Incidental Mutation 'R6156:Or8g22'
ID 489591
Institutional Source Beutler Lab
Gene Symbol Or8g22
Ensembl Gene ENSMUSG00000095194
Gene Name olfactory receptor family 8 subfamily G member 22, pseudogene 1
Synonyms Olfr936, MOR171-37, EG628171, GA_x6K02T2PVTD-32743332-32742397
MMRRC Submission 044303-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.073) question?
Stock # R6156 (G1)
Quality Score 225.009
Status Validated
Chromosome 9
Chromosomal Location 38957910-38958845 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 38958671 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Leucine at position 15 (M15L)
Ref Sequence ENSEMBL: ENSMUSP00000137209 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000178303] [ENSMUST00000216912]
AlphaFold J3KMV2
Predicted Effect noncoding transcript
Transcript: ENSMUST00000104850
Predicted Effect possibly damaging
Transcript: ENSMUST00000178303
AA Change: M15L

PolyPhen 2 Score 0.897 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000137209
Gene: ENSMUSG00000095194
AA Change: M15L

DomainStartEndE-ValueType
Pfam:7tm_1 1 246 6e-21 PFAM
Pfam:7tm_4 1 264 6.9e-49 PFAM
Predicted Effect unknown
Transcript: ENSMUST00000216912
AA Change: H59L
Meta Mutation Damage Score 0.0895 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 97.9%
  • 20x: 93.9%
Validation Efficiency 97% (68/70)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Feb 2010]
Allele List at MGI
Other mutations in this stock
Total: 71 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adcy8 T G 15: 64,689,488 (GRCm39) probably null Het
Ank2 T C 3: 126,737,886 (GRCm39) D2579G probably damaging Het
Atp6v1b1 G C 6: 83,735,115 (GRCm39) G423R probably damaging Het
B4galnt3 T C 6: 120,191,801 (GRCm39) N644S probably benign Het
Bhmt1b C A 18: 87,775,231 (GRCm39) Y251* probably null Het
Capsl T G 15: 9,465,920 (GRCm39) M132R probably damaging Het
Cep120 A G 18: 53,836,295 (GRCm39) Y797H probably benign Het
Cimip4 T C 15: 78,263,013 (GRCm39) T214A probably damaging Het
Clec2e T A 6: 129,072,061 (GRCm39) D106V possibly damaging Het
Col6a2 C T 10: 76,440,004 (GRCm39) V634I possibly damaging Het
Dis3 T C 14: 99,336,215 (GRCm39) E97G probably benign Het
Dlec1 T C 9: 118,939,281 (GRCm39) probably null Het
Dock2 C A 11: 34,197,789 (GRCm39) V1484F possibly damaging Het
Ephb2 T A 4: 136,388,816 (GRCm39) M593L probably benign Het
Fcgrt T C 7: 44,751,484 (GRCm39) T125A probably benign Het
Gabbr1 T C 17: 37,359,319 (GRCm39) I98T probably benign Het
Gbp10 G A 5: 105,384,015 (GRCm39) probably benign Het
Gfod1 T C 13: 43,354,514 (GRCm39) S154G possibly damaging Het
Ggt5 C T 10: 75,445,160 (GRCm39) T389I probably damaging Het
Got2 A G 8: 96,598,896 (GRCm39) F169L probably benign Het
Gse1 A G 8: 121,215,866 (GRCm39) K5E possibly damaging Het
Hyal5 T C 6: 24,891,437 (GRCm39) I417T possibly damaging Het
Igkv4-91 G T 6: 68,745,607 (GRCm39) T97K probably damaging Het
Il4i1 T C 7: 44,489,608 (GRCm39) Y458H possibly damaging Het
Impg1 A T 9: 80,230,106 (GRCm39) C740S probably damaging Het
Itgb1 C G 8: 129,458,535 (GRCm39) T788R possibly damaging Het
Lman2l A G 1: 36,477,907 (GRCm39) V143A probably damaging Het
Ltbp4 G T 7: 27,029,587 (GRCm39) T136K unknown Het
Macf1 A G 4: 123,366,073 (GRCm39) I1331T probably benign Het
Mmp11 G A 10: 75,762,325 (GRCm39) A336V probably damaging Het
Myh2 A T 11: 67,071,879 (GRCm39) I536F probably damaging Het
Myh4 A G 11: 67,141,618 (GRCm39) M826V probably benign Het
Naca T C 10: 127,875,160 (GRCm39) probably benign Het
Nr4a2 A G 2: 57,002,364 (GRCm39) Y30H probably damaging Het
Or12j4 A G 7: 140,046,758 (GRCm39) T215A probably benign Het
Or1e35 A T 11: 73,797,447 (GRCm39) Y290* probably null Het
Or2n1d T A 17: 38,646,064 (GRCm39) N5K probably damaging Het
Or4a67 T A 2: 88,597,934 (GRCm39) I242L probably benign Het
Or4f14d A T 2: 111,960,445 (GRCm39) L237Q probably damaging Het
Or4k42 A T 2: 111,320,095 (GRCm39) M136K probably damaging Het
Or4z4 A G 19: 12,076,484 (GRCm39) V173A possibly damaging Het
Paqr3 A C 5: 97,256,128 (GRCm39) L82R probably damaging Het
Pex6 C T 17: 47,031,567 (GRCm39) P456S probably benign Het
Pih1d2 A T 9: 50,532,452 (GRCm39) K186I possibly damaging Het
Plekhh3 A G 11: 101,061,013 (GRCm39) probably benign Het
Ptpn23 C A 9: 110,216,849 (GRCm39) probably benign Het
Rcor3 T A 1: 191,812,142 (GRCm39) probably benign Het
Rgs11 T A 17: 26,429,439 (GRCm39) Y403* probably null Het
Scn10a T C 9: 119,464,649 (GRCm39) N984D probably benign Het
Snx14 C T 9: 88,289,392 (GRCm39) A287T possibly damaging Het
Stx3 T C 19: 11,780,874 (GRCm39) D33G probably damaging Het
Tacc2 A G 7: 130,227,494 (GRCm39) K1393R probably damaging Het
Tas2r129 T C 6: 132,928,455 (GRCm39) S131P probably benign Het
Tbx15 G T 3: 99,220,431 (GRCm39) probably null Het
Thada A G 17: 84,700,795 (GRCm39) V1237A probably damaging Het
Tnc A G 4: 63,888,589 (GRCm39) Y1735H probably damaging Het
Ttc22 A G 4: 106,495,780 (GRCm39) K378R probably benign Het
Tubg2 A G 11: 101,051,635 (GRCm39) K287E possibly damaging Het
Ugt3a1 T C 15: 9,310,762 (GRCm39) I348T possibly damaging Het
Unc79 A G 12: 103,027,717 (GRCm39) N436S probably damaging Het
Unc80 A T 1: 66,651,409 (GRCm39) I1585F probably benign Het
Vmn2r104 T C 17: 20,261,909 (GRCm39) Y407C probably damaging Het
Vmn2r108 T A 17: 20,692,447 (GRCm39) L136F probably benign Het
Vmn2r38 A G 7: 9,097,611 (GRCm39) S161P probably damaging Het
Vmn2r90 T C 17: 17,953,606 (GRCm39) I590T probably benign Het
Washc5 T C 15: 59,217,248 (GRCm39) E323G probably damaging Het
Wdhd1 C T 14: 47,505,653 (GRCm39) G273D probably damaging Het
Xpo6 G T 7: 125,708,016 (GRCm39) Q851K probably damaging Het
Zfp386 T C 12: 116,023,526 (GRCm39) S380P probably damaging Het
Zfp536 A G 7: 37,173,281 (GRCm39) C274R unknown Het
Zfp64 A G 2: 168,768,088 (GRCm39) I508T probably benign Het
Other mutations in Or8g22
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01928:Or8g22 APN 9 38,958,709 (GRCm39) missense unknown
R0086:Or8g22 UTSW 9 38,958,191 (GRCm39) missense probably benign 0.00
R0561:Or8g22 UTSW 9 38,958,669 (GRCm39) missense probably damaging 0.99
R0650:Or8g22 UTSW 9 38,957,996 (GRCm39) missense probably benign 0.01
R1221:Or8g22 UTSW 9 38,958,483 (GRCm39) missense probably damaging 1.00
R1384:Or8g22 UTSW 9 38,958,200 (GRCm39) missense possibly damaging 0.70
R1680:Or8g22 UTSW 9 38,958,296 (GRCm39) missense probably benign 0.43
R1733:Or8g22 UTSW 9 38,958,678 (GRCm39) missense unknown
R3767:Or8g22 UTSW 9 38,958,707 (GRCm39) missense unknown
R4786:Or8g22 UTSW 9 38,958,783 (GRCm39) nonsense probably null
R4944:Or8g22 UTSW 9 38,958,158 (GRCm39) missense probably damaging 1.00
R5186:Or8g22 UTSW 9 38,958,265 (GRCm39) nonsense probably null
R5403:Or8g22 UTSW 9 38,957,999 (GRCm39) missense probably damaging 1.00
R6037:Or8g22 UTSW 9 38,958,403 (GRCm39) missense probably damaging 1.00
R6037:Or8g22 UTSW 9 38,958,403 (GRCm39) missense probably damaging 1.00
R6217:Or8g22 UTSW 9 38,958,039 (GRCm39) makesense probably null
R6711:Or8g22 UTSW 9 38,958,162 (GRCm39) makesense probably null
R6919:Or8g22 UTSW 9 38,958,827 (GRCm39) utr 5 prime probably benign
R7022:Or8g22 UTSW 9 38,958,379 (GRCm39) nonsense probably null
R7275:Or8g22 UTSW 9 38,958,815 (GRCm39) utr 5 prime probably benign
R7290:Or8g22 UTSW 9 38,958,694 (GRCm39) missense unknown
R7644:Or8g22 UTSW 9 38,958,638 (GRCm39) missense probably damaging 1.00
R8906:Or8g22 UTSW 9 38,958,077 (GRCm39) missense possibly damaging 0.87
R9099:Or8g22 UTSW 9 38,958,026 (GRCm39) missense probably benign 0.00
Z1176:Or8g22 UTSW 9 38,958,215 (GRCm39) missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- CAGCCAGCATGAAACATTCTG -3'
(R):5'- AGCAACTGTGTCCCTCTAAATC -3'

Sequencing Primer
(F):5'- GCCAGCATGAAACATTCTGAAACAAC -3'
(R):5'- CCTTTCAGAATCTGACTGAGAACATG -3'
Posted On 2017-10-10