Incidental Mutation 'IGL00331:Or8c15'
ID 4910
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or8c15
Ensembl Gene ENSMUSG00000093901
Gene Name olfactory receptor family 8 subfamily C member 15
Synonyms GA_x6K02T2PVTD-31889215-31890153, Olfr893, MOR170-11
Accession Numbers
Essential gene? Probably non essential (E-score: 0.168) question?
Stock # IGL00331
Quality Score
Status
Chromosome 9
Chromosomal Location 38120348-38121289 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 38120534 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Asparagine at position 60 (Y60N)
Ref Sequence ENSEMBL: ENSMUSP00000148719 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000093867] [ENSMUST00000211975]
AlphaFold K7N678
Predicted Effect probably damaging
Transcript: ENSMUST00000093867
AA Change: Y62N

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000091390
Gene: ENSMUSG00000093901
AA Change: Y62N

DomainStartEndE-ValueType
Pfam:7tm_4 33 309 1.2e-45 PFAM
Pfam:7tm_1 43 292 8e-20 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000211975
AA Change: Y60N

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Predicted Effect unknown
Transcript: ENSMUST00000212815
AA Change: Y9N
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aamp C A 1: 74,320,595 (GRCm39) probably benign Het
Adamts19 T A 18: 59,140,397 (GRCm39) probably benign Het
Afg3l1 T A 8: 124,214,128 (GRCm39) F190I probably benign Het
Alms1 T A 6: 85,618,353 (GRCm39) S2800T possibly damaging Het
Alox5 A T 6: 116,392,478 (GRCm39) W348R probably damaging Het
Atp13a5 G A 16: 29,085,766 (GRCm39) Q823* probably null Het
Atp6v1b2 T C 8: 69,541,586 (GRCm39) probably null Het
Chuk T C 19: 44,076,462 (GRCm39) I416M possibly damaging Het
Cimip2b G A 4: 43,428,158 (GRCm39) R100W possibly damaging Het
Dmbt1 A T 7: 130,701,020 (GRCm39) Q1066L possibly damaging Het
Dnah5 A G 15: 28,421,766 (GRCm39) T3873A probably damaging Het
Endog C T 2: 30,062,912 (GRCm39) T184M probably damaging Het
Fcgbp T C 7: 27,800,966 (GRCm39) probably benign Het
Flii A G 11: 60,606,659 (GRCm39) I1061T probably benign Het
Hdac2 T A 10: 36,873,067 (GRCm39) N308K probably damaging Het
Hoxa2 T G 6: 52,140,497 (GRCm39) Y163S probably damaging Het
Hsd3b7 T C 7: 127,402,144 (GRCm39) L263P probably damaging Het
Klf17 T C 4: 117,618,235 (GRCm39) T41A probably benign Het
Lrrfip1 T C 1: 90,996,343 (GRCm39) M42T probably damaging Het
Mapk8ip1 C T 2: 92,215,533 (GRCm39) V614I probably benign Het
Mocs1 T G 17: 49,742,292 (GRCm39) probably null Het
Moxd1 T C 10: 24,158,453 (GRCm39) probably benign Het
Mterf1a T C 5: 3,941,610 (GRCm39) E86G probably damaging Het
Muc4 A G 16: 32,574,613 (GRCm39) D1021G probably benign Het
Nomo1 T C 7: 45,694,760 (GRCm39) S212P possibly damaging Het
Or5b116 A G 19: 13,422,988 (GRCm39) D204G probably benign Het
Phf21a A C 2: 92,178,374 (GRCm39) T385P probably damaging Het
Piwil4 A T 9: 14,626,327 (GRCm39) probably benign Het
Pknox1 T C 17: 31,818,619 (GRCm39) probably null Het
Prr14l T C 5: 32,988,410 (GRCm39) I362V probably benign Het
Sergef C T 7: 46,284,844 (GRCm39) probably null Het
Sez6l T C 5: 112,572,511 (GRCm39) D948G probably damaging Het
Skor1 A T 9: 63,053,723 (GRCm39) L54Q probably damaging Het
Sntn C T 14: 13,679,086 (GRCm38) Q87* probably null Het
Syde2 A G 3: 145,720,096 (GRCm39) K772E possibly damaging Het
Taf2 T A 15: 54,934,845 (GRCm39) probably null Het
Tbc1d13 T A 2: 30,030,523 (GRCm39) Y113N probably damaging Het
Tmem154 T C 3: 84,591,722 (GRCm39) F91L probably benign Het
Tmem63a A G 1: 180,794,062 (GRCm39) D533G possibly damaging Het
Tmprss15 A T 16: 78,782,882 (GRCm39) N712K possibly damaging Het
Trip12 A T 1: 84,708,262 (GRCm39) D603E probably damaging Het
Trmt11 T C 10: 30,442,445 (GRCm39) D246G probably damaging Het
Vmn1r174 T A 7: 23,453,958 (GRCm39) M208K possibly damaging Het
Wdr54 T C 6: 83,132,755 (GRCm39) H33R probably benign Het
Zfp207 A G 11: 80,279,828 (GRCm39) D111G probably benign Het
Other mutations in Or8c15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00914:Or8c15 APN 9 38,121,095 (GRCm39) splice site probably null
IGL01563:Or8c15 APN 9 38,120,997 (GRCm39) missense probably damaging 1.00
IGL01696:Or8c15 APN 9 38,120,345 (GRCm39) unclassified probably benign
IGL02064:Or8c15 APN 9 38,120,874 (GRCm39) missense probably damaging 1.00
IGL02605:Or8c15 APN 9 38,120,532 (GRCm39) missense probably damaging 0.99
R0415:Or8c15 UTSW 9 38,121,269 (GRCm39) missense probably benign
R0463:Or8c15 UTSW 9 38,120,360 (GRCm39) missense probably benign 0.00
R0843:Or8c15 UTSW 9 38,120,579 (GRCm39) missense possibly damaging 0.81
R1441:Or8c15 UTSW 9 38,120,777 (GRCm39) missense probably damaging 1.00
R1939:Or8c15 UTSW 9 38,120,725 (GRCm39) nonsense probably null
R2512:Or8c15 UTSW 9 38,120,670 (GRCm39) missense probably damaging 1.00
R4890:Or8c15 UTSW 9 38,120,586 (GRCm39) missense probably benign 0.00
R5439:Or8c15 UTSW 9 38,121,050 (GRCm39) missense probably benign 0.00
R6918:Or8c15 UTSW 9 38,120,948 (GRCm39) missense possibly damaging 0.95
R7621:Or8c15 UTSW 9 38,120,447 (GRCm39) missense probably benign 0.09
R7715:Or8c15 UTSW 9 38,120,775 (GRCm39) missense probably benign 0.30
R7940:Or8c15 UTSW 9 38,120,496 (GRCm39) missense probably benign 0.00
R8710:Or8c15 UTSW 9 38,121,066 (GRCm39) missense possibly damaging 0.60
R8712:Or8c15 UTSW 9 38,121,099 (GRCm39) missense probably benign 0.39
R8882:Or8c15 UTSW 9 38,120,461 (GRCm39) nonsense probably null
Posted On 2012-04-20