,945 (GRCm39) missense possibly damaging 0.53
R0402:Vmn2r19 UTSW 6 123,313,141 (GRCm39) missense probably damaging 1.00
R0411:Vmn2r19 UTSW 6 123,286,703 (GRCm39) missense probably damaging 0.98
R0554:Vmn2r19 UTSW 6 123,313,102 (GRCm39) missense probably damaging 0.99
R0578:Vmn2r19 UTSW 6 123,312,931 (GRCm39) missense probably damaging 1.00
R1102:Vmn2r19 UTSW 6 123,313,132 (GRCm39) missense probably benign 0.28
R1652:Vmn2r19 UTSW 6 123,292,656 (GRCm39) missense possibly damaging 0.68
R1663:Vmn2r19 UTSW 6 123,313,411 (GRCm39) missense probably benign 0.11
R1817:Vmn2r19 UTSW 6 123,307,011 (GRCm39) missense possibly damaging 0.80
R1866:Vmn2r19 UTSW 6 123,308,597 (GRCm39) critical splice donor site probably null
R1928:Vmn2r19 UTSW 6 123,308,589 (GRCm39) missense probably damaging 1.00
R1997:Vmn2r19 UTSW 6 123,292,880 (GRCm39) missense probably damaging 0.98
R2013:Vmn2r19 UTSW 6 123,292,954 (GRCm39) missense probably benign 0.01
R2015:Vmn2r19 UTSW 6 123,292,954 (GRCm39) missense probably benign 0.01
R2088:Vmn2r19 UTSW 6 123,312,795 (GRCm39) missense probably damaging 1.00
R2126:Vmn2r19 UTSW 6 123,293,033 (GRCm39) missense possibly damaging 0.82
R2128:Vmn2r19 UTSW 6 123,285,289 (GRCm39) splice site probably null
R2256:Vmn2r19 UTSW 6 123,306,845 (GRCm39) missense probably benign 0.20
R2517:Vmn2r19 UTSW 6 123,306,937 (GRCm39) missense probably benign 0.19
R3753:Vmn2r19 UTSW 6 123,292,548 (GRCm39) missense possibly damaging 0.80
R3817:Vmn2r19 UTSW 6 123,286,601 (GRCm39) missense probably damaging 1.00
R3929:Vmn2r19 UTSW 6 123,292,587 (GRCm39) missense probably benign 0.01
R3934:Vmn2r19 UTSW 6 123,292,628 (GRCm39) missense probably damaging 1.00
R4232:Vmn2r19 UTSW 6 123,306,871 (GRCm39) missense probably benign
R4574:Vmn2r19 UTSW 6 123,292,939 (GRCm39) missense probably benign 0.01
R4886:Vmn2r19 UTSW 6 123,286,800 (GRCm39) missense probably benign 0.05
R4995:Vmn2r19 UTSW 6 123,306,869 (GRCm39) missense probably benign 0.00
R5107:Vmn2r19 UTSW 6 123,286,602 (GRCm39) nonsense probably null
R5232:Vmn2r19 UTSW 6 123,312,916 (GRCm39) missense probably benign
R6105:Vmn2r19 UTSW 6 123,293,054 (GRCm39) missense possibly damaging 0.70
R6280:Vmn2r19 UTSW 6 123,313,212 (GRCm39) missense probably benign
R6393:Vmn2r19 UTSW 6 123,293,112 (GRCm39) missense possibly damaging 0.80
R6502:Vmn2r19 UTSW 6 123,293,067 (GRCm39) missense possibly damaging 0.68
R6617:Vmn2r19 UTSW 6 123,313,494 (GRCm39) makesense probably null
R6742:Vmn2r19 UTSW 6 123,306,917 (GRCm39) missense possibly damaging 0.90
R7662:Vmn2r19 UTSW 6 123,308,521 (GRCm39) missense probably benign 0.33
R8041:Vmn2r19 UTSW 6 123,312,750 (GRCm39) missense possibly damaging 0.94
R8054:Vmn2r19 UTSW 6 123,292,998 (GRCm39) missense probably damaging 1.00
R8074:Vmn2r19 UTSW 6 123,312,904 (GRCm39) missense probably damaging 0.96
R8267:Vmn2r19 UTSW 6 123,313,221 (GRCm39) missense possibly damaging 0.50
R8287:Vmn2r19 UTSW 6 123,308,588 (GRCm39) missense probably damaging 1.00
R8937:Vmn2r19 UTSW 6 123,293,283 (GRCm39) critical splice donor site probably null
R9058:Vmn2r19 UTSW 6 123,313,021 (GRCm39) missense possibly damaging 0.53
R9119:Vmn2r19 UTSW 6 123,292,527 (GRCm39) missense possibly damaging 0.68
R9384:Vmn2r19 UTSW 6 123,292,923 (GRCm39) missense probably benign 0.00
X0058:Vmn2r19 UTSW 6 123,285,308 (GRCm39) missense probably benign 0.00
Z1088:Vmn2r19 UTSW 6 123,285,298 (GRCm39) missense probably benign 0.02
Z1177:Vmn2r19 UTSW 6 123,313,036 (GRCm39) missense possibly damaging 0.89
Predicted Primers PCR Primer
(F):5'- GGATTAGCCCTATGACAAATGTTTG -3'
(R):5'- AACAGCACATGGTTCTGAACAC -3'

Sequencing Primer
(F):5'- AGCCCTATGACAAATGTTTGATATAC -3'
(R):5'- TGGTTCTGAACACAAAGACACTTAC -3'
Posted On 2017-08-16