Incidental Mutation 'R6175:Lct'
| ID |
487657 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Lct
|
| Ensembl Gene |
ENSMUSG00000026354 |
| Gene Name |
lactase |
| Synonyms |
LPH, LOC226413, Lphl |
| MMRRC Submission |
044317-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R6175 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
1 |
| Chromosomal Location |
128212493-128256055 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 128255451 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Leucine to Proline
at position 197
(L197P)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000073190
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000027601]
[ENSMUST00000073490]
[ENSMUST00000190495]
|
| AlphaFold |
F8VPT3 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000027601
|
| SMART Domains |
Protein: ENSMUSP00000027601
Gene: ENSMUSG00000026355
| Domain | Start | End | E-Value | Type |
|---|
|
MCM
|
119 |
657 |
1.43e-270 |
SMART |
|
PDB:2LE8|A
|
710 |
821 |
1e-47 |
PDB |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000073490
AA Change: L197P
PolyPhen 2
Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
|
| SMART Domains |
Protein: ENSMUSP00000073190
Gene: ENSMUSG00000026354
AA Change: L197P
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Glyco_hydro_1
|
76 |
226 |
1.6e-19 |
PFAM |
|
low complexity region
|
322 |
340 |
N/A |
INTRINSIC |
|
Pfam:Glyco_hydro_1
|
380 |
849 |
4.8e-169 |
PFAM |
|
low complexity region
|
865 |
875 |
N/A |
INTRINSIC |
|
Pfam:Glyco_hydro_1
|
902 |
1368 |
3.7e-181 |
PFAM |
|
Pfam:Glyco_hydro_1
|
1377 |
1844 |
6.9e-183 |
PFAM |
|
transmembrane domain
|
1885 |
1907 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000190495
|
| SMART Domains |
Protein: ENSMUSP00000140308
Gene: ENSMUSG00000026355
| Domain | Start | End | E-Value | Type |
|---|
|
MCM
|
119 |
657 |
1.43e-270 |
SMART |
|
PDB:2LE8|A
|
710 |
783 |
3e-29 |
PDB |
|
| Meta Mutation Damage Score |
0.5111 |
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.5%
- 10x: 97.7%
- 20x: 93.2%
|
| Validation Efficiency |
97% (85/88) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the glycosyl hydrolase 1 family of proteins. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme is integral to the plasma membrane and has both phlorizin hydrolase activity and lactase activity. Mutations in this gene are associated with congenital lactase deficiency. Polymorphisms in this gene are associated with lactase persistence, in which intestinal lactase activity persists at childhood levels into adulthood. [provided by RefSeq, Jan 2016]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 88 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2610008E11Rik |
T |
C |
10: 78,902,448 (GRCm39) |
K623E |
probably damaging |
Het |
| A530064D06Rik |
T |
A |
17: 48,460,016 (GRCm39) |
S227C |
possibly damaging |
Het |
| Adam30 |
A |
T |
3: 98,070,266 (GRCm39) |
I700F |
probably damaging |
Het |
| Adam5 |
A |
T |
8: 25,276,167 (GRCm39) |
M500K |
probably benign |
Het |
| Adgb |
A |
T |
10: 10,274,687 (GRCm39) |
S755T |
possibly damaging |
Het |
| Adgrv1 |
C |
T |
13: 81,534,124 (GRCm39) |
G5819D |
probably damaging |
Het |
| Ank3 |
T |
A |
10: 69,763,557 (GRCm39) |
Y17N |
probably damaging |
Het |
| Ano2 |
A |
T |
6: 125,969,918 (GRCm39) |
M745L |
probably benign |
Het |
| Arap2 |
A |
G |
5: 62,872,074 (GRCm39) |
|
probably null |
Het |
| Atg2a |
A |
T |
19: 6,291,759 (GRCm39) |
|
probably benign |
Het |
| AU021092 |
G |
T |
16: 5,038,312 (GRCm39) |
|
probably null |
Het |
| Bbs1 |
A |
T |
19: 4,940,749 (GRCm39) |
L578Q |
probably damaging |
Het |
| Brd9 |
A |
T |
13: 74,108,433 (GRCm39) |
E589D |
probably damaging |
Het |
| Calr4 |
A |
G |
4: 109,101,442 (GRCm39) |
D108G |
probably benign |
Het |
| Ccdc82 |
A |
G |
9: 13,272,798 (GRCm39) |
D429G |
probably damaging |
Het |
| Cdh22 |
G |
T |
2: 164,988,550 (GRCm39) |
N268K |
probably damaging |
Het |
| Ceacam12 |
G |
A |
7: 17,801,312 (GRCm39) |
G97D |
probably damaging |
Het |
| Clcn1 |
A |
G |
6: 42,291,096 (GRCm39) |
D990G |
probably damaging |
Het |
| Cyp2c40 |
T |
C |
19: 39,801,004 (GRCm39) |
T84A |
probably benign |
Het |
| Dnah7a |
G |
A |
1: 53,472,181 (GRCm39) |
P3529S |
probably damaging |
Het |
| Dnah8 |
G |
A |
17: 30,967,542 (GRCm39) |
D2585N |
probably benign |
Het |
| Efna3 |
GAGCAGCAGCAGCAGCAGCAGC |
GAGCAGCAGCAGCAGCAGC |
3: 89,230,105 (GRCm39) |
|
probably benign |
Het |
| Ehd2 |
G |
A |
7: 15,697,389 (GRCm39) |
Q4* |
probably null |
Het |
| Eml5 |
A |
G |
12: 98,760,715 (GRCm39) |
V1726A |
possibly damaging |
Het |
| Esam |
A |
G |
9: 37,439,544 (GRCm39) |
T10A |
probably benign |
Het |
| Fbxl6 |
A |
G |
15: 76,422,633 (GRCm39) |
L95P |
probably benign |
Het |
| Fbxw18 |
T |
A |
9: 109,505,947 (GRCm39) |
L441F |
probably damaging |
Het |
| Fbxw4 |
A |
G |
19: 45,624,766 (GRCm39) |
S73P |
probably benign |
Het |
| Fndc1 |
T |
A |
17: 7,991,479 (GRCm39) |
H739L |
unknown |
Het |
| Foxp1 |
G |
A |
6: 98,943,037 (GRCm39) |
T237I |
probably damaging |
Het |
| Greb1 |
A |
T |
12: 16,724,771 (GRCm39) |
I1801N |
probably damaging |
Het |
| Hjurp |
GT |
GTT |
1: 88,194,246 (GRCm39) |
|
probably null |
Het |
| Hoxa13 |
G |
T |
6: 52,236,908 (GRCm39) |
N281K |
probably damaging |
Het |
| Hspg2 |
A |
G |
4: 137,296,829 (GRCm39) |
T4328A |
probably damaging |
Het |
| Htr2a |
C |
G |
14: 74,882,474 (GRCm39) |
Y153* |
probably null |
Het |
| Iglv1 |
C |
A |
16: 18,903,844 (GRCm39) |
A92S |
probably damaging |
Het |
| Itih1 |
A |
G |
14: 30,653,152 (GRCm39) |
S759P |
probably damaging |
Het |
| Kctd1 |
G |
T |
18: 15,102,688 (GRCm39) |
S831* |
probably null |
Het |
| Kif20a |
T |
A |
18: 34,761,199 (GRCm39) |
S265T |
probably damaging |
Het |
| Kif22 |
T |
A |
7: 126,630,228 (GRCm39) |
E436V |
possibly damaging |
Het |
| Kif27 |
A |
G |
13: 58,459,051 (GRCm39) |
W927R |
probably damaging |
Het |
| Lcorl |
G |
A |
5: 45,933,832 (GRCm39) |
P66L |
probably damaging |
Het |
| Lefty1 |
T |
C |
1: 180,762,714 (GRCm39) |
S14P |
unknown |
Het |
| Lnp1 |
A |
G |
16: 56,737,855 (GRCm39) |
S78P |
possibly damaging |
Het |
| Map3k19 |
A |
T |
1: 127,750,569 (GRCm39) |
H927Q |
probably benign |
Het |
| Meiosin |
C |
A |
7: 18,834,814 (GRCm39) |
|
probably benign |
Het |
| Mta3 |
A |
G |
17: 84,099,222 (GRCm39) |
T430A |
probably benign |
Het |
| Muc2 |
G |
T |
7: 141,282,875 (GRCm39) |
C627F |
probably damaging |
Het |
| Myh13 |
A |
G |
11: 67,245,588 (GRCm39) |
D1076G |
probably benign |
Het |
| Nck2 |
T |
A |
1: 43,572,729 (GRCm39) |
M1K |
probably null |
Het |
| Nipal1 |
A |
G |
5: 72,820,898 (GRCm39) |
N131S |
probably damaging |
Het |
| Nlrp9c |
T |
C |
7: 26,077,426 (GRCm39) |
|
probably null |
Het |
| Nr2f2 |
A |
G |
7: 70,007,946 (GRCm39) |
S179P |
probably damaging |
Het |
| Or1j16 |
A |
G |
2: 36,530,063 (GRCm39) |
D4G |
probably benign |
Het |
| Or1j21 |
A |
T |
2: 36,683,980 (GRCm39) |
H244L |
probably damaging |
Het |
| Or9g19 |
A |
T |
2: 85,600,652 (GRCm39) |
N169I |
probably benign |
Het |
| Oxt |
G |
T |
2: 130,418,163 (GRCm39) |
|
probably benign |
Het |
| Pank2 |
T |
A |
2: 131,122,181 (GRCm39) |
Y235* |
probably null |
Het |
| Pear1 |
A |
G |
3: 87,659,440 (GRCm39) |
L798P |
possibly damaging |
Het |
| Pex14 |
T |
C |
4: 149,046,156 (GRCm39) |
H258R |
probably benign |
Het |
| Pmpcb |
A |
G |
5: 21,962,031 (GRCm39) |
I487V |
probably benign |
Het |
| Ppie |
T |
C |
4: 123,031,362 (GRCm39) |
E44G |
probably benign |
Het |
| Ppp1r9a |
A |
T |
6: 4,905,639 (GRCm39) |
R65* |
probably null |
Het |
| Ralgapb |
T |
C |
2: 158,288,075 (GRCm39) |
S371P |
probably damaging |
Het |
| Ros1 |
T |
C |
10: 51,977,881 (GRCm39) |
H1455R |
probably benign |
Het |
| Sacs |
C |
A |
14: 61,450,275 (GRCm39) |
T4107K |
possibly damaging |
Het |
| Sec24a |
G |
A |
11: 51,622,718 (GRCm39) |
T386M |
probably damaging |
Het |
| Slc10a4 |
A |
T |
5: 73,169,593 (GRCm39) |
Y207F |
possibly damaging |
Het |
| Slc30a10 |
T |
C |
1: 185,187,508 (GRCm39) |
L83P |
probably damaging |
Het |
| Slc38a9 |
T |
A |
13: 112,840,093 (GRCm39) |
L324* |
probably null |
Het |
| Slc7a9 |
A |
T |
7: 35,165,277 (GRCm39) |
Q474L |
probably damaging |
Het |
| Smc5 |
C |
A |
19: 23,191,534 (GRCm39) |
V875L |
possibly damaging |
Het |
| Snap91 |
T |
C |
9: 86,707,053 (GRCm39) |
R246G |
probably damaging |
Het |
| Sned1 |
A |
G |
1: 93,203,196 (GRCm39) |
|
probably null |
Het |
| Spink14 |
G |
A |
18: 44,164,938 (GRCm39) |
G85E |
probably benign |
Het |
| Srsf11 |
C |
T |
3: 157,728,981 (GRCm39) |
|
probably benign |
Het |
| St13 |
A |
G |
15: 81,283,506 (GRCm39) |
|
probably null |
Het |
| Stk10 |
A |
G |
11: 32,553,761 (GRCm39) |
M593V |
possibly damaging |
Het |
| Tafa1 |
A |
G |
6: 96,092,721 (GRCm39) |
H35R |
probably benign |
Het |
| Tex21 |
C |
A |
12: 76,245,707 (GRCm39) |
A530S |
probably benign |
Het |
| Tln2 |
T |
A |
9: 67,131,363 (GRCm39) |
K1394N |
probably damaging |
Het |
| Trhr2 |
C |
A |
8: 123,084,118 (GRCm39) |
R294L |
probably damaging |
Het |
| Unc79 |
A |
T |
12: 103,149,708 (GRCm39) |
I2408F |
probably damaging |
Het |
| Wdr24 |
T |
C |
17: 26,045,552 (GRCm39) |
L429P |
probably damaging |
Het |
| Wwp2 |
T |
A |
8: 108,210,039 (GRCm39) |
I139N |
possibly damaging |
Het |
| Zfp111 |
G |
A |
7: 23,897,554 (GRCm39) |
R686C |
unknown |
Het |
| Zfp268 |
A |
T |
4: 145,350,811 (GRCm39) |
|
probably benign |
Het |
| Zyg11a |
A |
G |
4: 108,046,878 (GRCm39) |
V532A |
probably benign |
Het |
|
| Other mutations in Lct |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00777:Lct
|
APN |
1 |
128,215,293 (GRCm39) |
missense |
probably benign |
0.09 |
|
IGL00970:Lct
|
APN |
1 |
128,231,805 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01022:Lct
|
APN |
1 |
128,228,596 (GRCm39) |
missense |
probably benign |
|
|
IGL01878:Lct
|
APN |
1 |
128,222,003 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01892:Lct
|
APN |
1 |
128,235,342 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02307:Lct
|
APN |
1 |
128,214,327 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
IGL02434:Lct
|
APN |
1 |
128,231,527 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02559:Lct
|
APN |
1 |
128,222,003 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02623:Lct
|
APN |
1 |
128,235,988 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02818:Lct
|
APN |
1 |
128,227,905 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02949:Lct
|
APN |
1 |
128,240,869 (GRCm39) |
missense |
probably benign |
0.26 |
|
IGL02951:Lct
|
APN |
1 |
128,227,948 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03087:Lct
|
APN |
1 |
128,228,112 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
IGL03227:Lct
|
APN |
1 |
128,255,426 (GRCm39) |
missense |
probably benign |
0.09 |
|
ANU18:Lct
|
UTSW |
1 |
128,235,784 (GRCm39) |
nonsense |
probably null |
|
|
R0071:Lct
|
UTSW |
1 |
128,219,755 (GRCm39) |
nonsense |
probably null |
|
|
R0071:Lct
|
UTSW |
1 |
128,219,755 (GRCm39) |
nonsense |
probably null |
|
|
R0135:Lct
|
UTSW |
1 |
128,212,860 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0145:Lct
|
UTSW |
1 |
128,255,632 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0179:Lct
|
UTSW |
1 |
128,255,422 (GRCm39) |
missense |
probably benign |
|
|
R0331:Lct
|
UTSW |
1 |
128,226,479 (GRCm39) |
splice site |
probably benign |
|
|
R0366:Lct
|
UTSW |
1 |
128,214,199 (GRCm39) |
missense |
probably benign |
0.03 |
|
R0399:Lct
|
UTSW |
1 |
128,228,262 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0492:Lct
|
UTSW |
1 |
128,228,319 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0548:Lct
|
UTSW |
1 |
128,212,932 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0691:Lct
|
UTSW |
1 |
128,235,971 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0755:Lct
|
UTSW |
1 |
128,221,872 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R0839:Lct
|
UTSW |
1 |
128,214,346 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1128:Lct
|
UTSW |
1 |
128,229,046 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1135:Lct
|
UTSW |
1 |
128,221,861 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1321:Lct
|
UTSW |
1 |
128,227,759 (GRCm39) |
missense |
probably benign |
|
|
R1448:Lct
|
UTSW |
1 |
128,235,559 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1450:Lct
|
UTSW |
1 |
128,235,640 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1572:Lct
|
UTSW |
1 |
128,221,932 (GRCm39) |
missense |
probably benign |
0.25 |
|
R1582:Lct
|
UTSW |
1 |
128,228,299 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1668:Lct
|
UTSW |
1 |
128,215,459 (GRCm39) |
splice site |
probably null |
|
|
R1757:Lct
|
UTSW |
1 |
128,228,994 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1775:Lct
|
UTSW |
1 |
128,228,038 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1792:Lct
|
UTSW |
1 |
128,255,679 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R1815:Lct
|
UTSW |
1 |
128,227,896 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1932:Lct
|
UTSW |
1 |
128,221,898 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2325:Lct
|
UTSW |
1 |
128,231,963 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2381:Lct
|
UTSW |
1 |
128,231,858 (GRCm39) |
nonsense |
probably null |
|
|
R3001:Lct
|
UTSW |
1 |
128,231,963 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3002:Lct
|
UTSW |
1 |
128,231,963 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3003:Lct
|
UTSW |
1 |
128,231,963 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3011:Lct
|
UTSW |
1 |
128,229,109 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R3082:Lct
|
UTSW |
1 |
128,215,345 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3683:Lct
|
UTSW |
1 |
128,231,963 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3684:Lct
|
UTSW |
1 |
128,231,963 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3726:Lct
|
UTSW |
1 |
128,231,963 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3886:Lct
|
UTSW |
1 |
128,231,963 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3887:Lct
|
UTSW |
1 |
128,231,963 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3888:Lct
|
UTSW |
1 |
128,231,963 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4019:Lct
|
UTSW |
1 |
128,231,963 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4027:Lct
|
UTSW |
1 |
128,212,918 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4226:Lct
|
UTSW |
1 |
128,231,963 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4409:Lct
|
UTSW |
1 |
128,231,963 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4514:Lct
|
UTSW |
1 |
128,228,251 (GRCm39) |
missense |
probably benign |
|
|
R4570:Lct
|
UTSW |
1 |
128,227,641 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4776:Lct
|
UTSW |
1 |
128,228,124 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5001:Lct
|
UTSW |
1 |
128,235,978 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5021:Lct
|
UTSW |
1 |
128,228,302 (GRCm39) |
missense |
probably benign |
0.38 |
|
R5318:Lct
|
UTSW |
1 |
128,232,109 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5330:Lct
|
UTSW |
1 |
128,226,266 (GRCm39) |
missense |
probably benign |
0.06 |
|
R5385:Lct
|
UTSW |
1 |
128,239,354 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R5499:Lct
|
UTSW |
1 |
128,214,414 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5508:Lct
|
UTSW |
1 |
128,221,868 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5642:Lct
|
UTSW |
1 |
128,222,969 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5724:Lct
|
UTSW |
1 |
128,228,073 (GRCm39) |
missense |
probably benign |
|
|
R6026:Lct
|
UTSW |
1 |
128,227,755 (GRCm39) |
missense |
probably benign |
|
|
R6044:Lct
|
UTSW |
1 |
128,235,717 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R6277:Lct
|
UTSW |
1 |
128,231,974 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6412:Lct
|
UTSW |
1 |
128,255,455 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6480:Lct
|
UTSW |
1 |
128,222,057 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6526:Lct
|
UTSW |
1 |
128,228,215 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6620:Lct
|
UTSW |
1 |
128,222,809 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7214:Lct
|
UTSW |
1 |
128,228,197 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7308:Lct
|
UTSW |
1 |
128,246,824 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7577:Lct
|
UTSW |
1 |
128,228,469 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7626:Lct
|
UTSW |
1 |
128,212,932 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7737:Lct
|
UTSW |
1 |
128,226,430 (GRCm39) |
missense |
probably benign |
0.12 |
|
R7901:Lct
|
UTSW |
1 |
128,216,722 (GRCm39) |
missense |
probably benign |
0.44 |
|
R8033:Lct
|
UTSW |
1 |
128,212,996 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8373:Lct
|
UTSW |
1 |
128,231,577 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8504:Lct
|
UTSW |
1 |
128,215,306 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8751:Lct
|
UTSW |
1 |
128,221,534 (GRCm39) |
missense |
probably benign |
0.18 |
|
R8781:Lct
|
UTSW |
1 |
128,215,261 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8797:Lct
|
UTSW |
1 |
128,231,684 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R8926:Lct
|
UTSW |
1 |
128,228,148 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8949:Lct
|
UTSW |
1 |
128,221,929 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8992:Lct
|
UTSW |
1 |
128,228,299 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9138:Lct
|
UTSW |
1 |
128,227,894 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9260:Lct
|
UTSW |
1 |
128,227,704 (GRCm39) |
nonsense |
probably null |
|
|
R9416:Lct
|
UTSW |
1 |
128,228,329 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R9531:Lct
|
UTSW |
1 |
128,235,598 (GRCm39) |
missense |
probably benign |
0.00 |
|
X0052:Lct
|
UTSW |
1 |
128,235,367 (GRCm39) |
missense |
probably damaging |
1.00 |
|
YA93:Lct
|
UTSW |
1 |
128,229,057 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Lct
|
UTSW |
1 |
128,215,348 (GRCm39) |
nonsense |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- AGATGTTTCAGACAAATGCAGGAC -3'
(R):5'- TGGTCCTGTTCCACCAGATG -3'
Sequencing Primer
(F):5'- CCCCTTTGGAAATGTTCACATTACAG -3'
(R):5'- TGTTCCACCAGATGCCACC -3'
|
| Posted On |
2017-10-10 |
Incidental Mutation