Incidental Mutation 'R6132:Omd'
ID 487195
Institutional Source Beutler Lab
Gene Symbol Omd
Ensembl Gene ENSMUSG00000048368
Gene Name osteomodulin
Synonyms osteoadherin, SLRR2C, OSAD
MMRRC Submission 044279-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.079) question?
Stock # R6132 (G1)
Quality Score 225.009
Status Validated
Chromosome 13
Chromosomal Location 49735938-49746088 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 49743843 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Leucine at position 298 (I298L)
Ref Sequence ENSEMBL: ENSMUSP00000152066 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000021818] [ENSMUST00000065494] [ENSMUST00000221170]
AlphaFold O35103
Predicted Effect probably benign
Transcript: ENSMUST00000021818
SMART Domains Protein: ENSMUSP00000021818
Gene: ENSMUSG00000021391

DomainStartEndE-ValueType
coiled coil region 1 34 N/A INTRINSIC
Pfam:CENP-P 102 278 3.9e-89 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000065494
AA Change: I298L

PolyPhen 2 Score 0.969 (Sensitivity: 0.77; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000065706
Gene: ENSMUSG00000048368
AA Change: I298L

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
LRRNT 61 95 3.14e-11 SMART
LRR 115 139 2.15e2 SMART
LRR 140 160 2.2e1 SMART
LRR 162 184 4.21e1 SMART
LRR 185 210 1.01e2 SMART
LRR 211 234 6.96e0 SMART
LRR 235 255 8.49e1 SMART
LRR 256 279 1.76e-1 SMART
LRR 300 322 7.8e1 SMART
Blast:LRR 330 353 6e-8 BLAST
low complexity region 385 391 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000221170
AA Change: I298L

PolyPhen 2 Score 0.969 (Sensitivity: 0.77; Specificity: 0.95)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000221751
Meta Mutation Damage Score 0.1337 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.2%
  • 20x: 94.9%
Validation Efficiency 96% (49/51)
MGI Phenotype PHENOTYPE: Homozygous mutation of this gene results in impaired cued contextual conditioning behavior. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca15 T C 7: 119,960,643 (GRCm39) Y702H probably benign Het
Adgrv1 G T 13: 81,654,195 (GRCm39) N2225K probably benign Het
Afg3l2 G T 18: 67,554,329 (GRCm39) L458M probably damaging Het
Alkbh5 G T 11: 60,428,821 (GRCm39) probably benign Het
Atp5mc1 A G 11: 95,965,850 (GRCm39) M1T probably null Het
Crebrf C T 17: 26,982,377 (GRCm39) P588S probably benign Het
Ctsr A C 13: 61,309,582 (GRCm39) probably null Het
Cyp2c68 A G 19: 39,691,858 (GRCm39) V355A possibly damaging Het
Ddx52 A G 11: 83,850,283 (GRCm39) K555E possibly damaging Het
Depdc5 T A 5: 33,067,811 (GRCm39) S410T probably damaging Het
Dhx30 A T 9: 109,914,847 (GRCm39) I884N probably damaging Het
Dlg1 A T 16: 31,655,059 (GRCm39) N518I possibly damaging Het
Dnah12 T A 14: 26,439,066 (GRCm39) I506N probably damaging Het
Efcab6 A G 15: 83,917,173 (GRCm39) L129P probably damaging Het
Erap1 A G 13: 74,808,401 (GRCm39) N38D probably benign Het
Esf1 A G 2: 140,001,699 (GRCm39) F383L probably benign Het
Exoc4 A G 6: 33,735,033 (GRCm39) E550G probably damaging Het
Fbxo44 G A 4: 148,240,565 (GRCm39) T221I probably benign Het
Gal3st2b A T 1: 93,867,688 (GRCm39) M112L possibly damaging Het
Golph3l C G 3: 95,499,145 (GRCm39) P96A probably benign Het
Gprc6a T A 10: 51,491,356 (GRCm39) I727F possibly damaging Het
Grin3b T C 10: 79,812,274 (GRCm39) L479P probably damaging Het
Kdm5a C T 6: 120,351,892 (GRCm39) H161Y probably damaging Het
Lman2 A G 13: 55,510,038 (GRCm39) S73P probably benign Het
Map3k19 T C 1: 127,778,213 (GRCm39) N4S possibly damaging Het
Mkln1 G A 6: 31,408,155 (GRCm39) V161M probably damaging Het
Mmel1 C T 4: 154,979,475 (GRCm39) H728Y probably damaging Het
Nova2 G A 7: 18,691,794 (GRCm39) A244T unknown Het
Nrcam T A 12: 44,617,007 (GRCm39) Y668N probably damaging Het
Oacyl G T 18: 65,859,426 (GRCm39) G255W probably damaging Het
Or5ac19 A G 16: 59,089,367 (GRCm39) V221A probably damaging Het
Or5ak24 A T 2: 85,260,490 (GRCm39) S228T probably benign Het
Or8b36 ATTGCTGTTT ATTGCTGTTTGCTGTTT 9: 37,937,836 (GRCm39) probably null Het
Otor A T 2: 142,920,520 (GRCm39) D34V probably damaging Het
Otx1 A T 11: 21,949,406 (GRCm39) L24H probably damaging Het
Pwwp2a A G 11: 43,596,455 (GRCm39) Y540C probably damaging Het
Rttn T A 18: 89,133,770 (GRCm39) probably null Het
S1pr4 G A 10: 81,335,030 (GRCm39) A148V probably benign Het
Scn10a C T 9: 119,442,761 (GRCm39) V1495M possibly damaging Het
Sel1l3 T C 5: 53,357,531 (GRCm39) K154E possibly damaging Het
Sema3a T G 5: 13,573,142 (GRCm39) probably null Het
Slf2 T A 19: 44,949,300 (GRCm39) N870K possibly damaging Het
Spmip6 C T 4: 41,517,160 (GRCm39) M1I probably null Het
Syne2 T C 12: 75,991,921 (GRCm39) V1962A probably benign Het
Tarbp1 T A 8: 127,161,548 (GRCm39) I1219F probably benign Het
Tet1 A C 10: 62,649,079 (GRCm39) C173W probably damaging Het
Tnn A G 1: 159,973,641 (GRCm39) F242S probably damaging Het
Tollip A G 7: 141,443,334 (GRCm39) S174P probably benign Het
Tsr3 G T 17: 25,460,835 (GRCm39) D234Y probably null Het
Vmn2r106 T C 17: 20,488,666 (GRCm39) T578A probably benign Het
Zfp457 G T 13: 67,441,360 (GRCm39) S309* probably null Het
Other mutations in Omd
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01976:Omd APN 13 49,743,119 (GRCm39) nonsense probably null
IGL01982:Omd APN 13 49,742,973 (GRCm39) missense possibly damaging 0.88
IGL02678:Omd APN 13 49,745,757 (GRCm39) missense probably benign 0.37
IGL03069:Omd APN 13 49,745,870 (GRCm39) utr 3 prime probably benign
R1036:Omd UTSW 13 49,743,447 (GRCm39) missense probably damaging 1.00
R3954:Omd UTSW 13 49,743,213 (GRCm39) missense probably benign 0.00
R4030:Omd UTSW 13 49,743,125 (GRCm39) missense probably benign 0.08
R4335:Omd UTSW 13 49,743,712 (GRCm39) missense probably benign 0.02
R5095:Omd UTSW 13 49,743,174 (GRCm39) missense possibly damaging 0.95
R5137:Omd UTSW 13 49,743,552 (GRCm39) missense probably benign 0.05
R5400:Omd UTSW 13 49,745,703 (GRCm39) missense probably benign 0.37
R5596:Omd UTSW 13 49,745,814 (GRCm39) missense probably benign 0.16
R5930:Omd UTSW 13 49,743,112 (GRCm39) missense possibly damaging 0.63
R6294:Omd UTSW 13 49,743,467 (GRCm39) missense probably damaging 1.00
R6454:Omd UTSW 13 49,743,345 (GRCm39) missense probably damaging 0.99
R6680:Omd UTSW 13 49,743,004 (GRCm39) missense possibly damaging 0.74
R6704:Omd UTSW 13 49,743,349 (GRCm39) missense probably damaging 1.00
R6932:Omd UTSW 13 49,743,710 (GRCm39) missense probably damaging 1.00
R7427:Omd UTSW 13 49,745,745 (GRCm39) missense possibly damaging 0.68
R7884:Omd UTSW 13 49,743,630 (GRCm39) missense probably damaging 1.00
R7971:Omd UTSW 13 49,743,730 (GRCm39) missense probably benign 0.00
R8129:Omd UTSW 13 49,745,565 (GRCm39) missense probably damaging 0.99
R8399:Omd UTSW 13 49,743,345 (GRCm39) missense possibly damaging 0.50
R8914:Omd UTSW 13 49,745,718 (GRCm39) missense probably damaging 1.00
R8959:Omd UTSW 13 49,745,790 (GRCm39) missense possibly damaging 0.57
R8984:Omd UTSW 13 49,743,576 (GRCm39) missense possibly damaging 0.92
R9415:Omd UTSW 13 49,745,837 (GRCm39) missense probably benign
R9718:Omd UTSW 13 49,743,336 (GRCm39) missense probably damaging 1.00
R9723:Omd UTSW 13 49,743,838 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AATCAATGCCCCTTGGATTGC -3'
(R):5'- CCATTCTTTCATCAGACATGTTGG -3'

Sequencing Primer
(F):5'- GGATTGCCTTCATCACTTATGTATC -3'
(R):5'- TCCCTAAATACCACTCTTGT -3'
Posted On 2017-10-10