Incidental Mutation 'R6154:Zfp451'
ID 489421
Institutional Source Beutler Lab
Gene Symbol Zfp451
Ensembl Gene ENSMUSG00000042197
Gene Name zinc finger protein 451
Synonyms 4930515K21Rik, Kiaa0576-hp, 4933435G09Rik
MMRRC Submission 044301-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R6154 (G1)
Quality Score 225.009
Status Validated
Chromosome 1
Chromosomal Location 33800626-33853676 bp(-) (GRCm39)
Type of Mutation intron
DNA Base Change (assembly) A to T at 33842627 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000141813 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000019861] [ENSMUST00000044455] [ENSMUST00000115167] [ENSMUST00000139143] [ENSMUST00000194656]
AlphaFold Q8C0P7
Predicted Effect probably benign
Transcript: ENSMUST00000019861
SMART Domains Protein: ENSMUSP00000019861
Gene: ENSMUSG00000042197

DomainStartEndE-ValueType
coiled coil region 81 109 N/A INTRINSIC
ZnF_C2H2 169 195 1.63e1 SMART
ZnF_C2H2 212 232 1.18e2 SMART
ZnF_C2H2 253 277 1.73e0 SMART
ZnF_C2H2 315 335 2.03e2 SMART
ZnF_C2H2 362 385 3.75e1 SMART
ZnF_C2H2 494 517 2.91e-2 SMART
ZnF_C2H2 527 550 5.4e1 SMART
low complexity region 558 577 N/A INTRINSIC
ZnF_C2H2 604 629 1.55e1 SMART
ZnF_C2H2 634 657 2.29e0 SMART
ZnF_C2H2 665 687 1.64e-1 SMART
ZnF_C2H2 751 774 6.75e0 SMART
ZnF_C2H2 787 810 4.94e0 SMART
Predicted Effect unknown
Transcript: ENSMUST00000044455
AA Change: V85D
SMART Domains Protein: ENSMUSP00000044372
Gene: ENSMUSG00000042197
AA Change: V85D

DomainStartEndE-ValueType
low complexity region 92 98 N/A INTRINSIC
Pfam:LAP2alpha 344 499 2.5e-11 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000115167
SMART Domains Protein: ENSMUSP00000110821
Gene: ENSMUSG00000042197

DomainStartEndE-ValueType
coiled coil region 81 109 N/A INTRINSIC
ZnF_C2H2 169 195 1.63e1 SMART
ZnF_C2H2 212 232 1.18e2 SMART
ZnF_C2H2 253 277 1.73e0 SMART
ZnF_C2H2 315 335 2.03e2 SMART
ZnF_C2H2 362 385 3.75e1 SMART
ZnF_C2H2 494 517 2.91e-2 SMART
ZnF_C2H2 527 550 5.4e1 SMART
low complexity region 558 577 N/A INTRINSIC
ZnF_C2H2 604 629 1.55e1 SMART
ZnF_C2H2 634 657 2.29e0 SMART
ZnF_C2H2 665 687 1.64e-1 SMART
ZnF_C2H2 751 774 6.75e0 SMART
ZnF_C2H2 787 810 4.94e0 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000130376
SMART Domains Protein: ENSMUSP00000118047
Gene: ENSMUSG00000042197

DomainStartEndE-ValueType
ZnF_C2H2 30 56 1.63e1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000139143
Predicted Effect noncoding transcript
Transcript: ENSMUST00000140163
Predicted Effect probably benign
Transcript: ENSMUST00000194656
SMART Domains Protein: ENSMUSP00000141813
Gene: ENSMUSG00000042197

DomainStartEndE-ValueType
ZnF_C2H2 127 153 6.9e-2 SMART
ZnF_C2H2 170 190 5e-1 SMART
ZnF_C2H2 211 235 7.2e-3 SMART
Meta Mutation Damage Score 0.0925 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.1%
  • 20x: 94.8%
Validation Efficiency 97% (70/72)
Allele List at MGI
Other mutations in this stock
Total: 72 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acss3 T G 10: 106,959,210 (GRCm39) I79L probably benign Het
Adam6a C T 12: 113,509,292 (GRCm39) T555I probably benign Het
Adap1 A G 5: 139,293,531 (GRCm39) V60A possibly damaging Het
Afg3l2 G T 18: 67,554,329 (GRCm39) L458M probably damaging Het
Angpt1 T C 15: 42,387,051 (GRCm39) E101G probably damaging Het
Asxl2 T C 12: 3,546,593 (GRCm39) V459A possibly damaging Het
Cabs1 C T 5: 88,127,613 (GRCm39) T88I possibly damaging Het
Camta2 G A 11: 70,569,211 (GRCm39) A578V probably damaging Het
Cdc16 A G 8: 13,818,609 (GRCm39) N316D possibly damaging Het
Chrm3 T A 13: 9,928,476 (GRCm39) M187L possibly damaging Het
Clcn4 T C 7: 7,294,481 (GRCm39) T367A probably benign Het
Clcn7 T C 17: 25,376,928 (GRCm39) S654P probably damaging Het
Col6a3 T A 1: 90,701,387 (GRCm39) T2510S unknown Het
Crisp4 T C 1: 18,193,012 (GRCm39) E192G possibly damaging Het
Dmbt1 T A 7: 130,711,370 (GRCm39) probably null Het
Dnah5 T G 15: 28,204,177 (GRCm39) L18R probably benign Het
Dnah9 T G 11: 65,746,164 (GRCm39) D3983A probably benign Het
Dock5 C A 14: 68,097,361 (GRCm39) V71L probably benign Het
Dync1h1 T C 12: 110,584,427 (GRCm39) V610A probably damaging Het
Dynlrb2 A G 8: 117,242,428 (GRCm39) Y86C probably benign Het
Ep400 T C 5: 110,903,799 (GRCm39) I267V probably damaging Het
Gaa A G 11: 119,169,178 (GRCm39) Y575C probably damaging Het
Gm8094 T A 14: 42,934,020 (GRCm39) D24V probably benign Het
Grina T C 15: 76,133,087 (GRCm39) I244T possibly damaging Het
Haus6 A G 4: 86,501,993 (GRCm39) L626P possibly damaging Het
Hexd A T 11: 121,112,097 (GRCm39) H439L probably benign Het
Ifna12 A T 4: 88,521,531 (GRCm39) C5* probably null Het
Igf2bp2 G T 16: 21,894,843 (GRCm39) S300* probably null Het
Ighv6-5 T C 12: 114,380,362 (GRCm39) R71G probably benign Het
Lrrc37 A G 11: 103,504,969 (GRCm39) V2333A probably benign Het
Lrrn4cl T C 19: 8,829,252 (GRCm39) S77P probably damaging Het
Mast4 A G 13: 102,923,929 (GRCm39) L302P probably damaging Het
Mink1 T C 11: 70,500,927 (GRCm39) V831A possibly damaging Het
Mme T A 3: 63,207,674 (GRCm39) I40N probably damaging Het
Myh2 A G 11: 67,077,438 (GRCm39) T858A probably benign Het
Ncbp3 T A 11: 72,940,700 (GRCm39) Y67N probably damaging Het
Nedd1 T A 10: 92,534,104 (GRCm39) I349F possibly damaging Het
Nek11 A T 9: 105,200,368 (GRCm39) *81K probably null Het
Nrip1 A G 16: 76,090,718 (GRCm39) Y280H probably damaging Het
Obsl1 T C 1: 75,476,788 (GRCm39) D722G probably benign Het
Or10ag55-ps1 T G 2: 87,139,902 (GRCm39) S256R probably benign Het
Or2m12 A T 16: 19,105,181 (GRCm39) I104K probably damaging Het
Or4c29 A G 2: 88,740,734 (GRCm39) M1T probably null Het
Or5i1 A G 2: 87,613,100 (GRCm39) D72G possibly damaging Het
Or6c7 C T 10: 129,323,545 (GRCm39) T222I probably damaging Het
Pcdhb6 A G 18: 37,467,966 (GRCm39) I296V probably benign Het
Pcnx2 G T 8: 126,489,552 (GRCm39) L1681M probably damaging Het
Pdlim5 T C 3: 141,983,674 (GRCm39) R360G possibly damaging Het
Peli2 C T 14: 48,488,051 (GRCm39) Q81* probably null Het
Pitpnb C T 5: 111,486,263 (GRCm39) Q56* probably null Het
Ppp1r3a A G 6: 14,754,603 (GRCm39) S215P possibly damaging Het
Prrt3 A G 6: 113,471,989 (GRCm39) Y728H probably damaging Het
Rsf1 A AAGGCGACGG 7: 97,229,111 (GRCm39) probably null Het
Rsf1 GCG GCGACGGCGACG 7: 97,229,114 (GRCm39) probably benign Het
Sbno1 T C 5: 124,516,542 (GRCm39) H1277R possibly damaging Het
Siglecg C A 7: 43,061,441 (GRCm39) N481K possibly damaging Het
Sirt6 C T 10: 81,462,339 (GRCm39) G20D probably damaging Het
Sit1 C A 4: 43,482,981 (GRCm39) R89S probably benign Het
Slc7a12 A G 3: 14,546,094 (GRCm39) R80G probably damaging Het
Smok3c T A 5: 138,062,747 (GRCm39) M78K probably benign Het
Stk10 T A 11: 32,553,654 (GRCm39) probably null Het
Tada2b A G 5: 36,634,008 (GRCm39) V190A probably damaging Het
Tnk1 C T 11: 69,747,780 (GRCm39) V41I probably damaging Het
Tpr T A 1: 150,299,567 (GRCm39) V1146E probably benign Het
Trappc9 T C 15: 72,929,930 (GRCm39) D142G probably benign Het
Trpm3 T C 19: 22,965,178 (GRCm39) Y1558H probably damaging Het
Unc5c C A 3: 141,383,914 (GRCm39) S97R probably damaging Het
Vmn1r172 T C 7: 23,359,583 (GRCm39) I156T probably damaging Het
Vmn2r51 A T 7: 9,821,921 (GRCm39) M588K possibly damaging Het
Vps26a T G 10: 62,304,119 (GRCm39) E117D probably damaging Het
Zfp534 C A 4: 147,759,145 (GRCm39) R508I probably benign Het
Zp3r C T 1: 130,526,642 (GRCm39) C187Y probably damaging Het
Other mutations in Zfp451
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00225:Zfp451 APN 1 33,825,621 (GRCm39) intron probably benign
IGL00423:Zfp451 APN 1 33,816,660 (GRCm39) missense probably benign 0.44
IGL00925:Zfp451 APN 1 33,815,342 (GRCm39) unclassified probably benign
IGL00971:Zfp451 APN 1 33,822,234 (GRCm39) missense probably benign 0.01
IGL01521:Zfp451 APN 1 33,816,412 (GRCm39) splice site probably null
IGL01672:Zfp451 APN 1 33,801,247 (GRCm39) missense probably benign 0.33
IGL01826:Zfp451 APN 1 33,821,243 (GRCm39) missense probably damaging 1.00
IGL02298:Zfp451 APN 1 33,812,002 (GRCm39) missense probably damaging 0.98
IGL02343:Zfp451 APN 1 33,815,574 (GRCm39) missense probably damaging 1.00
IGL03150:Zfp451 APN 1 33,816,535 (GRCm39) missense probably damaging 1.00
IGL03257:Zfp451 APN 1 33,816,129 (GRCm39) missense possibly damaging 0.90
R0006:Zfp451 UTSW 1 33,841,861 (GRCm39) intron probably benign
R0068:Zfp451 UTSW 1 33,816,706 (GRCm39) missense probably damaging 1.00
R0068:Zfp451 UTSW 1 33,816,706 (GRCm39) missense probably damaging 1.00
R0358:Zfp451 UTSW 1 33,816,810 (GRCm39) missense probably damaging 1.00
R0441:Zfp451 UTSW 1 33,816,126 (GRCm39) missense probably damaging 0.96
R0483:Zfp451 UTSW 1 33,809,991 (GRCm39) splice site probably benign
R0745:Zfp451 UTSW 1 33,809,929 (GRCm39) nonsense probably null
R1469:Zfp451 UTSW 1 33,808,894 (GRCm39) missense possibly damaging 0.93
R1469:Zfp451 UTSW 1 33,808,894 (GRCm39) missense possibly damaging 0.93
R1486:Zfp451 UTSW 1 33,816,808 (GRCm39) missense probably damaging 0.99
R1774:Zfp451 UTSW 1 33,852,849 (GRCm39) missense probably benign 0.02
R1929:Zfp451 UTSW 1 33,822,937 (GRCm39) missense probably benign 0.12
R1929:Zfp451 UTSW 1 33,821,274 (GRCm39) missense probably damaging 1.00
R1933:Zfp451 UTSW 1 33,816,903 (GRCm39) missense probably damaging 1.00
R2108:Zfp451 UTSW 1 33,818,248 (GRCm39) missense possibly damaging 0.93
R2225:Zfp451 UTSW 1 33,809,988 (GRCm39) splice site probably benign
R2372:Zfp451 UTSW 1 33,819,133 (GRCm39) splice site probably null
R3923:Zfp451 UTSW 1 33,818,126 (GRCm39) missense probably null 1.00
R4295:Zfp451 UTSW 1 33,816,836 (GRCm39) missense probably damaging 0.99
R4409:Zfp451 UTSW 1 33,816,494 (GRCm39) missense probably damaging 1.00
R4617:Zfp451 UTSW 1 33,841,752 (GRCm39) intron probably benign
R4757:Zfp451 UTSW 1 33,804,939 (GRCm39) missense probably damaging 0.98
R4777:Zfp451 UTSW 1 33,821,186 (GRCm39) missense possibly damaging 0.80
R4906:Zfp451 UTSW 1 33,844,465 (GRCm39) missense probably damaging 1.00
R4964:Zfp451 UTSW 1 33,816,942 (GRCm39) missense probably damaging 1.00
R5128:Zfp451 UTSW 1 33,842,014 (GRCm39) intron probably benign
R5129:Zfp451 UTSW 1 33,842,014 (GRCm39) intron probably benign
R5383:Zfp451 UTSW 1 33,852,887 (GRCm39) missense probably damaging 1.00
R5446:Zfp451 UTSW 1 33,816,609 (GRCm39) missense probably damaging 1.00
R6228:Zfp451 UTSW 1 33,842,219 (GRCm39) intron probably benign
R6272:Zfp451 UTSW 1 33,842,325 (GRCm39) intron probably benign
R6296:Zfp451 UTSW 1 33,808,898 (GRCm39) nonsense probably null
R6321:Zfp451 UTSW 1 33,852,816 (GRCm39) missense probably damaging 1.00
R6445:Zfp451 UTSW 1 33,812,092 (GRCm39) missense probably damaging 1.00
R6528:Zfp451 UTSW 1 33,816,862 (GRCm39) missense probably damaging 1.00
R6562:Zfp451 UTSW 1 33,801,260 (GRCm39) missense possibly damaging 0.90
R6739:Zfp451 UTSW 1 33,842,675 (GRCm39) intron probably benign
R6911:Zfp451 UTSW 1 33,842,537 (GRCm39) intron probably benign
R7042:Zfp451 UTSW 1 33,816,474 (GRCm39) missense probably damaging 1.00
R7044:Zfp451 UTSW 1 33,841,248 (GRCm39) intron probably benign
R7071:Zfp451 UTSW 1 33,815,825 (GRCm39) missense possibly damaging 0.96
R7082:Zfp451 UTSW 1 33,811,972 (GRCm39) critical splice donor site probably null
R7123:Zfp451 UTSW 1 33,815,950 (GRCm39) missense probably damaging 1.00
R7149:Zfp451 UTSW 1 33,816,405 (GRCm39) missense probably damaging 1.00
R7179:Zfp451 UTSW 1 33,841,651 (GRCm39) missense unknown
R7185:Zfp451 UTSW 1 33,808,974 (GRCm39) missense probably damaging 1.00
R7228:Zfp451 UTSW 1 33,842,475 (GRCm39) missense unknown
R7402:Zfp451 UTSW 1 33,852,843 (GRCm39) missense probably benign
R7462:Zfp451 UTSW 1 33,816,094 (GRCm39) missense probably damaging 1.00
R7488:Zfp451 UTSW 1 33,818,221 (GRCm39) missense probably benign 0.22
R7507:Zfp451 UTSW 1 33,808,840 (GRCm39) missense probably damaging 1.00
R7774:Zfp451 UTSW 1 33,844,474 (GRCm39) missense probably benign 0.20
R7835:Zfp451 UTSW 1 33,812,060 (GRCm39) missense probably damaging 1.00
R7979:Zfp451 UTSW 1 33,821,219 (GRCm39) missense probably benign 0.01
R8123:Zfp451 UTSW 1 33,801,248 (GRCm39) missense possibly damaging 0.92
R8137:Zfp451 UTSW 1 33,821,156 (GRCm39) missense possibly damaging 0.57
R8938:Zfp451 UTSW 1 33,842,063 (GRCm39) intron probably benign
R8974:Zfp451 UTSW 1 33,816,535 (GRCm39) missense probably damaging 1.00
R9036:Zfp451 UTSW 1 33,815,562 (GRCm39) missense probably damaging 1.00
RF005:Zfp451 UTSW 1 33,815,873 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- AAGGCAGAGTCTGATTACTTTGTG -3'
(R):5'- TATCTTTGGCCGGCCTATAGTG -3'

Sequencing Primer
(F):5'- AGAGTCTGATTACTTTGTGGTTTAAG -3'
(R):5'- GCCGGCCTATAGTGGATTG -3'
Posted On 2017-10-10