Incidental Mutation 'R6125:H1f0'
ID 487367
Institutional Source Beutler Lab
Gene Symbol H1f0
Ensembl Gene ENSMUSG00000096210
Gene Name H1.0 linker histone
Synonyms H1-0, H1fv, D130017D06Rik
MMRRC Submission 044272-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R6125 (G1)
Quality Score 225.009
Status Validated
Chromosome 15
Chromosomal Location 78912650-78914704 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 78913070 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Asparagine at position 50 (I50N)
Ref Sequence ENSEMBL: ENSMUSP00000137309 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000006544] [ENSMUST00000171999] [ENSMUST00000180086]
AlphaFold P10922
Predicted Effect probably benign
Transcript: ENSMUST00000006544
SMART Domains Protein: ENSMUSP00000006544
Gene: ENSMUSG00000006378

DomainStartEndE-ValueType
Pfam:Aminotran_1_2 63 405 8.8e-72 PFAM
Pfam:Aminotran_5 77 236 1.1e-7 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000171999
SMART Domains Protein: ENSMUSP00000131649
Gene: ENSMUSG00000116378

DomainStartEndE-ValueType
Pfam:Aminotran_1_2 63 379 2e-64 PFAM
Pfam:Aminotran_5 77 236 4.7e-8 PFAM
Pfam:Cys_Met_Meta_PP 93 240 2.4e-6 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000180086
AA Change: I50N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000137309
Gene: ENSMUSG00000096210
AA Change: I50N

DomainStartEndE-ValueType
H15 22 87 2.82e-27 SMART
low complexity region 108 194 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000229276
Predicted Effect noncoding transcript
Transcript: ENSMUST00000229708
Predicted Effect noncoding transcript
Transcript: ENSMUST00000230293
Meta Mutation Damage Score 0.9025 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.4%
  • 10x: 97.3%
  • 20x: 91.5%
Validation Efficiency 97% (65/67)
MGI Phenotype FUNCTION: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-independent histone that is a member of the histone H1 family. [provided by RefSeq, Oct 2015]
PHENOTYPE: Mice homozygous for a knock-out allele are viable, fertile and overtly normal with no apparent anatomic or histologic abnormalities or defects in cell division patterns. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 64 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arhgef11 T C 3: 87,636,909 (GRCm39) F1023S probably damaging Het
Atp1a1 G A 3: 101,498,023 (GRCm39) R255C probably damaging Het
Bbs12 A G 3: 37,374,700 (GRCm39) I383V probably benign Het
Cacna1h G A 17: 25,604,668 (GRCm39) P1215L probably benign Het
Calm5 A T 13: 3,904,491 (GRCm39) K62* probably null Het
Chd8 T A 14: 52,444,491 (GRCm39) H398L probably benign Het
Cspg4b A G 13: 113,454,217 (GRCm39) T88A probably benign Het
Dlgap2 A T 8: 14,777,193 (GRCm39) H146L possibly damaging Het
Dop1a G A 9: 86,403,186 (GRCm39) R1462H probably damaging Het
Dusp29 C A 14: 21,736,758 (GRCm39) V115L probably benign Het
Dync2h1 T C 9: 7,168,706 (GRCm39) N369S probably damaging Het
Fer1l4 A C 2: 155,888,907 (GRCm39) V422G probably damaging Het
Fstl4 T C 11: 53,077,130 (GRCm39) M629T probably benign Het
Galnt18 A G 7: 111,084,400 (GRCm39) Y507H probably damaging Het
Gar1 C A 3: 129,624,399 (GRCm39) probably benign Het
Gm19402 T C 10: 77,526,507 (GRCm39) T29A probably damaging Het
Gm826 A G 2: 160,169,034 (GRCm39) F92L unknown Het
H2-DMb1 A G 17: 34,376,439 (GRCm39) Y186C probably damaging Het
Hgf A G 5: 16,803,159 (GRCm39) N357S probably damaging Het
Hjurp GT GTT 1: 88,194,246 (GRCm39) probably null Het
Hsf2 T C 10: 57,388,101 (GRCm39) V415A probably benign Het
Ins2 C A 7: 142,233,430 (GRCm39) probably null Het
Kel A T 6: 41,667,720 (GRCm39) F89L probably damaging Het
Lratd2 T C 15: 60,695,146 (GRCm39) N200S probably damaging Het
Lrrc37a T C 11: 103,392,386 (GRCm39) D1013G probably benign Het
Ltbp4 C A 7: 27,027,180 (GRCm39) G397C probably damaging Het
Madd A G 2: 90,982,797 (GRCm39) probably null Het
Map4k4 A G 1: 40,043,125 (GRCm39) D660G possibly damaging Het
Mdm4 G A 1: 132,922,248 (GRCm39) T298I possibly damaging Het
Mlip G A 9: 77,137,764 (GRCm39) S381L probably damaging Het
Mpdz A T 4: 81,215,764 (GRCm39) C1487S probably benign Het
Mtus1 A G 8: 41,537,576 (GRCm39) S47P probably damaging Het
Nek1 T C 8: 61,481,735 (GRCm39) S217P probably damaging Het
Or10ag59 T C 2: 87,405,590 (GRCm39) I54T probably benign Het
Or5b123 C T 19: 13,597,249 (GRCm39) A241V probably benign Het
Pcdhb10 T C 18: 37,546,679 (GRCm39) V585A possibly damaging Het
Perm1 A G 4: 156,302,176 (GRCm39) E240G probably benign Het
Pkdrej T C 15: 85,700,585 (GRCm39) T1784A probably damaging Het
Pnpla8 C T 12: 44,354,772 (GRCm39) T644M possibly damaging Het
Rgs2 T C 1: 143,879,763 (GRCm39) K32E probably damaging Het
Scyl3 A T 1: 163,778,145 (GRCm39) M428L probably benign Het
Slc30a8 A G 15: 52,198,530 (GRCm39) D325G probably benign Het
Slc5a9 G T 4: 111,741,002 (GRCm39) T548K probably damaging Het
Slc9b2 G A 3: 135,036,457 (GRCm39) probably null Het
Slco3a1 C T 7: 73,968,254 (GRCm39) D489N probably benign Het
Slit3 T C 11: 35,461,560 (GRCm39) probably null Het
Stk39 C A 2: 68,222,468 (GRCm39) G199C probably damaging Het
Tbx1 A G 16: 18,402,216 (GRCm39) F263L probably damaging Het
Tcf21 G T 10: 22,695,665 (GRCm39) N46K probably benign Het
Tdrd9 T A 12: 112,034,632 (GRCm39) M1357K possibly damaging Het
Tll1 A G 8: 64,504,521 (GRCm39) L625P probably damaging Het
Tmem131 G A 1: 36,847,387 (GRCm39) S1237L possibly damaging Het
Trdv5 T C 14: 54,386,298 (GRCm39) K56E possibly damaging Het
Triml2 G A 8: 43,640,659 (GRCm39) V172I probably benign Het
Trmt44 C A 5: 35,722,842 (GRCm39) D409Y probably damaging Het
Ube2o C T 11: 116,432,204 (GRCm39) A921T probably damaging Het
Ube2o T C 11: 116,435,576 (GRCm39) D404G possibly damaging Het
Ube4b T C 4: 149,483,203 (GRCm39) T22A probably benign Het
Ugp2 A T 11: 21,279,815 (GRCm39) F327L probably damaging Het
Virma T C 4: 11,521,172 (GRCm39) S910P probably damaging Het
Vmn2r9 A G 5: 108,990,836 (GRCm39) Y842H probably benign Het
Zfhx4 A G 3: 5,463,871 (GRCm39) D1368G possibly damaging Het
Zfp980 T A 4: 145,429,208 (GRCm39) *646R probably null Het
Zranb3 T A 1: 127,887,482 (GRCm39) N982Y probably benign Het
Other mutations in H1f0
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02830:H1f0 APN 15 78,913,511 (GRCm39) unclassified probably benign
R1720:H1f0 UTSW 15 78,913,195 (GRCm39) missense possibly damaging 0.82
R5054:H1f0 UTSW 15 78,912,973 (GRCm39) missense probably damaging 0.99
R7350:H1f0 UTSW 15 78,913,103 (GRCm39) missense probably damaging 1.00
R7404:H1f0 UTSW 15 78,913,080 (GRCm39) nonsense probably null
R9432:H1f0 UTSW 15 78,912,947 (GRCm39) missense probably damaging 1.00
R9433:H1f0 UTSW 15 78,912,947 (GRCm39) missense probably damaging 1.00
R9453:H1f0 UTSW 15 78,912,947 (GRCm39) missense probably damaging 1.00
R9557:H1f0 UTSW 15 78,912,947 (GRCm39) missense probably damaging 1.00
R9749:H1f0 UTSW 15 78,913,217 (GRCm39) missense probably benign 0.16
Predicted Primers PCR Primer
(F):5'- ATCGGAAGGCTCCTTGAACAG -3'
(R):5'- TGGAGTGGCCACTTTCTTGAC -3'

Sequencing Primer
(F):5'- CTCCTTGAACAGTGGGAGCAG -3'
(R):5'- GGTCTTCTTGAAAGCCACCGAC -3'
Posted On 2017-10-10