Incidental Mutation 'R6178:Or10aa3'
ID 487857
Institutional Source Beutler Lab
Gene Symbol Or10aa3
Ensembl Gene ENSMUSG00000047048
Gene Name olfactory receptor family 10 subfamily AA member 3
Synonyms GA_x6K02T2P20D-21124681-21123743, MOR123-2, Olfr432
MMRRC Submission 044320-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.057) question?
Stock # R6178 (G1)
Quality Score 225.009
Status Validated
Chromosome 1
Chromosomal Location 173877941-173878879 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 173878533 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Phenylalanine at position 198 (Y198F)
Ref Sequence ENSEMBL: ENSMUSP00000150596 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000062665] [ENSMUST00000213211] [ENSMUST00000213381]
AlphaFold E9Q8M2
Predicted Effect probably benign
Transcript: ENSMUST00000062665
AA Change: Y198F

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000060341
Gene: ENSMUSG00000047048
AA Change: Y198F

DomainStartEndE-ValueType
Pfam:7tm_4 31 306 3.7e-47 PFAM
Pfam:7TM_GPCR_Srsx 35 307 1.2e-7 PFAM
Pfam:7tm_1 41 289 6.5e-21 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000192435
Predicted Effect probably benign
Transcript: ENSMUST00000213211
AA Change: Y198F

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Predicted Effect probably benign
Transcript: ENSMUST00000213381
AA Change: Y198F

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 97.9%
  • 20x: 94.0%
Validation Efficiency 98% (54/55)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 58 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc6 T C 7: 45,678,468 (GRCm39) I61V probably benign Het
Afg3l2 G A 18: 67,542,598 (GRCm39) T616I possibly damaging Het
Aktip T C 8: 91,852,671 (GRCm39) N195S probably damaging Het
Ankfy1 G A 11: 72,645,285 (GRCm39) C788Y probably benign Het
Atg7 T A 6: 114,701,856 (GRCm39) I621N probably damaging Het
Becn1 T A 11: 101,182,336 (GRCm39) I283F probably damaging Het
Btnl12 T C 16: 37,676,422 (GRCm39) Y115C probably damaging Het
C4b T C 17: 34,952,380 (GRCm39) T1220A probably benign Het
Celsr1 C A 15: 85,785,222 (GRCm39) R3004M probably benign Het
Clspn A T 4: 126,471,529 (GRCm39) probably null Het
Csmd3 T C 15: 48,536,854 (GRCm39) Y116C probably damaging Het
Dcp1a T G 14: 30,245,261 (GRCm39) *603G probably null Het
Dmrtc1b C T X: 101,757,169 (GRCm39) P205S possibly damaging Het
Fev G T 1: 74,923,698 (GRCm39) probably benign Het
Fry T A 5: 150,377,987 (GRCm39) V393E probably damaging Het
Gm30646 A G 7: 30,132,081 (GRCm39) probably null Het
Gm3676 C T 14: 41,363,452 (GRCm39) E175K probably benign Het
Gm4847 T C 1: 166,469,905 (GRCm39) Y56C probably damaging Het
Gm5422 T C 10: 31,125,688 (GRCm39) noncoding transcript Het
Gstm6 A G 3: 107,848,397 (GRCm39) V174A probably benign Het
Isoc1 G T 18: 58,804,664 (GRCm39) V191F possibly damaging Het
Kalrn T A 16: 33,874,009 (GRCm39) D132V possibly damaging Het
Kcp T C 6: 29,482,887 (GRCm39) D1394G possibly damaging Het
Marchf10 T G 11: 105,280,440 (GRCm39) D615A probably damaging Het
Mau2 A G 8: 70,495,187 (GRCm39) I50T probably damaging Het
Mgp A G 6: 136,849,722 (GRCm39) C79R probably damaging Het
Mpdz T A 4: 81,226,602 (GRCm39) K1344N probably damaging Het
Mrgpre T A 7: 143,334,708 (GRCm39) Y265F possibly damaging Het
Mro G A 18: 74,006,295 (GRCm39) V80M possibly damaging Het
Mrpl44 G T 1: 79,755,895 (GRCm39) C167F possibly damaging Het
Muc5b A G 7: 141,410,079 (GRCm39) M1218V probably null Het
Naa16 T C 14: 79,620,780 (GRCm39) I100V possibly damaging Het
Nup205 A T 6: 35,220,778 (GRCm39) Y1860F possibly damaging Het
Or14c40 A G 7: 86,313,819 (GRCm39) I316M probably benign Het
Or1e16 AGCGGTCGTAGGC AGC 11: 73,286,480 (GRCm39) probably null Het
Or4c103 T C 2: 88,513,977 (GRCm39) Y33C probably damaging Het
Plcb3 A G 19: 6,932,071 (GRCm39) probably null Het
Pnpla3 G A 15: 84,065,132 (GRCm39) A309T probably benign Het
Ranbp10 A G 8: 106,498,296 (GRCm39) S624P possibly damaging Het
Ripor2 T C 13: 24,894,113 (GRCm39) S714P possibly damaging Het
Robo4 C T 9: 37,316,926 (GRCm39) Q414* probably null Het
Shc2 A G 10: 79,465,954 (GRCm39) I161T probably damaging Het
Slc35b2 C T 17: 45,877,302 (GRCm39) T143I probably benign Het
Slc39a13 T C 2: 90,898,880 (GRCm39) D77G probably damaging Het
Snx6 A C 12: 54,807,249 (GRCm39) D243E probably damaging Het
Taar8b A G 10: 23,967,711 (GRCm39) V161A probably benign Het
Tbr1 T A 2: 61,635,159 (GRCm39) D36E possibly damaging Het
Tdpoz2 T C 3: 93,559,618 (GRCm39) N118S probably benign Het
Tgfb1i1 T C 7: 127,852,517 (GRCm39) F478L probably damaging Het
Tmprss11f T C 5: 86,704,837 (GRCm39) D27G probably benign Het
Trim30d T G 7: 104,137,202 (GRCm39) M1L probably damaging Het
Trpm7 A G 2: 126,679,301 (GRCm39) V420A probably damaging Het
Ubap2 G T 4: 41,206,981 (GRCm39) P199H probably benign Het
Ubash3b T C 9: 40,926,212 (GRCm39) T512A probably damaging Het
Zfp65 G A 13: 67,858,437 (GRCm39) P76S probably benign Het
Zic5 A T 14: 122,696,748 (GRCm39) H622Q unknown Het
Zpld1 A T 16: 55,053,993 (GRCm39) N266K probably damaging Het
Zswim1 A G 2: 164,667,972 (GRCm39) probably null Het
Other mutations in Or10aa3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01025:Or10aa3 APN 1 173,878,251 (GRCm39) missense probably damaging 1.00
IGL03002:Or10aa3 APN 1 173,878,191 (GRCm39) missense probably benign 0.03
R0020:Or10aa3 UTSW 1 173,878,413 (GRCm39) missense probably damaging 0.99
R0386:Or10aa3 UTSW 1 173,877,965 (GRCm39) missense probably benign 0.00
R1735:Or10aa3 UTSW 1 173,878,365 (GRCm39) missense probably benign
R1932:Or10aa3 UTSW 1 173,878,244 (GRCm39) missense probably damaging 1.00
R2363:Or10aa3 UTSW 1 173,878,814 (GRCm39) missense probably damaging 1.00
R3930:Or10aa3 UTSW 1 173,878,076 (GRCm39) missense probably damaging 1.00
R4024:Or10aa3 UTSW 1 173,878,683 (GRCm39) missense probably benign 0.00
R4777:Or10aa3 UTSW 1 173,878,244 (GRCm39) missense probably damaging 1.00
R4946:Or10aa3 UTSW 1 173,878,400 (GRCm39) missense possibly damaging 0.95
R5250:Or10aa3 UTSW 1 173,878,838 (GRCm39) missense probably benign
R5646:Or10aa3 UTSW 1 173,878,853 (GRCm39) nonsense probably null
R6634:Or10aa3 UTSW 1 173,878,535 (GRCm39) missense probably benign 0.11
R7578:Or10aa3 UTSW 1 173,878,266 (GRCm39) missense possibly damaging 0.71
R7653:Or10aa3 UTSW 1 173,878,488 (GRCm39) missense probably benign 0.36
R8110:Or10aa3 UTSW 1 173,878,091 (GRCm39) missense probably benign 0.01
R8426:Or10aa3 UTSW 1 173,878,146 (GRCm39) missense probably damaging 1.00
R9008:Or10aa3 UTSW 1 173,878,413 (GRCm39) missense probably damaging 0.99
R9408:Or10aa3 UTSW 1 173,878,329 (GRCm39) missense
RF014:Or10aa3 UTSW 1 173,878,553 (GRCm39) missense possibly damaging 0.68
Predicted Primers PCR Primer
(F):5'- ACTCATGAGCAGACAGGTACAG -3'
(R):5'- CCTTCAGCTCGAATCTCTGG -3'

Sequencing Primer
(F):5'- TACAGAAACAGTTAGTTGGGGTTAC -3'
(R):5'- TGGGCCCACATAGACAATG -3'
Posted On 2017-10-10