Incidental Mutation 'R6035:Dapk1'
| ID |
486533 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Dapk1
|
| Ensembl Gene |
ENSMUSG00000021559 |
| Gene Name |
death associated protein kinase 1 |
| Synonyms |
DAP-Kinase, D13Ucla1, 2810425C21Rik, 2310039H24Rik |
| MMRRC Submission |
044207-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R6035 (G1)
|
| Quality Score |
115.008 |
|
Status
|
Validated
|
| Chromosome |
13 |
| Chromosomal Location |
60749761-60911005 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 60909013 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Cysteine to Serine
at position 1209
(C1209S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000153607
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000044083]
[ENSMUST00000077453]
[ENSMUST00000226059]
|
| AlphaFold |
Q80YE7 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000044083
AA Change: C1209S
PolyPhen 2
Score 0.458 (Sensitivity: 0.89; Specificity: 0.90)
|
| SMART Domains |
Protein: ENSMUSP00000040825
Gene: ENSMUSG00000021559
AA Change: C1209S
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
13 |
275 |
6.35e-99 |
SMART |
|
low complexity region
|
295 |
306 |
N/A |
INTRINSIC |
|
ANK
|
378 |
407 |
5.09e-2 |
SMART |
|
ANK
|
411 |
440 |
6.61e-1 |
SMART |
|
ANK
|
444 |
473 |
7.64e-6 |
SMART |
|
ANK
|
477 |
506 |
2.13e-4 |
SMART |
|
ANK
|
510 |
539 |
1.31e-4 |
SMART |
|
ANK
|
543 |
572 |
7.83e-3 |
SMART |
|
ANK
|
576 |
605 |
8.52e-4 |
SMART |
|
ANK
|
609 |
638 |
1.85e-4 |
SMART |
|
ANK
|
642 |
671 |
7.29e2 |
SMART |
|
low complexity region
|
711 |
725 |
N/A |
INTRINSIC |
|
DEATH
|
1299 |
1396 |
2.65e-18 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000077453
AA Change: C1209S
PolyPhen 2
Score 0.458 (Sensitivity: 0.89; Specificity: 0.90)
|
| SMART Domains |
Protein: ENSMUSP00000076666
Gene: ENSMUSG00000021559
AA Change: C1209S
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
13 |
275 |
6.35e-99 |
SMART |
|
low complexity region
|
295 |
306 |
N/A |
INTRINSIC |
|
ANK
|
378 |
407 |
5.09e-2 |
SMART |
|
ANK
|
411 |
440 |
6.61e-1 |
SMART |
|
ANK
|
444 |
473 |
7.64e-6 |
SMART |
|
ANK
|
477 |
506 |
2.13e-4 |
SMART |
|
ANK
|
510 |
539 |
1.31e-4 |
SMART |
|
ANK
|
543 |
572 |
7.83e-3 |
SMART |
|
ANK
|
576 |
605 |
8.52e-4 |
SMART |
|
ANK
|
609 |
638 |
1.85e-4 |
SMART |
|
ANK
|
642 |
671 |
7.29e2 |
SMART |
|
low complexity region
|
711 |
725 |
N/A |
INTRINSIC |
|
Pfam:COR
|
984 |
1176 |
4.2e-10 |
PFAM |
|
DEATH
|
1299 |
1396 |
2.65e-18 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000225952
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000226059
AA Change: C1209S
PolyPhen 2
Score 0.458 (Sensitivity: 0.89; Specificity: 0.90)
|
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.6%
- 10x: 98.1%
- 20x: 94.6%
|
| Validation Efficiency |
84% (62/74) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Death-associated protein kinase 1 is a positive mediator of gamma-interferon induced programmed cell death. DAPK1 encodes a structurally unique 160-kD calmodulin dependent serine-threonine kinase that carries 8 ankyrin repeats and 2 putative P-loop consensus sites. It is a tumor suppressor candidate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
PHENOTYPE: Mice homozygous for a knock-out allele show decreased sensitivity to ER stress-induced cell death and reduced tunicamycin-induced kidney damage. Mice homozygous for a gene trapped allele show decreased infarct size and neuronal death with improved neurological scores after ischemic brain injury. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 80 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| A2m |
G |
T |
6: 121,615,353 (GRCm39) |
G76W |
probably damaging |
Het |
| Abca17 |
A |
T |
17: 24,500,219 (GRCm39) |
F1324Y |
possibly damaging |
Het |
| Abca8b |
A |
T |
11: 109,862,686 (GRCm39) |
|
probably null |
Het |
| Abcc12 |
A |
G |
8: 87,244,033 (GRCm39) |
M1040T |
probably damaging |
Het |
| Abtb1 |
A |
G |
6: 88,818,788 (GRCm39) |
F7L |
probably damaging |
Het |
| Adcy9 |
T |
C |
16: 4,122,377 (GRCm39) |
T558A |
probably benign |
Het |
| Adgrb1 |
A |
T |
15: 74,412,292 (GRCm39) |
T424S |
possibly damaging |
Het |
| Afg3l2 |
G |
T |
18: 67,554,329 (GRCm39) |
L458M |
probably damaging |
Het |
| Ankrd31 |
C |
A |
13: 96,968,721 (GRCm39) |
P786Q |
probably benign |
Het |
| Arhgap39 |
G |
T |
15: 76,621,424 (GRCm39) |
Y392* |
probably null |
Het |
| Ash1l |
T |
C |
3: 88,892,326 (GRCm39) |
Y1402H |
probably damaging |
Het |
| Carmil2 |
G |
T |
8: 106,419,195 (GRCm39) |
W749L |
probably benign |
Het |
| Ccar1 |
A |
G |
10: 62,587,564 (GRCm39) |
Y867H |
unknown |
Het |
| Cdh13 |
A |
G |
8: 119,232,437 (GRCm39) |
D47G |
probably benign |
Het |
| Chst9 |
T |
A |
18: 15,585,910 (GRCm39) |
T218S |
probably benign |
Het |
| Clec2i |
G |
A |
6: 128,870,587 (GRCm39) |
V67I |
probably benign |
Het |
| Cox7a2 |
T |
A |
9: 79,667,028 (GRCm39) |
|
probably benign |
Het |
| Cplx3 |
A |
G |
9: 57,519,030 (GRCm39) |
|
probably null |
Het |
| Cpz |
A |
G |
5: 35,674,929 (GRCm39) |
C107R |
probably damaging |
Het |
| Ddx41 |
T |
C |
13: 55,681,781 (GRCm39) |
M307V |
probably benign |
Het |
| Defa24 |
A |
G |
8: 22,224,565 (GRCm39) |
I5V |
probably benign |
Het |
| Dgcr8 |
A |
T |
16: 18,076,178 (GRCm39) |
N2K |
probably damaging |
Het |
| Ebf2 |
A |
G |
14: 67,476,423 (GRCm39) |
D131G |
probably damaging |
Het |
| Fam149b |
C |
T |
14: 20,427,985 (GRCm39) |
R424C |
probably damaging |
Het |
| Fbln2 |
G |
A |
6: 91,240,335 (GRCm39) |
V714M |
probably damaging |
Het |
| Fgf5 |
T |
C |
5: 98,423,385 (GRCm39) |
Y257H |
probably damaging |
Het |
| Fmo3 |
A |
C |
1: 162,791,605 (GRCm39) |
V224G |
probably damaging |
Het |
| Gigyf2 |
T |
C |
1: 87,338,450 (GRCm39) |
I394T |
possibly damaging |
Het |
| Glmn |
T |
A |
5: 107,741,746 (GRCm39) |
|
probably null |
Het |
| Greb1l |
T |
C |
18: 10,501,025 (GRCm39) |
I385T |
possibly damaging |
Het |
| Grhl1 |
C |
A |
12: 24,658,449 (GRCm39) |
Q365K |
probably benign |
Het |
| Gsdme |
G |
A |
6: 50,206,306 (GRCm39) |
T179M |
probably damaging |
Het |
| Gtf2a1l |
A |
G |
17: 89,018,962 (GRCm39) |
T349A |
probably benign |
Het |
| Hax1 |
GTCATCATCATCATCATC |
GTCATCATCATCATCATCATC |
3: 89,905,247 (GRCm39) |
|
probably benign |
Het |
| Il5ra |
G |
A |
6: 106,718,226 (GRCm39) |
T76I |
probably damaging |
Het |
| Itga8 |
T |
C |
2: 12,196,525 (GRCm39) |
T631A |
probably benign |
Het |
| Kcnh6 |
G |
A |
11: 105,909,978 (GRCm39) |
|
probably null |
Het |
| Krt26 |
C |
T |
11: 99,224,415 (GRCm39) |
E368K |
probably benign |
Het |
| Lhx9 |
T |
C |
1: 138,766,281 (GRCm39) |
D169G |
possibly damaging |
Het |
| Lmod3 |
A |
G |
6: 97,224,234 (GRCm39) |
L529P |
probably damaging |
Het |
| Nup155 |
A |
G |
15: 8,173,577 (GRCm39) |
T891A |
probably benign |
Het |
| Or11g24 |
A |
G |
14: 50,661,984 (GRCm39) |
T3A |
probably benign |
Het |
| Or1e1 |
T |
C |
11: 73,244,582 (GRCm39) |
M1T |
probably null |
Het |
| Or1j13 |
T |
A |
2: 36,369,996 (GRCm39) |
I49F |
probably damaging |
Het |
| Or1p4-ps1 |
T |
C |
11: 74,208,285 (GRCm39) |
*145R |
probably null |
Het |
| Or8b36 |
ATTGCTGTTT |
ATTGCTGTTTGCTGTTT |
9: 37,937,836 (GRCm39) |
|
probably null |
Het |
| Papln |
G |
C |
12: 83,821,454 (GRCm39) |
G262A |
probably damaging |
Het |
| Pdcd1lg2 |
G |
A |
19: 29,423,435 (GRCm39) |
V160I |
probably benign |
Het |
| Pde8b |
A |
G |
13: 95,164,105 (GRCm39) |
|
probably benign |
Het |
| Ppme1 |
G |
A |
7: 100,004,002 (GRCm39) |
R68* |
probably null |
Het |
| Prob1 |
T |
C |
18: 35,787,835 (GRCm39) |
S140G |
probably benign |
Het |
| Ptprn2 |
A |
T |
12: 117,219,215 (GRCm39) |
N949Y |
probably damaging |
Het |
| Qser1 |
C |
A |
2: 104,617,468 (GRCm39) |
D1115Y |
probably damaging |
Het |
| Rad54l |
G |
T |
4: 115,954,666 (GRCm39) |
D674E |
probably damaging |
Het |
| Ripk4 |
T |
A |
16: 97,545,387 (GRCm39) |
D420V |
probably damaging |
Het |
| Ros1 |
G |
T |
10: 51,954,067 (GRCm39) |
S1857R |
probably benign |
Het |
| Rsf1 |
A |
G |
7: 97,311,316 (GRCm39) |
E682G |
probably benign |
Het |
| Rsf1 |
ATGGCG |
ATGGCGACGGTGGCG |
7: 97,229,111 (GRCm39) |
|
probably benign |
Homo |
| Samd4 |
G |
A |
14: 47,325,329 (GRCm39) |
R515H |
probably damaging |
Het |
| Selp |
T |
A |
1: 163,969,079 (GRCm39) |
W560R |
probably benign |
Het |
| Shc3 |
A |
T |
13: 51,615,468 (GRCm39) |
L163Q |
probably damaging |
Het |
| Shh |
G |
A |
5: 28,666,397 (GRCm39) |
A163V |
probably damaging |
Het |
| Slc17a8 |
T |
C |
10: 89,427,937 (GRCm39) |
R113G |
possibly damaging |
Het |
| Slc5a6 |
C |
A |
5: 31,206,168 (GRCm39) |
|
probably benign |
Het |
| Smarcd2 |
A |
G |
11: 106,157,715 (GRCm39) |
|
probably null |
Het |
| Sytl3 |
A |
G |
17: 6,995,664 (GRCm39) |
D148G |
probably damaging |
Het |
| Tnks |
G |
T |
8: 35,385,615 (GRCm39) |
H297Q |
possibly damaging |
Het |
| Trbv21 |
A |
T |
6: 41,179,568 (GRCm39) |
|
probably benign |
Het |
| Ube3c |
T |
C |
5: 29,806,161 (GRCm39) |
F268L |
probably benign |
Het |
| Ugt2b5 |
T |
C |
5: 87,287,541 (GRCm39) |
I209V |
probably benign |
Het |
| Usp1 |
A |
G |
4: 98,818,082 (GRCm39) |
N140S |
probably damaging |
Het |
| Vcam1 |
T |
C |
3: 115,919,606 (GRCm39) |
Y226C |
probably damaging |
Het |
| Vmn1r129 |
T |
A |
7: 21,094,534 (GRCm39) |
Q228L |
probably damaging |
Het |
| Vmn1r209 |
T |
A |
13: 22,990,202 (GRCm39) |
N163Y |
probably benign |
Het |
| Vmn1r85 |
A |
G |
7: 12,818,854 (GRCm39) |
S97P |
probably damaging |
Het |
| Vmn2r30 |
C |
T |
7: 7,337,350 (GRCm39) |
M95I |
probably benign |
Het |
| Vmn2r74 |
G |
A |
7: 85,601,098 (GRCm39) |
R847C |
probably damaging |
Het |
| Wdr70 |
G |
A |
15: 7,916,830 (GRCm39) |
T529I |
possibly damaging |
Het |
| Zfp532 |
T |
G |
18: 65,757,005 (GRCm39) |
S313A |
possibly damaging |
Het |
| Zhx3 |
A |
T |
2: 160,621,463 (GRCm39) |
N901K |
probably benign |
Het |
|
| Other mutations in Dapk1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00089:Dapk1
|
APN |
13 |
60,908,854 (GRCm39) |
missense |
probably benign |
0.23 |
|
IGL00500:Dapk1
|
APN |
13 |
60,908,618 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL00801:Dapk1
|
APN |
13 |
60,909,062 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL00903:Dapk1
|
APN |
13 |
60,909,211 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01468:Dapk1
|
APN |
13 |
60,908,612 (GRCm39) |
missense |
probably benign |
|
|
IGL01535:Dapk1
|
APN |
13 |
60,878,845 (GRCm39) |
splice site |
probably benign |
|
|
IGL01755:Dapk1
|
APN |
13 |
60,908,990 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
IGL01755:Dapk1
|
APN |
13 |
60,908,989 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL01862:Dapk1
|
APN |
13 |
60,874,424 (GRCm39) |
missense |
probably benign |
0.39 |
|
IGL01985:Dapk1
|
APN |
13 |
60,884,074 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02124:Dapk1
|
APN |
13 |
60,878,696 (GRCm39) |
missense |
probably benign |
|
|
IGL02376:Dapk1
|
APN |
13 |
60,844,208 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02449:Dapk1
|
APN |
13 |
60,867,584 (GRCm39) |
splice site |
probably benign |
|
|
IGL02490:Dapk1
|
APN |
13 |
60,897,148 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02503:Dapk1
|
APN |
13 |
60,909,621 (GRCm39) |
nonsense |
probably null |
|
|
IGL02516:Dapk1
|
APN |
13 |
60,844,161 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02544:Dapk1
|
APN |
13 |
60,899,031 (GRCm39) |
missense |
probably benign |
|
|
IGL02604:Dapk1
|
APN |
13 |
60,896,134 (GRCm39) |
missense |
probably benign |
|
|
IGL03035:Dapk1
|
APN |
13 |
60,864,587 (GRCm39) |
missense |
probably damaging |
0.99 |
|
H8562:Dapk1
|
UTSW |
13 |
60,909,126 (GRCm39) |
missense |
probably damaging |
0.98 |
|
P0026:Dapk1
|
UTSW |
13 |
60,865,963 (GRCm39) |
splice site |
probably benign |
|
|
R0116:Dapk1
|
UTSW |
13 |
60,908,914 (GRCm39) |
missense |
probably benign |
|
|
R0165:Dapk1
|
UTSW |
13 |
60,909,407 (GRCm39) |
missense |
probably benign |
0.39 |
|
R0357:Dapk1
|
UTSW |
13 |
60,877,372 (GRCm39) |
nonsense |
probably null |
|
|
R0446:Dapk1
|
UTSW |
13 |
60,873,101 (GRCm39) |
splice site |
probably null |
|
|
R0502:Dapk1
|
UTSW |
13 |
60,878,662 (GRCm39) |
splice site |
probably null |
|
|
R0503:Dapk1
|
UTSW |
13 |
60,878,662 (GRCm39) |
splice site |
probably null |
|
|
R0597:Dapk1
|
UTSW |
13 |
60,909,198 (GRCm39) |
missense |
probably benign |
0.40 |
|
R0614:Dapk1
|
UTSW |
13 |
60,865,946 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0751:Dapk1
|
UTSW |
13 |
60,844,112 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0930:Dapk1
|
UTSW |
13 |
60,905,262 (GRCm39) |
missense |
probably benign |
0.14 |
|
R1023:Dapk1
|
UTSW |
13 |
60,878,799 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1033:Dapk1
|
UTSW |
13 |
60,869,679 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1101:Dapk1
|
UTSW |
13 |
60,864,599 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1184:Dapk1
|
UTSW |
13 |
60,844,112 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1430:Dapk1
|
UTSW |
13 |
60,901,957 (GRCm39) |
missense |
probably benign |
0.28 |
|
R1630:Dapk1
|
UTSW |
13 |
60,877,345 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1681:Dapk1
|
UTSW |
13 |
60,866,278 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1799:Dapk1
|
UTSW |
13 |
60,867,468 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2012:Dapk1
|
UTSW |
13 |
60,869,671 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2068:Dapk1
|
UTSW |
13 |
60,899,022 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2131:Dapk1
|
UTSW |
13 |
60,909,481 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R2131:Dapk1
|
UTSW |
13 |
60,877,345 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R2154:Dapk1
|
UTSW |
13 |
60,877,317 (GRCm39) |
missense |
probably benign |
0.36 |
|
R2288:Dapk1
|
UTSW |
13 |
60,909,563 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2312:Dapk1
|
UTSW |
13 |
60,905,167 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2362:Dapk1
|
UTSW |
13 |
60,878,745 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2400:Dapk1
|
UTSW |
13 |
60,900,030 (GRCm39) |
missense |
probably benign |
0.34 |
|
R2909:Dapk1
|
UTSW |
13 |
60,864,631 (GRCm39) |
critical splice donor site |
probably null |
|
|
R2926:Dapk1
|
UTSW |
13 |
60,867,564 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R3741:Dapk1
|
UTSW |
13 |
60,896,014 (GRCm39) |
missense |
probably benign |
0.09 |
|
R3810:Dapk1
|
UTSW |
13 |
60,908,503 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4374:Dapk1
|
UTSW |
13 |
60,867,498 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4375:Dapk1
|
UTSW |
13 |
60,909,403 (GRCm39) |
missense |
probably benign |
|
|
R4377:Dapk1
|
UTSW |
13 |
60,867,498 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4490:Dapk1
|
UTSW |
13 |
60,865,942 (GRCm39) |
missense |
probably benign |
0.26 |
|
R4576:Dapk1
|
UTSW |
13 |
60,869,636 (GRCm39) |
missense |
probably benign |
0.13 |
|
R4599:Dapk1
|
UTSW |
13 |
60,865,861 (GRCm39) |
missense |
probably benign |
0.22 |
|
R4682:Dapk1
|
UTSW |
13 |
60,898,961 (GRCm39) |
missense |
probably benign |
0.41 |
|
R4717:Dapk1
|
UTSW |
13 |
60,874,476 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4775:Dapk1
|
UTSW |
13 |
60,897,156 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4790:Dapk1
|
UTSW |
13 |
60,870,919 (GRCm39) |
frame shift |
probably null |
|
|
R4897:Dapk1
|
UTSW |
13 |
60,909,600 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4931:Dapk1
|
UTSW |
13 |
60,908,774 (GRCm39) |
missense |
probably benign |
0.04 |
|
R5113:Dapk1
|
UTSW |
13 |
60,869,592 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5503:Dapk1
|
UTSW |
13 |
60,873,126 (GRCm39) |
missense |
probably benign |
0.15 |
|
R5948:Dapk1
|
UTSW |
13 |
60,877,209 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6012:Dapk1
|
UTSW |
13 |
60,909,476 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6035:Dapk1
|
UTSW |
13 |
60,909,013 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R6268:Dapk1
|
UTSW |
13 |
60,909,580 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R6330:Dapk1
|
UTSW |
13 |
60,909,140 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6331:Dapk1
|
UTSW |
13 |
60,877,256 (GRCm39) |
nonsense |
probably null |
|
|
R6553:Dapk1
|
UTSW |
13 |
60,908,975 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6598:Dapk1
|
UTSW |
13 |
60,909,161 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6602:Dapk1
|
UTSW |
13 |
60,897,018 (GRCm39) |
missense |
probably benign |
0.20 |
|
R6640:Dapk1
|
UTSW |
13 |
60,864,628 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6684:Dapk1
|
UTSW |
13 |
60,908,708 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6747:Dapk1
|
UTSW |
13 |
60,873,154 (GRCm39) |
missense |
probably benign |
0.22 |
|
R6799:Dapk1
|
UTSW |
13 |
60,900,049 (GRCm39) |
missense |
probably benign |
|
|
R6809:Dapk1
|
UTSW |
13 |
60,899,103 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6915:Dapk1
|
UTSW |
13 |
60,844,256 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6949:Dapk1
|
UTSW |
13 |
60,884,138 (GRCm39) |
missense |
probably benign |
0.11 |
|
R6979:Dapk1
|
UTSW |
13 |
60,896,095 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7161:Dapk1
|
UTSW |
13 |
60,844,209 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R7171:Dapk1
|
UTSW |
13 |
60,909,599 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7199:Dapk1
|
UTSW |
13 |
60,902,024 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7203:Dapk1
|
UTSW |
13 |
60,844,149 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R7404:Dapk1
|
UTSW |
13 |
60,867,455 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7448:Dapk1
|
UTSW |
13 |
60,898,990 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7480:Dapk1
|
UTSW |
13 |
60,905,311 (GRCm39) |
missense |
probably benign |
0.18 |
|
R7532:Dapk1
|
UTSW |
13 |
60,878,700 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7574:Dapk1
|
UTSW |
13 |
60,908,987 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7711:Dapk1
|
UTSW |
13 |
60,909,365 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7753:Dapk1
|
UTSW |
13 |
60,899,007 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R7804:Dapk1
|
UTSW |
13 |
60,873,153 (GRCm39) |
missense |
probably benign |
0.41 |
|
R7822:Dapk1
|
UTSW |
13 |
60,873,715 (GRCm39) |
missense |
probably benign |
0.05 |
|
R7973:Dapk1
|
UTSW |
13 |
60,909,377 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8103:Dapk1
|
UTSW |
13 |
60,897,009 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8121:Dapk1
|
UTSW |
13 |
60,909,212 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8245:Dapk1
|
UTSW |
13 |
60,878,710 (GRCm39) |
missense |
probably benign |
|
|
R8401:Dapk1
|
UTSW |
13 |
60,870,904 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8419:Dapk1
|
UTSW |
13 |
60,887,911 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8926:Dapk1
|
UTSW |
13 |
60,908,734 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9063:Dapk1
|
UTSW |
13 |
60,866,264 (GRCm39) |
missense |
probably benign |
0.06 |
|
R9131:Dapk1
|
UTSW |
13 |
60,909,208 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9176:Dapk1
|
UTSW |
13 |
60,866,262 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9301:Dapk1
|
UTSW |
13 |
60,866,125 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R9407:Dapk1
|
UTSW |
13 |
60,898,991 (GRCm39) |
nonsense |
probably null |
|
|
R9491:Dapk1
|
UTSW |
13 |
60,877,369 (GRCm39) |
missense |
probably benign |
0.44 |
|
R9510:Dapk1
|
UTSW |
13 |
60,910,203 (GRCm39) |
missense |
unknown |
|
|
R9624:Dapk1
|
UTSW |
13 |
60,895,937 (GRCm39) |
missense |
probably benign |
0.31 |
|
R9726:Dapk1
|
UTSW |
13 |
60,898,948 (GRCm39) |
missense |
probably benign |
0.25 |
|
R9794:Dapk1
|
UTSW |
13 |
60,909,082 (GRCm39) |
missense |
probably damaging |
0.98 |
|
Z1176:Dapk1
|
UTSW |
13 |
60,908,618 (GRCm39) |
frame shift |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- ATTGTCCCTGTAGAGCACCTC -3'
(R):5'- AACTCTCTTTCAGGGTCTGC -3'
Sequencing Primer
(F):5'- GTGGCATCTTTCACAAAGTTCAGGTC -3'
(R):5'- TCTGCGCACGGAAGAAGTC -3'
|
| Posted On |
2017-08-16 |
Incidental Mutation