Incidental Mutation 'R6124:Or10ak13'
ID 485863
Institutional Source Beutler Lab
Gene Symbol Or10ak13
Ensembl Gene ENSMUSG00000111159
Gene Name olfactory receptor family 10 subfamily AK member 13
Synonyms Olfr219-ps1, GA_x6K02SYWGW3-414-3, MOR259-10, GA_x6K02T2QD9B-18767132-18768073, Olfr1337
MMRRC Submission 044271-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.197) question?
Stock # R6124 (G1)
Quality Score 225.009
Status Not validated
Chromosome 4
Chromosomal Location 118638833-118639783 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 118639392 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Phenylalanine at position 130 (C130F)
Ref Sequence ENSEMBL: ENSMUSP00000076483 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000077247]
AlphaFold A2ACY8
Predicted Effect probably damaging
Transcript: ENSMUST00000077247
AA Change: C130F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000076483
Gene: ENSMUSG00000111159
AA Change: C130F

DomainStartEndE-ValueType
Pfam:7tm_4 34 310 7.8e-53 PFAM
Pfam:7TM_GPCR_Srsx 38 308 8.5e-7 PFAM
Pfam:7tm_1 44 293 8.3e-23 PFAM
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.0%
  • 20x: 94.4%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2900026A02Rik T C 5: 113,331,622 (GRCm39) N864S probably benign Het
Ank2 C T 3: 127,041,800 (GRCm39) V35M probably benign Het
Apc2 T C 10: 80,142,185 (GRCm39) M368T probably damaging Het
Atp8b3 G A 10: 80,365,515 (GRCm39) T413M probably damaging Het
Cxcr4 A G 1: 128,517,397 (GRCm39) L86P probably damaging Het
Cyfip1 A G 7: 55,547,691 (GRCm39) Y598C probably benign Het
Epg5 A G 18: 78,073,260 (GRCm39) N2428D probably benign Het
Fastkd3 C T 13: 68,738,337 (GRCm39) Q32* probably null Het
Fkbpl G A 17: 34,864,303 (GRCm39) A24T probably benign Het
Gm5422 A G 10: 31,125,396 (GRCm39) noncoding transcript Het
Gm9913 T A 2: 125,348,393 (GRCm39) probably benign Het
Hgfac A G 5: 35,201,728 (GRCm39) N287S probably benign Het
Hook3 A T 8: 26,549,300 (GRCm39) N181K probably benign Het
Hormad1 A G 3: 95,483,613 (GRCm39) T142A probably benign Het
Klrh1 A T 6: 129,745,098 (GRCm39) F166Y probably benign Het
Kplce G T 3: 92,776,365 (GRCm39) P106Q probably damaging Het
Lonrf1 T A 8: 36,696,354 (GRCm39) N565I probably damaging Het
Mast1 A G 8: 85,651,936 (GRCm39) S349P probably benign Het
Mcee T A 7: 64,050,023 (GRCm39) N51K probably damaging Het
Mfsd6 A C 1: 52,747,411 (GRCm39) F485V probably damaging Het
Mptx2 G A 1: 173,102,414 (GRCm39) L92F probably benign Het
Nlrp6 T A 7: 140,503,160 (GRCm39) V422E probably damaging Het
Nrap A G 19: 56,374,458 (GRCm39) S23P probably damaging Het
Nsd2 T A 5: 34,000,610 (GRCm39) H42Q probably benign Het
Obscn A T 11: 58,969,870 (GRCm39) S91T probably benign Het
Or10j2 T A 1: 173,097,846 (GRCm39) Y35N probably damaging Het
Or13a20 A T 7: 140,232,507 (GRCm39) D205V probably damaging Het
Or5p72 A T 7: 108,022,725 (GRCm39) probably null Het
Or6c215 G A 10: 129,637,689 (GRCm39) A235V probably damaging Het
Or6c215 C A 10: 129,637,690 (GRCm39) A235S probably damaging Het
Or6d15 T C 6: 116,559,446 (GRCm39) I154V probably benign Het
Papss2 T A 19: 32,614,528 (GRCm39) N81K probably damaging Het
Plekhn1 A G 4: 156,309,696 (GRCm39) I147T possibly damaging Het
Ptgfrn C T 3: 100,980,405 (GRCm39) E312K probably damaging Het
Serpinb1b T C 13: 33,277,796 (GRCm39) V343A probably benign Het
Sis T C 3: 72,860,544 (GRCm39) N261S possibly damaging Het
Slc41a2 T C 10: 83,133,116 (GRCm39) N310S probably damaging Het
Slco3a1 C T 7: 73,968,254 (GRCm39) D489N probably benign Het
Snrnp48 T A 13: 38,400,439 (GRCm39) I182N possibly damaging Het
Tppp2 A T 14: 52,156,937 (GRCm39) T105S probably benign Het
Vav3 C T 3: 109,571,681 (GRCm39) T201M probably damaging Het
Vmn1r19 A C 6: 57,381,602 (GRCm39) M52L probably benign Het
Vmn2r94 T A 17: 18,464,321 (GRCm39) R656S probably benign Het
Other mutations in Or10ak13
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02203:Or10ak13 APN 4 118,639,626 (GRCm39) missense possibly damaging 0.95
IGL02626:Or10ak13 APN 4 118,639,531 (GRCm39) missense probably damaging 0.98
IGL02699:Or10ak13 APN 4 118,639,349 (GRCm39) nonsense probably null
IGL02754:Or10ak13 APN 4 118,639,117 (GRCm39) missense possibly damaging 0.90
IGL03287:Or10ak13 APN 4 118,639,551 (GRCm39) missense possibly damaging 0.64
R1341:Or10ak13 UTSW 4 118,639,579 (GRCm39) missense probably benign 0.01
R4894:Or10ak13 UTSW 4 118,639,483 (GRCm39) missense probably damaging 1.00
R6515:Or10ak13 UTSW 4 118,639,467 (GRCm39) missense probably benign 0.13
R6529:Or10ak13 UTSW 4 118,638,907 (GRCm39) missense probably benign 0.15
R7040:Or10ak13 UTSW 4 118,639,183 (GRCm39) missense probably benign 0.00
R7398:Or10ak13 UTSW 4 118,638,896 (GRCm39) missense possibly damaging 0.80
R7684:Or10ak13 UTSW 4 118,639,471 (GRCm39) missense probably benign 0.40
R8377:Or10ak13 UTSW 4 118,639,203 (GRCm39) missense probably benign 0.22
R8717:Or10ak13 UTSW 4 118,638,996 (GRCm39) missense probably damaging 1.00
R9369:Or10ak13 UTSW 4 118,639,077 (GRCm39) missense probably benign 0.31
R9594:Or10ak13 UTSW 4 118,638,952 (GRCm39) missense probably benign
Z1189:Or10ak13 UTSW 4 118,639,284 (GRCm39) missense possibly damaging 0.85
Predicted Primers PCR Primer
(F):5'- AGTCCACCATCTCAATGACATGAG -3'
(R):5'- ATCTCCCTGTTGGATATGGGC -3'

Sequencing Primer
(F):5'- TGACATGAGTATCCATGCAAGC -3'
(R):5'- TGGATATGGGCTATGTCACCACC -3'
Posted On 2017-08-16