Incidental Mutation 'R6106:Psg16'
ID485507
Institutional Source Beutler Lab
Gene Symbol Psg16
Ensembl Gene ENSMUSG00000066760
Gene Namepregnancy specific glycoprotein 16
SynonymsbCEA, Cea11
MMRRC Submission 044256-MU
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #R6106 (G1)
Quality Score225.009
Status Not validated
Chromosome7
Chromosomal Location17074040-17133450 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 17095166 bp
ZygosityHeterozygous
Amino Acid Change Phenylalanine to Tyrosine at position 225 (F225Y)
Ref Sequence ENSEMBL: ENSMUSP00000113025 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071399] [ENSMUST00000118367] [ENSMUST00000152671]
Predicted Effect possibly damaging
Transcript: ENSMUST00000071399
AA Change: F225Y

PolyPhen 2 Score 0.726 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000071348
Gene: ENSMUSG00000066760
AA Change: F225Y

DomainStartEndE-ValueType
IG_like 6 52 1.42e2 SMART
IG 71 172 1.21e-2 SMART
IG 191 292 2.56e-1 SMART
IG_like 302 395 5.13e0 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000118367
AA Change: F225Y

PolyPhen 2 Score 0.726 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000113025
Gene: ENSMUSG00000066760
AA Change: F225Y

DomainStartEndE-ValueType
IG_like 6 52 1.42e2 SMART
IG 71 172 1.21e-2 SMART
IG 191 292 2.56e-1 SMART
IGc2 308 372 3.56e-9 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000131153
Predicted Effect probably benign
Transcript: ENSMUST00000152671
SMART Domains Protein: ENSMUSP00000118977
Gene: ENSMUSG00000066760

DomainStartEndE-ValueType
low complexity region 24 40 N/A INTRINSIC
IG 46 143 4.29e-3 SMART
IG 162 261 2.94e-1 SMART
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.3%
  • 20x: 95.3%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2010300C02Rik T C 1: 37,613,412 T1105A possibly damaging Het
Ace A G 11: 105,989,012 E726G probably damaging Het
Adgrl4 A G 3: 151,540,985 I641V possibly damaging Het
Apoa5 A T 9: 46,270,633 R336* probably null Het
Bfsp2 T A 9: 103,479,824 T135S probably benign Het
Calhm2 A T 19: 47,133,062 Y223N probably damaging Het
Ccdc158 T C 5: 92,627,466 E960G probably benign Het
Ccdc80 T C 16: 45,096,710 S610P probably benign Het
Cdon T A 9: 35,455,408 Y193* probably null Het
Cept1 A T 3: 106,503,676 H400Q probably benign Het
Clspn T A 4: 126,590,641 N1197K probably benign Het
Cnot8 T C 11: 58,113,990 S172P probably damaging Het
Col14a1 T C 15: 55,520,008 I1794T probably damaging Het
Fam183b T C 11: 58,796,601 E66G probably damaging Het
Fam193a A T 5: 34,459,030 T564S possibly damaging Het
Galnt1 G A 18: 24,254,663 V154I probably benign Het
Gm14139 A G 2: 150,192,805 K349E probably damaging Het
Gstcd C A 3: 132,998,914 E526D probably benign Het
Ighv1-42 A C 12: 114,937,287 S59R probably benign Het
Morn3 A G 5: 123,046,760 C6R possibly damaging Het
Nrd1 A T 4: 109,044,585 K617M probably damaging Het
Olfr169 A G 16: 19,566,259 L208P probably damaging Het
Olfr632 A G 7: 103,938,193 H271R probably benign Het
Olfr883 T A 9: 38,026,466 I220N probably damaging Het
Olfr913 T C 9: 38,594,956 M245T probably benign Het
Pcdhb11 A G 18: 37,423,003 N462S probably damaging Het
Pfpl G T 19: 12,429,461 D359Y probably damaging Het
Phyhip T C 14: 70,461,859 V34A probably benign Het
Pigu A T 2: 155,297,196 I313N possibly damaging Het
Plch1 C T 3: 63,702,023 R912H probably damaging Het
Setdb2 T A 14: 59,423,449 K82* probably null Het
Sgms1 A G 19: 32,124,425 S394P possibly damaging Het
Slc16a1 T C 3: 104,652,994 L205P probably benign Het
Slc19a1 T A 10: 77,044,769 I380N probably damaging Het
Snx32 A G 19: 5,498,014 I131T probably benign Het
Sorbs3 T C 14: 70,192,604 probably null Het
Stc2 T A 11: 31,360,392 I215L probably benign Het
Tln2 C T 9: 67,323,020 A84T probably damaging Het
Tomm34 A G 2: 164,060,991 M133T probably benign Het
Usp43 A G 11: 67,879,907 S634P probably benign Het
Vmn2r59 T A 7: 42,012,325 R689* probably null Het
Vmn2r9 C T 5: 108,845,036 R536Q probably benign Het
Wdr24 C T 17: 25,824,605 H134Y probably benign Het
Zfhx2 T A 14: 55,068,310 probably null Het
Zfp608 G T 18: 54,987,872 H214Q possibly damaging Het
Zfp619 T C 7: 39,535,134 V196A probably benign Het
Other mutations in Psg16
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01993:Psg16 APN 7 17093706 missense probably benign 0.08
IGL02258:Psg16 APN 7 17095292 missense probably damaging 1.00
R0379:Psg16 UTSW 7 17130658 missense probably benign 0.09
R0389:Psg16 UTSW 7 17095163 missense probably benign
R0443:Psg16 UTSW 7 17095163 missense probably benign
R1231:Psg16 UTSW 7 17095305 nonsense probably null
R1594:Psg16 UTSW 7 17093823 missense probably damaging 1.00
R2064:Psg16 UTSW 7 17093748 missense possibly damaging 0.91
R2118:Psg16 UTSW 7 17090623 missense probably benign 0.33
R3806:Psg16 UTSW 7 17090684 missense probably benign 0.24
R4397:Psg16 UTSW 7 17090698 missense possibly damaging 0.68
R4583:Psg16 UTSW 7 17095172 missense probably benign 0.01
R4685:Psg16 UTSW 7 17090534 missense probably benign 0.00
R4929:Psg16 UTSW 7 17095106 missense possibly damaging 0.79
R5310:Psg16 UTSW 7 17090635 missense probably damaging 0.99
R6320:Psg16 UTSW 7 17088187 missense probably damaging 1.00
R6702:Psg16 UTSW 7 17090396 missense probably damaging 1.00
R6703:Psg16 UTSW 7 17090396 missense probably damaging 1.00
R7329:Psg16 UTSW 7 17090686 missense possibly damaging 0.86
Predicted Primers PCR Primer
(F):5'- GTCTTTCCACCAAGCACAATG -3'
(R):5'- CTGTTCACTTGGATTTGCACG -3'

Sequencing Primer
(F):5'- CAAGCACAATGATCACATGTAATG -3'
(R):5'- AGTGTATACAAGCCCGTG -3'
Posted On2017-08-16