Incidental Mutation 'R0526:Fcgr4'
ID 48890
Institutional Source Beutler Lab
Gene Symbol Fcgr4
Ensembl Gene ENSMUSG00000059089
Gene Name Fc receptor, IgG, low affinity IV
Synonyms CD16-2, 4833442P21Rik, Fcgr3a, FcgammaRIV
MMRRC Submission 038719-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.055) question?
Stock # R0526 (G1)
Quality Score 157
Status Not validated
Chromosome 1
Chromosomal Location 170846495-170857330 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 170856760 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Glutamine at position 209 (L209Q)
Ref Sequence ENSEMBL: ENSMUSP00000077873 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000078825]
AlphaFold A0A0B4J1G0
Predicted Effect probably damaging
Transcript: ENSMUST00000078825
AA Change: L209Q

PolyPhen 2 Score 0.977 (Sensitivity: 0.76; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000077873
Gene: ENSMUSG00000059089
AA Change: L209Q

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
IG 31 104 5.79e-9 SMART
IG 112 188 1.44e-4 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000083971
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.3%
  • 10x: 96.1%
  • 20x: 92.0%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit decreased susceptibility to induced arthritis and nephrotoxic nephritis. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 66 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700013G24Rik A T 4: 137,182,535 (GRCm39) N230I possibly damaging Het
4933427D14Rik G T 11: 72,060,609 (GRCm39) Q687K probably damaging Het
Actrt2 A G 4: 154,751,869 (GRCm39) L89P probably damaging Het
Adamts1 A C 16: 85,599,260 (GRCm39) S113R probably benign Het
Agxt2 G T 15: 10,373,948 (GRCm39) C118F probably damaging Het
Akap8 G A 17: 32,536,266 (GRCm39) T49I probably benign Het
Alk A T 17: 72,176,748 (GRCm39) W1519R probably damaging Het
Atf7ip T A 6: 136,536,803 (GRCm39) F12Y probably damaging Het
Atp13a5 A G 16: 29,167,558 (GRCm39) C131R probably damaging Het
Atp8b4 A G 2: 126,269,283 (GRCm39) L168P probably damaging Het
Blm G T 7: 80,155,641 (GRCm39) S346* probably null Het
Ccnt2 T G 1: 127,727,182 (GRCm39) C199G probably damaging Het
Cd151 A T 7: 141,050,504 (GRCm39) H219L probably damaging Het
Cd200r2 A T 16: 44,735,410 (GRCm39) R248S probably damaging Het
Cdh3 A G 8: 107,282,078 (GRCm39) D822G possibly damaging Het
Clec4b1 T C 6: 123,046,729 (GRCm39) probably null Het
Cluh C A 11: 74,556,812 (GRCm39) L951I probably benign Het
Cog7 A T 7: 121,562,494 (GRCm39) probably null Het
Col25a1 C A 3: 130,270,043 (GRCm39) P197Q probably damaging Het
Csde1 T A 3: 102,963,742 (GRCm39) S636R possibly damaging Het
Ect2l C A 10: 18,075,688 (GRCm39) C66F possibly damaging Het
Elac2 T C 11: 64,890,262 (GRCm39) M671T probably benign Het
Evi5 T C 5: 107,969,614 (GRCm39) N143S probably benign Het
Ext2 A G 2: 93,636,430 (GRCm39) V228A probably damaging Het
Fbxo38 A G 18: 62,639,051 (GRCm39) Y1084H probably damaging Het
Fgd3 C T 13: 49,450,000 (GRCm39) S83N probably benign Het
Gigyf2 T A 1: 87,349,215 (GRCm39) M664K probably benign Het
Il27ra A T 8: 84,766,128 (GRCm39) S219T probably benign Het
Itprid2 A G 2: 79,487,690 (GRCm39) D591G probably benign Het
Kif15 T C 9: 122,826,862 (GRCm39) V800A probably damaging Het
Lmo7 T A 14: 102,137,996 (GRCm39) D666E probably damaging Het
Lrp5 T C 19: 3,678,295 (GRCm39) D520G probably damaging Het
Lrriq3 T A 3: 154,893,934 (GRCm39) M545K probably benign Het
Lsm5 T A 6: 56,680,310 (GRCm39) D44V probably damaging Het
Man1c1 G T 4: 134,296,379 (GRCm39) Y430* probably null Het
Map4 T A 9: 109,866,346 (GRCm39) probably null Het
Megf6 A G 4: 154,343,398 (GRCm39) K561R probably benign Het
Myo1e T C 9: 70,229,680 (GRCm39) Y173H probably damaging Het
Myo6 T A 9: 80,190,823 (GRCm39) S791R possibly damaging Het
Nol11 C A 11: 107,075,597 (GRCm39) E144* probably null Het
Ntng2 C T 2: 29,087,074 (GRCm39) R416Q probably damaging Het
Nxpe3 T A 16: 55,686,880 (GRCm39) I43F possibly damaging Het
Or4g17 T A 2: 111,209,837 (GRCm39) V164E possibly damaging Het
Or5t5 A T 2: 86,616,691 (GRCm39) T206S possibly damaging Het
Pkd1l2 T C 8: 117,808,999 (GRCm39) I64V probably damaging Het
Prf1 G A 10: 61,136,033 (GRCm39) R103H probably benign Het
Rest A G 5: 77,428,874 (GRCm39) D431G probably damaging Het
Serpina10 A T 12: 103,583,127 (GRCm39) L439Q probably damaging Het
Sgk3 T G 1: 9,951,804 (GRCm39) V176G probably damaging Het
Slc19a3 A G 1: 83,000,454 (GRCm39) S188P probably damaging Het
Sorbs1 A G 19: 40,338,392 (GRCm39) I336T probably damaging Het
Strip1 C T 3: 107,527,355 (GRCm39) probably null Het
Syt4 T C 18: 31,576,799 (GRCm39) E185G possibly damaging Het
Tcaf3 T A 6: 42,566,738 (GRCm39) I784F probably damaging Het
Tgfbr3l G T 8: 4,299,439 (GRCm39) R74L possibly damaging Het
Thoc7 A G 14: 13,949,282 (GRCm38) M194T probably benign Het
Thsd7b T C 1: 129,879,129 (GRCm39) Y989H probably damaging Het
Tmem156 C T 5: 65,233,161 (GRCm39) V134I probably benign Het
Tnks A T 8: 35,320,457 (GRCm39) V738E probably benign Het
Trpm6 A T 19: 18,770,240 (GRCm39) I342F probably damaging Het
Vmn2r69 A T 7: 85,060,711 (GRCm39) V291D probably damaging Het
Wdr59 GGGTGGTG GGGTG 8: 112,207,172 (GRCm39) probably benign Het
Wnk1 T C 6: 119,928,953 (GRCm39) T1292A probably damaging Het
Yes1 T A 5: 32,812,584 (GRCm39) C285S probably benign Het
Zbed6 T C 1: 133,586,472 (GRCm39) I288M probably damaging Het
Zbtb49 T C 5: 38,371,263 (GRCm39) N206S probably benign Het
Other mutations in Fcgr4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01015:Fcgr4 APN 1 170,853,358 (GRCm39) missense possibly damaging 0.72
R0193:Fcgr4 UTSW 1 170,853,329 (GRCm39) missense possibly damaging 0.76
R1164:Fcgr4 UTSW 1 170,856,739 (GRCm39) missense possibly damaging 0.75
R1544:Fcgr4 UTSW 1 170,847,523 (GRCm39) missense probably damaging 1.00
R1716:Fcgr4 UTSW 1 170,847,672 (GRCm39) missense probably damaging 1.00
R1905:Fcgr4 UTSW 1 170,856,874 (GRCm39) missense probably damaging 0.99
R6012:Fcgr4 UTSW 1 170,853,233 (GRCm39) missense possibly damaging 0.80
R6043:Fcgr4 UTSW 1 170,847,699 (GRCm39) missense probably damaging 1.00
R6333:Fcgr4 UTSW 1 170,856,838 (GRCm39) missense probably damaging 0.97
R7034:Fcgr4 UTSW 1 170,847,657 (GRCm39) missense probably benign 0.00
R7036:Fcgr4 UTSW 1 170,847,657 (GRCm39) missense probably benign 0.00
R8123:Fcgr4 UTSW 1 170,847,572 (GRCm39) missense probably benign
R8791:Fcgr4 UTSW 1 170,847,477 (GRCm39) missense probably damaging 1.00
R9325:Fcgr4 UTSW 1 170,847,711 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GTAGACAACATACCTTGCCAGTCCC -3'
(R):5'- CAAAGCATGGTGACCAATGCAGC -3'

Sequencing Primer
(F):5'- GACTAAGCATCTGAGCTTCTGAG -3'
(R):5'- TGAGGTTGCAAGCTCCCAG -3'
Posted On 2013-06-12