Incidental Mutation 'R6130:Zfp87'
ID 487105
Institutional Source Beutler Lab
Gene Symbol Zfp87
Ensembl Gene ENSMUSG00000097333
Gene Name zinc finger protein 87
Synonyms Mzf22, 2210039O17Rik, 4631412O18Rik, Zfp72, KRAB4
MMRRC Submission 044277-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.096) question?
Stock # R6130 (G1)
Quality Score 225.009
Status Validated
Chromosome 13
Chromosomal Location 67663900-67674296 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 74520460 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamine to Leucine at position 206 (Q206L)
Ref Sequence ENSEMBL: ENSMUSP00000152502 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000091481] [ENSMUST00000223163]
AlphaFold Q8K2A4
Predicted Effect possibly damaging
Transcript: ENSMUST00000091481
AA Change: Q206L

PolyPhen 2 Score 0.745 (Sensitivity: 0.85; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000089063
Gene: ENSMUSG00000069184
AA Change: Q206L

DomainStartEndE-ValueType
KRAB 1 32 3.57e-1 SMART
ZnF_C2H2 48 70 5.42e-2 SMART
ZnF_C2H2 76 98 1.18e-2 SMART
ZnF_C2H2 104 126 2.05e-2 SMART
ZnF_C2H2 132 154 2.3e-5 SMART
ZnF_C2H2 160 181 2.45e0 SMART
ZnF_C2H2 187 209 1.92e-2 SMART
ZnF_C2H2 215 237 5.59e-4 SMART
ZnF_C2H2 243 265 4.87e-4 SMART
ZnF_C2H2 271 293 4.94e-5 SMART
ZnF_C2H2 299 321 9.08e-4 SMART
ZnF_C2H2 327 349 1.13e-4 SMART
ZnF_C2H2 355 377 3.16e-3 SMART
ZnF_C2H2 383 405 2.24e-3 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000223163
AA Change: Q206L

PolyPhen 2 Score 0.745 (Sensitivity: 0.85; Specificity: 0.92)
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.0%
  • 20x: 94.1%
Validation Efficiency 96% (46/48)
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930553M12Rik T C 4: 88,786,596 (GRCm39) I7M unknown Het
Abi3 T A 11: 95,727,921 (GRCm39) E90V probably damaging Het
Adgrv1 A C 13: 81,575,864 (GRCm39) V4834G probably damaging Het
Aen A T 7: 78,552,387 (GRCm39) probably null Het
Ankrd55 A G 13: 112,454,980 (GRCm39) D26G probably damaging Het
Antxr2 T C 5: 98,152,131 (GRCm39) E160G possibly damaging Het
Auts2 T C 5: 131,469,061 (GRCm39) H528R probably damaging Het
Casd1 A G 6: 4,641,948 (GRCm39) T742A probably damaging Het
Ccdc39 T C 3: 33,895,341 (GRCm39) probably null Het
Ctla4 T C 1: 60,951,650 (GRCm39) Y60H probably damaging Het
Dennd4b T C 3: 90,183,566 (GRCm39) L935P probably damaging Het
Dnah6 T A 6: 73,165,477 (GRCm39) T543S probably benign Het
Dnai3 A C 3: 145,748,559 (GRCm39) Y852D probably benign Het
Dnase1l1 C T X: 73,320,644 (GRCm39) probably null Het
Fbxo6 A T 4: 148,233,979 (GRCm39) I39N probably damaging Het
Fdxacb1 C T 9: 50,683,902 (GRCm39) R420* probably null Het
Flg A G 3: 93,200,023 (GRCm39) probably benign Het
Fpr1 T A 17: 18,097,897 (GRCm39) I31F probably benign Het
Gm10549 C A 18: 33,597,358 (GRCm39) probably benign Het
Gsta1 T A 9: 78,149,847 (GRCm39) F220Y probably damaging Het
Hmg20a T A 9: 56,395,891 (GRCm39) probably null Het
Igf2bp1 A C 11: 95,864,846 (GRCm39) L201R probably damaging Het
Jph3 G A 8: 122,479,826 (GRCm39) R168H probably damaging Het
Kif1a T A 1: 92,964,623 (GRCm39) I1318F probably damaging Het
Lamc2 T C 1: 153,012,523 (GRCm39) N717S probably benign Het
Lepr A T 4: 101,622,569 (GRCm39) S450C probably damaging Het
Muc16 A G 9: 18,501,994 (GRCm39) V6535A probably damaging Het
Myom3 A G 4: 135,489,882 (GRCm39) T18A probably benign Het
Nlrp5 A G 7: 23,103,598 (GRCm39) K22E probably benign Het
Obscn A C 11: 58,968,771 (GRCm39) S2534A possibly damaging Het
Or1j21 A T 2: 36,684,055 (GRCm39) D269V probably benign Het
Or2ak5 A G 11: 58,611,133 (GRCm39) V247A probably damaging Het
Pcdhga8 T A 18: 37,860,580 (GRCm39) N545K possibly damaging Het
Pcsk5 A T 19: 17,488,920 (GRCm39) Y967N probably damaging Het
Robo2 C T 16: 73,717,570 (GRCm39) G100S probably benign Het
Rsf1 G A 7: 97,229,117 (GRCm39) probably benign Het
Saxo4 G A 19: 10,455,128 (GRCm39) P233L probably benign Het
Scap A G 9: 110,209,447 (GRCm39) T707A possibly damaging Het
Scarf1 A G 11: 75,416,565 (GRCm39) Q669R probably benign Het
Scin T C 12: 40,119,435 (GRCm39) D531G probably benign Het
Sh2b3 T C 5: 121,953,626 (GRCm39) probably null Het
Slco1a6 T C 6: 142,032,155 (GRCm39) S657G probably benign Het
Stil T A 4: 114,887,058 (GRCm39) probably null Het
Syna T A 5: 134,587,122 (GRCm39) Q609L possibly damaging Het
Tmem59l A G 8: 70,937,255 (GRCm39) S271P probably damaging Het
Tns2 A G 15: 102,019,676 (GRCm39) E522G probably damaging Het
Trappc6a G A 7: 19,249,219 (GRCm39) A149T probably benign Het
Trim21 A T 7: 102,212,498 (GRCm39) L156H possibly damaging Het
Trpv3 A G 11: 73,187,309 (GRCm39) R714G possibly damaging Het
Other mutations in Zfp87
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02165:Zfp87 APN 13 67,665,989 (GRCm39) missense probably damaging 0.99
IGL02372:Zfp87 APN 13 67,668,739 (GRCm39) splice site probably benign
IGL03160:Zfp87 APN 13 67,669,392 (GRCm39) missense probably damaging 1.00
R0653:Zfp87 UTSW 13 74,520,190 (GRCm39) missense probably damaging 1.00
R0711:Zfp87 UTSW 13 74,524,544 (GRCm39) splice site probably benign
R1498:Zfp87 UTSW 13 74,520,736 (GRCm39) missense probably benign 0.01
R3801:Zfp87 UTSW 13 67,669,334 (GRCm39) missense probably damaging 1.00
R4032:Zfp87 UTSW 13 74,520,449 (GRCm39) missense possibly damaging 0.62
R4629:Zfp87 UTSW 13 74,520,512 (GRCm39) missense probably damaging 1.00
R4950:Zfp87 UTSW 13 67,666,018 (GRCm39) missense probably benign 0.20
R5604:Zfp87 UTSW 13 67,665,945 (GRCm39) missense probably damaging 1.00
R6111:Zfp87 UTSW 13 74,520,504 (GRCm39) missense probably benign 0.31
R6277:Zfp87 UTSW 13 74,520,643 (GRCm39) nonsense probably null
R6392:Zfp87 UTSW 13 67,664,986 (GRCm39) missense probably benign 0.00
R6800:Zfp87 UTSW 13 74,520,080 (GRCm39) missense probably benign 0.00
R6909:Zfp87 UTSW 13 74,519,861 (GRCm39) missense possibly damaging 0.47
R7009:Zfp87 UTSW 13 67,665,173 (GRCm39) missense probably damaging 1.00
R7183:Zfp87 UTSW 13 67,665,593 (GRCm39) missense probably damaging 1.00
R7298:Zfp87 UTSW 13 74,520,513 (GRCm39) missense possibly damaging 0.93
R7330:Zfp87 UTSW 13 74,523,153 (GRCm39) missense probably damaging 0.99
R7341:Zfp87 UTSW 13 74,520,467 (GRCm39) missense possibly damaging 0.68
R7448:Zfp87 UTSW 13 67,665,163 (GRCm39) missense probably benign 0.01
R7597:Zfp87 UTSW 13 67,665,412 (GRCm39) missense probably benign 0.06
R8696:Zfp87 UTSW 13 74,520,599 (GRCm39) missense probably damaging 1.00
R9280:Zfp87 UTSW 13 74,520,803 (GRCm39) missense probably benign 0.16
R9429:Zfp87 UTSW 13 74,520,703 (GRCm39) missense probably damaging 1.00
R9780:Zfp87 UTSW 13 67,665,241 (GRCm39) missense probably damaging 1.00
R9782:Zfp87 UTSW 13 74,520,932 (GRCm39) missense probably benign 0.00
RF014:Zfp87 UTSW 13 74,523,173 (GRCm39) missense probably benign 0.17
Z1176:Zfp87 UTSW 13 67,674,275 (GRCm39) start gained probably benign
Z1177:Zfp87 UTSW 13 74,519,911 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- GCTTTGCCACATTCGCTGC -3'
(R):5'- ACAATGTGGCAAAGCTTTTAGC -3'

Sequencing Primer
(F):5'- CCACATTCGCTGCATTTGTAGGG -3'
(R):5'- CCCTACAAATGTGAACAGTGTGGTC -3'
Posted On 2017-10-10