Mutagenetix > Incidental Mutation

Incidental Mutation 'R6105:Zfp111'

485467

Institutional Source

Beutler Lab

Gene Symbol

Zfp111

Ensembl Gene

ENSMUSG00000087598

Gene Name

zinc finger protein 111

Synonyms

MMRRC Submission

044255-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R6105 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

23890760-23907574 bp(-) (GRCm39)

Type of Mutation

splice site (4 bp from exon)

DNA Base Change (assembly)

T to C at 23902791 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000083169 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000056683] [ENSMUST00000073833] [ENSMUST00000073833] [ENSMUST00000086006]

AlphaFold

Q9R164

Predicted Effect

probably null
Transcript: ENSMUST00000056683

SMART Domains

Protein: ENSMUSP00000129484
Gene: ENSMUSG00000087598

Domain	Start	End	E-Value	Type
KRAB	9	64	1.8e-21	SMART
low complexity region	114	128	N/A	INTRINSIC
ZnF_C2H2	210	232	2.3e-7	SMART
ZnF_C2H2	266	288	5.7e-4	SMART
ZnF_C2H2	294	316	3.3e-4	SMART
ZnF_C2H2	322	343	4.3e-1	SMART
ZnF_C2H2	349	371	4.5e-8	SMART
ZnF_C2H2	377	399	2.1e-6	SMART
ZnF_C2H2	405	427	8e-6	SMART
ZnF_C2H2	433	455	9.9e-5	SMART
ZnF_C2H2	461	481	4.3e-2	SMART
ZnF_C2H2	489	511	2.7e-5	SMART
ZnF_C2H2	517	539	1.1e-6	SMART
ZnF_C2H2	545	567	1.8e-5	SMART
ZnF_C2H2	573	595	3.5e-6	SMART
ZnF_C2H2	601	623	2.9e-6	SMART
ZnF_C2H2	629	651	1.3e-6	SMART
ZnF_C2H2	657	679	2.2e-5	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000073833

SMART Domains

Protein: ENSMUSP00000083174
Gene: ENSMUSG00000087598

Domain	Start	End	E-Value	Type
KRAB	8	63	4.03e-19	SMART
low complexity region	113	127	N/A	INTRINSIC
ZnF_C2H2	209	231	5.29e-5	SMART
ZnF_C2H2	265	287	1.33e-1	SMART
ZnF_C2H2	293	315	7.67e-2	SMART
ZnF_C2H2	321	342	1.01e2	SMART
ZnF_C2H2	348	370	1e-5	SMART
ZnF_C2H2	376	398	4.87e-4	SMART
ZnF_C2H2	404	426	1.82e-3	SMART
ZnF_C2H2	432	454	2.36e-2	SMART
ZnF_C2H2	460	480	9.96e0	SMART
ZnF_C2H2	488	510	6.32e-3	SMART
ZnF_C2H2	516	538	2.61e-4	SMART
ZnF_C2H2	544	566	4.17e-3	SMART
ZnF_C2H2	572	594	7.9e-4	SMART
ZnF_C2H2	600	622	6.88e-4	SMART
ZnF_C2H2	628	650	3.21e-4	SMART
ZnF_C2H2	656	678	5.14e-3	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000073833

SMART Domains

Protein: ENSMUSP00000083174
Gene: ENSMUSG00000087598

Domain	Start	End	E-Value	Type
KRAB	8	63	4.03e-19	SMART
low complexity region	113	127	N/A	INTRINSIC
ZnF_C2H2	209	231	5.29e-5	SMART
ZnF_C2H2	265	287	1.33e-1	SMART
ZnF_C2H2	293	315	7.67e-2	SMART
ZnF_C2H2	321	342	1.01e2	SMART
ZnF_C2H2	348	370	1e-5	SMART
ZnF_C2H2	376	398	4.87e-4	SMART
ZnF_C2H2	404	426	1.82e-3	SMART
ZnF_C2H2	432	454	2.36e-2	SMART
ZnF_C2H2	460	480	9.96e0	SMART
ZnF_C2H2	488	510	6.32e-3	SMART
ZnF_C2H2	516	538	2.61e-4	SMART
ZnF_C2H2	544	566	4.17e-3	SMART
ZnF_C2H2	572	594	7.9e-4	SMART
ZnF_C2H2	600	622	6.88e-4	SMART
ZnF_C2H2	628	650	3.21e-4	SMART
ZnF_C2H2	656	678	5.14e-3	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000086006

SMART Domains

Protein: ENSMUSP00000083169
Gene: ENSMUSG00000087598

Domain	Start	End	E-Value	Type
KRAB	8	63	4.03e-19	SMART
low complexity region	113	127	N/A	INTRINSIC
ZnF_C2H2	209	231	5.29e-5	SMART
ZnF_C2H2	265	287	1.33e-1	SMART
ZnF_C2H2	293	315	7.67e-2	SMART
ZnF_C2H2	321	342	1.01e2	SMART
ZnF_C2H2	348	370	1e-5	SMART
ZnF_C2H2	376	398	4.87e-4	SMART
ZnF_C2H2	404	426	1.82e-3	SMART
ZnF_C2H2	432	454	2.36e-2	SMART
ZnF_C2H2	460	480	9.96e0	SMART
ZnF_C2H2	488	510	6.32e-3	SMART
ZnF_C2H2	516	538	2.61e-4	SMART
ZnF_C2H2	544	566	4.17e-3	SMART
ZnF_C2H2	572	594	7.9e-4	SMART
ZnF_C2H2	600	622	6.88e-4	SMART
ZnF_C2H2	628	650	3.21e-4	SMART
ZnF_C2H2	656	678	5.14e-3	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000142218

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000148050

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000160563

Coding Region Coverage

1x: 99.9%
3x: 99.6%
10x: 97.9%
20x: 94.0%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 38 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca13	T	C	11: 9,347,812 (GRCm39)	M3555T	probably damaging	Het
Adam9	A	T	8: 25,460,775 (GRCm39)	C570S	probably damaging	Het
Adh6b	T	A	3: 138,063,471 (GRCm39)	I350K	possibly damaging	Het
Ahnak	G	A	19: 8,981,463 (GRCm39)	V916I	probably benign	Het
Aldh4a1	C	T	4: 139,365,806 (GRCm39)	P266S	possibly damaging	Het
Cnot7	C	T	8: 40,963,078 (GRCm39)	R32Q	probably benign	Het
Cyb5a	G	A	18: 84,889,718 (GRCm39)	R49Q	possibly damaging	Het
Fbxo6	A	T	4: 148,233,979 (GRCm39)	I39N	probably damaging	Het
Glul	T	A	1: 153,782,177 (GRCm39)	Y137*	probably null	Het
Ipo8	A	G	6: 148,700,168 (GRCm39)	Y570H	probably damaging	Het
Kif2b	A	G	11: 91,466,814 (GRCm39)	S490P	probably benign	Het
Kxd1	A	T	8: 70,972,589 (GRCm39)	N33K	probably benign	Het
Man2a2	T	C	7: 80,016,749 (GRCm39)	D355G	probably damaging	Het
Map6	T	C	7: 98,917,314 (GRCm39)	V29A	probably damaging	Het
Mtmr3	T	C	11: 4,435,432 (GRCm39)	D1116G	probably damaging	Het
Or4p23	T	A	2: 88,577,184 (GRCm39)	H16L	probably benign	Het
Or8b52	A	G	9: 38,576,916 (GRCm39)	S75P	probably damaging	Het
Or8d2b	T	C	9: 38,788,604 (GRCm39)	L44P	possibly damaging	Het
Pak1ip1	T	A	13: 41,158,361 (GRCm39)	L78Q	probably damaging	Het
Phf10	C	T	17: 15,174,387 (GRCm39)		probably null	Het
Pikfyve	A	G	1: 65,303,504 (GRCm39)		probably null	Het
Pkd1l3	A	G	8: 110,367,478 (GRCm39)	D1225G	probably damaging	Het
Postn	A	G	3: 54,279,641 (GRCm39)		probably null	Het
Slc22a30	T	C	19: 8,315,232 (GRCm39)		probably null	Het
Specc1l	T	C	10: 75,084,466 (GRCm39)	S730P	probably damaging	Het
Steap2	T	A	5: 5,725,891 (GRCm39)	I378F	possibly damaging	Het
Sult4a1	T	A	15: 83,970,821 (GRCm39)	K195*	probably null	Het
Tgfb1i1	T	A	7: 127,847,589 (GRCm39)		probably null	Het
Thbs4	G	T	13: 92,911,993 (GRCm39)	Q246K	possibly damaging	Het
Tnfsf10	A	G	3: 27,389,698 (GRCm39)	Y253C	probably damaging	Het
Tnpo3	G	T	6: 29,588,042 (GRCm39)	C125*	probably null	Het
Trappc8	A	G	18: 20,979,504 (GRCm39)		probably null	Het
Trpm6	C	T	19: 18,831,112 (GRCm39)	R1326*	probably null	Het
Vmn2r19	A	C	6: 123,293,054 (GRCm39)	E365D	possibly damaging	Het
Vps18	A	G	2: 119,119,543 (GRCm39)	Y8C	probably damaging	Het
Zc3hav1l	A	G	6: 38,270,012 (GRCm39)	V279A	probably benign	Het
Zfp618	A	T	4: 63,051,478 (GRCm39)	Q753L	probably benign	Het
Zkscan17	A	T	11: 59,394,401 (GRCm39)	C67S	probably damaging	Het

Other mutations in Zfp111

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02569:Zfp111	APN	7	23,906,494 (GRCm39)	missense	possibly damaging	0.91
IGL02619:Zfp111	APN	7	23,899,113 (GRCm39)	missense	possibly damaging	0.75
FR4737:Zfp111	UTSW	7	23,899,230 (GRCm39)	small insertion	probably benign
FR4976:Zfp111	UTSW	7	23,899,232 (GRCm39)	small insertion	probably benign
FR4976:Zfp111	UTSW	7	23,898,462 (GRCm39)	missense	probably damaging	0.97
R0514:Zfp111	UTSW	7	23,898,568 (GRCm39)	missense	probably damaging	0.96
R3837:Zfp111	UTSW	7	23,898,891 (GRCm39)	missense	possibly damaging	0.53
R4682:Zfp111	UTSW	7	23,898,563 (GRCm39)	missense	probably damaging	0.98
R4844:Zfp111	UTSW	7	23,898,801 (GRCm39)	missense	probably damaging	0.99
R6175:Zfp111	UTSW	7	23,897,554 (GRCm39)	missense	unknown
R7276:Zfp111	UTSW	7	23,898,978 (GRCm39)	missense	probably damaging	1.00
R7584:Zfp111	UTSW	7	23,898,025 (GRCm39)	missense	possibly damaging	0.89
R8682:Zfp111	UTSW	7	23,897,983 (GRCm39)	missense	probably damaging	0.99
R9655:Zfp111	UTSW	7	23,898,543 (GRCm39)	missense	probably damaging	0.99
R9746:Zfp111	UTSW	7	23,898,067 (GRCm39)	missense	possibly damaging	0.93
X0018:Zfp111	UTSW	7	23,899,416 (GRCm39)	missense	possibly damaging	0.96

Predicted Primers

PCR Primer
(F):5'- CGTGGCATTGACTAAGACATAGC -3'
(R):5'- CATTGGGAATGAATCTGAGGTG -3'

Sequencing Primer
(F):5'- TGGTGGCTCACAACCATCTGTAAG -3'
(R):5'- AATGAATCTGAGGTGGCATGTGC -3'

Posted On

2017-08-16