Incidental Mutation 'R6107:Rnase10'
ID 485574
Institutional Source Beutler Lab
Gene Symbol Rnase10
Ensembl Gene ENSMUSG00000021872
Gene Name ribonuclease, RNase A family, 10 (non-active)
Synonyms 4930474F22Rik
MMRRC Submission 044257-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R6107 (G1)
Quality Score 203.009
Status Not validated
Chromosome 14
Chromosomal Location 51245208-51248215 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 51246751 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Glutamic Acid at position 43 (V43E)
Ref Sequence ENSEMBL: ENSMUSP00000022424 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000022424] [ENSMUST00000164632]
AlphaFold no structure available at present
Predicted Effect possibly damaging
Transcript: ENSMUST00000022424
AA Change: V43E

PolyPhen 2 Score 0.891 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000022424
Gene: ENSMUSG00000021872
AA Change: V43E

DomainStartEndE-ValueType
transmembrane domain 40 62 N/A INTRINSIC
low complexity region 87 98 N/A INTRINSIC
Pfam:RnaseA 132 244 2.2e-21 PFAM
Predicted Effect unknown
Transcript: ENSMUST00000164632
AA Change: V6E
SMART Domains Protein: ENSMUSP00000131065
Gene: ENSMUSG00000021872
AA Change: V6E

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
low complexity region 50 61 N/A INTRINSIC
Pfam:RnaseA 91 208 1.4e-21 PFAM
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.1%
  • 20x: 94.5%
Validation Efficiency
MGI Phenotype PHENOTYPE: Homozygous disruption of this gene leads to decreased bone mineral density, alterations in B cell, T cell and NK cell number, and abnormal circulating glucose, creatinine, chloride and serum albumin levels. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acyp2 C T 11: 30,456,354 (GRCm39) E98K possibly damaging Het
Adgrl3 A G 5: 81,836,410 (GRCm39) R723G probably damaging Het
Ankrd52 C A 10: 128,222,881 (GRCm39) N610K probably benign Het
Atp2a3 A G 11: 72,879,287 (GRCm39) probably null Het
Bahcc1 G A 11: 120,163,714 (GRCm39) A671T probably benign Het
Col6a5 A T 9: 105,769,471 (GRCm39) Y1764* probably null Het
E2f8 A G 7: 48,517,424 (GRCm39) V793A probably benign Het
Erbin A G 13: 103,970,400 (GRCm39) I1072T probably benign Het
Exoc2 T C 13: 31,060,780 (GRCm39) I575V probably benign Het
Fbxw19 C T 9: 109,324,834 (GRCm39) V28M probably damaging Het
Flt1 G A 5: 147,540,403 (GRCm39) T762M probably benign Het
Ghitm C A 14: 36,847,166 (GRCm39) A303S probably damaging Het
Gm18856 T A 13: 14,140,319 (GRCm39) probably benign Het
Gm5493 T A 17: 22,967,069 (GRCm39) H68Q possibly damaging Het
Hells T G 19: 38,942,093 (GRCm39) I461S probably benign Het
Inpp4a T A 1: 37,416,829 (GRCm39) I450N probably damaging Het
Kbtbd6 T A 14: 79,690,553 (GRCm39) V353D probably damaging Het
Kifap3 A T 1: 163,696,338 (GRCm39) T656S possibly damaging Het
Med23 A T 10: 24,781,932 (GRCm39) K713* probably null Het
Miga1 A T 3: 152,041,036 (GRCm39) F44I probably benign Het
Ngrn A G 7: 79,911,625 (GRCm39) E74G probably damaging Het
Or4k40 T C 2: 111,251,000 (GRCm39) S99G probably benign Het
Patl2 A T 2: 121,957,967 (GRCm39) L97Q probably damaging Het
Pcdha1 A G 18: 37,065,354 (GRCm39) I673V probably benign Het
Pcsk1 A G 13: 75,275,967 (GRCm39) T543A probably benign Het
Plch1 C T 3: 63,609,444 (GRCm39) R912H probably damaging Het
Prl8a8 A G 13: 27,695,447 (GRCm39) V100A possibly damaging Het
Robo1 A G 16: 72,780,717 (GRCm39) S816G probably benign Het
Slc25a34 C T 4: 141,350,806 (GRCm39) V68M probably benign Het
Slc25a48 A T 13: 56,612,891 (GRCm39) E263V probably damaging Het
Slc7a14 A G 3: 31,311,759 (GRCm39) V87A probably damaging Het
Slc8b1 A G 5: 120,667,665 (GRCm39) I433V probably damaging Het
Smurf1 A G 5: 144,831,314 (GRCm39) V259A possibly damaging Het
Spag6l T A 16: 16,599,652 (GRCm39) N270I possibly damaging Het
Tas2r113 G A 6: 132,869,977 (GRCm39) V2M probably damaging Het
Tnpo2 T C 8: 85,780,104 (GRCm39) V680A probably damaging Het
Ttyh3 A C 5: 140,619,317 (GRCm39) probably null Het
Ufl1 A G 4: 25,251,999 (GRCm39) S639P possibly damaging Het
Znfx1 A T 2: 166,879,001 (GRCm39) F928I possibly damaging Het
Other mutations in Rnase10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00161:Rnase10 APN 14 51,247,238 (GRCm39) missense possibly damaging 0.91
IGL01534:Rnase10 APN 14 51,245,436 (GRCm39) missense probably benign 0.00
IGL02082:Rnase10 APN 14 51,246,856 (GRCm39) missense probably damaging 1.00
IGL02661:Rnase10 APN 14 51,247,273 (GRCm39) missense probably damaging 1.00
R1254:Rnase10 UTSW 14 51,247,083 (GRCm39) missense probably damaging 0.99
R1989:Rnase10 UTSW 14 51,247,095 (GRCm39) missense probably benign 0.03
R3878:Rnase10 UTSW 14 51,246,889 (GRCm39) missense probably damaging 0.97
R5405:Rnase10 UTSW 14 51,247,317 (GRCm39) missense probably damaging 1.00
R5942:Rnase10 UTSW 14 51,246,735 (GRCm39) missense probably benign 0.08
R6994:Rnase10 UTSW 14 51,247,138 (GRCm39) missense probably damaging 1.00
R7138:Rnase10 UTSW 14 51,247,167 (GRCm39) missense probably damaging 1.00
R7186:Rnase10 UTSW 14 51,247,242 (GRCm39) missense probably damaging 1.00
R7848:Rnase10 UTSW 14 51,246,970 (GRCm39) missense possibly damaging 0.75
Predicted Primers PCR Primer
(F):5'- TAGCCACTTTCCAATCCTCAAG -3'
(R):5'- TAGCCAAGTGCCAGACCTTC -3'

Sequencing Primer
(F):5'- TCAAGACCCACACAGGAATGG -3'
(R):5'- AAGTGCCAGACCTTCTGTGG -3'
Posted On 2017-08-16