Incidental Mutation 'R6181:Cd200l1'
ID 488110
Institutional Source Beutler Lab
Gene Symbol Cd200l1
Ensembl Gene ENSMUSG00000053182
Gene Name CD200 molecule like 1
Synonyms iSEC1, LOC208166, LOC385647, Gm609
MMRRC Submission 044323-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.077) question?
Stock # R6181 (G1)
Quality Score 225.009
Status Not validated
Chromosome 16
Chromosomal Location 45232131-45313332 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 45238260 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 185 (S185P)
Ref Sequence ENSEMBL: ENSMUSP00000156066 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000114585] [ENSMUST00000232138]
AlphaFold E9Q573
Predicted Effect probably benign
Transcript: ENSMUST00000114585
AA Change: S298P

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000110233
Gene: ENSMUSG00000053182
AA Change: S298P

DomainStartEndE-ValueType
IG 18 125 2.21e-5 SMART
transmembrane domain 233 255 N/A INTRINSIC
low complexity region 275 289 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000144346
Predicted Effect probably benign
Transcript: ENSMUST00000232138
AA Change: S185P

PolyPhen 2 Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.4%
  • 20x: 95.6%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 74 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Akr1b7 A G 6: 34,392,313 (GRCm39) H42R possibly damaging Het
Ankrd26 T A 6: 118,525,838 (GRCm39) H369L probably benign Het
Ano7 T C 1: 93,323,081 (GRCm39) S474P probably damaging Het
Aox3 T C 1: 58,198,105 (GRCm39) V639A probably benign Het
Arhgef2 T A 3: 88,542,927 (GRCm39) V358E probably damaging Het
Brpf3 A G 17: 29,029,555 (GRCm39) Y505C probably damaging Het
Casd1 A G 6: 4,619,331 (GRCm39) T120A probably damaging Het
Ccdc121 A G 5: 31,645,399 (GRCm39) E384G probably damaging Het
Clasp1 T G 1: 118,347,547 (GRCm39) S32A probably benign Het
Clca3a2 A T 3: 144,796,469 (GRCm39) L246* probably null Het
Clcn7 A G 17: 25,370,702 (GRCm39) I353V possibly damaging Het
Cluap1 T A 16: 3,751,608 (GRCm39) D322E probably benign Het
Cmtm4 A C 8: 105,082,997 (GRCm39) probably null Het
Cntnap2 C T 6: 46,736,742 (GRCm39) P723S probably damaging Het
Col6a3 T A 1: 90,744,096 (GRCm39) T84S possibly damaging Het
Corin A G 5: 72,529,439 (GRCm39) probably null Het
Cubn G A 2: 13,354,687 (GRCm39) T1903I probably benign Het
Cyp27b1 A C 10: 126,886,279 (GRCm39) D320A probably damaging Het
Cyp2j6 G C 4: 96,424,323 (GRCm39) L145V probably damaging Het
Dennd2a T C 6: 39,462,554 (GRCm39) K652R probably benign Het
Dnah8 G A 17: 30,967,542 (GRCm39) D2585N probably benign Het
Dock1 T A 7: 134,760,251 (GRCm39) M1638K probably damaging Het
Efcab3 T C 11: 104,722,159 (GRCm39) S1924P probably benign Het
Eya1 T C 1: 14,373,096 (GRCm39) S8G probably damaging Het
Fam193a T A 5: 34,600,884 (GRCm39) probably null Het
Fbxw11 T A 11: 32,692,575 (GRCm39) N515K probably benign Het
Gm6408 T C 5: 146,420,582 (GRCm39) V154A possibly damaging Het
Guf1 A G 5: 69,719,059 (GRCm39) Y235C probably damaging Het
Hnrnpul2 C T 19: 8,800,596 (GRCm39) S224L possibly damaging Het
Igkv8-19 T A 6: 70,317,968 (GRCm39) D86V probably damaging Het
Iqcf1 A T 9: 106,379,174 (GRCm39) D61V probably damaging Het
Lrp5 T C 19: 3,678,427 (GRCm39) D476G probably damaging Het
Luzp1 A G 4: 136,270,578 (GRCm39) T934A probably benign Het
Mboat7 A T 7: 3,686,884 (GRCm39) Y319N probably benign Het
Mdn1 A G 4: 32,715,953 (GRCm39) E2045G probably damaging Het
Mfsd14b T C 13: 65,260,398 (GRCm39) R12G probably benign Het
Micall2 T A 5: 139,702,506 (GRCm39) T246S probably benign Het
Npepps A G 11: 97,132,830 (GRCm39) V299A probably damaging Het
Or2y11 T A 11: 49,443,120 (GRCm39) V182D probably damaging Het
P2ry13 A G 3: 59,117,328 (GRCm39) V150A probably benign Het
Pdc T C 1: 150,209,021 (GRCm39) I168T probably damaging Het
Pde8b C T 13: 95,223,316 (GRCm39) E313K probably benign Het
Pgap1 C T 1: 54,551,936 (GRCm39) G499R probably benign Het
Ppp1r15b T A 1: 133,060,261 (GRCm39) C259* probably null Het
Pramel21 T A 4: 143,342,828 (GRCm39) probably null Het
Ptgs1 A G 2: 36,141,131 (GRCm39) E526G probably damaging Het
Ptpn21 A G 12: 98,666,258 (GRCm39) L271P probably damaging Het
Rbm47 T C 5: 66,183,833 (GRCm39) T257A possibly damaging Het
Rfc3 C T 5: 151,570,985 (GRCm39) D104N probably damaging Het
Rhobtb3 A G 13: 76,058,808 (GRCm39) I330T probably benign Het
Rnf207 T C 4: 152,393,305 (GRCm39) T570A probably benign Het
Rusf1 A G 7: 127,896,632 (GRCm39) probably null Het
Sbpl T C 17: 24,172,466 (GRCm39) H151R probably damaging Het
Sstr3 T C 15: 78,423,661 (GRCm39) D362G probably benign Het
St7 T C 6: 17,694,363 (GRCm39) probably null Het
Tasor T A 14: 27,194,235 (GRCm39) M1145K probably benign Het
Tdrd6 A G 17: 43,939,788 (GRCm39) V420A probably damaging Het
Tet2 C A 3: 133,193,520 (GRCm39) E305* probably null Het
Tmem209 A T 6: 30,505,970 (GRCm39) V68E probably damaging Het
Tmod4 A T 3: 95,035,118 (GRCm39) I208F probably damaging Het
Tpo G A 12: 30,181,884 (GRCm39) L4F probably benign Het
Urb1 T C 16: 90,575,982 (GRCm39) H858R probably benign Het
Utrn A G 10: 12,615,200 (GRCm39) W324R probably damaging Het
V1rd19 T A 7: 23,702,640 (GRCm39) F35L possibly damaging Het
Vmn1r170 C A 7: 23,305,692 (GRCm39) N31K probably damaging Het
Vmn1r192 T A 13: 22,371,452 (GRCm39) Y256F probably damaging Het
Vmn2r124 T C 17: 18,294,019 (GRCm39) I702T possibly damaging Het
Vmn2r96 G A 17: 18,804,126 (GRCm39) A459T probably benign Het
Vwf G T 6: 125,543,109 (GRCm39) A132S probably damaging Het
Zfp202 G A 9: 40,118,638 (GRCm39) G17E probably damaging Het
Zfp608 A G 18: 55,028,700 (GRCm39) S1238P possibly damaging Het
Zfp804a G T 2: 82,087,486 (GRCm39) M438I probably damaging Het
Zgrf1 G A 3: 127,381,590 (GRCm39) G246S probably damaging Het
Zwint T C 10: 72,492,431 (GRCm39) V115A probably benign Het
Other mutations in Cd200l1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00435:Cd200l1 APN 16 45,264,483 (GRCm39) missense probably damaging 1.00
IGL02822:Cd200l1 APN 16 45,262,968 (GRCm39) missense probably damaging 0.99
PIT4618001:Cd200l1 UTSW 16 45,264,297 (GRCm39) missense probably benign 0.08
R0565:Cd200l1 UTSW 16 45,264,536 (GRCm39) intron probably benign
R1561:Cd200l1 UTSW 16 45,262,875 (GRCm39) missense possibly damaging 0.90
R4632:Cd200l1 UTSW 16 45,238,271 (GRCm39) missense probably benign 0.34
R4667:Cd200l1 UTSW 16 45,264,526 (GRCm39) missense probably benign 0.01
R5887:Cd200l1 UTSW 16 45,238,279 (GRCm39) missense probably damaging 0.99
R6562:Cd200l1 UTSW 16 45,264,442 (GRCm39) missense probably benign 0.03
R6922:Cd200l1 UTSW 16 45,264,294 (GRCm39) missense probably benign 0.31
R6961:Cd200l1 UTSW 16 45,264,366 (GRCm39) missense probably benign 0.32
R7830:Cd200l1 UTSW 16 45,262,917 (GRCm39) missense probably damaging 1.00
R8133:Cd200l1 UTSW 16 45,264,304 (GRCm39) missense probably benign
R8459:Cd200l1 UTSW 16 45,238,271 (GRCm39) missense probably benign 0.06
R8483:Cd200l1 UTSW 16 45,240,235 (GRCm39) missense possibly damaging 0.92
R8810:Cd200l1 UTSW 16 45,264,199 (GRCm39) missense probably benign 0.04
R8950:Cd200l1 UTSW 16 45,263,007 (GRCm39) missense possibly damaging 0.46
R8988:Cd200l1 UTSW 16 45,238,271 (GRCm39) missense probably benign 0.01
R9040:Cd200l1 UTSW 16 45,264,509 (GRCm39) missense possibly damaging 0.82
R9729:Cd200l1 UTSW 16 45,264,237 (GRCm39) missense possibly damaging 0.63
X0011:Cd200l1 UTSW 16 45,240,234 (GRCm39) missense possibly damaging 0.92
X0019:Cd200l1 UTSW 16 45,263,008 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- CTACTGCACAGGAGGGTAATTATAG -3'
(R):5'- TTTTGCAATGTGCTGCCATG -3'

Sequencing Primer
(F):5'- CTGTGTGCTGCATATTTTTAAAACC -3'
(R):5'- CAATGTGCTGCCATGGAGGG -3'
Posted On 2017-10-10