Incidental Mutation 'R6168:Or6c203'
ID 490262
Institutional Source Beutler Lab
Gene Symbol Or6c203
Ensembl Gene ENSMUSG00000107662
Gene Name olfactory receptor family 6 subfamily C member 203
Synonyms MOR114-3, GA_x6K02T2PULF-10860457-10859522, Olfr772
MMRRC Submission 044430-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.131) question?
Stock # R6168 (G1)
Quality Score 225.009
Status Not validated
Chromosome 10
Chromosomal Location 129009920-129010923 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 129010035 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Serine at position 285 (F285S)
Ref Sequence ENSEMBL: ENSMUSP00000148854 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000169800] [ENSMUST00000214672]
AlphaFold Q8VGC5
Predicted Effect noncoding transcript
Transcript: ENSMUST00000122783
Predicted Effect probably damaging
Transcript: ENSMUST00000169800
AA Change: F285S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000132389
Gene: ENSMUSG00000107662
AA Change: F285S

DomainStartEndE-ValueType
Pfam:7tm_4 28 307 1.6e-47 PFAM
Pfam:7tm_1 38 287 1.1e-21 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000214672
AA Change: F285S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.2%
  • 20x: 95.1%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4932414N04Rik C T 2: 68,571,827 (GRCm39) L568F possibly damaging Het
Adam3 A T 8: 25,171,630 (GRCm39) probably null Het
Adamts13 G T 2: 26,894,898 (GRCm39) A1069S probably benign Het
Adarb1 A G 10: 77,158,153 (GRCm39) L98P probably damaging Het
Ahnak2 T C 12: 112,747,750 (GRCm39) E1035G probably benign Het
Alox12b T A 11: 69,060,460 (GRCm39) I672N probably damaging Het
Ark2n A G 18: 77,761,653 (GRCm39) S220P probably damaging Het
Ash1l C T 3: 88,960,080 (GRCm39) R2271* probably null Het
Atf7ip A G 6: 136,536,817 (GRCm39) T17A probably damaging Het
Col6a5 A G 9: 105,752,986 (GRCm39) probably null Het
Crcp A G 5: 130,066,737 (GRCm39) N41S probably damaging Het
Defb15 A C 8: 22,420,069 (GRCm39) N19K possibly damaging Het
Dnah7a T A 1: 53,450,727 (GRCm39) D3901V probably damaging Het
Dnah7b A C 1: 46,329,863 (GRCm39) T3236P probably damaging Het
Dnmbp A G 19: 43,838,679 (GRCm39) S608P probably damaging Het
Efcab12 T C 6: 115,791,577 (GRCm39) K532E probably damaging Het
Fbrsl1 C T 5: 110,543,922 (GRCm39) V54M probably damaging Het
Gm14496 T A 2: 181,642,750 (GRCm39) V807E probably damaging Het
Hoxa2 A G 6: 52,140,461 (GRCm39) L175P probably damaging Het
Igkv4-58 A C 6: 69,477,281 (GRCm39) D105E probably damaging Het
Igkv8-27 A T 6: 70,148,880 (GRCm39) S91R probably benign Het
Itgax T C 7: 127,732,269 (GRCm39) V175A probably damaging Het
Kcnc2 A G 10: 112,291,661 (GRCm39) D283G probably benign Het
Lepr G A 4: 101,592,789 (GRCm39) G135R probably damaging Het
Mcf2l A G 8: 13,051,823 (GRCm39) S378G probably benign Het
Mta1 T A 12: 113,086,739 (GRCm39) D145E probably damaging Het
Nkd1 T A 8: 89,311,859 (GRCm39) N44K probably damaging Het
Notch2 A G 3: 98,052,533 (GRCm39) K2010E probably damaging Het
Nsd3 G A 8: 26,181,188 (GRCm39) G930S probably null Het
Or2w1 T G 13: 21,317,399 (GRCm39) I151M possibly damaging Het
Or8g35 A G 9: 39,381,953 (GRCm39) L23P probably damaging Het
Or8k3 T G 2: 86,058,938 (GRCm39) I126L probably damaging Het
Or8u8 T C 2: 86,012,309 (GRCm39) I49V probably damaging Het
Pde4c G A 8: 71,202,688 (GRCm39) E625K probably benign Het
Pdgfb T C 15: 79,884,587 (GRCm39) T151A probably benign Het
Pik3r5 T C 11: 68,383,501 (GRCm39) V440A probably benign Het
Piwil2 T C 14: 70,632,800 (GRCm39) T591A probably benign Het
Ppm1l A G 3: 69,456,740 (GRCm39) D219G probably damaging Het
Psmc6 T C 14: 45,581,140 (GRCm39) I312T probably damaging Het
Rasl10a T C 11: 5,008,442 (GRCm39) V46A possibly damaging Het
Rhov T C 2: 119,101,453 (GRCm39) Y51C probably damaging Het
S100a16 C T 3: 90,449,879 (GRCm39) Q121* probably null Het
Slc5a12 T C 2: 110,447,089 (GRCm39) V199A probably damaging Het
Slc6a7 A T 18: 61,134,734 (GRCm39) M447K probably benign Het
Tarbp1 A G 8: 127,175,144 (GRCm39) V764A possibly damaging Het
Vmn1r197 T C 13: 22,512,678 (GRCm39) Y200H possibly damaging Het
Vmn2r102 G A 17: 19,914,402 (GRCm39) A656T possibly damaging Het
Vmn2r49 G T 7: 9,718,713 (GRCm39) D450E probably benign Het
Wdr7 T A 18: 63,911,048 (GRCm39) N813K probably damaging Het
Yeats2 T C 16: 19,998,308 (GRCm39) S288P probably benign Het
Zfta T C 19: 7,400,305 (GRCm39) V257A probably benign Het
Zswim6 G A 13: 107,924,299 (GRCm39) noncoding transcript Het
Other mutations in Or6c203
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02512:Or6c203 APN 10 129,010,119 (GRCm39) missense possibly damaging 0.65
IGL03072:Or6c203 APN 10 129,010,358 (GRCm39) missense probably damaging 1.00
IGL03336:Or6c203 APN 10 129,010,098 (GRCm39) missense probably benign 0.00
R1852:Or6c203 UTSW 10 129,010,197 (GRCm39) missense probably benign 0.00
R2496:Or6c203 UTSW 10 129,009,966 (GRCm39) missense probably benign 0.00
R6031:Or6c203 UTSW 10 129,010,224 (GRCm39) missense probably benign 0.14
R6031:Or6c203 UTSW 10 129,010,224 (GRCm39) missense probably benign 0.14
R7454:Or6c203 UTSW 10 129,010,324 (GRCm39) missense probably damaging 1.00
R7669:Or6c203 UTSW 10 129,010,128 (GRCm39) missense probably damaging 1.00
R7905:Or6c203 UTSW 10 129,010,056 (GRCm39) missense probably damaging 0.99
R8307:Or6c203 UTSW 10 129,010,101 (GRCm39) missense probably benign 0.00
R8830:Or6c203 UTSW 10 129,010,715 (GRCm39) nonsense probably null
R9405:Or6c203 UTSW 10 129,010,165 (GRCm39) missense probably benign 0.08
Predicted Primers PCR Primer
(F):5'- AGCAGGAAAGTCAGTCGACC -3'
(R):5'- CACTCATTATAACGCTGGTGTGTG -3'

Sequencing Primer
(F):5'- TCGACCACAAAGAGAAAGAGTGTTC -3'
(R):5'- CATCAAGACAGTTCTTAGATTCCC -3'
Posted On 2017-10-10