Mutagenetix > Incidental Mutation

Incidental Mutation 'R6178:Csmd3'

487897

Institutional Source

Beutler Lab

Gene Symbol

Csmd3

Ensembl Gene

ENSMUSG00000022311

Gene Name

CUB and Sushi multiple domains 3

Synonyms

4930500N14Rik

MMRRC Submission

044320-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R6178 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

47444033-48655459 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 48536854 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Cysteine at position 116 (Y116C)

Ref Sequence

ENSEMBL: ENSMUSP00000124775 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000100670] [ENSMUST00000160658] [ENSMUST00000162830]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000100670
AA Change: Y116C

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)

SMART Domains

Protein: ENSMUSP00000098235
Gene: ENSMUSG00000022311
AA Change: Y116C

Domain	Start	End	E-Value	Type
CUB	65	173	8.79e-30	SMART
CCP	178	235	1.77e-11	SMART
CUB	241	345	2.29e-28	SMART
low complexity region	370	387	N/A	INTRINSIC
CCP	486	543	6.9e-14	SMART
CUB	548	659	9.22e-24	SMART
CCP	664	717	1.29e-13	SMART
CUB	721	829	6.87e-32	SMART
CCP	834	891	5.19e-9	SMART
CUB	895	1003	3.23e-37	SMART
CCP	1010	1063	1.82e-13	SMART
CUB	1067	1177	4.87e-23	SMART
CCP	1182	1237	1.82e-13	SMART
CUB	1241	1349	5.02e-25	SMART
CCP	1354	1410	2.5e-11	SMART
CUB	1414	1523	6.27e-26	SMART
CCP	1528	1584	4.41e-12	SMART
CUB	1588	1696	5.37e-34	SMART
CCP	1701	1758	1.18e-12	SMART
CUB	1762	1870	2.27e-23	SMART
CCP	1878	1935	1.84e-9	SMART
CUB	1939	2047	1.8e-35	SMART
CCP	2052	2107	4.48e-13	SMART
CUB	2111	2219	3.95e-32	SMART
CCP	2224	2279	4.02e-15	SMART
CUB	2283	2390	1.74e-33	SMART
CCP	2395	2452	5.82e-12	SMART
CUB	2457	2567	5.3e-24	SMART
CCP	2569	2627	2.11e-9	SMART
CCP	2632	2689	8.23e-12	SMART
CCP	2694	2754	8.56e-10	SMART
CCP	2759	2812	1.14e-14	SMART
CCP	2817	2870	4.76e-17	SMART
CCP	2875	2928	1.85e-14	SMART
CCP	2933	2990	9.9e-15	SMART
CCP	2995	3048	1.79e-12	SMART
CCP	3056	3109	1.72e-14	SMART
CCP	3114	3168	3.17e-13	SMART
CCP	3173	3228	1.25e-11	SMART
CCP	3233	3286	1.25e-11	SMART
CCP	3291	3344	8.23e-12	SMART
CCP	3352	3406	5.6e-14	SMART
CCP	3411	3466	1.89e-11	SMART
transmembrane domain	3630	3652	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000160655

Predicted Effect

probably benign
Transcript: ENSMUST00000160658
AA Change: Y116C

PolyPhen 2 Score 0.300 (Sensitivity: 0.90; Specificity: 0.89)

SMART Domains

Protein: ENSMUSP00000124753
Gene: ENSMUSG00000022311
AA Change: Y116C

Domain	Start	End	E-Value	Type
CUB	65	173	8.79e-30	SMART
CCP	178	235	1.77e-11	SMART
CUB	241	345	2.29e-28	SMART
CCP	382	439	6.9e-14	SMART
CUB	444	555	9.22e-24	SMART
CCP	560	613	1.29e-13	SMART
CUB	617	725	6.87e-32	SMART
CCP	730	787	5.19e-9	SMART
CUB	791	899	3.23e-37	SMART
CCP	906	959	1.82e-13	SMART
CUB	963	1073	4.87e-23	SMART
CCP	1078	1133	1.82e-13	SMART
CUB	1137	1245	5.02e-25	SMART
CCP	1250	1306	2.5e-11	SMART
CUB	1310	1419	6.27e-26	SMART
CCP	1424	1480	4.41e-12	SMART
CUB	1484	1592	5.37e-34	SMART
CCP	1597	1654	1.18e-12	SMART
CUB	1658	1766	2.27e-23	SMART
CCP	1774	1831	1.84e-9	SMART
CUB	1835	1943	1.8e-35	SMART
CCP	1948	2003	4.48e-13	SMART
CUB	2007	2115	3.95e-32	SMART
CCP	2120	2175	4.02e-15	SMART
CUB	2179	2286	1.74e-33	SMART
CCP	2291	2348	5.82e-12	SMART
CUB	2353	2463	5.3e-24	SMART
CCP	2465	2523	2.11e-9	SMART
CCP	2528	2585	8.23e-12	SMART
CCP	2590	2643	1.14e-14	SMART
CCP	2648	2701	4.76e-17	SMART
CCP	2706	2759	1.85e-14	SMART
CCP	2764	2821	9.9e-15	SMART
CCP	2826	2879	1.79e-12	SMART
CCP	2887	2940	1.72e-14	SMART
CCP	2945	2999	3.17e-13	SMART
CCP	3004	3059	1.25e-11	SMART
CCP	3064	3117	1.25e-11	SMART
CCP	3122	3175	8.23e-12	SMART
CCP	3183	3237	5.6e-14	SMART
CCP	3242	3297	1.89e-11	SMART
transmembrane domain	3461	3483	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000160716

Predicted Effect

probably damaging
Transcript: ENSMUST00000162830
AA Change: Y116C

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)

SMART Domains

Protein: ENSMUSP00000124775
Gene: ENSMUSG00000022311
AA Change: Y116C

Domain	Start	End	E-Value	Type
CUB	65	173	8.79e-30	SMART
CCP	178	235	1.77e-11	SMART
CUB	241	345	2.29e-28	SMART
low complexity region	370	387	N/A	INTRINSIC
CCP	486	543	6.9e-14	SMART
CUB	548	659	9.22e-24	SMART
CCP	664	717	1.29e-13	SMART
CUB	721	829	6.87e-32	SMART
CCP	834	891	5.19e-9	SMART
CUB	895	1003	3.23e-37	SMART
CCP	1010	1063	1.82e-13	SMART
CUB	1067	1177	4.87e-23	SMART
CCP	1182	1237	1.82e-13	SMART
CUB	1241	1349	5.02e-25	SMART
CCP	1354	1410	2.5e-11	SMART
CUB	1414	1523	6.27e-26	SMART
CCP	1528	1584	4.41e-12	SMART
CUB	1588	1696	5.37e-34	SMART
CCP	1701	1758	1.18e-12	SMART
CUB	1762	1870	2.27e-23	SMART
CCP	1878	1935	1.84e-9	SMART
CUB	1939	2047	1.8e-35	SMART
CCP	2052	2107	4.48e-13	SMART
CUB	2111	2219	3.95e-32	SMART
CCP	2224	2279	4.02e-15	SMART
CUB	2283	2390	1.74e-33	SMART
CCP	2395	2452	5.82e-12	SMART
CUB	2457	2567	5.3e-24	SMART
CCP	2569	2627	2.11e-9	SMART
CCP	2632	2689	8.23e-12	SMART
CCP	2694	2754	8.56e-10	SMART
CCP	2759	2812	1.14e-14	SMART
CCP	2817	2870	4.76e-17	SMART
CCP	2875	2928	1.85e-14	SMART
CCP	2933	2990	9.9e-15	SMART
CCP	2995	3048	1.79e-12	SMART
CCP	3056	3109	1.72e-14	SMART
CCP	3114	3168	3.17e-13	SMART
CCP	3173	3228	1.25e-11	SMART
CCP	3233	3286	1.25e-11	SMART
CCP	3291	3344	8.23e-12	SMART
CCP	3352	3406	5.6e-14	SMART
CCP	3411	3466	1.89e-11	SMART
transmembrane domain	3630	3652	N/A	INTRINSIC

Meta Mutation Damage Score

0.7322

Coding Region Coverage

1x: 99.9%
3x: 99.6%
10x: 97.9%
20x: 94.0%

Validation Efficiency

98% (54/55)

Allele List at MGI

Other mutations in this stock

Total: 58 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcc6	T	C	7: 45,678,468 (GRCm39)	I61V	probably benign	Het
Afg3l2	G	A	18: 67,542,598 (GRCm39)	T616I	possibly damaging	Het
Aktip	T	C	8: 91,852,671 (GRCm39)	N195S	probably damaging	Het
Ankfy1	G	A	11: 72,645,285 (GRCm39)	C788Y	probably benign	Het
Atg7	T	A	6: 114,701,856 (GRCm39)	I621N	probably damaging	Het
Becn1	T	A	11: 101,182,336 (GRCm39)	I283F	probably damaging	Het
Btnl12	T	C	16: 37,676,422 (GRCm39)	Y115C	probably damaging	Het
C4b	T	C	17: 34,952,380 (GRCm39)	T1220A	probably benign	Het
Celsr1	C	A	15: 85,785,222 (GRCm39)	R3004M	probably benign	Het
Clspn	A	T	4: 126,471,529 (GRCm39)		probably null	Het
Dcp1a	T	G	14: 30,245,261 (GRCm39)	*603G	probably null	Het
Dmrtc1b	C	T	X: 101,757,169 (GRCm39)	P205S	possibly damaging	Het
Fev	G	T	1: 74,923,698 (GRCm39)		probably benign	Het
Fry	T	A	5: 150,377,987 (GRCm39)	V393E	probably damaging	Het
Gm30646	A	G	7: 30,132,081 (GRCm39)		probably null	Het
Gm3676	C	T	14: 41,363,452 (GRCm39)	E175K	probably benign	Het
Gm4847	T	C	1: 166,469,905 (GRCm39)	Y56C	probably damaging	Het
Gm5422	T	C	10: 31,125,688 (GRCm39)		noncoding transcript	Het
Gstm6	A	G	3: 107,848,397 (GRCm39)	V174A	probably benign	Het
Isoc1	G	T	18: 58,804,664 (GRCm39)	V191F	possibly damaging	Het
Kalrn	T	A	16: 33,874,009 (GRCm39)	D132V	possibly damaging	Het
Kcp	T	C	6: 29,482,887 (GRCm39)	D1394G	possibly damaging	Het
Marchf10	T	G	11: 105,280,440 (GRCm39)	D615A	probably damaging	Het
Mau2	A	G	8: 70,495,187 (GRCm39)	I50T	probably damaging	Het
Mgp	A	G	6: 136,849,722 (GRCm39)	C79R	probably damaging	Het
Mpdz	T	A	4: 81,226,602 (GRCm39)	K1344N	probably damaging	Het
Mrgpre	T	A	7: 143,334,708 (GRCm39)	Y265F	possibly damaging	Het
Mro	G	A	18: 74,006,295 (GRCm39)	V80M	possibly damaging	Het
Mrpl44	G	T	1: 79,755,895 (GRCm39)	C167F	possibly damaging	Het
Muc5b	A	G	7: 141,410,079 (GRCm39)	M1218V	probably null	Het
Naa16	T	C	14: 79,620,780 (GRCm39)	I100V	possibly damaging	Het
Nup205	A	T	6: 35,220,778 (GRCm39)	Y1860F	possibly damaging	Het
Or10aa3	A	T	1: 173,878,533 (GRCm39)	Y198F	probably benign	Het
Or14c40	A	G	7: 86,313,819 (GRCm39)	I316M	probably benign	Het
Or1e16	AGCGGTCGTAGGC	AGC	11: 73,286,480 (GRCm39)		probably null	Het
Or4c103	T	C	2: 88,513,977 (GRCm39)	Y33C	probably damaging	Het
Plcb3	A	G	19: 6,932,071 (GRCm39)		probably null	Het
Pnpla3	G	A	15: 84,065,132 (GRCm39)	A309T	probably benign	Het
Ranbp10	A	G	8: 106,498,296 (GRCm39)	S624P	possibly damaging	Het
Ripor2	T	C	13: 24,894,113 (GRCm39)	S714P	possibly damaging	Het
Robo4	C	T	9: 37,316,926 (GRCm39)	Q414*	probably null	Het
Shc2	A	G	10: 79,465,954 (GRCm39)	I161T	probably damaging	Het
Slc35b2	C	T	17: 45,877,302 (GRCm39)	T143I	probably benign	Het
Slc39a13	T	C	2: 90,898,880 (GRCm39)	D77G	probably damaging	Het
Snx6	A	C	12: 54,807,249 (GRCm39)	D243E	probably damaging	Het
Taar8b	A	G	10: 23,967,711 (GRCm39)	V161A	probably benign	Het
Tbr1	T	A	2: 61,635,159 (GRCm39)	D36E	possibly damaging	Het
Tdpoz2	T	C	3: 93,559,618 (GRCm39)	N118S	probably benign	Het
Tgfb1i1	T	C	7: 127,852,517 (GRCm39)	F478L	probably damaging	Het
Tmprss11f	T	C	5: 86,704,837 (GRCm39)	D27G	probably benign	Het
Trim30d	T	G	7: 104,137,202 (GRCm39)	M1L	probably damaging	Het
Trpm7	A	G	2: 126,679,301 (GRCm39)	V420A	probably damaging	Het
Ubap2	G	T	4: 41,206,981 (GRCm39)	P199H	probably benign	Het
Ubash3b	T	C	9: 40,926,212 (GRCm39)	T512A	probably damaging	Het
Zfp65	G	A	13: 67,858,437 (GRCm39)	P76S	probably benign	Het
Zic5	A	T	14: 122,696,748 (GRCm39)	H622Q	unknown	Het
Zpld1	A	T	16: 55,053,993 (GRCm39)	N266K	probably damaging	Het
Zswim1	A	G	2: 164,667,972 (GRCm39)		probably null	Het

Other mutations in Csmd3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00158:Csmd3	APN	15	48,150,891 (GRCm39)	missense	possibly damaging	0.61
IGL00591:Csmd3	APN	15	47,868,279 (GRCm39)	missense	probably damaging	1.00
IGL00668:Csmd3	APN	15	47,777,341 (GRCm39)	missense	probably damaging	1.00
IGL00753:Csmd3	APN	15	47,507,631 (GRCm39)	missense	probably damaging	1.00
IGL00773:Csmd3	APN	15	47,454,115 (GRCm39)	missense	probably damaging	0.96
IGL00926:Csmd3	APN	15	47,574,360 (GRCm39)	missense	possibly damaging	0.87
IGL00942:Csmd3	APN	15	47,710,502 (GRCm39)	critical splice donor site	probably null
IGL01080:Csmd3	APN	15	47,744,799 (GRCm39)	missense	probably benign	0.12
IGL01314:Csmd3	APN	15	47,713,151 (GRCm39)	missense	probably damaging	1.00
IGL01326:Csmd3	APN	15	47,713,181 (GRCm39)	missense	probably benign	0.06
IGL01393:Csmd3	APN	15	48,320,995 (GRCm39)	missense	possibly damaging	0.88
IGL01432:Csmd3	APN	15	47,596,895 (GRCm39)	missense	probably damaging	1.00
IGL01519:Csmd3	APN	15	47,460,246 (GRCm39)	missense	probably benign	0.31
IGL01530:Csmd3	APN	15	47,533,013 (GRCm39)	missense	probably damaging	1.00
IGL01530:Csmd3	APN	15	47,701,833 (GRCm39)	missense	possibly damaging	0.95
IGL01547:Csmd3	APN	15	47,747,013 (GRCm39)	missense	probably benign	0.41
IGL01594:Csmd3	APN	15	47,492,635 (GRCm39)	missense	probably benign	0.01
IGL01618:Csmd3	APN	15	47,874,479 (GRCm39)	missense	probably benign	0.05
IGL01670:Csmd3	APN	15	47,475,225 (GRCm39)	missense	probably damaging	1.00
IGL01680:Csmd3	APN	15	47,833,426 (GRCm39)	missense	probably damaging	1.00
IGL01734:Csmd3	APN	15	48,048,700 (GRCm39)	missense	probably damaging	1.00
IGL01777:Csmd3	APN	15	47,561,594 (GRCm39)	missense	probably benign	0.06
IGL01779:Csmd3	APN	15	47,721,290 (GRCm39)	missense	probably benign	0.10
IGL01820:Csmd3	APN	15	47,470,538 (GRCm39)	nonsense	probably null
IGL01843:Csmd3	APN	15	47,522,395 (GRCm39)	splice site	probably benign
IGL01919:Csmd3	APN	15	47,539,168 (GRCm39)	missense	possibly damaging	0.62
IGL01986:Csmd3	APN	15	47,522,591 (GRCm39)	missense	possibly damaging	0.82
IGL02049:Csmd3	APN	15	47,864,870 (GRCm39)	missense	possibly damaging	0.91
IGL02065:Csmd3	APN	15	47,530,024 (GRCm39)	missense	probably damaging	1.00
IGL02112:Csmd3	APN	15	48,177,265 (GRCm39)	missense	possibly damaging	0.95
IGL02133:Csmd3	APN	15	47,721,338 (GRCm39)	missense	possibly damaging	0.86
IGL02203:Csmd3	APN	15	47,713,073 (GRCm39)	splice site	probably null
IGL02215:Csmd3	APN	15	47,449,084 (GRCm39)	missense	probably damaging	1.00
IGL02234:Csmd3	APN	15	47,811,512 (GRCm39)	missense	probably damaging	1.00
IGL02326:Csmd3	APN	15	47,619,359 (GRCm39)	splice site	probably benign
IGL02478:Csmd3	APN	15	47,701,794 (GRCm39)	splice site	probably benign
IGL02491:Csmd3	APN	15	47,777,511 (GRCm39)	splice site	probably benign
IGL02598:Csmd3	APN	15	47,533,086 (GRCm39)	missense	probably damaging	0.98
IGL02626:Csmd3	APN	15	47,567,503 (GRCm39)	splice site	probably benign
IGL02696:Csmd3	APN	15	47,533,065 (GRCm39)	missense	probably benign	0.33
IGL02876:Csmd3	APN	15	47,469,492 (GRCm39)	splice site	probably benign
IGL02971:Csmd3	APN	15	47,777,325 (GRCm39)	splice site	probably benign
IGL03068:Csmd3	APN	15	47,710,517 (GRCm39)	missense	possibly damaging	0.69
IGL03087:Csmd3	APN	15	47,840,429 (GRCm39)	missense	probably damaging	1.00
IGL03114:Csmd3	APN	15	47,683,847 (GRCm39)	missense	probably damaging	0.99
IGL03146:Csmd3	APN	15	47,744,873 (GRCm39)	missense	probably benign	0.25
IGL03193:Csmd3	APN	15	47,492,626 (GRCm39)	splice site	probably benign
IGL03274:Csmd3	APN	15	47,508,900 (GRCm39)	missense	probably damaging	1.00
R0040:Csmd3	UTSW	15	47,497,212 (GRCm39)	missense	probably damaging	1.00
R0071:Csmd3	UTSW	15	47,460,217 (GRCm39)	missense	probably benign	0.04
R0071:Csmd3	UTSW	15	47,460,217 (GRCm39)	missense	probably benign	0.04
R0119:Csmd3	UTSW	15	47,710,527 (GRCm39)	missense	probably benign	0.08
R0124:Csmd3	UTSW	15	47,454,112 (GRCm39)	missense	probably damaging	1.00
R0127:Csmd3	UTSW	15	47,845,326 (GRCm39)	missense	probably benign	0.45
R0136:Csmd3	UTSW	15	47,710,527 (GRCm39)	missense	probably benign	0.08
R0201:Csmd3	UTSW	15	47,483,125 (GRCm39)	splice site	probably benign
R0240:Csmd3	UTSW	15	47,492,635 (GRCm39)	missense	probably benign	0.05
R0240:Csmd3	UTSW	15	47,492,635 (GRCm39)	missense	probably benign	0.05
R0318:Csmd3	UTSW	15	47,522,549 (GRCm39)	missense	probably damaging	1.00
R0369:Csmd3	UTSW	15	47,833,543 (GRCm39)	missense	probably damaging	1.00
R0391:Csmd3	UTSW	15	47,520,969 (GRCm39)	missense	probably damaging	1.00
R0499:Csmd3	UTSW	15	47,710,527 (GRCm39)	missense	probably benign	0.08
R0506:Csmd3	UTSW	15	48,320,907 (GRCm39)	missense	probably benign	0.00
R0606:Csmd3	UTSW	15	48,321,058 (GRCm39)	missense	probably benign
R0639:Csmd3	UTSW	15	47,777,336 (GRCm39)	missense	probably damaging	1.00
R0658:Csmd3	UTSW	15	47,874,543 (GRCm39)	missense	possibly damaging	0.66
R0673:Csmd3	UTSW	15	47,777,336 (GRCm39)	missense	probably damaging	1.00
R0689:Csmd3	UTSW	15	47,619,421 (GRCm39)	missense	probably benign	0.19
R0696:Csmd3	UTSW	15	47,710,569 (GRCm39)	missense	probably benign	0.01
R0799:Csmd3	UTSW	15	48,048,780 (GRCm39)	splice site	probably benign
R0834:Csmd3	UTSW	15	47,747,073 (GRCm39)	intron	probably benign
R0894:Csmd3	UTSW	15	47,721,316 (GRCm39)	missense	possibly damaging	0.95
R0926:Csmd3	UTSW	15	47,840,429 (GRCm39)	missense	probably damaging	1.00
R0943:Csmd3	UTSW	15	47,539,135 (GRCm39)	missense	probably damaging	0.99
R0944:Csmd3	UTSW	15	47,475,227 (GRCm39)	missense	probably damaging	1.00
R0967:Csmd3	UTSW	15	47,721,227 (GRCm39)	missense	probably null	0.89
R0973:Csmd3	UTSW	15	47,522,485 (GRCm39)	missense	probably damaging	1.00
R1055:Csmd3	UTSW	15	47,744,933 (GRCm39)	missense	probably damaging	1.00
R1066:Csmd3	UTSW	15	47,777,361 (GRCm39)	missense	probably damaging	1.00
R1086:Csmd3	UTSW	15	47,559,151 (GRCm39)	missense	probably damaging	0.99
R1103:Csmd3	UTSW	15	47,811,402 (GRCm39)	missense	probably damaging	1.00
R1136:Csmd3	UTSW	15	47,539,213 (GRCm39)	missense	probably damaging	1.00
R1139:Csmd3	UTSW	15	47,559,232 (GRCm39)	missense	probably damaging	1.00
R1158:Csmd3	UTSW	15	48,156,170 (GRCm39)	splice site	probably null
R1215:Csmd3	UTSW	15	47,868,227 (GRCm39)	splice site	probably null
R1233:Csmd3	UTSW	15	48,536,927 (GRCm39)	missense	probably damaging	1.00
R1271:Csmd3	UTSW	15	47,874,455 (GRCm39)	missense	probably benign	0.11
R1469:Csmd3	UTSW	15	47,532,598 (GRCm39)	nonsense	probably null
R1469:Csmd3	UTSW	15	47,532,598 (GRCm39)	nonsense	probably null
R1479:Csmd3	UTSW	15	47,721,282 (GRCm39)	missense	probably damaging	1.00
R1480:Csmd3	UTSW	15	47,595,325 (GRCm39)	missense	possibly damaging	0.90
R1526:Csmd3	UTSW	15	47,449,028 (GRCm39)	critical splice donor site	probably null
R1527:Csmd3	UTSW	15	47,811,483 (GRCm39)	missense	probably benign	0.08
R1539:Csmd3	UTSW	15	47,683,794 (GRCm39)	missense	probably benign	0.24
R1544:Csmd3	UTSW	15	47,475,294 (GRCm39)	splice site	probably null
R1548:Csmd3	UTSW	15	47,845,371 (GRCm39)	missense	possibly damaging	0.91
R1574:Csmd3	UTSW	15	47,559,257 (GRCm39)	splice site	probably null
R1574:Csmd3	UTSW	15	47,559,257 (GRCm39)	splice site	probably null
R1619:Csmd3	UTSW	15	47,813,346 (GRCm39)	missense	probably damaging	1.00
R1630:Csmd3	UTSW	15	47,701,918 (GRCm39)	missense	possibly damaging	0.66
R1665:Csmd3	UTSW	15	47,560,185 (GRCm39)	missense	probably damaging	1.00
R1680:Csmd3	UTSW	15	47,604,566 (GRCm39)	missense	probably damaging	1.00
R1725:Csmd3	UTSW	15	47,460,203 (GRCm39)	missense	probably damaging	1.00
R1743:Csmd3	UTSW	15	48,485,485 (GRCm39)	missense	probably damaging	1.00
R1749:Csmd3	UTSW	15	47,449,056 (GRCm39)	missense	probably damaging	1.00
R1752:Csmd3	UTSW	15	47,523,669 (GRCm39)	missense	probably benign	0.15
R1769:Csmd3	UTSW	15	47,567,505 (GRCm39)	splice site	probably benign
R1775:Csmd3	UTSW	15	47,763,135 (GRCm39)	missense	probably damaging	0.99
R1795:Csmd3	UTSW	15	47,721,316 (GRCm39)	missense	possibly damaging	0.95
R1819:Csmd3	UTSW	15	47,617,131 (GRCm39)	missense	possibly damaging	0.56
R1840:Csmd3	UTSW	15	47,470,560 (GRCm39)	missense	probably damaging	1.00
R1860:Csmd3	UTSW	15	47,522,588 (GRCm39)	missense	probably damaging	1.00
R1861:Csmd3	UTSW	15	47,522,588 (GRCm39)	missense	probably damaging	1.00
R1879:Csmd3	UTSW	15	47,520,915 (GRCm39)	missense	possibly damaging	0.90
R1958:Csmd3	UTSW	15	47,868,035 (GRCm39)	critical splice donor site	probably null
R1965:Csmd3	UTSW	15	47,713,144 (GRCm39)	missense	probably benign	0.15
R1970:Csmd3	UTSW	15	48,536,927 (GRCm39)	missense	probably damaging	1.00
R2029:Csmd3	UTSW	15	47,701,975 (GRCm39)	missense	probably damaging	1.00
R2051:Csmd3	UTSW	15	48,485,389 (GRCm39)	critical splice donor site	probably null
R2108:Csmd3	UTSW	15	47,868,257 (GRCm39)	missense	possibly damaging	0.81
R2132:Csmd3	UTSW	15	48,320,899 (GRCm39)	missense	probably benign	0.06
R2146:Csmd3	UTSW	15	47,604,632 (GRCm39)	frame shift	probably null
R2147:Csmd3	UTSW	15	47,604,632 (GRCm39)	frame shift	probably null
R2148:Csmd3	UTSW	15	47,604,632 (GRCm39)	frame shift	probably null
R2157:Csmd3	UTSW	15	47,559,183 (GRCm39)	missense	probably damaging	0.99
R2159:Csmd3	UTSW	15	47,604,632 (GRCm39)	frame shift	probably null
R2160:Csmd3	UTSW	15	47,604,632 (GRCm39)	frame shift	probably null
R2161:Csmd3	UTSW	15	47,604,632 (GRCm39)	frame shift	probably null
R2162:Csmd3	UTSW	15	47,604,632 (GRCm39)	frame shift	probably null
R2164:Csmd3	UTSW	15	47,604,632 (GRCm39)	frame shift	probably null
R2213:Csmd3	UTSW	15	47,683,843 (GRCm39)	missense	possibly damaging	0.92
R2301:Csmd3	UTSW	15	47,595,394 (GRCm39)	missense	probably damaging	1.00
R2302:Csmd3	UTSW	15	48,177,447 (GRCm39)	missense	probably benign
R2355:Csmd3	UTSW	15	47,604,632 (GRCm39)	frame shift	probably null
R2497:Csmd3	UTSW	15	47,604,632 (GRCm39)	frame shift	probably null
R2509:Csmd3	UTSW	15	47,604,632 (GRCm39)	frame shift	probably null
R2566:Csmd3	UTSW	15	47,604,632 (GRCm39)	frame shift	probably null
R2567:Csmd3	UTSW	15	47,604,632 (GRCm39)	frame shift	probably null
R2568:Csmd3	UTSW	15	47,604,632 (GRCm39)	frame shift	probably null
R2570:Csmd3	UTSW	15	47,604,632 (GRCm39)	frame shift	probably null
R2571:Csmd3	UTSW	15	47,604,632 (GRCm39)	frame shift	probably null
R2870:Csmd3	UTSW	15	47,721,320 (GRCm39)	missense	probably damaging	1.00
R2870:Csmd3	UTSW	15	47,721,320 (GRCm39)	missense	probably damaging	1.00
R2907:Csmd3	UTSW	15	47,874,449 (GRCm39)	missense	probably damaging	0.99
R3116:Csmd3	UTSW	15	47,520,995 (GRCm39)	missense	probably damaging	1.00
R3423:Csmd3	UTSW	15	47,710,648 (GRCm39)	missense	probably damaging	0.98
R3425:Csmd3	UTSW	15	47,710,648 (GRCm39)	missense	probably damaging	0.98
R3508:Csmd3	UTSW	15	47,604,632 (GRCm39)	frame shift	probably null
R3746:Csmd3	UTSW	15	47,713,162 (GRCm39)	missense	probably benign	0.04
R3813:Csmd3	UTSW	15	48,655,209 (GRCm39)	missense	possibly damaging	0.82
R3832:Csmd3	UTSW	15	47,604,632 (GRCm39)	frame shift	probably null
R3959:Csmd3	UTSW	15	47,507,585 (GRCm39)	missense	probably benign	0.18
R4042:Csmd3	UTSW	15	47,477,480 (GRCm39)	missense	probably damaging	1.00
R4043:Csmd3	UTSW	15	47,619,362 (GRCm39)	critical splice donor site	probably null
R4191:Csmd3	UTSW	15	47,710,667 (GRCm39)	missense	probably damaging	0.99
R4192:Csmd3	UTSW	15	47,710,667 (GRCm39)	missense	probably damaging	0.99
R4419:Csmd3	UTSW	15	47,567,707 (GRCm39)	missense	probably damaging	1.00
R4426:Csmd3	UTSW	15	47,532,581 (GRCm39)	missense	possibly damaging	0.51
R4434:Csmd3	UTSW	15	47,763,191 (GRCm39)	missense	possibly damaging	0.68
R4438:Csmd3	UTSW	15	47,763,191 (GRCm39)	missense	possibly damaging	0.68
R4490:Csmd3	UTSW	15	48,177,429 (GRCm39)	missense	possibly damaging	0.83
R4562:Csmd3	UTSW	15	47,763,240 (GRCm39)	missense	probably benign	0.32
R4604:Csmd3	UTSW	15	47,868,211 (GRCm39)	missense	possibly damaging	0.90
R4620:Csmd3	UTSW	15	47,449,149 (GRCm39)	missense	probably benign	0.09
R4632:Csmd3	UTSW	15	47,874,605 (GRCm39)	missense	probably damaging	0.99
R4679:Csmd3	UTSW	15	48,024,479 (GRCm39)	nonsense	probably null
R4696:Csmd3	UTSW	15	47,777,364 (GRCm39)	missense	probably benign	0.24
R4718:Csmd3	UTSW	15	47,561,546 (GRCm39)	nonsense	probably null
R4723:Csmd3	UTSW	15	47,532,556 (GRCm39)	missense	probably benign	0.29
R4801:Csmd3	UTSW	15	47,484,688 (GRCm39)	missense	probably damaging	1.00
R4802:Csmd3	UTSW	15	47,484,688 (GRCm39)	missense	probably damaging	1.00
R4806:Csmd3	UTSW	15	48,177,464 (GRCm39)	missense	probably benign
R4816:Csmd3	UTSW	15	47,721,330 (GRCm39)	missense	possibly damaging	0.68
R4935:Csmd3	UTSW	15	48,024,480 (GRCm39)	missense	probably damaging	1.00
R4955:Csmd3	UTSW	15	48,536,914 (GRCm39)	missense	probably damaging	0.99
R4991:Csmd3	UTSW	15	47,864,874 (GRCm39)	missense	probably damaging	1.00
R5031:Csmd3	UTSW	15	47,522,588 (GRCm39)	missense	probably damaging	1.00
R5034:Csmd3	UTSW	15	47,492,683 (GRCm39)	missense	possibly damaging	0.94
R5035:Csmd3	UTSW	15	47,454,175 (GRCm39)	missense	probably damaging	1.00
R5120:Csmd3	UTSW	15	48,536,891 (GRCm39)	nonsense	probably null
R5224:Csmd3	UTSW	15	47,752,080 (GRCm39)	missense	possibly damaging	0.91
R5235:Csmd3	UTSW	15	47,492,674 (GRCm39)	missense	probably benign	0.20
R5279:Csmd3	UTSW	15	48,655,340 (GRCm39)	splice site	probably null
R5360:Csmd3	UTSW	15	47,532,599 (GRCm39)	missense	probably damaging	0.99
R5365:Csmd3	UTSW	15	47,868,145 (GRCm39)	missense	possibly damaging	0.68
R5379:Csmd3	UTSW	15	47,499,846 (GRCm39)	nonsense	probably null
R5381:Csmd3	UTSW	15	47,604,611 (GRCm39)	missense	probably benign	0.21
R5393:Csmd3	UTSW	15	47,497,099 (GRCm39)	missense	probably damaging	1.00
R5413:Csmd3	UTSW	15	47,701,831 (GRCm39)	missense	probably damaging	1.00
R5549:Csmd3	UTSW	15	48,048,753 (GRCm39)	missense	probably damaging	0.98
R5550:Csmd3	UTSW	15	48,048,753 (GRCm39)	missense	probably damaging	0.98
R5551:Csmd3	UTSW	15	48,177,492 (GRCm39)	missense	probably benign	0.13
R5567:Csmd3	UTSW	15	47,508,864 (GRCm39)	missense	possibly damaging	0.92
R5621:Csmd3	UTSW	15	48,177,374 (GRCm39)	missense	possibly damaging	0.84
R5668:Csmd3	UTSW	15	47,559,151 (GRCm39)	missense	possibly damaging	0.48
R5677:Csmd3	UTSW	15	48,485,447 (GRCm39)	missense	probably damaging	0.98
R5701:Csmd3	UTSW	15	48,403,729 (GRCm39)	missense	probably damaging	0.99
R5701:Csmd3	UTSW	15	47,513,617 (GRCm39)	missense	probably damaging	1.00
R5871:Csmd3	UTSW	15	47,752,112 (GRCm39)	missense	probably damaging	0.98
R5872:Csmd3	UTSW	15	47,445,923 (GRCm39)	missense	probably damaging	1.00
R5874:Csmd3	UTSW	15	47,507,666 (GRCm39)	missense	probably damaging	1.00
R5952:Csmd3	UTSW	15	47,596,901 (GRCm39)	missense	probably damaging	0.98
R5956:Csmd3	UTSW	15	48,655,278 (GRCm39)	missense	possibly damaging	0.84
R5966:Csmd3	UTSW	15	47,713,135 (GRCm39)	missense	probably damaging	0.96
R5969:Csmd3	UTSW	15	47,811,386 (GRCm39)	missense	probably damaging	1.00
R5989:Csmd3	UTSW	15	47,454,160 (GRCm39)	missense	possibly damaging	0.69
R6017:Csmd3	UTSW	15	48,177,408 (GRCm39)	missense	possibly damaging	0.95
R6057:Csmd3	UTSW	15	47,618,787 (GRCm39)	missense	probably damaging	1.00
R6127:Csmd3	UTSW	15	47,513,624 (GRCm39)	missense	probably damaging	1.00
R6198:Csmd3	UTSW	15	48,177,273 (GRCm39)	missense	probably benign	0.28
R6213:Csmd3	UTSW	15	47,492,656 (GRCm39)	missense	probably damaging	1.00
R6256:Csmd3	UTSW	15	47,533,125 (GRCm39)	missense	probably damaging	1.00
R6274:Csmd3	UTSW	15	47,484,833 (GRCm39)	missense	probably benign
R6327:Csmd3	UTSW	15	47,744,783 (GRCm39)	missense	probably damaging	1.00
R6354:Csmd3	UTSW	15	47,744,885 (GRCm39)	missense	probably damaging	1.00
R6405:Csmd3	UTSW	15	47,683,767 (GRCm39)	missense	probably damaging	0.99
R6410:Csmd3	UTSW	15	48,536,803 (GRCm39)	missense	probably damaging	1.00
R6416:Csmd3	UTSW	15	48,536,956 (GRCm39)	missense	probably damaging	1.00
R6463:Csmd3	UTSW	15	47,539,875 (GRCm39)	missense	probably damaging	1.00
R6536:Csmd3	UTSW	15	47,701,863 (GRCm39)	missense	probably damaging	1.00
R6625:Csmd3	UTSW	15	47,470,471 (GRCm39)	missense	probably benign	0.02
R6695:Csmd3	UTSW	15	47,721,230 (GRCm39)	missense	probably damaging	0.99
R6895:Csmd3	UTSW	15	47,529,910 (GRCm39)	splice site	probably null
R6906:Csmd3	UTSW	15	47,710,569 (GRCm39)	missense	probably benign	0.01
R6914:Csmd3	UTSW	15	47,874,534 (GRCm39)	missense	possibly damaging	0.53
R6920:Csmd3	UTSW	15	47,507,601 (GRCm39)	missense	probably damaging	1.00
R7024:Csmd3	UTSW	15	47,574,387 (GRCm39)	missense	probably damaging	1.00
R7178:Csmd3	UTSW	15	47,454,170 (GRCm39)	missense
R7192:Csmd3	UTSW	15	47,567,633 (GRCm39)	missense
R7220:Csmd3	UTSW	15	48,320,994 (GRCm39)	missense	probably damaging	0.99
R7362:Csmd3	UTSW	15	47,619,388 (GRCm39)	missense	possibly damaging	0.65
R7380:Csmd3	UTSW	15	47,450,361 (GRCm39)	missense
R7397:Csmd3	UTSW	15	47,559,130 (GRCm39)	missense
R7467:Csmd3	UTSW	15	47,492,640 (GRCm39)	missense
R7585:Csmd3	UTSW	15	48,485,471 (GRCm39)	missense	possibly damaging	0.76
R7623:Csmd3	UTSW	15	47,813,334 (GRCm39)	missense
R7649:Csmd3	UTSW	15	47,532,539 (GRCm39)	missense
R7691:Csmd3	UTSW	15	47,604,569 (GRCm39)	missense
R7695:Csmd3	UTSW	15	47,683,777 (GRCm39)	missense
R7759:Csmd3	UTSW	15	47,561,569 (GRCm39)	missense
R7817:Csmd3	UTSW	15	47,721,356 (GRCm39)	missense	probably damaging	0.99
R8052:Csmd3	UTSW	15	47,569,783 (GRCm39)	missense
R8089:Csmd3	UTSW	15	47,532,603 (GRCm39)	missense
R8110:Csmd3	UTSW	15	47,507,666 (GRCm39)	missense	probably damaging	1.00
R8152:Csmd3	UTSW	15	47,532,860 (GRCm39)	splice site	probably null
R8323:Csmd3	UTSW	15	47,561,547 (GRCm39)	missense
R8341:Csmd3	UTSW	15	47,561,547 (GRCm39)	missense
R8353:Csmd3	UTSW	15	47,813,349 (GRCm39)	missense	probably damaging	1.00
R8364:Csmd3	UTSW	15	48,536,837 (GRCm39)	missense	probably damaging	1.00
R8405:Csmd3	UTSW	15	47,619,379 (GRCm39)	missense	probably damaging	1.00
R8412:Csmd3	UTSW	15	47,499,794 (GRCm39)	missense
R8436:Csmd3	UTSW	15	47,868,218 (GRCm39)	missense	probably damaging	0.97
R8516:Csmd3	UTSW	15	47,492,761 (GRCm39)	nonsense	probably null
R8553:Csmd3	UTSW	15	47,484,724 (GRCm39)	missense	possibly damaging	0.52
R8554:Csmd3	UTSW	15	47,507,538 (GRCm39)	missense	probably benign	0.32
R8678:Csmd3	UTSW	15	47,499,849 (GRCm39)	missense
R8751:Csmd3	UTSW	15	47,845,402 (GRCm39)	missense
R8758:Csmd3	UTSW	15	47,469,593 (GRCm39)	missense
R8768:Csmd3	UTSW	15	47,561,572 (GRCm39)	missense
R8785:Csmd3	UTSW	15	48,177,482 (GRCm39)	missense	probably benign	0.00
R8788:Csmd3	UTSW	15	47,470,513 (GRCm39)	missense
R8798:Csmd3	UTSW	15	47,595,382 (GRCm39)	missense
R8801:Csmd3	UTSW	15	48,321,024 (GRCm39)	missense	possibly damaging	0.70
R8811:Csmd3	UTSW	15	47,560,139 (GRCm39)	missense
R8844:Csmd3	UTSW	15	48,536,815 (GRCm39)	missense	probably damaging	0.98
R8844:Csmd3	UTSW	15	47,604,590 (GRCm39)	missense	probably damaging	0.96
R8892:Csmd3	UTSW	15	47,604,634 (GRCm39)	missense
R8897:Csmd3	UTSW	15	48,222,739 (GRCm39)	missense	probably benign	0.06
R9001:Csmd3	UTSW	15	47,596,901 (GRCm39)	missense
R9007:Csmd3	UTSW	15	47,751,892 (GRCm39)	intron	probably benign
R9016:Csmd3	UTSW	15	47,522,438 (GRCm39)	missense
R9039:Csmd3	UTSW	15	47,483,308 (GRCm39)	splice site	probably benign
R9109:Csmd3	UTSW	15	47,617,187 (GRCm39)	missense
R9121:Csmd3	UTSW	15	47,683,774 (GRCm39)	missense
R9155:Csmd3	UTSW	15	47,449,051 (GRCm39)	missense
R9176:Csmd3	UTSW	15	47,864,937 (GRCm39)	missense
R9281:Csmd3	UTSW	15	47,460,272 (GRCm39)	missense
R9298:Csmd3	UTSW	15	47,617,187 (GRCm39)	missense
R9304:Csmd3	UTSW	15	47,569,805 (GRCm39)	missense
R9343:Csmd3	UTSW	15	48,015,001 (GRCm39)	missense	probably damaging	1.00
R9367:Csmd3	UTSW	15	47,567,564 (GRCm39)	missense
R9405:Csmd3	UTSW	15	47,539,187 (GRCm39)	missense
R9448:Csmd3	UTSW	15	47,460,315 (GRCm39)	missense
R9460:Csmd3	UTSW	15	47,617,130 (GRCm39)	missense
R9481:Csmd3	UTSW	15	47,470,459 (GRCm39)	missense
R9520:Csmd3	UTSW	15	47,561,608 (GRCm39)	missense
R9551:Csmd3	UTSW	15	48,655,356 (GRCm39)	start gained	probably benign
R9552:Csmd3	UTSW	15	48,655,356 (GRCm39)	start gained	probably benign
R9568:Csmd3	UTSW	15	48,150,942 (GRCm39)	missense	probably damaging	0.97
R9571:Csmd3	UTSW	15	48,655,398 (GRCm39)	start gained	probably benign
R9607:Csmd3	UTSW	15	47,618,811 (GRCm39)	missense	probably damaging	0.98
R9621:Csmd3	UTSW	15	47,713,116 (GRCm39)	missense
R9671:Csmd3	UTSW	15	47,845,299 (GRCm39)	missense
R9718:Csmd3	UTSW	15	47,560,083 (GRCm39)	missense
U24488:Csmd3	UTSW	15	47,573,795 (GRCm39)	missense	probably damaging	1.00
V8831:Csmd3	UTSW	15	48,321,092 (GRCm39)	missense	probably damaging	0.96
X0021:Csmd3	UTSW	15	47,833,489 (GRCm39)	nonsense	probably null
Z1088:Csmd3	UTSW	15	47,710,677 (GRCm39)	missense	probably damaging	0.98
Z1088:Csmd3	UTSW	15	47,499,789 (GRCm39)	missense	probably damaging	1.00
Z1177:Csmd3	UTSW	15	47,596,813 (GRCm39)	missense
Z1177:Csmd3	UTSW	15	47,539,130 (GRCm39)	missense

Predicted Primers

PCR Primer
(F):5'- TCACCTGAATAGTACATACTTGTTCG -3'
(R):5'- ACAACTAACAGGTTTTGAAACTTTTC -3'

Sequencing Primer
(F):5'- CTCTACCTCTAGTGTACCAC -3'
(R):5'- AACCATGTCTATTTGTCTTGTGTTGC -3'

Posted On

2017-10-10