Mutagenetix > Incidental Mutation

Incidental Mutation 'R0524:Or2g1'

48809

Institutional Source

Beutler Lab

Gene Symbol

Or2g1

Ensembl Gene

ENSMUSG00000045202

Gene Name

olfactory receptor family 2 subfamily G member 1

Synonyms

MOR256-9, GA_x6K02T2PSCP-2255106-2256035, Olfr123

MMRRC Submission

038717-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.068) question?

Stock #

R0524 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

38106337-38107266 bp(+) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

A to T at 38106496 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Lysine to Stop codon at position 54 (K54*)

Ref Sequence

ENSEMBL: ENSMUSP00000149802 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000054748] [ENSMUST00000214770] [ENSMUST00000215168] [ENSMUST00000216051] [ENSMUST00000216478]

AlphaFold

Q8VFQ1

Predicted Effect

probably null
Transcript: ENSMUST00000054748
AA Change: K54*

SMART Domains

Protein: ENSMUSP00000058678
Gene: ENSMUSG00000045202
AA Change: K54*

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srv	23	163	2.9e-6	PFAM
Pfam:7tm_4	29	306	2.3e-44	PFAM
Pfam:7TM_GPCR_Srsx	33	144	2.4e-5	PFAM
Pfam:7tm_1	39	288	1.1e-22	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000174446

Predicted Effect

probably null
Transcript: ENSMUST00000214770
AA Change: K54*

Predicted Effect

probably benign
Transcript: ENSMUST00000215168

Predicted Effect

probably null
Transcript: ENSMUST00000216051
AA Change: K54*

Predicted Effect

probably benign
Transcript: ENSMUST00000216478

Coding Region Coverage

1x: 99.5%
3x: 98.7%
10x: 96.4%
20x: 92.4%

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 50 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acbd3	CGAGGAGGAGGAGGAGGA	CGAGGAGGAGGAGGA	1: 180,574,624 (GRCm39)		probably benign	Het
Adamts16	T	C	13: 70,949,013 (GRCm39)	E216G	probably benign	Het
Aoc3	C	A	11: 101,228,337 (GRCm39)	P715T	probably damaging	Het
Bnipl	T	C	3: 95,157,140 (GRCm39)	D33G	probably benign	Het
Celsr2	T	C	3: 108,308,903 (GRCm39)	H1701R	probably damaging	Het
Clca3b	T	A	3: 144,531,082 (GRCm39)	H756L	probably benign	Het
Clca4a	A	G	3: 144,675,154 (GRCm39)	W159R	probably damaging	Het
Ddx49	A	T	8: 70,749,574 (GRCm39)	I252N	probably damaging	Het
Duox2	T	C	2: 122,112,317 (GRCm39)	T1290A	possibly damaging	Het
Fam111a	T	A	19: 12,565,412 (GRCm39)	I431K	probably damaging	Het
Fam135b	A	T	15: 71,334,133 (GRCm39)	D1020E	probably benign	Het
Flii	A	G	11: 60,610,887 (GRCm39)	V514A	probably damaging	Het
Frmpd1	A	G	4: 45,283,774 (GRCm39)	D865G	probably benign	Het
Frmpd1	G	A	4: 45,256,902 (GRCm39)	V157M	probably damaging	Het
Gsr	G	A	8: 34,159,208 (GRCm39)		probably null	Het
H1f11-ps	T	A	19: 47,158,933 (GRCm39)	K214M	unknown	Het
Hps3	A	T	3: 20,066,940 (GRCm39)	V542E	probably damaging	Het
Kcnj5	A	G	9: 32,234,270 (GRCm39)	I15T	probably benign	Het
Kif2b	T	C	11: 91,466,550 (GRCm39)	R578G	probably benign	Het
Lamb2	A	G	9: 108,361,571 (GRCm39)	R676G	possibly damaging	Het
Mrpl40	A	G	16: 18,692,302 (GRCm39)	F94S	possibly damaging	Het
Myo7b	C	T	18: 32,146,477 (GRCm39)	V103M	possibly damaging	Het
Nmt2	T	A	2: 3,306,474 (GRCm39)	W69R	probably benign	Het
Nsd3	C	A	8: 26,190,605 (GRCm39)	Q1130K	possibly damaging	Het
Olfml1	T	C	7: 107,189,384 (GRCm39)	S150P	probably damaging	Het
Or5b116	A	G	19: 13,423,228 (GRCm39)	N284S	probably damaging	Het
Pask	A	T	1: 93,238,556 (GRCm39)	W1310R	probably damaging	Het
Pcdh18	T	C	3: 49,710,091 (GRCm39)	Q408R	probably damaging	Het
Pfkm	A	G	15: 98,029,488 (GRCm39)	I700V	probably benign	Het
Pias1	A	G	9: 62,859,460 (GRCm39)	V16A	probably damaging	Het
Pnpla8	C	T	12: 44,330,401 (GRCm39)	Q318*	probably null	Het
Ppp1cc	C	T	5: 122,310,833 (GRCm39)	R142*	probably null	Het
Pygl	T	A	12: 70,254,498 (GRCm39)	N149I	probably damaging	Het
Rapgef6	T	A	11: 54,581,110 (GRCm39)	S1285T	probably benign	Het
Rdh13	A	C	7: 4,447,296 (GRCm39)	C10W	probably damaging	Het
Rgr	A	T	14: 36,760,252 (GRCm39)	C273S	probably benign	Het
Ripk4	G	T	16: 97,556,487 (GRCm39)	Y22*	probably null	Het
Slc34a2	G	A	5: 53,222,215 (GRCm39)	W302*	probably null	Het
Smarce1	G	A	11: 99,104,888 (GRCm39)	T263M	probably damaging	Het
Sypl1	C	T	12: 33,017,564 (GRCm39)	P94L	possibly damaging	Het
Tet3	A	G	6: 83,356,924 (GRCm39)	I878T	probably damaging	Het
Tmem232	A	G	17: 65,792,937 (GRCm39)	S87P	probably damaging	Het
Tmem260	A	G	14: 48,709,935 (GRCm39)	T163A	probably benign	Het
Ttn	T	C	2: 76,555,796 (GRCm39)	Y30403C	probably damaging	Het
Ubash3b	A	T	9: 40,927,904 (GRCm39)	M468K	probably benign	Het
Ulk4	A	G	9: 121,081,717 (GRCm39)		probably null	Het
Vmn1r72	A	G	7: 11,403,719 (GRCm39)	F243S	probably benign	Het
Wrap73	A	G	4: 154,229,764 (GRCm39)	Y45C	probably damaging	Het
Zfp704	T	C	3: 9,674,424 (GRCm39)	D119G	unknown	Het
Zfp719	A	G	7: 43,238,677 (GRCm39)		probably null	Het

Other mutations in Or2g1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01409:Or2g1	APN	17	38,106,413 (GRCm39)	missense	probably damaging	0.99
IGL03030:Or2g1	APN	17	38,107,162 (GRCm39)	missense	probably damaging	1.00
IGL03107:Or2g1	APN	17	38,106,679 (GRCm39)	missense	probably benign	0.01
R0329:Or2g1	UTSW	17	38,106,880 (GRCm39)	missense	probably benign	0.01
R0330:Or2g1	UTSW	17	38,106,880 (GRCm39)	missense	probably benign	0.01
R0581:Or2g1	UTSW	17	38,106,993 (GRCm39)	missense	probably damaging	1.00
R1288:Or2g1	UTSW	17	38,106,584 (GRCm39)	missense	probably damaging	0.98
R1897:Or2g1	UTSW	17	38,107,075 (GRCm39)	missense	probably benign	0.22
R3751:Or2g1	UTSW	17	38,107,123 (GRCm39)	missense	possibly damaging	0.95
R3753:Or2g1	UTSW	17	38,107,123 (GRCm39)	missense	possibly damaging	0.95
R3780:Or2g1	UTSW	17	38,106,895 (GRCm39)	missense	probably damaging	1.00
R3947:Or2g1	UTSW	17	38,107,006 (GRCm39)	missense	probably benign
R5925:Or2g1	UTSW	17	38,106,482 (GRCm39)	missense	probably benign	0.00
R5987:Or2g1	UTSW	17	38,107,248 (GRCm39)	missense	probably benign
R6369:Or2g1	UTSW	17	38,106,387 (GRCm39)	missense	probably benign	0.02
R6891:Or2g1	UTSW	17	38,106,395 (GRCm39)	missense	probably benign
R7320:Or2g1	UTSW	17	38,107,248 (GRCm39)	missense	probably benign
R7997:Or2g1	UTSW	17	38,107,053 (GRCm39)	nonsense	probably null
R8153:Or2g1	UTSW	17	38,106,367 (GRCm39)	missense	probably benign	0.00
R8793:Or2g1	UTSW	17	38,107,255 (GRCm39)	missense	probably benign	0.21
R9348:Or2g1	UTSW	17	38,106,992 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- ACGGGGATGATCAACAGCAGTGTC -3'
(R):5'- CTTCACAGAAGAAGTGGTGGAGCC -3'

Sequencing Primer
(F):5'- ACAGCAGTGTCAGTAGTGACTTC -3'
(R):5'- ACTGAGCCATGAGATTCCTG -3'

Posted On

2013-06-12