Incidental Mutation 'R6156:Vmn2r108'
ID 489619
Institutional Source Beutler Lab
Gene Symbol Vmn2r108
Ensembl Gene ENSMUSG00000091805
Gene Name vomeronasal 2, receptor 108
Synonyms EG627805
MMRRC Submission 044303-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.073) question?
Stock # R6156 (G1)
Quality Score 225.009
Status Validated
Chromosome 17
Chromosomal Location 20682635-20701498 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 20692447 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Phenylalanine at position 136 (L136F)
Ref Sequence ENSEMBL: ENSMUSP00000130373 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000167314]
AlphaFold E9PYS0
Predicted Effect probably benign
Transcript: ENSMUST00000167314
AA Change: L136F

PolyPhen 2 Score 0.032 (Sensitivity: 0.95; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000130373
Gene: ENSMUSG00000091805
AA Change: L136F

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
Pfam:ANF_receptor 83 467 6e-33 PFAM
Pfam:NCD3G 510 563 9.2e-22 PFAM
Pfam:7tm_3 593 831 2.2e-51 PFAM
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 97.9%
  • 20x: 93.9%
Validation Efficiency 97% (68/70)
Allele List at MGI
Other mutations in this stock
Total: 71 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adcy8 T G 15: 64,689,488 (GRCm39) probably null Het
Ank2 T C 3: 126,737,886 (GRCm39) D2579G probably damaging Het
Atp6v1b1 G C 6: 83,735,115 (GRCm39) G423R probably damaging Het
B4galnt3 T C 6: 120,191,801 (GRCm39) N644S probably benign Het
Bhmt1b C A 18: 87,775,231 (GRCm39) Y251* probably null Het
Capsl T G 15: 9,465,920 (GRCm39) M132R probably damaging Het
Cep120 A G 18: 53,836,295 (GRCm39) Y797H probably benign Het
Cimip4 T C 15: 78,263,013 (GRCm39) T214A probably damaging Het
Clec2e T A 6: 129,072,061 (GRCm39) D106V possibly damaging Het
Col6a2 C T 10: 76,440,004 (GRCm39) V634I possibly damaging Het
Dis3 T C 14: 99,336,215 (GRCm39) E97G probably benign Het
Dlec1 T C 9: 118,939,281 (GRCm39) probably null Het
Dock2 C A 11: 34,197,789 (GRCm39) V1484F possibly damaging Het
Ephb2 T A 4: 136,388,816 (GRCm39) M593L probably benign Het
Fcgrt T C 7: 44,751,484 (GRCm39) T125A probably benign Het
Gabbr1 T C 17: 37,359,319 (GRCm39) I98T probably benign Het
Gbp10 G A 5: 105,384,015 (GRCm39) probably benign Het
Gfod1 T C 13: 43,354,514 (GRCm39) S154G possibly damaging Het
Ggt5 C T 10: 75,445,160 (GRCm39) T389I probably damaging Het
Got2 A G 8: 96,598,896 (GRCm39) F169L probably benign Het
Gse1 A G 8: 121,215,866 (GRCm39) K5E possibly damaging Het
Hyal5 T C 6: 24,891,437 (GRCm39) I417T possibly damaging Het
Igkv4-91 G T 6: 68,745,607 (GRCm39) T97K probably damaging Het
Il4i1 T C 7: 44,489,608 (GRCm39) Y458H possibly damaging Het
Impg1 A T 9: 80,230,106 (GRCm39) C740S probably damaging Het
Itgb1 C G 8: 129,458,535 (GRCm39) T788R possibly damaging Het
Lman2l A G 1: 36,477,907 (GRCm39) V143A probably damaging Het
Ltbp4 G T 7: 27,029,587 (GRCm39) T136K unknown Het
Macf1 A G 4: 123,366,073 (GRCm39) I1331T probably benign Het
Mmp11 G A 10: 75,762,325 (GRCm39) A336V probably damaging Het
Myh2 A T 11: 67,071,879 (GRCm39) I536F probably damaging Het
Myh4 A G 11: 67,141,618 (GRCm39) M826V probably benign Het
Naca T C 10: 127,875,160 (GRCm39) probably benign Het
Nr4a2 A G 2: 57,002,364 (GRCm39) Y30H probably damaging Het
Or12j4 A G 7: 140,046,758 (GRCm39) T215A probably benign Het
Or1e35 A T 11: 73,797,447 (GRCm39) Y290* probably null Het
Or2n1d T A 17: 38,646,064 (GRCm39) N5K probably damaging Het
Or4a67 T A 2: 88,597,934 (GRCm39) I242L probably benign Het
Or4f14d A T 2: 111,960,445 (GRCm39) L237Q probably damaging Het
Or4k42 A T 2: 111,320,095 (GRCm39) M136K probably damaging Het
Or4z4 A G 19: 12,076,484 (GRCm39) V173A possibly damaging Het
Or8g22 T A 9: 38,958,671 (GRCm39) M15L possibly damaging Het
Paqr3 A C 5: 97,256,128 (GRCm39) L82R probably damaging Het
Pex6 C T 17: 47,031,567 (GRCm39) P456S probably benign Het
Pih1d2 A T 9: 50,532,452 (GRCm39) K186I possibly damaging Het
Plekhh3 A G 11: 101,061,013 (GRCm39) probably benign Het
Ptpn23 C A 9: 110,216,849 (GRCm39) probably benign Het
Rcor3 T A 1: 191,812,142 (GRCm39) probably benign Het
Rgs11 T A 17: 26,429,439 (GRCm39) Y403* probably null Het
Scn10a T C 9: 119,464,649 (GRCm39) N984D probably benign Het
Snx14 C T 9: 88,289,392 (GRCm39) A287T possibly damaging Het
Stx3 T C 19: 11,780,874 (GRCm39) D33G probably damaging Het
Tacc2 A G 7: 130,227,494 (GRCm39) K1393R probably damaging Het
Tas2r129 T C 6: 132,928,455 (GRCm39) S131P probably benign Het
Tbx15 G T 3: 99,220,431 (GRCm39) probably null Het
Thada A G 17: 84,700,795 (GRCm39) V1237A probably damaging Het
Tnc A G 4: 63,888,589 (GRCm39) Y1735H probably damaging Het
Ttc22 A G 4: 106,495,780 (GRCm39) K378R probably benign Het
Tubg2 A G 11: 101,051,635 (GRCm39) K287E possibly damaging Het
Ugt3a1 T C 15: 9,310,762 (GRCm39) I348T possibly damaging Het
Unc79 A G 12: 103,027,717 (GRCm39) N436S probably damaging Het
Unc80 A T 1: 66,651,409 (GRCm39) I1585F probably benign Het
Vmn2r104 T C 17: 20,261,909 (GRCm39) Y407C probably damaging Het
Vmn2r38 A G 7: 9,097,611 (GRCm39) S161P probably damaging Het
Vmn2r90 T C 17: 17,953,606 (GRCm39) I590T probably benign Het
Washc5 T C 15: 59,217,248 (GRCm39) E323G probably damaging Het
Wdhd1 C T 14: 47,505,653 (GRCm39) G273D probably damaging Het
Xpo6 G T 7: 125,708,016 (GRCm39) Q851K probably damaging Het
Zfp386 T C 12: 116,023,526 (GRCm39) S380P probably damaging Het
Zfp536 A G 7: 37,173,281 (GRCm39) C274R unknown Het
Zfp64 A G 2: 168,768,088 (GRCm39) I508T probably benign Het
Other mutations in Vmn2r108
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00903:Vmn2r108 APN 17 20,682,774 (GRCm39) missense probably damaging 0.98
IGL01143:Vmn2r108 APN 17 20,682,727 (GRCm39) missense possibly damaging 0.82
IGL01311:Vmn2r108 APN 17 20,682,939 (GRCm39) nonsense probably null
IGL01411:Vmn2r108 APN 17 20,691,282 (GRCm39) missense probably benign 0.01
IGL01414:Vmn2r108 APN 17 20,691,942 (GRCm39) missense probably benign 0.00
IGL01536:Vmn2r108 APN 17 20,683,543 (GRCm39) missense probably damaging 1.00
IGL01748:Vmn2r108 APN 17 20,683,476 (GRCm39) missense probably benign 0.03
IGL01769:Vmn2r108 APN 17 20,691,280 (GRCm39) missense probably benign 0.02
IGL02022:Vmn2r108 APN 17 20,691,987 (GRCm39) missense possibly damaging 0.77
IGL02041:Vmn2r108 APN 17 20,683,398 (GRCm39) missense probably damaging 1.00
IGL02049:Vmn2r108 APN 17 20,691,608 (GRCm39) missense probably benign 0.00
IGL02344:Vmn2r108 APN 17 20,689,405 (GRCm39) missense probably damaging 1.00
IGL02939:Vmn2r108 APN 17 20,691,545 (GRCm39) missense probably benign 0.05
IGL03202:Vmn2r108 APN 17 20,691,319 (GRCm39) nonsense probably null
PIT4498001:Vmn2r108 UTSW 17 20,683,279 (GRCm39) missense probably damaging 1.00
R0112:Vmn2r108 UTSW 17 20,691,897 (GRCm39) missense probably benign 0.07
R0505:Vmn2r108 UTSW 17 20,683,096 (GRCm39) missense possibly damaging 0.77
R0833:Vmn2r108 UTSW 17 20,691,721 (GRCm39) missense probably benign
R0836:Vmn2r108 UTSW 17 20,691,721 (GRCm39) missense probably benign
R0943:Vmn2r108 UTSW 17 20,691,397 (GRCm39) nonsense probably null
R1411:Vmn2r108 UTSW 17 20,683,107 (GRCm39) missense probably damaging 0.98
R1442:Vmn2r108 UTSW 17 20,692,623 (GRCm39) nonsense probably null
R1587:Vmn2r108 UTSW 17 20,692,383 (GRCm39) missense probably damaging 1.00
R1751:Vmn2r108 UTSW 17 20,682,786 (GRCm39) missense probably damaging 1.00
R1773:Vmn2r108 UTSW 17 20,689,335 (GRCm39) missense probably damaging 1.00
R2021:Vmn2r108 UTSW 17 20,691,252 (GRCm39) missense probably benign 0.00
R2159:Vmn2r108 UTSW 17 20,689,363 (GRCm39) missense probably benign 0.41
R2224:Vmn2r108 UTSW 17 20,701,295 (GRCm39) nonsense probably null
R2226:Vmn2r108 UTSW 17 20,701,295 (GRCm39) nonsense probably null
R2517:Vmn2r108 UTSW 17 20,692,577 (GRCm39) missense probably damaging 1.00
R3710:Vmn2r108 UTSW 17 20,682,932 (GRCm39) missense probably benign
R4470:Vmn2r108 UTSW 17 20,682,990 (GRCm39) missense probably damaging 1.00
R4686:Vmn2r108 UTSW 17 20,691,636 (GRCm39) missense probably damaging 0.99
R4729:Vmn2r108 UTSW 17 20,692,632 (GRCm39) missense probably damaging 0.99
R4799:Vmn2r108 UTSW 17 20,682,891 (GRCm39) missense probably damaging 1.00
R4993:Vmn2r108 UTSW 17 20,701,449 (GRCm39) missense probably benign 0.04
R5088:Vmn2r108 UTSW 17 20,690,454 (GRCm39) missense possibly damaging 0.46
R5213:Vmn2r108 UTSW 17 20,691,755 (GRCm39) missense probably benign 0.00
R5289:Vmn2r108 UTSW 17 20,691,866 (GRCm39) missense probably damaging 1.00
R5290:Vmn2r108 UTSW 17 20,691,665 (GRCm39) missense probably benign 0.00
R5713:Vmn2r108 UTSW 17 20,691,290 (GRCm39) missense probably damaging 1.00
R5753:Vmn2r108 UTSW 17 20,683,179 (GRCm39) missense probably damaging 0.99
R5792:Vmn2r108 UTSW 17 20,683,398 (GRCm39) missense probably damaging 0.99
R5798:Vmn2r108 UTSW 17 20,692,545 (GRCm39) missense probably benign 0.39
R5897:Vmn2r108 UTSW 17 20,691,580 (GRCm39) missense probably benign 0.01
R6018:Vmn2r108 UTSW 17 20,683,268 (GRCm39) missense possibly damaging 0.83
R6093:Vmn2r108 UTSW 17 20,701,402 (GRCm39) missense probably benign 0.00
R6199:Vmn2r108 UTSW 17 20,682,644 (GRCm39) missense probably benign 0.01
R6259:Vmn2r108 UTSW 17 20,683,371 (GRCm39) missense possibly damaging 0.95
R6309:Vmn2r108 UTSW 17 20,691,660 (GRCm39) missense probably damaging 0.98
R6324:Vmn2r108 UTSW 17 20,691,977 (GRCm39) nonsense probably null
R6364:Vmn2r108 UTSW 17 20,691,260 (GRCm39) missense probably benign 0.00
R6446:Vmn2r108 UTSW 17 20,692,609 (GRCm39) nonsense probably null
R6541:Vmn2r108 UTSW 17 20,701,480 (GRCm39) missense probably benign 0.02
R7025:Vmn2r108 UTSW 17 20,691,345 (GRCm39) missense possibly damaging 0.67
R7063:Vmn2r108 UTSW 17 20,701,410 (GRCm39) missense probably damaging 1.00
R7092:Vmn2r108 UTSW 17 20,701,338 (GRCm39) missense probably benign 0.10
R7096:Vmn2r108 UTSW 17 20,682,762 (GRCm39) missense probably damaging 1.00
R7203:Vmn2r108 UTSW 17 20,683,038 (GRCm39) missense probably benign 0.12
R7458:Vmn2r108 UTSW 17 20,692,532 (GRCm39) missense probably benign 0.17
R7619:Vmn2r108 UTSW 17 20,692,457 (GRCm39) missense probably benign 0.02
R7841:Vmn2r108 UTSW 17 20,690,305 (GRCm39) critical splice donor site probably null
R7944:Vmn2r108 UTSW 17 20,691,890 (GRCm39) missense probably damaging 0.99
R8048:Vmn2r108 UTSW 17 20,691,762 (GRCm39) missense probably benign 0.29
R8213:Vmn2r108 UTSW 17 20,690,350 (GRCm39) missense probably benign 0.03
R8218:Vmn2r108 UTSW 17 20,683,465 (GRCm39) missense probably damaging 1.00
R8507:Vmn2r108 UTSW 17 20,683,195 (GRCm39) nonsense probably null
R8708:Vmn2r108 UTSW 17 20,682,687 (GRCm39) missense probably damaging 0.98
R8845:Vmn2r108 UTSW 17 20,691,361 (GRCm39) missense probably benign 0.03
R9030:Vmn2r108 UTSW 17 20,690,312 (GRCm39) missense probably benign 0.01
R9226:Vmn2r108 UTSW 17 20,691,330 (GRCm39) missense probably benign
R9278:Vmn2r108 UTSW 17 20,692,561 (GRCm39) missense probably benign 0.11
X0022:Vmn2r108 UTSW 17 20,691,371 (GRCm39) missense probably damaging 1.00
Z1088:Vmn2r108 UTSW 17 20,691,375 (GRCm39) missense probably benign 0.01
Z1177:Vmn2r108 UTSW 17 20,691,219 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- ATTGCTGTCCTAGTGTCTGGATAC -3'
(R):5'- CCAACCAAGTTCTACATATTCATGG -3'

Sequencing Primer
(F):5'- CCCCTCTTATAGTTTTAAAACACCTG -3'
(R):5'- ATGTGGTCCATATTGTATTCCTCCTG -3'
Posted On 2017-10-10