Incidental Mutation 'R6152:Sult6b2'
ID 489333
Institutional Source Beutler Lab
Gene Symbol Sult6b2
Ensembl Gene ENSMUSG00000048473
Gene Name sulfotransferase family 6B, member 2
Synonyms LOC330440, Gm766
MMRRC Submission 044299-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.075) question?
Stock # R6152 (G1)
Quality Score 225.009
Status Not validated
Chromosome 6
Chromosomal Location 142731507-142750192 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 142750102 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Arginine at position 5 (S5R)
Ref Sequence ENSEMBL: ENSMUSP00000138527 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000111768] [ENSMUST00000156662]
AlphaFold B7ZWN4
Predicted Effect probably benign
Transcript: ENSMUST00000111768
AA Change: S5R

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000107398
Gene: ENSMUSG00000048473
AA Change: S5R

DomainStartEndE-ValueType
Pfam:Sulfotransfer_1 37 276 1.5e-64 PFAM
Pfam:Sulfotransfer_3 38 200 1.6e-10 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000156662
AA Change: S5R

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000138527
Gene: ENSMUSG00000048473
AA Change: S5R

DomainStartEndE-ValueType
Pfam:Sulfotransfer_1 74 157 5.6e-21 PFAM
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.0%
  • 20x: 94.3%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca5 A G 11: 110,204,187 (GRCm39) C363R probably damaging Het
Afg3l2 G T 18: 67,554,329 (GRCm39) L458M probably damaging Het
Anln A C 9: 22,271,803 (GRCm39) I684R probably damaging Het
Atoh7 A T 10: 62,936,278 (GRCm39) D115V probably damaging Het
Atp11a T A 8: 12,896,100 (GRCm39) I223K probably damaging Het
Cabs1 C T 5: 88,127,613 (GRCm39) T88I possibly damaging Het
Cblb T A 16: 51,961,419 (GRCm39) C345S probably damaging Het
Cep250 A G 2: 155,823,358 (GRCm39) E1003G possibly damaging Het
Chpf C T 1: 75,452,287 (GRCm39) R389H possibly damaging Het
Cntnap5c A G 17: 58,593,881 (GRCm39) D740G possibly damaging Het
Col19a1 T C 1: 24,413,702 (GRCm39) T411A unknown Het
Dgat2 T C 7: 98,813,885 (GRCm39) N99S probably benign Het
Fbxo7 A T 10: 85,860,560 (GRCm39) T56S probably benign Het
Gm15130 T A 2: 110,974,950 (GRCm39) Q71L unknown Het
Gpr161 T A 1: 165,137,864 (GRCm39) V150E possibly damaging Het
Hmcn1 T C 1: 150,441,176 (GRCm39) E5360G probably damaging Het
Hmg20a A G 9: 56,388,892 (GRCm39) D153G probably damaging Het
Hrct1 T A 4: 43,727,498 (GRCm39) V46D possibly damaging Het
Idh1 T C 1: 65,198,689 (GRCm39) T394A probably damaging Het
Kazn A G 4: 141,836,598 (GRCm39) I547T unknown Het
Klhdc3 A T 17: 46,988,633 (GRCm39) I142N probably damaging Het
Lrrc39 G T 3: 116,364,624 (GRCm39) probably null Het
Mamdc4 T C 2: 25,457,451 (GRCm39) D510G probably damaging Het
Mcm2 TTCTGATAGATGGTCTG TTCTG 6: 88,866,891 (GRCm39) probably benign Het
Ndfip2 A G 14: 105,535,538 (GRCm39) I275V possibly damaging Het
Or1i2 T C 10: 78,448,409 (GRCm39) D22G probably benign Het
Or5b24 A T 19: 12,912,851 (GRCm39) I250L probably benign Het
Pacsin2 A C 15: 83,261,900 (GRCm39) D154E probably damaging Het
Pcdhb5 T A 18: 37,455,886 (GRCm39) C755* probably null Het
Pcnx2 T C 8: 126,480,491 (GRCm39) S1939G probably damaging Het
Pfkl A T 10: 77,825,985 (GRCm39) H602Q probably benign Het
Pon3 G A 6: 5,221,716 (GRCm39) R305C probably damaging Het
Prpf6 A G 2: 181,263,580 (GRCm39) R147G probably damaging Het
Sh3yl1 A G 12: 30,992,034 (GRCm39) E201G probably benign Het
Slc25a36 A G 9: 96,982,210 (GRCm39) Y22H probably damaging Het
Susd2 C T 10: 75,473,853 (GRCm39) A581T probably damaging Het
Tysnd1 A G 10: 61,532,113 (GRCm39) D255G probably damaging Het
Zbtb6 A C 2: 37,319,255 (GRCm39) I224M probably benign Het
Zdhhc8 G T 16: 18,041,202 (GRCm39) N719K possibly damaging Het
Zkscan16 A G 4: 58,946,260 (GRCm39) E45G possibly damaging Het
Other mutations in Sult6b2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00436:Sult6b2 APN 6 142,743,563 (GRCm39) splice site probably benign
IGL00694:Sult6b2 APN 6 142,736,015 (GRCm39) missense possibly damaging 0.92
IGL01146:Sult6b2 APN 6 142,750,034 (GRCm39) missense probably benign 0.00
IGL01886:Sult6b2 APN 6 142,735,852 (GRCm39) critical splice donor site probably null
IGL02385:Sult6b2 APN 6 142,747,498 (GRCm39) missense probably benign 0.01
IGL02477:Sult6b2 APN 6 142,747,447 (GRCm39) missense probably damaging 1.00
R0088:Sult6b2 UTSW 6 142,743,675 (GRCm39) missense probably damaging 1.00
R2850:Sult6b2 UTSW 6 142,743,613 (GRCm39) missense probably benign 0.18
R4015:Sult6b2 UTSW 6 142,735,988 (GRCm39) missense possibly damaging 0.89
R4667:Sult6b2 UTSW 6 142,747,421 (GRCm39) nonsense probably null
R5172:Sult6b2 UTSW 6 142,743,657 (GRCm39) missense probably damaging 1.00
R5973:Sult6b2 UTSW 6 142,736,021 (GRCm39) missense probably benign 0.01
R6893:Sult6b2 UTSW 6 142,750,025 (GRCm39) missense possibly damaging 0.63
R7667:Sult6b2 UTSW 6 142,732,085 (GRCm39) missense probably benign 0.10
R7853:Sult6b2 UTSW 6 142,747,524 (GRCm39) missense not run
R8071:Sult6b2 UTSW 6 142,735,868 (GRCm39) missense probably damaging 1.00
R8225:Sult6b2 UTSW 6 142,750,055 (GRCm39) missense probably benign 0.00
R8344:Sult6b2 UTSW 6 142,736,022 (GRCm39) missense probably benign 0.13
Predicted Primers PCR Primer
(F):5'- GTTGCATCTCTGTATCTTATAGAACAC -3'
(R):5'- AGACATTGGCTCAGTTGTGG -3'

Sequencing Primer
(F):5'- AATGTTTCTATACCTCTTACTGTTGC -3'
(R):5'- ATTCTTCTAGAGAGCTGCAAAAGG -3'
Posted On 2017-10-10