Incidental Mutation 'R6155:Or11h4'
ID 489541
Institutional Source Beutler Lab
Gene Symbol Or11h4
Ensembl Gene ENSMUSG00000059069
Gene Name olfactory receptor family 11 subfamily H member 4
Synonyms MOR106-1, Olfr749, GA_x6K02T2PMLR-6484046-6483105
MMRRC Submission 044302-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.064) question?
Stock # R6155 (G1)
Quality Score 225.009
Status Not validated
Chromosome 14
Chromosomal Location 50973676-50981781 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 50974076 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 181 (D181G)
Ref Sequence ENSEMBL: ENSMUSP00000150627 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000074674] [ENSMUST00000214290]
AlphaFold E9Q438
Predicted Effect probably benign
Transcript: ENSMUST00000074674
AA Change: D181G

PolyPhen 2 Score 0.020 (Sensitivity: 0.95; Specificity: 0.80)
SMART Domains Protein: ENSMUSP00000074242
Gene: ENSMUSG00000059069
AA Change: D181G

DomainStartEndE-ValueType
Pfam:7tm_4 30 307 5.2e-53 PFAM
Pfam:7tm_1 40 289 7.3e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000214290
AA Change: D181G

PolyPhen 2 Score 0.020 (Sensitivity: 0.95; Specificity: 0.80)
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 97.9%
  • 20x: 94.1%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
PHENOTYPE: A reporter allele shows expression of this olfactory receptor by embryonic day 15.5 and throughout olfactory development there is an increase in the numbers of expressing olfactory sensory neurons with expression localized to the dorsal main olfactory epithelium. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 68 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcg3 T C 5: 105,111,510 (GRCm39) Y319C probably benign Het
Actn4 A C 7: 28,595,566 (GRCm39) I763S probably damaging Het
Actr8 G A 14: 29,700,546 (GRCm39) probably null Het
Adrb1 T C 19: 56,711,336 (GRCm39) L178P probably damaging Het
Afap1 A G 5: 36,092,953 (GRCm39) Y19C unknown Het
Ankrd36 A G 11: 5,637,442 (GRCm39) E1337G probably benign Het
Arl4a A C 12: 40,086,519 (GRCm39) V76G probably damaging Het
Bmp1 A T 14: 70,745,447 (GRCm39) I246K probably damaging Het
Camk4 A T 18: 33,072,500 (GRCm39) T18S unknown Het
Cep152 T C 2: 125,423,620 (GRCm39) H927R probably benign Het
Clca3a2 A G 3: 144,525,118 (GRCm39) I38T probably damaging Het
Clec2g A C 6: 128,957,236 (GRCm39) T54P probably damaging Het
Cox20 A G 1: 178,149,362 (GRCm39) E31G possibly damaging Het
Crispld1 T A 1: 17,823,241 (GRCm39) H407Q probably benign Het
Csmd1 T C 8: 15,953,231 (GRCm39) I3417V probably benign Het
Dhtkd1 A C 2: 5,915,170 (GRCm39) H700Q probably null Het
Dnah10 G A 5: 124,847,663 (GRCm39) V1516M probably damaging Het
Dnah10 A G 5: 124,862,239 (GRCm39) T2165A probably damaging Het
Dock2 C G 11: 34,244,123 (GRCm39) M1072I probably benign Het
F11 T A 8: 45,705,119 (GRCm39) T141S probably damaging Het
Gabra6 T A 11: 42,207,350 (GRCm39) I245F probably damaging Het
H2-T5 G A 17: 36,478,399 (GRCm39) A211V possibly damaging Het
Herc1 T A 9: 66,340,705 (GRCm39) C1685S possibly damaging Het
Iftap A T 2: 101,406,355 (GRCm39) probably null Het
Il20 G T 1: 130,838,477 (GRCm39) D73E probably damaging Het
Ireb2 C A 9: 54,793,811 (GRCm39) P247Q probably damaging Het
Kcng3 T C 17: 83,895,807 (GRCm39) I220V probably benign Het
Lce1j T G 3: 92,696,379 (GRCm39) Q133P unknown Het
Lgals9 C T 11: 78,854,331 (GRCm39) A287T probably benign Het
Lrrc52 A G 1: 167,294,296 (GRCm39) probably benign Het
Map3k5 A T 10: 19,994,187 (GRCm39) H1027L probably benign Het
Morc3 A G 16: 93,659,313 (GRCm39) D407G possibly damaging Het
Myom1 T C 17: 71,415,690 (GRCm39) probably null Het
Ncapg2 T C 12: 116,401,631 (GRCm39) F673S possibly damaging Het
Ncoa6 T C 2: 155,249,368 (GRCm39) D1312G probably damaging Het
Nkx1-1 A T 5: 33,588,395 (GRCm39) F298I probably damaging Het
Npas2 G A 1: 39,326,557 (GRCm39) R14Q probably damaging Het
Npas4 C T 19: 5,036,898 (GRCm39) C422Y probably damaging Het
Or2y11 T A 11: 49,443,411 (GRCm39) I279N possibly damaging Het
Or4c123 A G 2: 89,126,765 (GRCm39) L283S probably damaging Het
Or5p4 T C 7: 107,680,493 (GRCm39) V164A probably benign Het
Pcdhga4 T C 18: 37,819,546 (GRCm39) I365T probably damaging Het
Pear1 T A 3: 87,666,875 (GRCm39) T37S probably damaging Het
Pkn2 A T 3: 142,559,454 (GRCm39) F24I probably benign Het
Plcb3 G A 19: 6,943,533 (GRCm39) A122V probably damaging Het
Pnliprp1 T C 19: 58,718,565 (GRCm39) probably null Het
Pramel28 T A 4: 143,691,712 (GRCm39) H337L probably benign Het
Psmb3 T A 11: 97,603,278 (GRCm39) F164I probably damaging Het
Ptch2 T A 4: 116,954,105 (GRCm39) F45Y probably damaging Het
Ptpn23 C A 9: 110,216,849 (GRCm39) probably benign Het
Pusl1 A G 4: 155,975,005 (GRCm39) S199P probably damaging Het
Rasgrp2 C A 19: 6,452,531 (GRCm39) L35I probably damaging Het
Rictor T C 15: 6,823,458 (GRCm39) L1545P probably benign Het
Rtn4r A T 16: 17,969,258 (GRCm39) M229L probably benign Het
Ruvbl1 A T 6: 88,456,107 (GRCm39) probably null Het
Slc35b3 A T 13: 39,128,572 (GRCm39) S30T probably damaging Het
Sorcs3 T C 19: 48,387,136 (GRCm39) V207A possibly damaging Het
Sox13 A G 1: 133,321,005 (GRCm39) S2P probably damaging Het
Sptbn1 A C 11: 30,087,403 (GRCm39) L999R probably damaging Het
Taf4 A G 2: 179,555,317 (GRCm39) V1015A probably damaging Het
Top3b T C 16: 16,709,373 (GRCm39) L687P probably damaging Het
Tpp2 T A 1: 43,995,649 (GRCm39) V268E probably damaging Het
Ttc6 T C 12: 57,784,402 (GRCm39) Y1824H possibly damaging Het
Txk A G 5: 72,858,069 (GRCm39) Y360H probably damaging Het
Vmn2r57 T C 7: 41,078,114 (GRCm39) I115V probably benign Het
Vmn2r98 T C 17: 19,286,143 (GRCm39) S214P possibly damaging Het
Zbtb48 T C 4: 152,106,495 (GRCm39) probably null Het
Zzz3 A G 3: 152,133,319 (GRCm39) I126V possibly damaging Het
Other mutations in Or11h4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03188:Or11h4 APN 14 50,974,315 (GRCm39) nonsense probably null
R0141:Or11h4 UTSW 14 50,973,840 (GRCm39) missense possibly damaging 0.94
R0462:Or11h4 UTSW 14 50,974,554 (GRCm39) missense probably benign
R1424:Or11h4 UTSW 14 50,974,521 (GRCm39) missense probably benign
R1791:Or11h4 UTSW 14 50,974,144 (GRCm39) small insertion probably benign
R1912:Or11h4 UTSW 14 50,974,235 (GRCm39) missense probably damaging 1.00
R2069:Or11h4 UTSW 14 50,974,033 (GRCm39) missense possibly damaging 0.51
R2171:Or11h4 UTSW 14 50,973,876 (GRCm39) missense probably benign 0.33
R2176:Or11h4 UTSW 14 50,973,681 (GRCm39) missense probably benign
R2184:Or11h4 UTSW 14 50,974,059 (GRCm39) missense probably damaging 0.98
R3158:Or11h4 UTSW 14 50,974,271 (GRCm39) missense probably benign 0.01
R5068:Or11h4 UTSW 14 50,974,531 (GRCm39) missense probably benign 0.02
R5069:Or11h4 UTSW 14 50,974,531 (GRCm39) missense probably benign 0.02
R5070:Or11h4 UTSW 14 50,974,531 (GRCm39) missense probably benign 0.02
R5733:Or11h4 UTSW 14 50,974,509 (GRCm39) missense probably benign 0.32
R6728:Or11h4 UTSW 14 50,974,296 (GRCm39) missense possibly damaging 0.61
R7033:Or11h4 UTSW 14 50,974,164 (GRCm39) missense possibly damaging 0.78
R7276:Or11h4 UTSW 14 50,974,187 (GRCm39) missense possibly damaging 0.90
R7535:Or11h4 UTSW 14 50,974,122 (GRCm39) missense probably benign 0.37
R8124:Or11h4 UTSW 14 50,973,743 (GRCm39) missense probably benign 0.03
R9021:Or11h4 UTSW 14 50,974,554 (GRCm39) missense probably benign
R9632:Or11h4 UTSW 14 50,974,199 (GRCm39) missense probably benign 0.42
R9710:Or11h4 UTSW 14 50,974,199 (GRCm39) missense probably benign 0.42
Predicted Primers PCR Primer
(F):5'- ACCACAGGTAGAGAAGGCCTTTC -3'
(R):5'- AACTGAATGTCTCTTCCTGGC -3'

Sequencing Primer
(F):5'- TAGAGAAGGCCTTTCGTCGGC -3'
(R):5'- ATAGGTACCTGGCCATTTGC -3'
Posted On 2017-10-10