Incidental Mutation 'R6148:Or4c15'
ID 488996
Institutional Source Beutler Lab
Gene Symbol Or4c15
Ensembl Gene ENSMUSG00000075112
Gene Name olfactory receptor family 4 subfamily C member 15
Synonyms MOR233-16P, MOR233-21, GA_x6K02T2Q125-50409367-50408432, Olfr1211
MMRRC Submission 044295-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.076) question?
Stock # R6148 (G1)
Quality Score 225.009
Status Validated
Chromosome 2
Chromosomal Location 88759722-88764870 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 88760597 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Isoleucine at position 21 (V21I)
Ref Sequence ENSEMBL: ENSMUSP00000150571 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099808] [ENSMUST00000213412] [ENSMUST00000215205]
AlphaFold Q7TR09
Predicted Effect probably benign
Transcript: ENSMUST00000099808
AA Change: V21I

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
SMART Domains Protein: ENSMUSP00000097396
Gene: ENSMUSG00000075112
AA Change: V21I

DomainStartEndE-ValueType
Pfam:7tm_4 29 303 9.5e-49 PFAM
Pfam:7tm_1 39 286 2.5e-14 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000141958
Predicted Effect probably benign
Transcript: ENSMUST00000213412
AA Change: V21I

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
Predicted Effect probably benign
Transcript: ENSMUST00000215205
AA Change: V21I

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
Meta Mutation Damage Score 0.0798 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.1%
  • 20x: 94.6%
Validation Efficiency 95% (61/64)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2700049A03Rik T A 12: 71,234,200 (GRCm39) C1067S possibly damaging Het
AAdacl4fm3 T C 4: 144,447,887 (GRCm39) T30A possibly damaging Het
Agbl3 T A 6: 34,834,688 (GRCm39) S952R possibly damaging Het
Ano9 A G 7: 140,686,698 (GRCm39) Y429H probably damaging Het
Bbs7 C A 3: 36,667,415 (GRCm39) R7L probably damaging Het
Birc2 T A 9: 7,849,684 (GRCm39) D535V possibly damaging Het
Catsper4 A G 4: 133,945,240 (GRCm39) V206A probably damaging Het
Ccdc73 T G 2: 104,822,482 (GRCm39) S810R possibly damaging Het
Cd177 A T 7: 24,443,698 (GRCm39) L800* probably null Het
Cd34 T C 1: 194,630,316 (GRCm39) probably null Het
Cep78 G A 19: 15,959,150 (GRCm39) R95* probably null Het
Cfap69 T C 5: 5,713,996 (GRCm39) D12G probably benign Het
Cpne7 A G 8: 123,854,171 (GRCm39) D286G probably benign Het
Cwc22 ATCTCTCTCTCTCTCTCT ATCTCTCTCTCTCTCT 2: 77,759,803 (GRCm39) probably null Het
Cxcl5 A T 5: 90,907,565 (GRCm39) I46L probably benign Het
Cyp19a1 C T 9: 54,087,540 (GRCm39) G59D probably damaging Het
Dclre1c A G 2: 3,438,742 (GRCm39) D35G probably damaging Het
Defa41 A G 8: 21,692,428 (GRCm39) N83S probably benign Het
Dvl1 A G 4: 155,939,409 (GRCm39) Y279C probably damaging Het
Fes A G 7: 80,030,044 (GRCm39) L578P probably damaging Het
Fkbpl G A 17: 34,864,303 (GRCm39) A24T probably benign Het
Fmn2 T C 1: 174,494,229 (GRCm39) S1248P probably damaging Het
Fmo1 T G 1: 162,679,088 (GRCm39) S53R probably damaging Het
Gabrg1 A T 5: 70,931,804 (GRCm39) M313K probably damaging Het
Galnt10 T C 11: 57,675,474 (GRCm39) C578R probably damaging Het
Gpr39 T C 1: 125,800,323 (GRCm39) V358A probably damaging Het
Gsap A G 5: 21,431,323 (GRCm39) R216G probably damaging Het
Gsap A T 5: 21,475,575 (GRCm39) T570S probably benign Het
Gucy2d A T 7: 98,093,030 (GRCm39) I136L probably benign Het
Hap1 A T 11: 100,240,218 (GRCm39) V294E probably damaging Het
Ipo8 A G 6: 148,701,278 (GRCm39) V514A probably damaging Het
Irf5 T C 6: 29,535,958 (GRCm39) L324P probably damaging Het
Itsn1 C T 16: 91,613,740 (GRCm39) R251C probably damaging Het
Klf11 T C 12: 24,701,567 (GRCm39) probably null Het
Kpna6 G A 4: 129,543,099 (GRCm39) Q439* probably null Het
Mark4 A T 7: 19,163,441 (GRCm39) S563T probably benign Het
Mrpl21 A T 19: 3,333,084 (GRCm39) I5L probably benign Het
Muc4 T C 16: 32,753,802 (GRCm38) I1226T probably benign Het
Myrf G A 19: 10,189,839 (GRCm39) T815I probably damaging Het
Olfr515-ps1 A T 7: 108,444,178 (GRCm39) probably null Het
Or10d4c G T 9: 39,558,555 (GRCm39) D178Y probably damaging Het
Or11g27 A G 14: 50,771,778 (GRCm39) N303S probably benign Het
Or52n3 A G 7: 104,530,289 (GRCm39) Y125C possibly damaging Het
Os9 T C 10: 126,935,812 (GRCm39) D280G probably benign Het
Pcdhb14 A G 18: 37,582,283 (GRCm39) N463S probably damaging Het
Pex19 G A 1: 171,961,606 (GRCm39) E271K probably damaging Het
Ppdpf G A 2: 180,829,641 (GRCm39) S32N probably benign Het
Prdm2 A G 4: 142,859,477 (GRCm39) I1271T probably benign Het
Rbbp4 T C 4: 129,215,751 (GRCm39) T262A probably benign Het
Rnd2 C T 11: 101,359,825 (GRCm39) L57F probably damaging Het
Spaca9 G A 2: 28,583,793 (GRCm39) R64W probably damaging Het
Sult1e1 A T 5: 87,727,770 (GRCm39) S171T probably damaging Het
Tns1 T C 1: 73,992,612 (GRCm39) T689A probably damaging Het
Unc13c G C 9: 73,600,648 (GRCm39) N1365K probably benign Het
Vmn2r52 T C 7: 9,905,090 (GRCm39) I250V probably benign Het
Vmn2r55 C A 7: 12,402,069 (GRCm39) L406F probably benign Het
Wdcp T C 12: 4,900,621 (GRCm39) V159A possibly damaging Het
Zbtb3 C T 19: 8,781,560 (GRCm39) A391V probably benign Het
Znhit1 A T 5: 137,011,487 (GRCm39) S109T probably benign Het
Other mutations in Or4c15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02724:Or4c15 APN 2 88,759,792 (GRCm39) missense probably damaging 1.00
IGL02936:Or4c15 APN 2 88,760,128 (GRCm39) missense probably benign 0.01
IGL02960:Or4c15 APN 2 88,760,128 (GRCm39) missense possibly damaging 0.80
IGL02989:Or4c15 APN 2 88,760,048 (GRCm39) missense possibly damaging 0.72
R0193:Or4c15 UTSW 2 88,760,627 (GRCm39) missense probably benign 0.01
R0413:Or4c15 UTSW 2 88,759,906 (GRCm39) missense probably benign 0.16
R1644:Or4c15 UTSW 2 88,759,731 (GRCm39) missense probably benign 0.01
R3715:Or4c15 UTSW 2 88,759,757 (GRCm39) missense probably benign 0.07
R4019:Or4c15 UTSW 2 88,760,080 (GRCm39) missense probably benign 0.02
R4722:Or4c15 UTSW 2 88,760,324 (GRCm39) missense possibly damaging 0.91
R4751:Or4c15 UTSW 2 88,760,258 (GRCm39) missense probably damaging 1.00
R4859:Or4c15 UTSW 2 88,760,627 (GRCm39) missense probably benign 0.01
R5053:Or4c15 UTSW 2 88,760,597 (GRCm39) missense probably benign 0.02
R7064:Or4c15 UTSW 2 88,759,853 (GRCm39) missense probably benign 0.00
R7527:Or4c15 UTSW 2 88,760,434 (GRCm39) missense probably benign 0.00
R7584:Or4c15 UTSW 2 88,760,149 (GRCm39) missense probably damaging 1.00
R7989:Or4c15 UTSW 2 88,759,858 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- CATCTTTGGTGTGATGACAGAAGAG -3'
(R):5'- CATGTGTTGGGCAAAGCAC -3'

Sequencing Primer
(F):5'- TGACAGAAGAGAAGCATGCATCC -3'
(R):5'- TTGGGCAAAGCACTGTTTTC -3'
Posted On 2017-10-10