Incidental Mutation 'R6181:Micall2'
ID 488075
Institutional Source Beutler Lab
Gene Symbol Micall2
Ensembl Gene ENSMUSG00000036718
Gene Name MICAL-like 2
Synonyms MICAL-L2, Jrab, A930021H16Rik
MMRRC Submission 044323-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.352) question?
Stock # R6181 (G1)
Quality Score 225.009
Status Not validated
Chromosome 5
Chromosomal Location 139692451-139722091 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 139702506 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Serine at position 246 (T246S)
Ref Sequence ENSEMBL: ENSMUSP00000039707 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000044642] [ENSMUST00000170773]
AlphaFold Q3TN34
Predicted Effect probably benign
Transcript: ENSMUST00000044642
AA Change: T246S

PolyPhen 2 Score 0.405 (Sensitivity: 0.89; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000039707
Gene: ENSMUSG00000036718
AA Change: T246S

DomainStartEndE-ValueType
CH 3 102 4.34e-20 SMART
LIM 187 241 1.62e-5 SMART
low complexity region 242 253 N/A INTRINSIC
low complexity region 326 344 N/A INTRINSIC
low complexity region 428 489 N/A INTRINSIC
low complexity region 502 518 N/A INTRINSIC
low complexity region 728 746 N/A INTRINSIC
low complexity region 755 770 N/A INTRINSIC
DUF3585 840 980 3.1e-63 SMART
Predicted Effect unknown
Transcript: ENSMUST00000170773
AA Change: T163S
SMART Domains Protein: ENSMUSP00000127937
Gene: ENSMUSG00000036718
AA Change: T163S

DomainStartEndE-ValueType
SCOP:d1bkra_ 1 25 9e-5 SMART
Blast:DUF3585 1 45 2e-7 BLAST
LIM 104 158 1.62e-5 SMART
low complexity region 159 170 N/A INTRINSIC
low complexity region 243 261 N/A INTRINSIC
low complexity region 345 406 N/A INTRINSIC
low complexity region 419 435 N/A INTRINSIC
low complexity region 645 663 N/A INTRINSIC
low complexity region 672 687 N/A INTRINSIC
DUF3585 757 897 3.1e-63 SMART
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.4%
  • 20x: 95.6%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 74 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Akr1b7 A G 6: 34,392,313 (GRCm39) H42R possibly damaging Het
Ankrd26 T A 6: 118,525,838 (GRCm39) H369L probably benign Het
Ano7 T C 1: 93,323,081 (GRCm39) S474P probably damaging Het
Aox3 T C 1: 58,198,105 (GRCm39) V639A probably benign Het
Arhgef2 T A 3: 88,542,927 (GRCm39) V358E probably damaging Het
Brpf3 A G 17: 29,029,555 (GRCm39) Y505C probably damaging Het
Casd1 A G 6: 4,619,331 (GRCm39) T120A probably damaging Het
Ccdc121 A G 5: 31,645,399 (GRCm39) E384G probably damaging Het
Cd200l1 A G 16: 45,238,260 (GRCm39) S185P probably benign Het
Clasp1 T G 1: 118,347,547 (GRCm39) S32A probably benign Het
Clca3a2 A T 3: 144,796,469 (GRCm39) L246* probably null Het
Clcn7 A G 17: 25,370,702 (GRCm39) I353V possibly damaging Het
Cluap1 T A 16: 3,751,608 (GRCm39) D322E probably benign Het
Cmtm4 A C 8: 105,082,997 (GRCm39) probably null Het
Cntnap2 C T 6: 46,736,742 (GRCm39) P723S probably damaging Het
Col6a3 T A 1: 90,744,096 (GRCm39) T84S possibly damaging Het
Corin A G 5: 72,529,439 (GRCm39) probably null Het
Cubn G A 2: 13,354,687 (GRCm39) T1903I probably benign Het
Cyp27b1 A C 10: 126,886,279 (GRCm39) D320A probably damaging Het
Cyp2j6 G C 4: 96,424,323 (GRCm39) L145V probably damaging Het
Dennd2a T C 6: 39,462,554 (GRCm39) K652R probably benign Het
Dnah8 G A 17: 30,967,542 (GRCm39) D2585N probably benign Het
Dock1 T A 7: 134,760,251 (GRCm39) M1638K probably damaging Het
Efcab3 T C 11: 104,722,159 (GRCm39) S1924P probably benign Het
Eya1 T C 1: 14,373,096 (GRCm39) S8G probably damaging Het
Fam193a T A 5: 34,600,884 (GRCm39) probably null Het
Fbxw11 T A 11: 32,692,575 (GRCm39) N515K probably benign Het
Gm6408 T C 5: 146,420,582 (GRCm39) V154A possibly damaging Het
Guf1 A G 5: 69,719,059 (GRCm39) Y235C probably damaging Het
Hnrnpul2 C T 19: 8,800,596 (GRCm39) S224L possibly damaging Het
Igkv8-19 T A 6: 70,317,968 (GRCm39) D86V probably damaging Het
Iqcf1 A T 9: 106,379,174 (GRCm39) D61V probably damaging Het
Lrp5 T C 19: 3,678,427 (GRCm39) D476G probably damaging Het
Luzp1 A G 4: 136,270,578 (GRCm39) T934A probably benign Het
Mboat7 A T 7: 3,686,884 (GRCm39) Y319N probably benign Het
Mdn1 A G 4: 32,715,953 (GRCm39) E2045G probably damaging Het
Mfsd14b T C 13: 65,260,398 (GRCm39) R12G probably benign Het
Npepps A G 11: 97,132,830 (GRCm39) V299A probably damaging Het
Or2y11 T A 11: 49,443,120 (GRCm39) V182D probably damaging Het
P2ry13 A G 3: 59,117,328 (GRCm39) V150A probably benign Het
Pdc T C 1: 150,209,021 (GRCm39) I168T probably damaging Het
Pde8b C T 13: 95,223,316 (GRCm39) E313K probably benign Het
Pgap1 C T 1: 54,551,936 (GRCm39) G499R probably benign Het
Ppp1r15b T A 1: 133,060,261 (GRCm39) C259* probably null Het
Pramel21 T A 4: 143,342,828 (GRCm39) probably null Het
Ptgs1 A G 2: 36,141,131 (GRCm39) E526G probably damaging Het
Ptpn21 A G 12: 98,666,258 (GRCm39) L271P probably damaging Het
Rbm47 T C 5: 66,183,833 (GRCm39) T257A possibly damaging Het
Rfc3 C T 5: 151,570,985 (GRCm39) D104N probably damaging Het
Rhobtb3 A G 13: 76,058,808 (GRCm39) I330T probably benign Het
Rnf207 T C 4: 152,393,305 (GRCm39) T570A probably benign Het
Rusf1 A G 7: 127,896,632 (GRCm39) probably null Het
Sbpl T C 17: 24,172,466 (GRCm39) H151R probably damaging Het
Sstr3 T C 15: 78,423,661 (GRCm39) D362G probably benign Het
St7 T C 6: 17,694,363 (GRCm39) probably null Het
Tasor T A 14: 27,194,235 (GRCm39) M1145K probably benign Het
Tdrd6 A G 17: 43,939,788 (GRCm39) V420A probably damaging Het
Tet2 C A 3: 133,193,520 (GRCm39) E305* probably null Het
Tmem209 A T 6: 30,505,970 (GRCm39) V68E probably damaging Het
Tmod4 A T 3: 95,035,118 (GRCm39) I208F probably damaging Het
Tpo G A 12: 30,181,884 (GRCm39) L4F probably benign Het
Urb1 T C 16: 90,575,982 (GRCm39) H858R probably benign Het
Utrn A G 10: 12,615,200 (GRCm39) W324R probably damaging Het
V1rd19 T A 7: 23,702,640 (GRCm39) F35L possibly damaging Het
Vmn1r170 C A 7: 23,305,692 (GRCm39) N31K probably damaging Het
Vmn1r192 T A 13: 22,371,452 (GRCm39) Y256F probably damaging Het
Vmn2r124 T C 17: 18,294,019 (GRCm39) I702T possibly damaging Het
Vmn2r96 G A 17: 18,804,126 (GRCm39) A459T probably benign Het
Vwf G T 6: 125,543,109 (GRCm39) A132S probably damaging Het
Zfp202 G A 9: 40,118,638 (GRCm39) G17E probably damaging Het
Zfp608 A G 18: 55,028,700 (GRCm39) S1238P possibly damaging Het
Zfp804a G T 2: 82,087,486 (GRCm39) M438I probably damaging Het
Zgrf1 G A 3: 127,381,590 (GRCm39) G246S probably damaging Het
Zwint T C 10: 72,492,431 (GRCm39) V115A probably benign Het
Other mutations in Micall2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00231:Micall2 APN 5 139,703,311 (GRCm39) critical splice acceptor site probably null
IGL00496:Micall2 APN 5 139,702,083 (GRCm39) missense probably benign 0.01
IGL02641:Micall2 APN 5 139,705,094 (GRCm39) missense probably damaging 1.00
IGL03245:Micall2 APN 5 139,705,014 (GRCm39) missense probably damaging 1.00
IGL03252:Micall2 APN 5 139,702,481 (GRCm39) missense probably benign 0.01
R1214:Micall2 UTSW 5 139,697,396 (GRCm39) missense probably damaging 0.97
R1468:Micall2 UTSW 5 139,705,097 (GRCm39) missense probably damaging 1.00
R1468:Micall2 UTSW 5 139,705,097 (GRCm39) missense probably damaging 1.00
R1831:Micall2 UTSW 5 139,702,508 (GRCm39) missense probably benign 0.09
R1833:Micall2 UTSW 5 139,702,508 (GRCm39) missense probably benign 0.09
R1969:Micall2 UTSW 5 139,721,885 (GRCm39) missense probably damaging 1.00
R2023:Micall2 UTSW 5 139,703,266 (GRCm39) missense possibly damaging 0.51
R2060:Micall2 UTSW 5 139,697,317 (GRCm39) missense probably damaging 0.98
R2330:Micall2 UTSW 5 139,703,270 (GRCm39) missense probably damaging 1.00
R3820:Micall2 UTSW 5 139,701,611 (GRCm39) missense possibly damaging 0.92
R4299:Micall2 UTSW 5 139,695,226 (GRCm39) intron probably benign
R4334:Micall2 UTSW 5 139,699,105 (GRCm39) missense probably damaging 1.00
R4451:Micall2 UTSW 5 139,692,852 (GRCm39) missense probably damaging 1.00
R4769:Micall2 UTSW 5 139,692,641 (GRCm39) missense probably damaging 0.97
R4911:Micall2 UTSW 5 139,702,580 (GRCm39) missense probably damaging 1.00
R4996:Micall2 UTSW 5 139,696,344 (GRCm39) missense probably benign 0.31
R5118:Micall2 UTSW 5 139,702,202 (GRCm39) missense probably damaging 1.00
R5155:Micall2 UTSW 5 139,695,986 (GRCm39) missense probably damaging 1.00
R5475:Micall2 UTSW 5 139,702,224 (GRCm39) missense probably damaging 1.00
R5750:Micall2 UTSW 5 139,701,456 (GRCm39) splice site probably null
R5998:Micall2 UTSW 5 139,692,666 (GRCm39) critical splice acceptor site probably null
R6852:Micall2 UTSW 5 139,701,548 (GRCm39) missense possibly damaging 0.90
R7046:Micall2 UTSW 5 139,694,699 (GRCm39) unclassified probably benign
R7395:Micall2 UTSW 5 139,702,124 (GRCm39) missense possibly damaging 0.78
R8514:Micall2 UTSW 5 139,701,977 (GRCm39) missense probably damaging 1.00
R8889:Micall2 UTSW 5 139,703,254 (GRCm39) missense probably damaging 0.98
R8892:Micall2 UTSW 5 139,703,254 (GRCm39) missense probably damaging 0.98
R8960:Micall2 UTSW 5 139,702,025 (GRCm39) missense probably benign 0.23
R9060:Micall2 UTSW 5 139,705,035 (GRCm39) missense probably damaging 1.00
R9209:Micall2 UTSW 5 139,696,170 (GRCm39) missense unknown
R9227:Micall2 UTSW 5 139,701,827 (GRCm39) missense unknown
R9230:Micall2 UTSW 5 139,701,827 (GRCm39) missense unknown
R9260:Micall2 UTSW 5 139,695,453 (GRCm39) missense unknown
R9452:Micall2 UTSW 5 139,703,311 (GRCm39) critical splice acceptor site probably null
Z1088:Micall2 UTSW 5 139,702,050 (GRCm39) missense probably benign 0.12
Z1088:Micall2 UTSW 5 139,692,649 (GRCm39) missense probably damaging 1.00
Z1177:Micall2 UTSW 5 139,696,057 (GRCm39) missense unknown
Predicted Primers PCR Primer
(F):5'- CGTCTGGACAAAACCTTTGG -3'
(R):5'- GCATTTGCTGGAAGGGTCAG -3'

Sequencing Primer
(F):5'- ACAAAACCTTTGGCGGTTG -3'
(R):5'- TGGAAGGGTCAGCCACTG -3'
Posted On 2017-10-10