Mutagenetix > Incidental Mutation

Incidental Mutation 'R6106:Cdon'

485511

Institutional Source

Beutler Lab

Gene Symbol

Cdon

Ensembl Gene

ENSMUSG00000038119

Gene Name

cell adhesion molecule-related/down-regulated by oncogenes

Synonyms

CAM-related/down-regulated by oncogenes, CDO

MMRRC Submission

044256-MU

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.351) question?

Stock #

R6106 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

35332836-35418948 bp(+) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

T to A at 35366704 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Stop codon at position 193 (Y193*)

Ref Sequence

ENSEMBL: ENSMUSP00000117499 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000042842] [ENSMUST00000119129] [ENSMUST00000137200] [ENSMUST00000151682] [ENSMUST00000154652]

AlphaFold

Q32MD9

Predicted Effect

probably null
Transcript: ENSMUST00000042842
AA Change: Y193*

SMART Domains

Protein: ENSMUSP00000045547
Gene: ENSMUSG00000038119
AA Change: Y193*

Domain	Start	End	E-Value	Type
signal peptide	1	24	N/A	INTRINSIC
IGc2	40	103	1.35e-9	SMART
IG	125	212	7.25e-1	SMART
IGc2	233	296	1.38e-6	SMART
IGc2	323	386	4.62e-17	SMART
IGc2	416	506	5e-13	SMART
FN3	573	660	2.18e-2	SMART
FN3	717	800	1.89e-11	SMART
FN3	822	909	7.01e-6	SMART
transmembrane domain	962	984	N/A	INTRINSIC
low complexity region	1101	1111	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000119129
AA Change: Y193*

SMART Domains

Protein: ENSMUSP00000113977
Gene: ENSMUSG00000038119
AA Change: Y193*

Domain	Start	End	E-Value	Type
signal peptide	1	24	N/A	INTRINSIC
IGc2	40	103	1.35e-9	SMART
IG	125	212	7.25e-1	SMART
IGc2	233	296	1.38e-6	SMART
IGc2	323	386	4.62e-17	SMART
IGc2	416	506	5e-13	SMART
FN3	573	660	2.18e-2	SMART
FN3	717	800	1.89e-11	SMART
FN3	822	909	7.01e-6	SMART
transmembrane domain	962	984	N/A	INTRINSIC
low complexity region	1101	1111	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000127264

SMART Domains

Protein: ENSMUSP00000115216
Gene: ENSMUSG00000038119

Domain	Start	End	E-Value	Type
IGc2	1	51	6.26e-5	SMART
IG_like	18	62	1.06e2	SMART
IGc2	81	134	6.45e-7	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000137200

Predicted Effect

probably benign
Transcript: ENSMUST00000151682

SMART Domains

Protein: ENSMUSP00000119206
Gene: ENSMUSG00000038119

Domain	Start	End	E-Value	Type
IGc2	40	103	1.35e-9	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000154652
AA Change: Y193*

SMART Domains

Protein: ENSMUSP00000117499
Gene: ENSMUSG00000038119
AA Change: Y193*

Domain	Start	End	E-Value	Type
signal peptide	1	24	N/A	INTRINSIC
IGc2	40	103	1.35e-9	SMART
IG	125	212	7.25e-1	SMART
IGc2	233	296	1.38e-6	SMART
IGc2	323	386	4.62e-17	SMART
IGc2	416	506	5e-13	SMART
FN3	573	660	2.18e-2	SMART

Coding Region Coverage

1x: 99.9%
3x: 99.6%
10x: 98.3%
20x: 95.3%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a cell surface receptor that is a member of the immunoglobulin superfamily. The encoded protein contains three fibronectin type III domains and five immunoglobulin-like C2-type domains. This protein is a member of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells and positively regulates myogenesis. [provided by RefSeq, Aug 2011]
PHENOTYPE: Homozygous null mice display facial defects characteristic of microform holoprosencephaly, are runted, and are prone to death prior to weaning. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 46 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ace	A	G	11: 105,879,838 (GRCm39)	E726G	probably damaging	Het
Adgrl4	A	G	3: 151,246,622 (GRCm39)	I641V	possibly damaging	Het
Apoa5	A	T	9: 46,181,931 (GRCm39)	R336*	probably null	Het
Bfsp2	T	A	9: 103,357,023 (GRCm39)	T135S	probably benign	Het
Calhm2	A	T	19: 47,121,501 (GRCm39)	Y223N	probably damaging	Het
Ccdc158	T	C	5: 92,775,325 (GRCm39)	E960G	probably benign	Het
Ccdc80	T	C	16: 44,917,073 (GRCm39)	S610P	probably benign	Het
Cept1	A	T	3: 106,410,992 (GRCm39)	H400Q	probably benign	Het
Cfap144	T	C	11: 58,687,427 (GRCm39)	E66G	probably damaging	Het
Clspn	T	A	4: 126,484,434 (GRCm39)	N1197K	probably benign	Het
Cnot8	T	C	11: 58,004,816 (GRCm39)	S172P	probably damaging	Het
Col14a1	T	C	15: 55,383,404 (GRCm39)	I1794T	probably damaging	Het
Cracdl	T	C	1: 37,652,493 (GRCm39)	T1105A	possibly damaging	Het
Fam193a	A	T	5: 34,616,374 (GRCm39)	T564S	possibly damaging	Het
Galnt1	G	A	18: 24,387,720 (GRCm39)	V154I	probably benign	Het
Gstcd	C	A	3: 132,704,675 (GRCm39)	E526D	probably benign	Het
Ighv1-42	A	C	12: 114,900,907 (GRCm39)	S59R	probably benign	Het
Morn3	A	G	5: 123,184,823 (GRCm39)	C6R	possibly damaging	Het
Nrdc	A	T	4: 108,901,782 (GRCm39)	K617M	probably damaging	Het
Or2aj4	A	G	16: 19,385,009 (GRCm39)	L208P	probably damaging	Het
Or51ai2	A	G	7: 103,587,400 (GRCm39)	H271R	probably benign	Het
Or8b36	T	A	9: 37,937,762 (GRCm39)	I220N	probably damaging	Het
Or8b49	T	C	9: 38,506,252 (GRCm39)	M245T	probably benign	Het
Pcdhb11	A	G	18: 37,556,056 (GRCm39)	N462S	probably damaging	Het
Pfpl	G	T	19: 12,406,825 (GRCm39)	D359Y	probably damaging	Het
Phyhip	T	C	14: 70,699,299 (GRCm39)	V34A	probably benign	Het
Pigu	A	T	2: 155,139,116 (GRCm39)	I313N	possibly damaging	Het
Plch1	C	T	3: 63,609,444 (GRCm39)	R912H	probably damaging	Het
Psg16	T	A	7: 16,829,091 (GRCm39)	F225Y	possibly damaging	Het
Setdb2	T	A	14: 59,660,898 (GRCm39)	K82*	probably null	Het
Sgms1	A	G	19: 32,101,825 (GRCm39)	S394P	possibly damaging	Het
Slc16a1	T	C	3: 104,560,310 (GRCm39)	L205P	probably benign	Het
Slc19a1	T	A	10: 76,880,603 (GRCm39)	I380N	probably damaging	Het
Snx32	A	G	19: 5,548,042 (GRCm39)	I131T	probably benign	Het
Sorbs3	T	C	14: 70,430,053 (GRCm39)		probably null	Het
Stc2	T	A	11: 31,310,392 (GRCm39)	I215L	probably benign	Het
Tln2	C	T	9: 67,230,302 (GRCm39)	A84T	probably damaging	Het
Tomm34	A	G	2: 163,902,911 (GRCm39)	M133T	probably benign	Het
Usp43	A	G	11: 67,770,733 (GRCm39)	S634P	probably benign	Het
Vmn2r59	T	A	7: 41,661,749 (GRCm39)	R689*	probably null	Het
Vmn2r9	C	T	5: 108,992,902 (GRCm39)	R536Q	probably benign	Het
Wdr24	C	T	17: 26,043,579 (GRCm39)	H134Y	probably benign	Het
Zfhx2	T	A	14: 55,305,767 (GRCm39)		probably null	Het
Zfp1004	A	G	2: 150,034,725 (GRCm39)	K349E	probably damaging	Het
Zfp608	G	T	18: 55,120,944 (GRCm39)	H214Q	possibly damaging	Het
Zfp619	T	C	7: 39,184,558 (GRCm39)	V196A	probably benign	Het

Other mutations in Cdon

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00832:Cdon	APN	9	35,389,412 (GRCm39)	missense	probably damaging	1.00
IGL01307:Cdon	APN	9	35,368,860 (GRCm39)	missense	probably benign	0.01
IGL01528:Cdon	APN	9	35,381,403 (GRCm39)	missense	possibly damaging	0.95
IGL01663:Cdon	APN	9	35,394,510 (GRCm39)	missense	possibly damaging	0.57
IGL01723:Cdon	APN	9	35,414,634 (GRCm39)	missense	probably benign	0.05
IGL02200:Cdon	APN	9	35,394,405 (GRCm39)	missense	probably benign	0.28
IGL02444:Cdon	APN	9	35,384,744 (GRCm39)	missense	probably benign	0.09
IGL02547:Cdon	APN	9	35,389,950 (GRCm39)	missense	probably damaging	1.00
IGL02620:Cdon	APN	9	35,364,095 (GRCm39)	missense	probably benign	0.00
IGL02861:Cdon	APN	9	35,398,253 (GRCm39)	missense	probably damaging	0.96
IGL02894:Cdon	APN	9	35,366,722 (GRCm39)	missense	probably benign	0.01
IGL03153:Cdon	APN	9	35,389,255 (GRCm39)	missense	probably damaging	1.00
IGL03206:Cdon	APN	9	35,414,602 (GRCm39)	missense	probably benign
IGL03374:Cdon	APN	9	35,389,299 (GRCm39)	missense	possibly damaging	0.46
corleone	UTSW	9	35,398,252 (GRCm39)	nonsense	probably null
indentured	UTSW	9	35,363,402 (GRCm39)	start codon destroyed	probably null	1.00
Molar	UTSW	9	35,375,191 (GRCm39)	missense	probably benign	0.15
Servitude	UTSW	9	35,388,244 (GRCm39)	missense	probably damaging	1.00
PIT4280001:Cdon	UTSW	9	35,398,231 (GRCm39)	missense	probably damaging	1.00
R0045:Cdon	UTSW	9	35,398,103 (GRCm39)	missense	probably benign
R0045:Cdon	UTSW	9	35,398,103 (GRCm39)	missense	probably benign
R0064:Cdon	UTSW	9	35,400,523 (GRCm39)	missense	probably benign	0.03
R0396:Cdon	UTSW	9	35,381,426 (GRCm39)	missense	probably damaging	1.00
R0403:Cdon	UTSW	9	35,384,796 (GRCm39)	missense	probably benign	0.00
R0490:Cdon	UTSW	9	35,363,978 (GRCm39)	missense	probably damaging	1.00
R0547:Cdon	UTSW	9	35,368,794 (GRCm39)	missense	possibly damaging	0.88
R0609:Cdon	UTSW	9	35,389,907 (GRCm39)	missense	probably damaging	1.00
R0645:Cdon	UTSW	9	35,388,379 (GRCm39)	splice site	probably null
R0781:Cdon	UTSW	9	35,367,733 (GRCm39)	splice site	probably benign
R1110:Cdon	UTSW	9	35,367,733 (GRCm39)	splice site	probably benign
R1391:Cdon	UTSW	9	35,415,485 (GRCm39)	missense	possibly damaging	0.51
R1574:Cdon	UTSW	9	35,364,233 (GRCm39)	splice site	probably benign
R1851:Cdon	UTSW	9	35,394,454 (GRCm39)	missense	probably damaging	1.00
R2031:Cdon	UTSW	9	35,415,370 (GRCm39)	missense	probably damaging	0.96
R2230:Cdon	UTSW	9	35,403,222 (GRCm39)	critical splice donor site	probably null
R3683:Cdon	UTSW	9	35,400,328 (GRCm39)	missense	possibly damaging	0.89
R3684:Cdon	UTSW	9	35,400,328 (GRCm39)	missense	possibly damaging	0.89
R3685:Cdon	UTSW	9	35,400,328 (GRCm39)	missense	possibly damaging	0.89
R3941:Cdon	UTSW	9	35,375,467 (GRCm39)	missense	probably benign	0.09
R4030:Cdon	UTSW	9	35,403,202 (GRCm39)	missense	probably damaging	1.00
R4084:Cdon	UTSW	9	35,389,427 (GRCm39)	missense	probably damaging	0.98
R4462:Cdon	UTSW	9	35,368,876 (GRCm39)	missense	probably damaging	0.97
R4569:Cdon	UTSW	9	35,388,265 (GRCm39)	missense	probably damaging	1.00
R4677:Cdon	UTSW	9	35,389,901 (GRCm39)	missense	probably damaging	1.00
R4869:Cdon	UTSW	9	35,364,200 (GRCm39)	missense	possibly damaging	0.71
R5032:Cdon	UTSW	9	35,400,330 (GRCm39)	missense	probably damaging	1.00
R5047:Cdon	UTSW	9	35,389,935 (GRCm39)	missense	probably damaging	1.00
R5214:Cdon	UTSW	9	35,394,504 (GRCm39)	missense	probably damaging	1.00
R5341:Cdon	UTSW	9	35,381,431 (GRCm39)	missense	probably damaging	1.00
R5410:Cdon	UTSW	9	35,381,331 (GRCm39)	missense	probably damaging	0.99
R5581:Cdon	UTSW	9	35,415,377 (GRCm39)	missense	probably benign	0.01
R5696:Cdon	UTSW	9	35,403,162 (GRCm39)	missense	possibly damaging	0.69
R5757:Cdon	UTSW	9	35,364,068 (GRCm39)	missense	probably damaging	0.98
R5802:Cdon	UTSW	9	35,365,716 (GRCm39)	missense	probably damaging	0.99
R5845:Cdon	UTSW	9	35,368,762 (GRCm39)	missense	probably damaging	1.00
R5949:Cdon	UTSW	9	35,398,247 (GRCm39)	missense	probably benign	0.32
R6245:Cdon	UTSW	9	35,388,235 (GRCm39)	missense	probably damaging	1.00
R6845:Cdon	UTSW	9	35,398,252 (GRCm39)	nonsense	probably null
R6896:Cdon	UTSW	9	35,363,402 (GRCm39)	start codon destroyed	probably null	1.00
R7060:Cdon	UTSW	9	35,398,205 (GRCm39)	missense	probably damaging	1.00
R7076:Cdon	UTSW	9	35,415,446 (GRCm39)	missense	probably benign	0.00
R7184:Cdon	UTSW	9	35,375,191 (GRCm39)	missense	probably benign	0.15
R7382:Cdon	UTSW	9	35,389,944 (GRCm39)	missense	probably damaging	1.00
R7763:Cdon	UTSW	9	35,365,711 (GRCm39)	nonsense	probably null
R7857:Cdon	UTSW	9	35,367,908 (GRCm39)	missense	possibly damaging	0.79
R7885:Cdon	UTSW	9	35,367,818 (GRCm39)	missense	probably benign	0.01
R7894:Cdon	UTSW	9	35,388,244 (GRCm39)	missense	probably damaging	1.00
R7984:Cdon	UTSW	9	35,414,598 (GRCm39)	missense	probably benign	0.00
R8287:Cdon	UTSW	9	35,375,225 (GRCm39)	missense	probably benign
R8428:Cdon	UTSW	9	35,403,163 (GRCm39)	missense	probably benign	0.21
R8519:Cdon	UTSW	9	35,389,950 (GRCm39)	missense	probably damaging	1.00
R8698:Cdon	UTSW	9	35,398,269 (GRCm39)	critical splice donor site	probably null
R8797:Cdon	UTSW	9	35,389,931 (GRCm39)	missense	probably damaging	1.00
R8995:Cdon	UTSW	9	35,398,093 (GRCm39)	missense	probably damaging	1.00
R9090:Cdon	UTSW	9	35,403,175 (GRCm39)	missense	probably damaging	0.98
R9177:Cdon	UTSW	9	35,381,230 (GRCm39)	missense	probably benign	0.00
R9200:Cdon	UTSW	9	35,414,617 (GRCm39)	missense	probably benign	0.00
R9271:Cdon	UTSW	9	35,403,175 (GRCm39)	missense	probably damaging	0.98
R9330:Cdon	UTSW	9	35,400,275 (GRCm39)	nonsense	probably null
R9477:Cdon	UTSW	9	35,403,201 (GRCm39)	missense	probably damaging	1.00
R9612:Cdon	UTSW	9	35,398,201 (GRCm39)	missense	probably damaging	1.00
R9730:Cdon	UTSW	9	35,398,263 (GRCm39)	missense	probably benign	0.00
Z1177:Cdon	UTSW	9	35,403,196 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- GTAAAGCTCAACAGTGGCTG -3'
(R):5'- GGTATAGGACTATCCATAACACACC -3'

Sequencing Primer
(F):5'- CTCTCACGTGCTGGGATTATAGAC -3'
(R):5'- CTACTTCCAGGGAATATGAGTGC -3'

Posted On

2017-08-16