Incidental Mutation 'R6181:Corin'
| ID |
488074 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Corin
|
| Ensembl Gene |
ENSMUSG00000005220 |
| Gene Name |
corin, serine peptidase |
| Synonyms |
Lrp4 |
| MMRRC Submission |
044323-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.267)
|
| Stock # |
R6181 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
5 |
| Chromosomal Location |
72457368-72661816 bp(-) (GRCm39) |
| Type of Mutation |
critical splice donor site (2 bp from exon) |
| DNA Base Change (assembly) |
A to G
at 72529439 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000135511
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000005352]
[ENSMUST00000167460]
[ENSMUST00000175766]
[ENSMUST00000175766]
[ENSMUST00000176974]
[ENSMUST00000176974]
[ENSMUST00000177290]
[ENSMUST00000177290]
|
| AlphaFold |
Q9Z319 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000005352
|
| SMART Domains |
Protein: ENSMUSP00000005352
Gene: ENSMUSG00000005220
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
3 |
15 |
N/A |
INTRINSIC |
|
transmembrane domain
|
113 |
135 |
N/A |
INTRINSIC |
|
FRI
|
205 |
318 |
6.15e-11 |
SMART |
|
LDLa
|
336 |
372 |
1.31e-8 |
SMART |
|
LDLa
|
373 |
408 |
1.5e-8 |
SMART |
|
LDLa
|
409 |
447 |
5.47e-11 |
SMART |
|
LDLa
|
448 |
484 |
1.22e-8 |
SMART |
|
low complexity region
|
508 |
521 |
N/A |
INTRINSIC |
|
FRI
|
522 |
643 |
2.75e-31 |
SMART |
|
LDLa
|
647 |
684 |
2.19e-10 |
SMART |
|
LDLa
|
685 |
722 |
1.76e-5 |
SMART |
|
LDLa
|
723 |
759 |
4.18e-7 |
SMART |
|
SR
|
758 |
853 |
3.99e-10 |
SMART |
|
Tryp_SPc
|
868 |
1097 |
5.45e-76 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000167460
|
| SMART Domains |
Protein: ENSMUSP00000127389
Gene: ENSMUSG00000005220
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
47 |
69 |
N/A |
INTRINSIC |
|
FRI
|
139 |
252 |
6.15e-11 |
SMART |
|
LDLa
|
270 |
306 |
1.31e-8 |
SMART |
|
LDLa
|
307 |
342 |
1.5e-8 |
SMART |
|
LDLa
|
343 |
381 |
5.47e-11 |
SMART |
|
LDLa
|
382 |
418 |
1.22e-8 |
SMART |
|
low complexity region
|
442 |
455 |
N/A |
INTRINSIC |
|
FRI
|
456 |
577 |
2.75e-31 |
SMART |
|
LDLa
|
581 |
618 |
2.19e-10 |
SMART |
|
LDLa
|
619 |
656 |
1.76e-5 |
SMART |
|
LDLa
|
657 |
693 |
4.18e-7 |
SMART |
|
SR
|
692 |
787 |
3.99e-10 |
SMART |
|
Tryp_SPc
|
802 |
1031 |
5.45e-76 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000175766
|
| SMART Domains |
Protein: ENSMUSP00000135889
Gene: ENSMUSG00000005220
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
45 |
67 |
N/A |
INTRINSIC |
|
FRI
|
137 |
250 |
6.15e-11 |
SMART |
|
LDLa
|
268 |
304 |
1.31e-8 |
SMART |
|
LDLa
|
305 |
343 |
2.07e-11 |
SMART |
|
low complexity region
|
367 |
380 |
N/A |
INTRINSIC |
|
FRI
|
381 |
502 |
2.75e-31 |
SMART |
|
LDLa
|
506 |
543 |
2.19e-10 |
SMART |
|
LDLa
|
544 |
581 |
1.76e-5 |
SMART |
|
LDLa
|
582 |
618 |
4.18e-7 |
SMART |
|
SR
|
617 |
712 |
3.99e-10 |
SMART |
|
Tryp_SPc
|
727 |
956 |
5.45e-76 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000175766
|
| SMART Domains |
Protein: ENSMUSP00000135889
Gene: ENSMUSG00000005220
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
45 |
67 |
N/A |
INTRINSIC |
|
FRI
|
137 |
250 |
6.15e-11 |
SMART |
|
LDLa
|
268 |
304 |
1.31e-8 |
SMART |
|
LDLa
|
305 |
343 |
2.07e-11 |
SMART |
|
low complexity region
|
367 |
380 |
N/A |
INTRINSIC |
|
FRI
|
381 |
502 |
2.75e-31 |
SMART |
|
LDLa
|
506 |
543 |
2.19e-10 |
SMART |
|
LDLa
|
544 |
581 |
1.76e-5 |
SMART |
|
LDLa
|
582 |
618 |
4.18e-7 |
SMART |
|
SR
|
617 |
712 |
3.99e-10 |
SMART |
|
Tryp_SPc
|
727 |
956 |
5.45e-76 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000176396
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000176439
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000176974
|
| SMART Domains |
Protein: ENSMUSP00000135722
Gene: ENSMUSG00000005220
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
47 |
69 |
N/A |
INTRINSIC |
|
FRI
|
139 |
252 |
6.15e-11 |
SMART |
|
LDLa
|
270 |
306 |
1.31e-8 |
SMART |
|
LDLa
|
307 |
344 |
3.86e-11 |
SMART |
|
LDLa
|
345 |
381 |
1.22e-8 |
SMART |
|
low complexity region
|
405 |
418 |
N/A |
INTRINSIC |
|
FRI
|
419 |
540 |
2.75e-31 |
SMART |
|
LDLa
|
544 |
581 |
2.19e-10 |
SMART |
|
LDLa
|
582 |
619 |
1.76e-5 |
SMART |
|
LDLa
|
620 |
656 |
4.18e-7 |
SMART |
|
SR
|
655 |
750 |
3.99e-10 |
SMART |
|
Tryp_SPc
|
765 |
994 |
5.45e-76 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000176974
|
| SMART Domains |
Protein: ENSMUSP00000135722
Gene: ENSMUSG00000005220
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
47 |
69 |
N/A |
INTRINSIC |
|
FRI
|
139 |
252 |
6.15e-11 |
SMART |
|
LDLa
|
270 |
306 |
1.31e-8 |
SMART |
|
LDLa
|
307 |
344 |
3.86e-11 |
SMART |
|
LDLa
|
345 |
381 |
1.22e-8 |
SMART |
|
low complexity region
|
405 |
418 |
N/A |
INTRINSIC |
|
FRI
|
419 |
540 |
2.75e-31 |
SMART |
|
LDLa
|
544 |
581 |
2.19e-10 |
SMART |
|
LDLa
|
582 |
619 |
1.76e-5 |
SMART |
|
LDLa
|
620 |
656 |
4.18e-7 |
SMART |
|
SR
|
655 |
750 |
3.99e-10 |
SMART |
|
Tryp_SPc
|
765 |
994 |
5.45e-76 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000177290
|
| SMART Domains |
Protein: ENSMUSP00000135511
Gene: ENSMUSG00000005220
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
47 |
69 |
N/A |
INTRINSIC |
|
FRI
|
72 |
185 |
6.15e-11 |
SMART |
|
LDLa
|
203 |
239 |
1.31e-8 |
SMART |
|
LDLa
|
240 |
275 |
1.5e-8 |
SMART |
|
LDLa
|
276 |
314 |
5.47e-11 |
SMART |
|
LDLa
|
315 |
351 |
1.22e-8 |
SMART |
|
low complexity region
|
375 |
388 |
N/A |
INTRINSIC |
|
FRI
|
389 |
510 |
2.75e-31 |
SMART |
|
LDLa
|
514 |
551 |
2.19e-10 |
SMART |
|
LDLa
|
552 |
589 |
1.76e-5 |
SMART |
|
LDLa
|
590 |
626 |
4.18e-7 |
SMART |
|
SR
|
625 |
720 |
3.99e-10 |
SMART |
|
Tryp_SPc
|
735 |
964 |
5.45e-76 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000177290
|
| SMART Domains |
Protein: ENSMUSP00000135511
Gene: ENSMUSG00000005220
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
47 |
69 |
N/A |
INTRINSIC |
|
FRI
|
72 |
185 |
6.15e-11 |
SMART |
|
LDLa
|
203 |
239 |
1.31e-8 |
SMART |
|
LDLa
|
240 |
275 |
1.5e-8 |
SMART |
|
LDLa
|
276 |
314 |
5.47e-11 |
SMART |
|
LDLa
|
315 |
351 |
1.22e-8 |
SMART |
|
low complexity region
|
375 |
388 |
N/A |
INTRINSIC |
|
FRI
|
389 |
510 |
2.75e-31 |
SMART |
|
LDLa
|
514 |
551 |
2.19e-10 |
SMART |
|
LDLa
|
552 |
589 |
1.76e-5 |
SMART |
|
LDLa
|
590 |
626 |
4.18e-7 |
SMART |
|
SR
|
625 |
720 |
3.99e-10 |
SMART |
|
Tryp_SPc
|
735 |
964 |
5.45e-76 |
SMART |
|
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.7%
- 10x: 98.4%
- 20x: 95.6%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the type II transmembrane serine protease class of the trypsin superfamily. Members of this family are composed of multiple structurally distinct domains. The encoded protein converts pro-atrial natriuretic peptide to biologically active atrial natriuretic peptide, a cardiac hormone that regulates blood volume and pressure. This protein may also function as a pro-brain-type natriuretic peptide convertase. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2013]
PHENOTYPE: Homozygous null mice display hypertension that is enhanced by high-salt diet and pregnancy, increased body weight, and cardiac hypertrophy. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 74 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Akr1b7 |
A |
G |
6: 34,392,313 (GRCm39) |
H42R |
possibly damaging |
Het |
| Ankrd26 |
T |
A |
6: 118,525,838 (GRCm39) |
H369L |
probably benign |
Het |
| Ano7 |
T |
C |
1: 93,323,081 (GRCm39) |
S474P |
probably damaging |
Het |
| Aox3 |
T |
C |
1: 58,198,105 (GRCm39) |
V639A |
probably benign |
Het |
| Arhgef2 |
T |
A |
3: 88,542,927 (GRCm39) |
V358E |
probably damaging |
Het |
| Brpf3 |
A |
G |
17: 29,029,555 (GRCm39) |
Y505C |
probably damaging |
Het |
| Casd1 |
A |
G |
6: 4,619,331 (GRCm39) |
T120A |
probably damaging |
Het |
| Ccdc121 |
A |
G |
5: 31,645,399 (GRCm39) |
E384G |
probably damaging |
Het |
| Cd200l1 |
A |
G |
16: 45,238,260 (GRCm39) |
S185P |
probably benign |
Het |
| Clasp1 |
T |
G |
1: 118,347,547 (GRCm39) |
S32A |
probably benign |
Het |
| Clca3a2 |
A |
T |
3: 144,796,469 (GRCm39) |
L246* |
probably null |
Het |
| Clcn7 |
A |
G |
17: 25,370,702 (GRCm39) |
I353V |
possibly damaging |
Het |
| Cluap1 |
T |
A |
16: 3,751,608 (GRCm39) |
D322E |
probably benign |
Het |
| Cmtm4 |
A |
C |
8: 105,082,997 (GRCm39) |
|
probably null |
Het |
| Cntnap2 |
C |
T |
6: 46,736,742 (GRCm39) |
P723S |
probably damaging |
Het |
| Col6a3 |
T |
A |
1: 90,744,096 (GRCm39) |
T84S |
possibly damaging |
Het |
| Cubn |
G |
A |
2: 13,354,687 (GRCm39) |
T1903I |
probably benign |
Het |
| Cyp27b1 |
A |
C |
10: 126,886,279 (GRCm39) |
D320A |
probably damaging |
Het |
| Cyp2j6 |
G |
C |
4: 96,424,323 (GRCm39) |
L145V |
probably damaging |
Het |
| Dennd2a |
T |
C |
6: 39,462,554 (GRCm39) |
K652R |
probably benign |
Het |
| Dnah8 |
G |
A |
17: 30,967,542 (GRCm39) |
D2585N |
probably benign |
Het |
| Dock1 |
T |
A |
7: 134,760,251 (GRCm39) |
M1638K |
probably damaging |
Het |
| Efcab3 |
T |
C |
11: 104,722,159 (GRCm39) |
S1924P |
probably benign |
Het |
| Eya1 |
T |
C |
1: 14,373,096 (GRCm39) |
S8G |
probably damaging |
Het |
| Fam193a |
T |
A |
5: 34,600,884 (GRCm39) |
|
probably null |
Het |
| Fbxw11 |
T |
A |
11: 32,692,575 (GRCm39) |
N515K |
probably benign |
Het |
| Gm6408 |
T |
C |
5: 146,420,582 (GRCm39) |
V154A |
possibly damaging |
Het |
| Guf1 |
A |
G |
5: 69,719,059 (GRCm39) |
Y235C |
probably damaging |
Het |
| Hnrnpul2 |
C |
T |
19: 8,800,596 (GRCm39) |
S224L |
possibly damaging |
Het |
| Igkv8-19 |
T |
A |
6: 70,317,968 (GRCm39) |
D86V |
probably damaging |
Het |
| Iqcf1 |
A |
T |
9: 106,379,174 (GRCm39) |
D61V |
probably damaging |
Het |
| Lrp5 |
T |
C |
19: 3,678,427 (GRCm39) |
D476G |
probably damaging |
Het |
| Luzp1 |
A |
G |
4: 136,270,578 (GRCm39) |
T934A |
probably benign |
Het |
| Mboat7 |
A |
T |
7: 3,686,884 (GRCm39) |
Y319N |
probably benign |
Het |
| Mdn1 |
A |
G |
4: 32,715,953 (GRCm39) |
E2045G |
probably damaging |
Het |
| Mfsd14b |
T |
C |
13: 65,260,398 (GRCm39) |
R12G |
probably benign |
Het |
| Micall2 |
T |
A |
5: 139,702,506 (GRCm39) |
T246S |
probably benign |
Het |
| Npepps |
A |
G |
11: 97,132,830 (GRCm39) |
V299A |
probably damaging |
Het |
| Or2y11 |
T |
A |
11: 49,443,120 (GRCm39) |
V182D |
probably damaging |
Het |
| P2ry13 |
A |
G |
3: 59,117,328 (GRCm39) |
V150A |
probably benign |
Het |
| Pdc |
T |
C |
1: 150,209,021 (GRCm39) |
I168T |
probably damaging |
Het |
| Pde8b |
C |
T |
13: 95,223,316 (GRCm39) |
E313K |
probably benign |
Het |
| Pgap1 |
C |
T |
1: 54,551,936 (GRCm39) |
G499R |
probably benign |
Het |
| Ppp1r15b |
T |
A |
1: 133,060,261 (GRCm39) |
C259* |
probably null |
Het |
| Pramel21 |
T |
A |
4: 143,342,828 (GRCm39) |
|
probably null |
Het |
| Ptgs1 |
A |
G |
2: 36,141,131 (GRCm39) |
E526G |
probably damaging |
Het |
| Ptpn21 |
A |
G |
12: 98,666,258 (GRCm39) |
L271P |
probably damaging |
Het |
| Rbm47 |
T |
C |
5: 66,183,833 (GRCm39) |
T257A |
possibly damaging |
Het |
| Rfc3 |
C |
T |
5: 151,570,985 (GRCm39) |
D104N |
probably damaging |
Het |
| Rhobtb3 |
A |
G |
13: 76,058,808 (GRCm39) |
I330T |
probably benign |
Het |
| Rnf207 |
T |
C |
4: 152,393,305 (GRCm39) |
T570A |
probably benign |
Het |
| Rusf1 |
A |
G |
7: 127,896,632 (GRCm39) |
|
probably null |
Het |
| Sbpl |
T |
C |
17: 24,172,466 (GRCm39) |
H151R |
probably damaging |
Het |
| Sstr3 |
T |
C |
15: 78,423,661 (GRCm39) |
D362G |
probably benign |
Het |
| St7 |
T |
C |
6: 17,694,363 (GRCm39) |
|
probably null |
Het |
| Tasor |
T |
A |
14: 27,194,235 (GRCm39) |
M1145K |
probably benign |
Het |
| Tdrd6 |
A |
G |
17: 43,939,788 (GRCm39) |
V420A |
probably damaging |
Het |
| Tet2 |
C |
A |
3: 133,193,520 (GRCm39) |
E305* |
probably null |
Het |
| Tmem209 |
A |
T |
6: 30,505,970 (GRCm39) |
V68E |
probably damaging |
Het |
| Tmod4 |
A |
T |
3: 95,035,118 (GRCm39) |
I208F |
probably damaging |
Het |
| Tpo |
G |
A |
12: 30,181,884 (GRCm39) |
L4F |
probably benign |
Het |
| Urb1 |
T |
C |
16: 90,575,982 (GRCm39) |
H858R |
probably benign |
Het |
| Utrn |
A |
G |
10: 12,615,200 (GRCm39) |
W324R |
probably damaging |
Het |
| V1rd19 |
T |
A |
7: 23,702,640 (GRCm39) |
F35L |
possibly damaging |
Het |
| Vmn1r170 |
C |
A |
7: 23,305,692 (GRCm39) |
N31K |
probably damaging |
Het |
| Vmn1r192 |
T |
A |
13: 22,371,452 (GRCm39) |
Y256F |
probably damaging |
Het |
| Vmn2r124 |
T |
C |
17: 18,294,019 (GRCm39) |
I702T |
possibly damaging |
Het |
| Vmn2r96 |
G |
A |
17: 18,804,126 (GRCm39) |
A459T |
probably benign |
Het |
| Vwf |
G |
T |
6: 125,543,109 (GRCm39) |
A132S |
probably damaging |
Het |
| Zfp202 |
G |
A |
9: 40,118,638 (GRCm39) |
G17E |
probably damaging |
Het |
| Zfp608 |
A |
G |
18: 55,028,700 (GRCm39) |
S1238P |
possibly damaging |
Het |
| Zfp804a |
G |
T |
2: 82,087,486 (GRCm39) |
M438I |
probably damaging |
Het |
| Zgrf1 |
G |
A |
3: 127,381,590 (GRCm39) |
G246S |
probably damaging |
Het |
| Zwint |
T |
C |
10: 72,492,431 (GRCm39) |
V115A |
probably benign |
Het |
|
| Other mutations in Corin |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00557:Corin
|
APN |
5 |
72,462,231 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01114:Corin
|
APN |
5 |
72,462,354 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01351:Corin
|
APN |
5 |
72,496,334 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01516:Corin
|
APN |
5 |
72,611,830 (GRCm39) |
nonsense |
probably null |
|
|
IGL01785:Corin
|
APN |
5 |
72,497,219 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01786:Corin
|
APN |
5 |
72,497,219 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01845:Corin
|
APN |
5 |
72,511,282 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02097:Corin
|
APN |
5 |
72,529,489 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02629:Corin
|
APN |
5 |
72,490,016 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03085:Corin
|
APN |
5 |
72,511,273 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03120:Corin
|
APN |
5 |
72,518,032 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03150:Corin
|
APN |
5 |
72,460,201 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03183:Corin
|
APN |
5 |
72,458,929 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03185:Corin
|
APN |
5 |
72,490,124 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03408:Corin
|
APN |
5 |
72,500,304 (GRCm39) |
missense |
probably benign |
0.40 |
|
alpaca
|
UTSW |
5 |
72,661,295 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R0078:Corin
|
UTSW |
5 |
72,611,816 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R0724:Corin
|
UTSW |
5 |
72,490,138 (GRCm39) |
splice site |
probably benign |
|
|
R1065:Corin
|
UTSW |
5 |
72,458,993 (GRCm39) |
nonsense |
probably null |
|
|
R1301:Corin
|
UTSW |
5 |
72,462,276 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R1466:Corin
|
UTSW |
5 |
72,460,133 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1466:Corin
|
UTSW |
5 |
72,460,133 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1520:Corin
|
UTSW |
5 |
72,488,238 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1584:Corin
|
UTSW |
5 |
72,460,133 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1617:Corin
|
UTSW |
5 |
72,661,295 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R1912:Corin
|
UTSW |
5 |
72,515,746 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2059:Corin
|
UTSW |
5 |
72,473,394 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R2173:Corin
|
UTSW |
5 |
72,661,422 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2242:Corin
|
UTSW |
5 |
72,490,054 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2373:Corin
|
UTSW |
5 |
72,496,381 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2850:Corin
|
UTSW |
5 |
72,462,298 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3683:Corin
|
UTSW |
5 |
72,488,198 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3684:Corin
|
UTSW |
5 |
72,488,198 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3790:Corin
|
UTSW |
5 |
72,592,641 (GRCm39) |
missense |
probably benign |
0.38 |
|
R3847:Corin
|
UTSW |
5 |
72,579,508 (GRCm39) |
missense |
probably benign |
0.13 |
|
R3926:Corin
|
UTSW |
5 |
72,529,473 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3939:Corin
|
UTSW |
5 |
72,497,222 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R3945:Corin
|
UTSW |
5 |
72,515,767 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4079:Corin
|
UTSW |
5 |
72,661,226 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4224:Corin
|
UTSW |
5 |
72,500,451 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4473:Corin
|
UTSW |
5 |
72,496,400 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4585:Corin
|
UTSW |
5 |
72,487,042 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4586:Corin
|
UTSW |
5 |
72,487,042 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4849:Corin
|
UTSW |
5 |
72,460,178 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4926:Corin
|
UTSW |
5 |
72,529,525 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5080:Corin
|
UTSW |
5 |
72,511,194 (GRCm39) |
intron |
probably benign |
|
|
R5138:Corin
|
UTSW |
5 |
72,496,402 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5262:Corin
|
UTSW |
5 |
72,462,298 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5268:Corin
|
UTSW |
5 |
72,500,362 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5302:Corin
|
UTSW |
5 |
72,473,441 (GRCm39) |
missense |
probably benign |
0.07 |
|
R5307:Corin
|
UTSW |
5 |
72,514,321 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5324:Corin
|
UTSW |
5 |
72,592,600 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5352:Corin
|
UTSW |
5 |
72,462,376 (GRCm39) |
missense |
probably benign |
0.04 |
|
R5373:Corin
|
UTSW |
5 |
72,462,296 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5374:Corin
|
UTSW |
5 |
72,462,296 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5484:Corin
|
UTSW |
5 |
72,515,827 (GRCm39) |
missense |
probably benign |
0.15 |
|
R5502:Corin
|
UTSW |
5 |
72,473,449 (GRCm39) |
nonsense |
probably null |
|
|
R5544:Corin
|
UTSW |
5 |
72,462,357 (GRCm39) |
nonsense |
probably null |
|
|
R5682:Corin
|
UTSW |
5 |
72,579,497 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R5818:Corin
|
UTSW |
5 |
72,592,738 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5992:Corin
|
UTSW |
5 |
72,473,732 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6115:Corin
|
UTSW |
5 |
72,518,072 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6317:Corin
|
UTSW |
5 |
72,496,388 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7053:Corin
|
UTSW |
5 |
72,458,870 (GRCm39) |
missense |
probably benign |
0.28 |
|
R7242:Corin
|
UTSW |
5 |
72,462,398 (GRCm39) |
missense |
probably benign |
0.14 |
|
R7452:Corin
|
UTSW |
5 |
72,592,590 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7783:Corin
|
UTSW |
5 |
72,458,967 (GRCm39) |
missense |
probably benign |
0.26 |
|
R7903:Corin
|
UTSW |
5 |
72,458,843 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7956:Corin
|
UTSW |
5 |
72,579,530 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8007:Corin
|
UTSW |
5 |
72,473,446 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8125:Corin
|
UTSW |
5 |
72,515,806 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8215:Corin
|
UTSW |
5 |
72,462,361 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8251:Corin
|
UTSW |
5 |
72,514,269 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8364:Corin
|
UTSW |
5 |
72,462,274 (GRCm39) |
missense |
probably benign |
|
|
R8505:Corin
|
UTSW |
5 |
72,592,750 (GRCm39) |
missense |
probably benign |
0.21 |
|
R8746:Corin
|
UTSW |
5 |
72,592,695 (GRCm39) |
missense |
probably benign |
0.31 |
|
R8887:Corin
|
UTSW |
5 |
72,486,953 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9484:Corin
|
UTSW |
5 |
72,497,280 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9640:Corin
|
UTSW |
5 |
72,592,597 (GRCm39) |
missense |
probably benign |
|
|
Z1177:Corin
|
UTSW |
5 |
72,611,836 (GRCm39) |
missense |
probably benign |
0.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TACATTGGTAAAGCAGCCGG -3'
(R):5'- GGGTTCTGGAAGGAAATCTGTC -3'
Sequencing Primer
(F):5'- TGCAAGCCCAACATGGTG -3'
(R):5'- GGTTCTGGAAGGAAATCTGTCAAATC -3'
|
| Posted On |
2017-10-10 |
Incidental Mutation