Incidental Mutation 'R6165:Syne1'
ID 490098
Institutional Source Beutler Lab
Gene Symbol Syne1
Ensembl Gene ENSMUSG00000096054
Gene Name spectrin repeat containing, nuclear envelope 1
Synonyms C130039F11Rik, enaptin165, SYNE-1, nesprin-1, A330049M09Rik
MMRRC Submission 044311-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R6165 (G1)
Quality Score 225.009
Status Validated
Chromosome 10
Chromosomal Location 4970917-5501482 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 5375678 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Glutamine at position 138 (L138Q)
Ref Sequence ENSEMBL: ENSMUSP00000150262 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000041639] [ENSMUST00000214945] [ENSMUST00000215295]
AlphaFold no structure available at present
Predicted Effect probably damaging
Transcript: ENSMUST00000041639
AA Change: L138Q

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000039440
Gene: ENSMUSG00000096054
AA Change: L138Q

DomainStartEndE-ValueType
CH 29 139 4.55e-14 SMART
low complexity region 145 167 N/A INTRINSIC
CH 187 285 9.67e-18 SMART
coiled coil region 425 452 N/A INTRINSIC
Blast:SPEC 493 599 2e-28 BLAST
Blast:SPEC 606 695 7e-40 BLAST
Blast:SPEC 701 815 1e-32 BLAST
Blast:SPEC 815 913 4e-41 BLAST
Blast:SPEC 920 1013 9e-53 BLAST
Blast:SPEC 1117 1219 2e-60 BLAST
coiled coil region 1267 1329 N/A INTRINSIC
low complexity region 1349 1368 N/A INTRINSIC
coiled coil region 1399 1427 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000214945
AA Change: L131Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000215295
AA Change: L138Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Meta Mutation Damage Score 0.8134 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.5%
  • 10x: 97.9%
  • 20x: 94.1%
Validation Efficiency 98% (47/48)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a spectrin repeat containing protein expressed in skeletal and smooth muscle, and peripheral blood lymphocytes, that localizes to the nuclear membrane. Mutations in this gene have been associated with autosomal recessive spinocerebellar ataxia 8, also referred to as autosomal recessive cerebellar ataxia type 1 or recessive ataxia of Beauce. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for an allele lacking the KASH domain exhibit neonatal and postnatal lethality, progressive muscular dystrophy, and limb weakness. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ankrd35 A G 3: 96,590,623 (GRCm39) E303G possibly damaging Het
Atosa A G 9: 74,932,954 (GRCm39) T974A probably damaging Het
C2cd5 T C 6: 142,995,954 (GRCm39) T389A possibly damaging Het
Catsperb T A 12: 101,542,075 (GRCm39) Y592N possibly damaging Het
Cfap91 A G 16: 38,154,173 (GRCm39) F124S possibly damaging Het
Cnot9 T C 1: 74,567,952 (GRCm39) V280A probably benign Het
Cyld A G 8: 89,473,561 (GRCm39) I927V possibly damaging Het
Etfdh A T 3: 79,512,251 (GRCm39) S490T probably benign Het
Fance C T 17: 28,545,068 (GRCm39) R150C probably benign Het
Far1 A G 7: 113,153,425 (GRCm39) K353E probably benign Het
Fbn1 T C 2: 125,174,283 (GRCm39) I1858V probably damaging Het
Frem1 T C 4: 82,874,492 (GRCm39) K1359E probably benign Het
Ghdc T G 11: 100,659,928 (GRCm39) E273A possibly damaging Het
Gpt A G 15: 76,582,170 (GRCm39) D209G probably benign Het
Hspb7 T C 4: 141,149,862 (GRCm39) F83L probably benign Het
Itga7 A G 10: 128,778,804 (GRCm39) I306M probably benign Het
Itgb5 A G 16: 33,719,612 (GRCm39) E261G probably benign Het
Kcnj14 G T 7: 45,469,424 (GRCm39) A27E possibly damaging Het
Kif13b A G 14: 64,979,760 (GRCm39) H470R probably damaging Het
Macroh2a1 A T 13: 56,252,268 (GRCm39) N108K probably damaging Het
Morc3 T C 16: 93,638,271 (GRCm39) F18L probably damaging Het
Mrgprb8 T A 7: 48,038,565 (GRCm39) C79S possibly damaging Het
Mroh2b T A 15: 4,947,832 (GRCm39) M549K probably benign Het
Msl1 T C 11: 98,695,673 (GRCm39) V563A probably damaging Het
Nwd1 C T 8: 73,388,814 (GRCm39) R81W probably damaging Het
Or5b124 A T 19: 13,610,507 (GRCm39) I11F possibly damaging Het
Or5b124 C T 19: 13,610,952 (GRCm39) A159V probably benign Het
Phf2 C A 13: 48,967,341 (GRCm39) probably null Het
Pjvk T G 2: 76,480,562 (GRCm39) probably null Het
Rgl2 A G 17: 34,150,739 (GRCm39) T66A probably benign Het
Rsf1 ATGGCG ATGGCGACGGTGGCG 7: 97,229,111 (GRCm39) probably benign Het
Rtkn G T 6: 83,122,944 (GRCm39) E67D probably damaging Het
Serpinb9 T A 13: 33,192,807 (GRCm39) F121L possibly damaging Het
Slc34a1 G A 13: 23,999,053 (GRCm39) V149I probably benign Het
Sobp A G 10: 42,898,599 (GRCm39) S329P probably damaging Het
Tfr2 T A 5: 137,578,519 (GRCm39) V449D probably damaging Het
Tmem151b T C 17: 45,856,711 (GRCm39) Y243C probably damaging Het
Trank1 T C 9: 111,220,940 (GRCm39) V2559A probably benign Het
Trim35 T C 14: 66,546,654 (GRCm39) Y474H probably damaging Het
Uso1 A T 5: 92,335,126 (GRCm39) L495F probably damaging Het
Wdr24 A G 17: 26,045,395 (GRCm39) I377V probably benign Het
Xpo5 T A 17: 46,546,883 (GRCm39) V878D possibly damaging Het
Zfc3h1 A G 10: 115,256,574 (GRCm39) I1515V probably benign Het
Zfp319 CA C 8: 96,054,733 (GRCm39) 489 probably null Het
Zfp384 T G 6: 125,001,896 (GRCm39) probably null Het
Zfp704 G T 3: 9,508,946 (GRCm39) P416T probably benign Het
Zfr C T 15: 12,146,331 (GRCm39) A294V unknown Het
Other mutations in Syne1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00684:Syne1 APN 10 5,342,167 (GRCm38) synonymous probably benign
IGL00725:Syne1 APN 10 5,344,922 (GRCm38) missense possibly damaging 0.48
IGL00799:Syne1 APN 10 5,347,878 (GRCm38) missense probably benign 0.00
IGL01087:Syne1 APN 10 5,375,708 (GRCm39) missense probably damaging 1.00
IGL01123:Syne1 APN 10 5,294,921 (GRCm39) nonsense probably null
IGL01147:Syne1 APN 10 5,002,691 (GRCm39) nonsense probably null
IGL01150:Syne1 APN 10 5,393,154 (GRCm39) missense probably damaging 1.00
IGL01154:Syne1 APN 10 5,310,848 (GRCm39) missense probably damaging 1.00
IGL01727:Syne1 APN 10 4,997,842 (GRCm39) missense probably damaging 0.99
IGL01761:Syne1 APN 10 5,355,456 (GRCm39) missense probably damaging 1.00
IGL01793:Syne1 APN 10 5,302,191 (GRCm39) missense possibly damaging 0.67
IGL01961:Syne1 APN 10 4,993,723 (GRCm39) missense possibly damaging 0.94
IGL01975:Syne1 APN 10 5,018,908 (GRCm39) intron probably benign
IGL02152:Syne1 APN 10 5,374,382 (GRCm39) missense probably damaging 1.00
IGL02423:Syne1 APN 10 5,318,295 (GRCm39) missense probably benign 0.00
IGL02457:Syne1 APN 10 5,292,167 (GRCm39) missense probably damaging 1.00
IGL02543:Syne1 APN 10 4,993,618 (GRCm39) missense probably damaging 0.97
IGL02836:Syne1 APN 10 5,359,875 (GRCm39) splice site probably benign
IGL03141:Syne1 APN 10 5,374,261 (GRCm39) missense probably damaging 1.00
FR4548:Syne1 UTSW 10 4,982,969 (GRCm39) missense probably benign 0.09
IGL02799:Syne1 UTSW 10 5,309,059 (GRCm39) missense probably damaging 1.00
PIT4305001:Syne1 UTSW 10 5,283,023 (GRCm39) missense probably damaging 1.00
PIT4687001:Syne1 UTSW 10 5,308,390 (GRCm39) missense possibly damaging 0.87
R0004:Syne1 UTSW 10 5,393,132 (GRCm39) splice site probably benign
R0110:Syne1 UTSW 10 5,317,600 (GRCm39) missense probably damaging 1.00
R0165:Syne1 UTSW 10 4,983,096 (GRCm39) missense probably benign 0.28
R0194:Syne1 UTSW 10 5,374,311 (GRCm39) missense probably benign
R0311:Syne1 UTSW 10 5,298,943 (GRCm39) missense possibly damaging 0.92
R0328:Syne1 UTSW 10 5,298,945 (GRCm39) missense possibly damaging 0.62
R0379:Syne1 UTSW 10 5,491,989 (GRCm39) missense probably damaging 1.00
R0387:Syne1 UTSW 10 5,301,029 (GRCm39) missense probably benign
R0452:Syne1 UTSW 10 5,355,435 (GRCm39) missense probably damaging 0.98
R0456:Syne1 UTSW 10 5,292,252 (GRCm39) missense probably benign 0.04
R0457:Syne1 UTSW 10 4,972,041 (GRCm39) missense probably damaging 1.00
R0469:Syne1 UTSW 10 5,317,600 (GRCm39) missense probably damaging 1.00
R0510:Syne1 UTSW 10 5,317,600 (GRCm39) missense probably damaging 1.00
R0533:Syne1 UTSW 10 5,308,438 (GRCm39) missense probably benign 0.00
R0617:Syne1 UTSW 10 5,300,933 (GRCm39) missense probably damaging 1.00
R0690:Syne1 UTSW 10 4,983,138 (GRCm39) splice site probably benign
R0964:Syne1 UTSW 10 4,993,652 (GRCm39) missense possibly damaging 0.95
R1133:Syne1 UTSW 10 5,299,044 (GRCm39) missense possibly damaging 0.77
R1327:Syne1 UTSW 10 4,998,925 (GRCm39) splice site probably benign
R1339:Syne1 UTSW 10 5,317,571 (GRCm39) missense probably damaging 1.00
R1531:Syne1 UTSW 10 5,297,875 (GRCm39) nonsense probably null
R1558:Syne1 UTSW 10 5,299,280 (GRCm39) nonsense probably null
R1633:Syne1 UTSW 10 5,299,388 (GRCm39) missense probably damaging 1.00
R1642:Syne1 UTSW 10 5,298,694 (GRCm39) missense possibly damaging 0.94
R1658:Syne1 UTSW 10 5,317,616 (GRCm39) missense probably benign 0.03
R1753:Syne1 UTSW 10 5,317,621 (GRCm39) missense probably benign 0.28
R1759:Syne1 UTSW 10 5,299,369 (GRCm39) missense probably damaging 1.00
R1792:Syne1 UTSW 10 4,990,975 (GRCm39) missense probably damaging 1.00
R2076:Syne1 UTSW 10 4,990,897 (GRCm39) missense probably damaging 0.99
R2079:Syne1 UTSW 10 5,311,502 (GRCm39) missense probably benign 0.01
R2102:Syne1 UTSW 10 5,006,514 (GRCm39) missense probably damaging 1.00
R2233:Syne1 UTSW 10 4,991,484 (GRCm39) missense probably benign 0.01
R2305:Syne1 UTSW 10 4,997,573 (GRCm39) missense probably damaging 0.97
R3435:Syne1 UTSW 10 5,298,565 (GRCm39) missense probably damaging 1.00
R3749:Syne1 UTSW 10 5,002,267 (GRCm39) splice site probably benign
R3876:Syne1 UTSW 10 5,002,345 (GRCm39) missense possibly damaging 0.57
R3895:Syne1 UTSW 10 5,355,456 (GRCm39) missense probably damaging 0.98
R3974:Syne1 UTSW 10 4,993,630 (GRCm39) missense probably benign 0.06
R4042:Syne1 UTSW 10 4,991,584 (GRCm39) missense probably benign 0.21
R4120:Syne1 UTSW 10 5,359,798 (GRCm39) missense probably damaging 1.00
R4201:Syne1 UTSW 10 5,297,870 (GRCm39) missense probably benign
R4364:Syne1 UTSW 10 5,303,987 (GRCm39) missense probably damaging 0.96
R4498:Syne1 UTSW 10 4,981,768 (GRCm39) missense probably benign 0.00
R4767:Syne1 UTSW 10 5,294,866 (GRCm39) nonsense probably null
R4804:Syne1 UTSW 10 5,299,310 (GRCm39) missense possibly damaging 0.95
R4917:Syne1 UTSW 10 5,007,909 (GRCm39) missense probably damaging 1.00
R4930:Syne1 UTSW 10 5,002,777 (GRCm39) missense probably damaging 0.99
R5081:Syne1 UTSW 10 4,997,767 (GRCm39) missense probably benign 0.04
R5089:Syne1 UTSW 10 5,355,444 (GRCm39) nonsense probably null
R5174:Syne1 UTSW 10 4,991,490 (GRCm39) missense probably damaging 0.99
R5205:Syne1 UTSW 10 5,002,295 (GRCm39) missense probably benign 0.05
R5303:Syne1 UTSW 10 5,370,464 (GRCm39) missense probably benign 0.00
R5384:Syne1 UTSW 10 4,991,494 (GRCm39) missense probably benign 0.00
R5385:Syne1 UTSW 10 4,991,494 (GRCm39) missense probably benign 0.00
R5392:Syne1 UTSW 10 5,298,661 (GRCm39) missense probably damaging 1.00
R5442:Syne1 UTSW 10 5,293,473 (GRCm39) missense probably benign 0.09
R5750:Syne1 UTSW 10 5,289,209 (GRCm39) missense probably benign 0.01
R5935:Syne1 UTSW 10 5,310,706 (GRCm39) splice site probably null
R6015:Syne1 UTSW 10 5,296,819 (GRCm39) critical splice donor site probably null
R6023:Syne1 UTSW 10 5,393,223 (GRCm39) missense probably benign 0.09
R6049:Syne1 UTSW 10 5,297,926 (GRCm39) missense possibly damaging 0.79
R6084:Syne1 UTSW 10 5,298,994 (GRCm39) missense probably damaging 1.00
R6145:Syne1 UTSW 10 5,002,750 (GRCm39) missense probably damaging 1.00
R6164:Syne1 UTSW 10 5,011,429 (GRCm39) missense probably damaging 1.00
R6198:Syne1 UTSW 10 5,252,269 (GRCm39) missense probably damaging 0.99
R6217:Syne1 UTSW 10 5,243,761 (GRCm39) missense probably benign 0.00
R6247:Syne1 UTSW 10 5,299,071 (GRCm39) missense probably damaging 0.98
R6271:Syne1 UTSW 10 5,184,652 (GRCm39) missense probably damaging 1.00
R6338:Syne1 UTSW 10 5,205,475 (GRCm39) missense probably benign 0.00
R6344:Syne1 UTSW 10 4,972,212 (GRCm39) missense probably benign 0.08
R6434:Syne1 UTSW 10 5,268,422 (GRCm39) missense probably benign 0.01
R6476:Syne1 UTSW 10 5,104,531 (GRCm39) missense possibly damaging 0.88
R6479:Syne1 UTSW 10 5,406,826 (GRCm39) missense probably damaging 1.00
R6479:Syne1 UTSW 10 5,181,679 (GRCm39) nonsense probably null
R6546:Syne1 UTSW 10 5,168,645 (GRCm39) nonsense probably null
R6578:Syne1 UTSW 10 5,355,454 (GRCm39) nonsense probably null
R6611:Syne1 UTSW 10 4,995,273 (GRCm39) missense probably benign 0.01
R6615:Syne1 UTSW 10 5,251,340 (GRCm39) missense probably damaging 0.98
R6632:Syne1 UTSW 10 5,165,667 (GRCm39) critical splice donor site probably null
R6662:Syne1 UTSW 10 5,078,416 (GRCm39) missense probably damaging 1.00
R6677:Syne1 UTSW 10 4,990,942 (GRCm39) missense possibly damaging 0.82
R6764:Syne1 UTSW 10 5,179,011 (GRCm39) nonsense probably null
R6765:Syne1 UTSW 10 5,093,285 (GRCm39) splice site probably null
R6778:Syne1 UTSW 10 5,052,406 (GRCm39) missense probably damaging 0.97
R6851:Syne1 UTSW 10 5,212,703 (GRCm39) nonsense probably null
R6878:Syne1 UTSW 10 5,370,388 (GRCm39) missense possibly damaging 0.78
R6883:Syne1 UTSW 10 5,181,704 (GRCm39) nonsense probably null
R6910:Syne1 UTSW 10 4,998,887 (GRCm39) missense probably benign 0.01
R6916:Syne1 UTSW 10 5,177,912 (GRCm39) missense probably benign 0.00
R6925:Syne1 UTSW 10 5,076,682 (GRCm39) missense probably benign 0.00
R6943:Syne1 UTSW 10 5,033,940 (GRCm39) missense probably benign
R6947:Syne1 UTSW 10 5,125,789 (GRCm39) missense probably damaging 1.00
R6965:Syne1 UTSW 10 5,179,120 (GRCm39) missense possibly damaging 0.66
R6968:Syne1 UTSW 10 5,067,041 (GRCm39) missense probably benign 0.09
R7043:Syne1 UTSW 10 5,022,193 (GRCm39) missense possibly damaging 0.77
R7059:Syne1 UTSW 10 5,296,859 (GRCm39) missense probably damaging 1.00
R7067:Syne1 UTSW 10 5,184,586 (GRCm39) missense probably damaging 1.00
R7087:Syne1 UTSW 10 5,492,024 (GRCm39) start gained probably benign
R7099:Syne1 UTSW 10 5,073,744 (GRCm39) missense probably benign 0.43
R7107:Syne1 UTSW 10 5,082,078 (GRCm39) missense probably damaging 1.00
R7120:Syne1 UTSW 10 5,243,971 (GRCm39) missense probably benign
R7127:Syne1 UTSW 10 5,193,180 (GRCm39) missense probably damaging 1.00
R7128:Syne1 UTSW 10 5,193,180 (GRCm39) missense probably damaging 1.00
R7131:Syne1 UTSW 10 5,178,221 (GRCm39) missense probably damaging 1.00
R7132:Syne1 UTSW 10 5,193,180 (GRCm39) missense probably damaging 1.00
R7133:Syne1 UTSW 10 5,181,592 (GRCm39) missense probably damaging 1.00
R7135:Syne1 UTSW 10 5,183,409 (GRCm39) missense probably benign 0.01
R7147:Syne1 UTSW 10 5,199,340 (GRCm39) missense probably damaging 1.00
R7158:Syne1 UTSW 10 5,007,931 (GRCm39) missense probably damaging 1.00
R7189:Syne1 UTSW 10 5,374,295 (GRCm39) missense probably benign 0.03
R7193:Syne1 UTSW 10 5,183,406 (GRCm39) missense probably damaging 1.00
R7194:Syne1 UTSW 10 5,060,859 (GRCm39) missense probably damaging 1.00
R7233:Syne1 UTSW 10 5,252,160 (GRCm39) missense probably damaging 1.00
R7255:Syne1 UTSW 10 5,283,446 (GRCm39) missense probably damaging 0.98
R7267:Syne1 UTSW 10 5,178,218 (GRCm39) missense probably damaging 1.00
R7294:Syne1 UTSW 10 5,047,483 (GRCm39) critical splice donor site probably null
R7303:Syne1 UTSW 10 5,206,805 (GRCm39) missense probably benign 0.04
R7313:Syne1 UTSW 10 4,997,635 (GRCm39) missense probably damaging 1.00
R7330:Syne1 UTSW 10 5,078,434 (GRCm39) missense probably benign 0.00
R7334:Syne1 UTSW 10 5,007,886 (GRCm39) missense probably damaging 1.00
R7363:Syne1 UTSW 10 5,090,970 (GRCm39) missense possibly damaging 0.45
R7400:Syne1 UTSW 10 5,168,580 (GRCm39) missense probably benign 0.12
R7425:Syne1 UTSW 10 5,375,760 (GRCm39) missense probably damaging 1.00
R7427:Syne1 UTSW 10 5,223,718 (GRCm39) missense probably damaging 0.98
R7446:Syne1 UTSW 10 5,172,266 (GRCm39) missense probably benign 0.00
R7462:Syne1 UTSW 10 5,002,793 (GRCm39) missense possibly damaging 0.87
R7502:Syne1 UTSW 10 5,283,446 (GRCm39) missense probably damaging 0.98
R7525:Syne1 UTSW 10 5,135,559 (GRCm39) critical splice acceptor site probably null
R7529:Syne1 UTSW 10 5,374,382 (GRCm39) missense probably damaging 1.00
R7577:Syne1 UTSW 10 5,074,820 (GRCm39) missense probably damaging 1.00
R7579:Syne1 UTSW 10 5,299,324 (GRCm39) missense probably damaging 1.00
R7594:Syne1 UTSW 10 5,165,190 (GRCm39) critical splice donor site probably null
R7646:Syne1 UTSW 10 5,122,949 (GRCm39) missense probably damaging 1.00
R7651:Syne1 UTSW 10 5,293,416 (GRCm39) missense probably damaging 1.00
R7651:Syne1 UTSW 10 5,155,074 (GRCm39) missense probably benign 0.38
R7669:Syne1 UTSW 10 5,011,531 (GRCm39) missense probably damaging 1.00
R7672:Syne1 UTSW 10 5,168,527 (GRCm39) missense probably benign 0.02
R7682:Syne1 UTSW 10 5,112,461 (GRCm39) missense probably benign
R7702:Syne1 UTSW 10 5,195,835 (GRCm39) missense probably damaging 1.00
R7767:Syne1 UTSW 10 5,283,632 (GRCm39) missense possibly damaging 0.49
R7767:Syne1 UTSW 10 5,283,560 (GRCm39) missense possibly damaging 0.60
R7829:Syne1 UTSW 10 5,292,293 (GRCm39) missense probably damaging 0.96
R7840:Syne1 UTSW 10 5,082,078 (GRCm39) missense probably damaging 1.00
R7859:Syne1 UTSW 10 5,107,683 (GRCm39) missense possibly damaging 0.80
R7899:Syne1 UTSW 10 5,177,956 (GRCm39) nonsense probably null
R7918:Syne1 UTSW 10 5,309,078 (GRCm39) missense possibly damaging 0.50
R7923:Syne1 UTSW 10 5,214,738 (GRCm39) missense probably damaging 1.00
R7946:Syne1 UTSW 10 5,200,919 (GRCm39) missense possibly damaging 0.92
R7966:Syne1 UTSW 10 5,066,965 (GRCm39) critical splice donor site probably null
R7975:Syne1 UTSW 10 4,981,786 (GRCm39) missense probably benign 0.00
R7981:Syne1 UTSW 10 5,179,248 (GRCm39) missense probably benign 0.04
R8053:Syne1 UTSW 10 5,002,658 (GRCm39) nonsense probably null
R8054:Syne1 UTSW 10 5,220,970 (GRCm39) missense probably benign 0.22
R8062:Syne1 UTSW 10 5,135,394 (GRCm39) critical splice donor site probably null
R8085:Syne1 UTSW 10 5,178,021 (GRCm39) missense possibly damaging 0.78
R8087:Syne1 UTSW 10 5,283,034 (GRCm39) missense probably benign
R8094:Syne1 UTSW 10 5,067,031 (GRCm39) missense probably damaging 0.98
R8310:Syne1 UTSW 10 5,297,829 (GRCm39) missense probably benign
R8325:Syne1 UTSW 10 5,096,257 (GRCm39) missense probably benign 0.15
R8342:Syne1 UTSW 10 5,058,622 (GRCm39) missense probably benign 0.18
R8353:Syne1 UTSW 10 5,300,983 (GRCm39) missense probably damaging 1.00
R8376:Syne1 UTSW 10 4,993,615 (GRCm39) missense probably benign 0.09
R8398:Syne1 UTSW 10 5,074,923 (GRCm39) missense probably damaging 1.00
R8434:Syne1 UTSW 10 5,073,057 (GRCm39) missense probably benign 0.00
R8436:Syne1 UTSW 10 5,178,659 (GRCm39) missense probably benign 0.26
R8459:Syne1 UTSW 10 5,374,277 (GRCm39) nonsense probably null
R8461:Syne1 UTSW 10 5,011,463 (GRCm39) missense probably benign 0.34
R8496:Syne1 UTSW 10 5,268,441 (GRCm39) missense probably damaging 0.99
R8496:Syne1 UTSW 10 5,178,896 (GRCm39) missense probably damaging 0.99
R8693:Syne1 UTSW 10 5,090,928 (GRCm39) missense possibly damaging 0.60
R8698:Syne1 UTSW 10 5,179,229 (GRCm39) missense probably damaging 1.00
R8701:Syne1 UTSW 10 5,155,026 (GRCm39) nonsense probably null
R8713:Syne1 UTSW 10 5,266,040 (GRCm39) missense probably damaging 1.00
R8724:Syne1 UTSW 10 5,033,861 (GRCm39) missense possibly damaging 0.77
R8729:Syne1 UTSW 10 5,179,275 (GRCm39) missense probably benign 0.00
R8742:Syne1 UTSW 10 5,058,661 (GRCm39) missense probably benign 0.09
R8757:Syne1 UTSW 10 5,144,618 (GRCm39) missense probably damaging 1.00
R8776:Syne1 UTSW 10 5,181,783 (GRCm39) missense possibly damaging 0.81
R8776-TAIL:Syne1 UTSW 10 5,181,783 (GRCm39) missense possibly damaging 0.81
R8778:Syne1 UTSW 10 5,309,066 (GRCm39) missense probably benign 0.00
R8801:Syne1 UTSW 10 5,308,335 (GRCm39) missense probably damaging 1.00
R8803:Syne1 UTSW 10 5,311,535 (GRCm39) missense probably damaging 1.00
R8808:Syne1 UTSW 10 5,309,074 (GRCm39) missense probably damaging 1.00
R8829:Syne1 UTSW 10 5,058,685 (GRCm39) missense probably benign
R8843:Syne1 UTSW 10 5,143,040 (GRCm39) missense possibly damaging 0.88
R8843:Syne1 UTSW 10 5,280,204 (GRCm39) missense probably benign 0.01
R8854:Syne1 UTSW 10 5,078,503 (GRCm39) missense probably benign 0.00
R8863:Syne1 UTSW 10 5,049,527 (GRCm39) missense probably damaging 1.00
R8864:Syne1 UTSW 10 5,370,473 (GRCm39) missense probably benign 0.01
R8881:Syne1 UTSW 10 5,223,639 (GRCm39) missense probably damaging 1.00
R8884:Syne1 UTSW 10 5,181,822 (GRCm39) missense possibly damaging 0.93
R8893:Syne1 UTSW 10 5,299,020 (GRCm39) nonsense probably null
R8958:Syne1 UTSW 10 5,181,768 (GRCm39) missense probably benign
R8964:Syne1 UTSW 10 5,060,872 (GRCm39) missense
R8975:Syne1 UTSW 10 5,161,945 (GRCm39) missense probably benign 0.04
R8987:Syne1 UTSW 10 5,177,579 (GRCm39) missense possibly damaging 0.92
R8992:Syne1 UTSW 10 5,135,508 (GRCm39) missense probably benign 0.01
R9005:Syne1 UTSW 10 5,155,406 (GRCm39) missense probably benign
R9084:Syne1 UTSW 10 5,289,240 (GRCm39) missense probably benign 0.01
R9117:Syne1 UTSW 10 5,053,667 (GRCm39) missense probably damaging 0.96
R9128:Syne1 UTSW 10 5,058,556 (GRCm39) missense probably benign 0.38
R9181:Syne1 UTSW 10 5,063,994 (GRCm39) missense probably damaging 0.99
R9189:Syne1 UTSW 10 5,172,289 (GRCm39) missense probably benign 0.00
R9189:Syne1 UTSW 10 5,123,008 (GRCm39) missense probably damaging 1.00
R9205:Syne1 UTSW 10 5,152,013 (GRCm39) nonsense probably null
R9217:Syne1 UTSW 10 5,299,324 (GRCm39) missense probably damaging 1.00
R9246:Syne1 UTSW 10 5,255,706 (GRCm39) missense probably benign 0.00
R9264:Syne1 UTSW 10 5,212,793 (GRCm39) missense probably damaging 1.00
R9273:Syne1 UTSW 10 4,990,901 (GRCm39) missense probably benign 0.16
R9315:Syne1 UTSW 10 5,283,553 (GRCm39) missense possibly damaging 0.79
R9331:Syne1 UTSW 10 5,073,666 (GRCm39) missense probably benign 0.45
R9355:Syne1 UTSW 10 5,318,255 (GRCm39) missense probably damaging 1.00
R9378:Syne1 UTSW 10 5,200,954 (GRCm39) missense probably damaging 0.96
R9389:Syne1 UTSW 10 5,179,193 (GRCm39) missense possibly damaging 0.65
R9395:Syne1 UTSW 10 5,261,728 (GRCm39) missense probably damaging 1.00
R9405:Syne1 UTSW 10 5,152,030 (GRCm39) missense probably damaging 1.00
R9417:Syne1 UTSW 10 5,082,021 (GRCm39) missense probably benign
R9419:Syne1 UTSW 10 5,155,071 (GRCm39) missense probably benign 0.01
R9473:Syne1 UTSW 10 5,198,258 (GRCm39) missense probably benign 0.00
R9484:Syne1 UTSW 10 5,170,359 (GRCm39) missense probably damaging 1.00
R9505:Syne1 UTSW 10 4,980,394 (GRCm39) missense probably benign 0.00
R9509:Syne1 UTSW 10 5,298,927 (GRCm39) critical splice donor site probably null
R9546:Syne1 UTSW 10 5,193,123 (GRCm39) missense probably damaging 1.00
R9567:Syne1 UTSW 10 5,196,386 (GRCm39) missense possibly damaging 0.54
R9601:Syne1 UTSW 10 5,209,270 (GRCm39) missense probably benign 0.23
R9619:Syne1 UTSW 10 5,090,909 (GRCm39) missense probably benign 0.03
R9621:Syne1 UTSW 10 5,273,887 (GRCm39) missense probably benign 0.01
R9623:Syne1 UTSW 10 5,152,009 (GRCm39) missense probably damaging 1.00
R9646:Syne1 UTSW 10 5,179,187 (GRCm39) missense possibly damaging 0.95
R9666:Syne1 UTSW 10 4,984,937 (GRCm39) missense probably damaging 1.00
R9677:Syne1 UTSW 10 5,215,125 (GRCm39) missense probably damaging 1.00
R9695:Syne1 UTSW 10 5,268,461 (GRCm39) missense probably benign 0.03
R9696:Syne1 UTSW 10 5,297,847 (GRCm39) missense probably benign 0.00
R9719:Syne1 UTSW 10 5,276,601 (GRCm39) missense possibly damaging 0.47
R9744:Syne1 UTSW 10 5,274,184 (GRCm39) missense probably benign 0.01
R9761:Syne1 UTSW 10 5,318,190 (GRCm39) critical splice donor site probably null
R9763:Syne1 UTSW 10 5,007,858 (GRCm39) missense probably benign 0.31
RF010:Syne1 UTSW 10 5,196,386 (GRCm39) missense possibly damaging 0.89
RF015:Syne1 UTSW 10 5,252,248 (GRCm39) missense probably benign 0.01
RF023:Syne1 UTSW 10 5,205,482 (GRCm39) missense probably damaging 1.00
X0017:Syne1 UTSW 10 5,296,917 (GRCm39) missense probably damaging 1.00
X0025:Syne1 UTSW 10 5,308,973 (GRCm39) nonsense probably null
X0063:Syne1 UTSW 10 5,002,354 (GRCm39) missense probably damaging 1.00
Z1176:Syne1 UTSW 10 5,280,251 (GRCm39) missense probably benign 0.10
Z1176:Syne1 UTSW 10 5,209,280 (GRCm39) missense probably benign
Z1176:Syne1 UTSW 10 5,198,364 (GRCm39) missense probably damaging 0.96
Z1177:Syne1 UTSW 10 5,209,349 (GRCm39) missense probably damaging 1.00
Z1177:Syne1 UTSW 10 5,093,230 (GRCm39) missense possibly damaging 0.78
Predicted Primers PCR Primer
(F):5'- TTTTATAAGGGTAGAGGGGTCACAC -3'
(R):5'- TGCCAGAACATAGGCATGCC -3'

Sequencing Primer
(F):5'- TTTAACCAAAGGGCGTGG -3'
(R):5'- GAACATAGGCATGCCCAAATG -3'
Posted On 2017-10-10