Incidental Mutation 'R6031:Or6c203'
ID 486286
Institutional Source Beutler Lab
Gene Symbol Or6c203
Ensembl Gene ENSMUSG00000107662
Gene Name olfactory receptor family 6 subfamily C member 203
Synonyms MOR114-3, GA_x6K02T2PULF-10860457-10859522, Olfr772
MMRRC Submission 044203-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.117) question?
Stock # R6031 (G1)
Quality Score 225.009
Status Not validated
Chromosome 10
Chromosomal Location 129009920-129010923 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 129010224 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 222 (V222A)
Ref Sequence ENSEMBL: ENSMUSP00000148854 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000169800] [ENSMUST00000214672]
AlphaFold Q8VGC5
Predicted Effect noncoding transcript
Transcript: ENSMUST00000122783
Predicted Effect probably benign
Transcript: ENSMUST00000169800
AA Change: V222A

PolyPhen 2 Score 0.136 (Sensitivity: 0.92; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000132389
Gene: ENSMUSG00000107662
AA Change: V222A

DomainStartEndE-ValueType
Pfam:7tm_4 28 307 1.6e-47 PFAM
Pfam:7tm_1 38 287 1.1e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000214672
AA Change: V222A

PolyPhen 2 Score 0.136 (Sensitivity: 0.92; Specificity: 0.86)
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.4%
  • 20x: 95.6%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 65 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700010I14Rik T C 17: 9,214,084 (GRCm39) Y304H possibly damaging Het
Add2 A G 6: 86,075,655 (GRCm39) E268G probably damaging Het
Akr1b1 A C 6: 34,289,609 (GRCm39) V67G probably benign Het
Alms1 A T 6: 85,599,937 (GRCm39) N1588Y probably damaging Het
Arhgap23 A T 11: 97,366,965 (GRCm39) D1082V probably damaging Het
Asb6 A G 2: 30,714,207 (GRCm39) V301A probably benign Het
Ascc3 C T 10: 50,718,279 (GRCm39) R1991* probably null Het
Atg7 T A 6: 114,648,194 (GRCm39) C31S probably benign Het
Camsap2 A T 1: 136,208,176 (GRCm39) N1105K possibly damaging Het
Ccdc125 C T 13: 100,820,877 (GRCm39) probably null Het
Ccdc63 T C 5: 122,267,799 (GRCm39) I56V possibly damaging Het
Cpd T C 11: 76,681,714 (GRCm39) E1143G probably benign Het
Cpt1a T A 19: 3,421,556 (GRCm39) probably null Het
Creb3l2 A T 6: 37,311,369 (GRCm39) D473E probably benign Het
Disp2 G T 2: 118,620,275 (GRCm39) V336L probably benign Het
Efr3b A G 12: 4,017,106 (GRCm39) I782T possibly damaging Het
Fam98a A G 17: 75,846,427 (GRCm39) V230A probably damaging Het
Fat3 T A 9: 15,899,788 (GRCm39) T3082S probably benign Het
Frmd3 T C 4: 74,105,688 (GRCm39) Y445H probably damaging Het
Galt G A 4: 41,757,202 (GRCm39) R185Q probably benign Het
Gatb T C 3: 85,520,818 (GRCm39) I309T possibly damaging Het
Gfi1b G A 2: 28,503,820 (GRCm39) Q127* probably null Het
Gfpt1 C A 6: 87,063,302 (GRCm39) T563N probably damaging Het
Gria1 A G 11: 57,108,608 (GRCm39) D237G probably damaging Het
Hspbp1 A T 7: 4,666,465 (GRCm39) V305D probably benign Het
Hyls1 G A 9: 35,472,480 (GRCm39) S312F probably benign Het
Iars1 T C 13: 49,859,307 (GRCm39) V9A probably damaging Het
Ipo4 G A 14: 55,869,596 (GRCm39) P355S probably damaging Het
Jade2 G T 11: 51,717,413 (GRCm39) C314* probably null Het
Kri1 T C 9: 21,186,565 (GRCm39) E597G probably benign Het
Mcub A G 3: 129,720,038 (GRCm39) Y152H probably damaging Het
Med23 C T 10: 24,779,646 (GRCm39) R542* probably null Het
Ndc80 T C 17: 71,818,483 (GRCm39) N291S probably benign Het
Nop2 T C 6: 125,110,529 (GRCm39) probably null Het
Nrxn1 T C 17: 90,896,218 (GRCm39) N984S probably damaging Het
Ntm A C 9: 28,920,671 (GRCm39) L86R probably damaging Het
Numa1 T A 7: 101,661,219 (GRCm39) D1847E possibly damaging Het
Odf2l A G 3: 144,845,624 (GRCm39) Q334R probably damaging Het
Or10ak11 A T 4: 118,687,588 (GRCm39) probably null Het
Or2ag2 C T 7: 106,485,134 (GRCm39) V297I possibly damaging Het
Or4a39 T A 2: 89,237,316 (GRCm39) T36S probably damaging Het
Or5ac17 T C 16: 59,036,296 (GRCm39) R227G probably benign Het
Or6ae1 A T 7: 139,742,722 (GRCm39) V47E possibly damaging Het
Pacc1 A G 1: 191,073,037 (GRCm39) R153G probably benign Het
Pcdhb19 A T 18: 37,630,776 (GRCm39) K190N probably damaging Het
Pdik1l A G 4: 134,006,352 (GRCm39) F197L probably damaging Het
Rnf113a2 T C 12: 84,464,764 (GRCm39) F219L probably damaging Het
Rnf208 A C 2: 25,133,776 (GRCm39) T157P probably damaging Het
RP23-145I16.3 A T 7: 141,930,451 (GRCm39) C364S probably damaging Het
Scn8a A T 15: 100,881,865 (GRCm39) D644V probably damaging Het
Thbs3 T A 3: 89,125,401 (GRCm39) C204S probably damaging Het
Tlr3 A G 8: 45,851,565 (GRCm39) I444T probably damaging Het
Trpm8 A T 1: 88,282,191 (GRCm39) I696F possibly damaging Het
Ttn A T 2: 76,660,941 (GRCm39) V7422D possibly damaging Het
Ufl1 A G 4: 25,278,038 (GRCm39) V139A probably benign Het
Uggt2 A T 14: 119,308,238 (GRCm39) V381D probably benign Het
Vgll3 T A 16: 65,636,367 (GRCm39) Y173N probably damaging Het
Vmn1r9 A G 6: 57,048,158 (GRCm39) T78A probably benign Het
Vps13b T A 15: 35,472,114 (GRCm39) L806M probably damaging Het
Vps13d A C 4: 144,895,079 (GRCm39) H394Q probably benign Het
Wdr53 T A 16: 32,075,536 (GRCm39) V247D probably damaging Het
Wdr81 A T 11: 75,338,695 (GRCm39) L1488Q probably damaging Het
Zc3h6 A G 2: 128,809,732 (GRCm39) D3G possibly damaging Het
Zfp93 G T 7: 23,975,725 (GRCm39) C570F probably damaging Het
Zfp943 C T 17: 22,212,357 (GRCm39) T481I probably benign Het
Other mutations in Or6c203
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02512:Or6c203 APN 10 129,010,119 (GRCm39) missense possibly damaging 0.65
IGL03072:Or6c203 APN 10 129,010,358 (GRCm39) missense probably damaging 1.00
IGL03336:Or6c203 APN 10 129,010,098 (GRCm39) missense probably benign 0.00
R1852:Or6c203 UTSW 10 129,010,197 (GRCm39) missense probably benign 0.00
R2496:Or6c203 UTSW 10 129,009,966 (GRCm39) missense probably benign 0.00
R6031:Or6c203 UTSW 10 129,010,224 (GRCm39) missense probably benign 0.14
R6168:Or6c203 UTSW 10 129,010,035 (GRCm39) missense probably damaging 1.00
R7454:Or6c203 UTSW 10 129,010,324 (GRCm39) missense probably damaging 1.00
R7669:Or6c203 UTSW 10 129,010,128 (GRCm39) missense probably damaging 1.00
R7905:Or6c203 UTSW 10 129,010,056 (GRCm39) missense probably damaging 0.99
R8307:Or6c203 UTSW 10 129,010,101 (GRCm39) missense probably benign 0.00
R8830:Or6c203 UTSW 10 129,010,715 (GRCm39) nonsense probably null
R9405:Or6c203 UTSW 10 129,010,165 (GRCm39) missense probably benign 0.08
Predicted Primers PCR Primer
(F):5'- ATTCCTAAGTGTGTAGATGAAGGGG -3'
(R):5'- AGCCTTGGCCTAAATCTGCAG -3'

Sequencing Primer
(F):5'- GGTTTAGCATAGGGGCAATGG -3'
(R):5'- TGGCCTAAATCTGCAGTTCTG -3'
Posted On 2017-08-16