Incidental Mutation 'R0525:Vps8'
| ID |
48873 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vps8
|
| Ensembl Gene |
ENSMUSG00000033653 |
| Gene Name |
VPS8 CORVET complex subunit |
| Synonyms |
|
| MMRRC Submission |
038718-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R0525 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
16 |
| Chromosomal Location |
21241868-21463430 bp(+) (GRCm39) |
| Type of Mutation |
critical splice donor site (1 bp from exon) |
| DNA Base Change (assembly) |
G to A
at 21358859 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000096191]
[ENSMUST00000096192]
[ENSMUST00000115397]
[ENSMUST00000115397]
[ENSMUST00000117598]
[ENSMUST00000118138]
[ENSMUST00000118923]
[ENSMUST00000122235]
[ENSMUST00000122235]
[ENSMUST00000156580]
|
| AlphaFold |
Q0P5W1 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000096191
|
| SMART Domains |
Protein: ENSMUSP00000093905
Gene: ENSMUSG00000033653
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
96 |
112 |
N/A |
INTRINSIC |
|
SCOP:d1g72a_
|
158 |
296 |
1e-8 |
SMART |
|
Blast:WD40
|
184 |
225 |
7e-22 |
BLAST |
|
Blast:WD40
|
228 |
268 |
5e-20 |
BLAST |
|
Pfam:Vps8
|
610 |
794 |
1.7e-61 |
PFAM |
|
low complexity region
|
992 |
1007 |
N/A |
INTRINSIC |
|
low complexity region
|
1085 |
1097 |
N/A |
INTRINSIC |
|
low complexity region
|
1126 |
1137 |
N/A |
INTRINSIC |
|
Blast:RING
|
1257 |
1277 |
1e-5 |
BLAST |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000096192
|
| SMART Domains |
Protein: ENSMUSP00000093906
Gene: ENSMUSG00000033653
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
96 |
112 |
N/A |
INTRINSIC |
|
SCOP:d1g72a_
|
158 |
298 |
1e-8 |
SMART |
|
Blast:WD40
|
186 |
227 |
8e-22 |
BLAST |
|
Blast:WD40
|
230 |
270 |
5e-20 |
BLAST |
|
Pfam:Vps8
|
612 |
796 |
1.4e-61 |
PFAM |
|
low complexity region
|
969 |
979 |
N/A |
INTRINSIC |
|
low complexity region
|
1057 |
1069 |
N/A |
INTRINSIC |
|
low complexity region
|
1098 |
1109 |
N/A |
INTRINSIC |
|
RING
|
1229 |
1280 |
1.23e-4 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000115397
|
| SMART Domains |
Protein: ENSMUSP00000111055
Gene: ENSMUSG00000033653
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
96 |
112 |
N/A |
INTRINSIC |
|
SCOP:d1g72a_
|
158 |
298 |
8e-9 |
SMART |
|
Blast:WD40
|
186 |
227 |
8e-22 |
BLAST |
|
Blast:WD40
|
230 |
270 |
5e-20 |
BLAST |
|
Pfam:Vps8
|
613 |
796 |
1.3e-61 |
PFAM |
|
low complexity region
|
994 |
1009 |
N/A |
INTRINSIC |
|
low complexity region
|
1087 |
1099 |
N/A |
INTRINSIC |
|
low complexity region
|
1128 |
1139 |
N/A |
INTRINSIC |
|
RING
|
1259 |
1310 |
1.23e-4 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000115397
|
| SMART Domains |
Protein: ENSMUSP00000111055
Gene: ENSMUSG00000033653
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
96 |
112 |
N/A |
INTRINSIC |
|
SCOP:d1g72a_
|
158 |
298 |
8e-9 |
SMART |
|
Blast:WD40
|
186 |
227 |
8e-22 |
BLAST |
|
Blast:WD40
|
230 |
270 |
5e-20 |
BLAST |
|
Pfam:Vps8
|
613 |
796 |
1.3e-61 |
PFAM |
|
low complexity region
|
994 |
1009 |
N/A |
INTRINSIC |
|
low complexity region
|
1087 |
1099 |
N/A |
INTRINSIC |
|
low complexity region
|
1128 |
1139 |
N/A |
INTRINSIC |
|
RING
|
1259 |
1310 |
1.23e-4 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000117598
|
| SMART Domains |
Protein: ENSMUSP00000112937
Gene: ENSMUSG00000033653
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
96 |
112 |
N/A |
INTRINSIC |
|
SCOP:d1g72a_
|
158 |
296 |
1e-8 |
SMART |
|
Blast:WD40
|
184 |
225 |
8e-22 |
BLAST |
|
Blast:WD40
|
228 |
268 |
5e-20 |
BLAST |
|
Pfam:Vps8
|
610 |
794 |
1.9e-61 |
PFAM |
|
low complexity region
|
992 |
1007 |
N/A |
INTRINSIC |
|
low complexity region
|
1085 |
1097 |
N/A |
INTRINSIC |
|
low complexity region
|
1126 |
1137 |
N/A |
INTRINSIC |
|
RING
|
1257 |
1308 |
1.23e-4 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000118138
|
| SMART Domains |
Protein: ENSMUSP00000113447
Gene: ENSMUSG00000033653
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Vps8
|
1 |
76 |
7.7e-21 |
PFAM |
|
low complexity region
|
274 |
289 |
N/A |
INTRINSIC |
|
low complexity region
|
367 |
379 |
N/A |
INTRINSIC |
|
low complexity region
|
408 |
419 |
N/A |
INTRINSIC |
|
RING
|
539 |
590 |
1.23e-4 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000118923
|
| SMART Domains |
Protein: ENSMUSP00000112636
Gene: ENSMUSG00000033653
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
96 |
112 |
N/A |
INTRINSIC |
|
SCOP:d1g72a_
|
158 |
298 |
9e-9 |
SMART |
|
Blast:WD40
|
186 |
227 |
8e-22 |
BLAST |
|
Blast:WD40
|
230 |
270 |
5e-20 |
BLAST |
|
Pfam:Vps8
|
612 |
796 |
1.9e-61 |
PFAM |
|
low complexity region
|
969 |
979 |
N/A |
INTRINSIC |
|
low complexity region
|
1057 |
1069 |
N/A |
INTRINSIC |
|
low complexity region
|
1098 |
1109 |
N/A |
INTRINSIC |
|
RING
|
1229 |
1280 |
1.23e-4 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000122235
|
| SMART Domains |
Protein: ENSMUSP00000112622
Gene: ENSMUSG00000033653
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
96 |
112 |
N/A |
INTRINSIC |
|
WD40
|
184 |
225 |
2.66e0 |
SMART |
|
WD40
|
228 |
269 |
5.5e1 |
SMART |
|
low complexity region
|
371 |
386 |
N/A |
INTRINSIC |
|
low complexity region
|
480 |
491 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000122235
|
| SMART Domains |
Protein: ENSMUSP00000112622
Gene: ENSMUSG00000033653
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
96 |
112 |
N/A |
INTRINSIC |
|
WD40
|
184 |
225 |
2.66e0 |
SMART |
|
WD40
|
228 |
269 |
5.5e1 |
SMART |
|
low complexity region
|
371 |
386 |
N/A |
INTRINSIC |
|
low complexity region
|
480 |
491 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000125487
|
| SMART Domains |
Protein: ENSMUSP00000114719
Gene: ENSMUSG00000033653
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Vps8
|
182 |
365 |
8.5e-62 |
PFAM |
|
low complexity region
|
563 |
578 |
N/A |
INTRINSIC |
|
low complexity region
|
656 |
668 |
N/A |
INTRINSIC |
|
low complexity region
|
697 |
708 |
N/A |
INTRINSIC |
|
RING
|
828 |
879 |
1.23e-4 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000156580
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000232357
|
| Meta Mutation Damage Score |
0.9586 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 96.7%
- 20x: 93.8%
|
| Validation Efficiency |
100% (72/72) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 69 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4933440M02Rik |
T |
A |
7: 124,930,671 (GRCm39) |
|
noncoding transcript |
Het |
| A930002H24Rik |
A |
G |
17: 64,170,642 (GRCm39) |
W49R |
unknown |
Het |
| Abca13 |
G |
A |
11: 9,243,371 (GRCm39) |
V1745M |
probably damaging |
Het |
| Abca16 |
T |
G |
7: 120,065,033 (GRCm39) |
Y563* |
probably null |
Het |
| Acot12 |
C |
T |
13: 91,908,186 (GRCm39) |
|
probably benign |
Het |
| Alms1 |
G |
A |
6: 85,564,742 (GRCm39) |
A39T |
unknown |
Het |
| Arid5b |
T |
C |
10: 67,933,676 (GRCm39) |
D742G |
possibly damaging |
Het |
| Atp1a4 |
G |
A |
1: 172,067,255 (GRCm39) |
|
probably benign |
Het |
| AU021092 |
T |
A |
16: 5,035,725 (GRCm39) |
E145V |
possibly damaging |
Het |
| Calr4 |
A |
T |
4: 109,099,461 (GRCm39) |
|
probably benign |
Het |
| Clip4 |
T |
A |
17: 72,106,093 (GRCm39) |
|
probably null |
Het |
| Cnpy4 |
A |
T |
5: 138,190,878 (GRCm39) |
H180L |
probably benign |
Het |
| Cyp2j9 |
T |
C |
4: 96,467,802 (GRCm39) |
|
probably null |
Het |
| Dgkq |
A |
G |
5: 108,802,481 (GRCm39) |
S406P |
probably damaging |
Het |
| Dhx8 |
G |
A |
11: 101,654,754 (GRCm39) |
C1014Y |
probably damaging |
Het |
| Dnah3 |
T |
C |
7: 119,527,977 (GRCm39) |
Y3824C |
probably damaging |
Het |
| Donson |
A |
T |
16: 91,483,133 (GRCm39) |
H69Q |
probably damaging |
Het |
| Dppa3 |
A |
G |
6: 122,606,939 (GRCm39) |
E143G |
probably damaging |
Het |
| Drg1 |
A |
G |
11: 3,212,545 (GRCm39) |
F96L |
probably damaging |
Het |
| Dvl1 |
A |
C |
4: 155,940,052 (GRCm39) |
T395P |
probably damaging |
Het |
| Eftud2 |
A |
T |
11: 102,730,079 (GRCm39) |
V897D |
probably damaging |
Het |
| Enpp6 |
A |
G |
8: 47,535,478 (GRCm39) |
N341S |
possibly damaging |
Het |
| F11 |
A |
G |
8: 45,706,086 (GRCm39) |
F100L |
probably benign |
Het |
| Fas |
T |
C |
19: 34,296,727 (GRCm39) |
Y189H |
probably damaging |
Het |
| Galnt14 |
G |
T |
17: 73,852,076 (GRCm39) |
S114R |
probably damaging |
Het |
| Gfpt2 |
A |
G |
11: 49,720,602 (GRCm39) |
I528V |
probably benign |
Het |
| Glt6d1 |
A |
G |
2: 25,684,280 (GRCm39) |
V242A |
possibly damaging |
Het |
| Grm1 |
A |
T |
10: 10,594,953 (GRCm39) |
|
probably benign |
Het |
| Gskip |
G |
A |
12: 105,665,224 (GRCm39) |
A88T |
probably damaging |
Het |
| Gtpbp1 |
A |
G |
15: 79,597,648 (GRCm39) |
I348V |
probably benign |
Het |
| Hnrnpul1 |
C |
A |
7: 25,440,308 (GRCm39) |
R316L |
possibly damaging |
Het |
| Il34 |
T |
C |
8: 111,474,915 (GRCm39) |
E121G |
probably damaging |
Het |
| Lrr1 |
T |
C |
12: 69,215,685 (GRCm39) |
L19P |
probably damaging |
Het |
| Mat2b |
A |
G |
11: 40,573,496 (GRCm39) |
|
probably benign |
Het |
| Mettl21e |
T |
C |
1: 44,245,542 (GRCm39) |
K235E |
probably damaging |
Het |
| Mir124-2hg |
T |
A |
3: 17,839,693 (GRCm39) |
E126V |
possibly damaging |
Het |
| Myh15 |
A |
G |
16: 48,952,414 (GRCm39) |
K828R |
probably benign |
Het |
| Myom3 |
A |
G |
4: 135,492,237 (GRCm39) |
D127G |
possibly damaging |
Het |
| Nek5 |
C |
A |
8: 22,569,093 (GRCm39) |
|
probably benign |
Het |
| Nudt7 |
A |
T |
8: 114,878,392 (GRCm39) |
|
probably null |
Het |
| Or10ag56 |
A |
T |
2: 87,139,693 (GRCm39) |
T187S |
probably benign |
Het |
| Or10d4c |
T |
G |
9: 39,558,767 (GRCm39) |
C248W |
probably damaging |
Het |
| Or1j4 |
T |
C |
2: 36,740,202 (GRCm39) |
L48P |
probably damaging |
Het |
| Or4a67 |
G |
A |
2: 88,597,658 (GRCm39) |
Q334* |
probably null |
Het |
| Or8k23 |
C |
T |
2: 86,186,619 (GRCm39) |
V36I |
probably benign |
Het |
| Phyhd1 |
A |
G |
2: 30,171,040 (GRCm39) |
H241R |
probably damaging |
Het |
| Pmch |
T |
C |
10: 87,927,262 (GRCm39) |
|
probably benign |
Het |
| Ror1 |
A |
G |
4: 100,298,717 (GRCm39) |
S697G |
probably damaging |
Het |
| Rslcan18 |
A |
G |
13: 67,260,322 (GRCm39) |
V25A |
probably benign |
Het |
| Sema6b |
T |
C |
17: 56,433,630 (GRCm39) |
H426R |
probably damaging |
Het |
| Serpina3g |
T |
C |
12: 104,204,598 (GRCm39) |
F9S |
probably damaging |
Het |
| Serpinb12 |
T |
A |
1: 106,874,432 (GRCm39) |
H52Q |
probably benign |
Het |
| Sh3gl1 |
T |
C |
17: 56,324,873 (GRCm39) |
K294R |
probably benign |
Het |
| Sidt1 |
G |
T |
16: 44,079,809 (GRCm39) |
T615K |
possibly damaging |
Het |
| Slc16a4 |
A |
C |
3: 107,205,255 (GRCm39) |
|
probably benign |
Het |
| Sned1 |
T |
A |
1: 93,199,696 (GRCm39) |
|
probably null |
Het |
| Sp2 |
A |
T |
11: 96,846,924 (GRCm39) |
|
probably benign |
Het |
| Steap1 |
T |
A |
5: 5,792,903 (GRCm39) |
I3F |
possibly damaging |
Het |
| Stxbp5l |
A |
T |
16: 36,950,159 (GRCm39) |
|
probably null |
Het |
| Tbc1d9 |
G |
T |
8: 83,995,614 (GRCm39) |
V968F |
probably benign |
Het |
| Tnfrsf21 |
C |
T |
17: 43,349,104 (GRCm39) |
H239Y |
probably benign |
Het |
| Triobp |
T |
C |
15: 78,858,098 (GRCm39) |
L1233P |
possibly damaging |
Het |
| Trp53bp1 |
C |
A |
2: 121,082,349 (GRCm39) |
A317S |
probably null |
Het |
| Trpc4ap |
A |
G |
2: 155,482,398 (GRCm39) |
F531L |
possibly damaging |
Het |
| Ugt1a10 |
C |
T |
1: 88,145,971 (GRCm39) |
P473L |
probably damaging |
Het |
| Vmn1r86 |
T |
C |
7: 12,836,088 (GRCm39) |
K213E |
probably benign |
Het |
| Wnk1 |
A |
T |
6: 119,903,525 (GRCm39) |
S2563T |
probably damaging |
Het |
| Yrdc |
C |
G |
4: 124,745,559 (GRCm39) |
R3G |
probably damaging |
Het |
| Zfp287 |
A |
T |
11: 62,606,070 (GRCm39) |
V279E |
probably benign |
Het |
|
| Other mutations in Vps8 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00500:Vps8
|
APN |
16 |
21,261,084 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
IGL00596:Vps8
|
APN |
16 |
21,267,162 (GRCm39) |
splice site |
probably benign |
|
|
IGL00985:Vps8
|
APN |
16 |
21,296,334 (GRCm39) |
splice site |
probably benign |
|
|
IGL01356:Vps8
|
APN |
16 |
21,336,107 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01375:Vps8
|
APN |
16 |
21,378,122 (GRCm39) |
nonsense |
probably null |
|
|
IGL01643:Vps8
|
APN |
16 |
21,336,972 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
IGL02159:Vps8
|
APN |
16 |
21,285,234 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
IGL02214:Vps8
|
APN |
16 |
21,336,035 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02465:Vps8
|
APN |
16 |
21,340,653 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02651:Vps8
|
APN |
16 |
21,336,086 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03174:Vps8
|
APN |
16 |
21,285,213 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03337:Vps8
|
APN |
16 |
21,381,918 (GRCm39) |
missense |
probably benign |
|
|
IGL03383:Vps8
|
APN |
16 |
21,254,573 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL03402:Vps8
|
APN |
16 |
21,267,148 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
empires
|
UTSW |
16 |
21,400,298 (GRCm39) |
nonsense |
probably null |
|
|
porky
|
UTSW |
16 |
21,279,988 (GRCm39) |
missense |
probably benign |
0.32 |
|
realm
|
UTSW |
16 |
21,363,986 (GRCm39) |
intron |
probably benign |
|
|
realms
|
UTSW |
16 |
21,262,938 (GRCm39) |
splice site |
probably null |
|
|
Reich
|
UTSW |
16 |
21,297,189 (GRCm39) |
missense |
probably benign |
0.29 |
|
reichen
|
UTSW |
16 |
21,325,575 (GRCm39) |
splice site |
probably benign |
|
|
IGL03052:Vps8
|
UTSW |
16 |
21,267,115 (GRCm39) |
missense |
probably damaging |
0.99 |
|
PIT4677001:Vps8
|
UTSW |
16 |
21,319,084 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R0066:Vps8
|
UTSW |
16 |
21,296,273 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R0066:Vps8
|
UTSW |
16 |
21,296,273 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R0125:Vps8
|
UTSW |
16 |
21,288,904 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0137:Vps8
|
UTSW |
16 |
21,323,136 (GRCm39) |
splice site |
probably benign |
|
|
R0362:Vps8
|
UTSW |
16 |
21,426,977 (GRCm39) |
intron |
probably benign |
|
|
R0384:Vps8
|
UTSW |
16 |
21,325,575 (GRCm39) |
splice site |
probably benign |
|
|
R0492:Vps8
|
UTSW |
16 |
21,261,107 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0531:Vps8
|
UTSW |
16 |
21,278,561 (GRCm39) |
intron |
probably benign |
|
|
R0605:Vps8
|
UTSW |
16 |
21,378,087 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0636:Vps8
|
UTSW |
16 |
21,253,683 (GRCm39) |
missense |
probably benign |
0.32 |
|
R0707:Vps8
|
UTSW |
16 |
21,261,107 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0840:Vps8
|
UTSW |
16 |
21,275,071 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1170:Vps8
|
UTSW |
16 |
21,278,570 (GRCm39) |
intron |
probably benign |
|
|
R1203:Vps8
|
UTSW |
16 |
21,330,307 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1482:Vps8
|
UTSW |
16 |
21,400,348 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1531:Vps8
|
UTSW |
16 |
21,285,226 (GRCm39) |
nonsense |
probably null |
|
|
R1642:Vps8
|
UTSW |
16 |
21,400,329 (GRCm39) |
missense |
probably benign |
|
|
R1956:Vps8
|
UTSW |
16 |
21,279,892 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2201:Vps8
|
UTSW |
16 |
21,395,507 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2287:Vps8
|
UTSW |
16 |
21,387,163 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2423:Vps8
|
UTSW |
16 |
21,378,087 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3151:Vps8
|
UTSW |
16 |
21,261,123 (GRCm39) |
missense |
probably benign |
0.04 |
|
R3943:Vps8
|
UTSW |
16 |
21,288,873 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3944:Vps8
|
UTSW |
16 |
21,288,873 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4043:Vps8
|
UTSW |
16 |
21,345,146 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4302:Vps8
|
UTSW |
16 |
21,314,664 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4398:Vps8
|
UTSW |
16 |
21,323,216 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4477:Vps8
|
UTSW |
16 |
21,363,986 (GRCm39) |
intron |
probably benign |
|
|
R4478:Vps8
|
UTSW |
16 |
21,363,986 (GRCm39) |
intron |
probably benign |
|
|
R4479:Vps8
|
UTSW |
16 |
21,363,986 (GRCm39) |
intron |
probably benign |
|
|
R4480:Vps8
|
UTSW |
16 |
21,363,986 (GRCm39) |
intron |
probably benign |
|
|
R4571:Vps8
|
UTSW |
16 |
21,254,525 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4653:Vps8
|
UTSW |
16 |
21,318,960 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4664:Vps8
|
UTSW |
16 |
21,262,938 (GRCm39) |
splice site |
probably null |
|
|
R4713:Vps8
|
UTSW |
16 |
21,261,189 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4726:Vps8
|
UTSW |
16 |
21,267,154 (GRCm39) |
splice site |
probably null |
|
|
R4959:Vps8
|
UTSW |
16 |
21,278,536 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4973:Vps8
|
UTSW |
16 |
21,278,536 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4975:Vps8
|
UTSW |
16 |
21,285,219 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4992:Vps8
|
UTSW |
16 |
21,280,158 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R5144:Vps8
|
UTSW |
16 |
21,378,103 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5168:Vps8
|
UTSW |
16 |
21,351,849 (GRCm39) |
missense |
probably benign |
0.05 |
|
R5168:Vps8
|
UTSW |
16 |
21,276,195 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5222:Vps8
|
UTSW |
16 |
21,400,298 (GRCm39) |
nonsense |
probably null |
|
|
R5231:Vps8
|
UTSW |
16 |
21,395,475 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5876:Vps8
|
UTSW |
16 |
21,280,189 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5963:Vps8
|
UTSW |
16 |
21,288,871 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R6010:Vps8
|
UTSW |
16 |
21,363,955 (GRCm39) |
intron |
probably benign |
|
|
R6023:Vps8
|
UTSW |
16 |
21,279,988 (GRCm39) |
missense |
probably benign |
0.32 |
|
R6173:Vps8
|
UTSW |
16 |
21,314,682 (GRCm39) |
splice site |
probably null |
|
|
R6185:Vps8
|
UTSW |
16 |
21,288,891 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6264:Vps8
|
UTSW |
16 |
21,378,099 (GRCm39) |
nonsense |
probably null |
|
|
R6409:Vps8
|
UTSW |
16 |
21,297,189 (GRCm39) |
missense |
probably benign |
0.29 |
|
R6522:Vps8
|
UTSW |
16 |
21,261,129 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6528:Vps8
|
UTSW |
16 |
21,372,875 (GRCm39) |
nonsense |
probably null |
|
|
R6784:Vps8
|
UTSW |
16 |
21,381,957 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7040:Vps8
|
UTSW |
16 |
21,393,772 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7072:Vps8
|
UTSW |
16 |
21,400,329 (GRCm39) |
missense |
probably benign |
|
|
R7103:Vps8
|
UTSW |
16 |
21,345,191 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7149:Vps8
|
UTSW |
16 |
21,278,526 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7195:Vps8
|
UTSW |
16 |
21,275,032 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7206:Vps8
|
UTSW |
16 |
21,276,171 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7403:Vps8
|
UTSW |
16 |
21,253,722 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R7782:Vps8
|
UTSW |
16 |
21,330,308 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R7806:Vps8
|
UTSW |
16 |
21,278,501 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7846:Vps8
|
UTSW |
16 |
21,351,070 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7943:Vps8
|
UTSW |
16 |
21,296,622 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R8075:Vps8
|
UTSW |
16 |
21,340,644 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8190:Vps8
|
UTSW |
16 |
21,393,780 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R8307:Vps8
|
UTSW |
16 |
21,314,652 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8483:Vps8
|
UTSW |
16 |
21,393,763 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8814:Vps8
|
UTSW |
16 |
21,395,400 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9064:Vps8
|
UTSW |
16 |
21,288,979 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9367:Vps8
|
UTSW |
16 |
21,340,668 (GRCm39) |
missense |
possibly damaging |
0.45 |
|
R9404:Vps8
|
UTSW |
16 |
21,426,927 (GRCm39) |
missense |
probably benign |
0.12 |
|
R9544:Vps8
|
UTSW |
16 |
21,336,893 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9570:Vps8
|
UTSW |
16 |
21,462,953 (GRCm39) |
missense |
probably benign |
0.10 |
|
R9634:Vps8
|
UTSW |
16 |
21,372,893 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9702:Vps8
|
UTSW |
16 |
21,462,883 (GRCm39) |
missense |
probably benign |
0.17 |
|
| Predicted Primers |
PCR Primer
(F):5'- AGGCTCATGACAGTACCAAGCCTC -3'
(R):5'- GATTAATGCACAGCTCCTCCCATCC -3'
Sequencing Primer
(F):5'- AGTACCAAGCCTCATGTCTATG -3'
(R):5'- acacaacataccacacaaacag -3'
|
| Posted On |
2013-06-12 |
Incidental Mutation