Mutagenetix > Incidental Mutation

Incidental Mutation 'R0530:Wdr87-ps'

49101

Institutional Source

Beutler Lab

Gene Symbol

Wdr87-ps

Ensembl Gene

ENSMUSG00000074224

Gene Name

WD repeat domain 87, pseudogene

Synonyms

4932431P20Rik

MMRRC Submission

038722-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R0530 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

29223968-29237480 bp(+) (GRCm39)

Type of Mutation

exon

DNA Base Change (assembly)

A to G at 29229545 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Gene Model

predicted gene model for transcript(s):

AlphaFold

no structure available at present

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000141713

SMART Domains

Protein: ENSMUSP00000120285
Gene: ENSMUSG00000074224

Domain	Start	End	E-Value	Type
Blast:WD40	94	134	1e-9	BLAST
WD40	139	176	1.59e1	SMART
WD40	228	269	9.51e1	SMART
WD40	272	311	3.33e-1	SMART
Blast:WD40	354	393	4e-15	BLAST
Blast:WD40	445	490	2e-22	BLAST
Blast:WD40	493	538	8e-15	BLAST
WD40	595	634	1.68e-6	SMART
low complexity region	701	710	N/A	INTRINSIC
low complexity region	915	926	N/A	INTRINSIC
coiled coil region	1135	1168	N/A	INTRINSIC
low complexity region	1211	1230	N/A	INTRINSIC
low complexity region	1239	1273	N/A	INTRINSIC
coiled coil region	1347	1375	N/A	INTRINSIC
coiled coil region	1399	1433	N/A	INTRINSIC
low complexity region	1435	1453	N/A	INTRINSIC
low complexity region	1497	1519	N/A	INTRINSIC
coiled coil region	1612	1707	N/A	INTRINSIC
coiled coil region	1731	1989	N/A	INTRINSIC
coiled coil region	2034	2072	N/A	INTRINSIC
coiled coil region	2127	2154	N/A	INTRINSIC
coiled coil region	2220	2302	N/A	INTRINSIC
coiled coil region	2357	2561	N/A	INTRINSIC
low complexity region	2993	2999	N/A	INTRINSIC

Meta Mutation Damage Score

0.1240

Coding Region Coverage

1x: 99.6%
3x: 98.7%
10x: 96.6%
20x: 93.1%

Validation Efficiency

96% (51/53)

Allele List at MGI

Other mutations in this stock

Total: 50 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcg3	A	G	5: 105,083,920 (GRCm39)	W617R	probably damaging	Het
Adam34l	A	T	8: 44,079,568 (GRCm39)	C219S	probably benign	Het
Cep83	A	T	10: 94,555,450 (GRCm39)		probably benign	Het
Ces1e	G	A	8: 93,946,149 (GRCm39)		probably benign	Het
Ckap2	A	G	8: 22,665,988 (GRCm39)		probably benign	Het
Clip1	C	A	5: 123,778,594 (GRCm39)	R443L	probably damaging	Het
Clmp	A	G	9: 40,672,302 (GRCm39)	D44G	probably benign	Het
Cntnap2	G	A	6: 46,506,839 (GRCm39)	Q304*	probably null	Het
Cst7	A	T	2: 150,412,435 (GRCm39)		probably benign	Het
Dclk3	A	T	9: 111,311,789 (GRCm39)	Y677F	probably damaging	Het
Dlat	G	T	9: 50,548,869 (GRCm39)	N562K	probably damaging	Het
Elmod1	A	T	9: 53,833,260 (GRCm39)	Y182N	probably damaging	Het
Fzd10	T	C	5: 128,679,077 (GRCm39)	F266L	probably damaging	Het
Gm8258	A	G	5: 104,923,952 (GRCm39)		noncoding transcript	Het
Gm9742	T	A	13: 8,080,041 (GRCm39)		noncoding transcript	Het
Hdlbp	T	C	1: 93,358,039 (GRCm39)		probably benign	Het
Itga8	A	G	2: 12,196,627 (GRCm39)	S597P	probably damaging	Het
Kndc1	A	T	7: 139,481,153 (GRCm39)	I80F	probably damaging	Het
Ktn1	A	G	14: 47,970,700 (GRCm39)	N1192S	probably benign	Het
Ldha	G	A	7: 46,503,417 (GRCm39)	V270M	probably damaging	Het
Lyst	T	C	13: 13,931,891 (GRCm39)		probably benign	Het
Map3k9	A	T	12: 81,769,256 (GRCm39)	F954I	probably benign	Het
Mroh2b	A	G	15: 4,963,877 (GRCm39)	N823S	probably damaging	Het
Mycbp2	A	T	14: 103,419,895 (GRCm39)	N2480K	probably damaging	Het
Nat1	A	G	8: 67,943,977 (GRCm39)	K121E	probably benign	Het
Neurl1b	T	A	17: 26,660,519 (GRCm39)		probably null	Het
Nnt	C	A	13: 119,531,257 (GRCm39)	L163F	probably damaging	Het
Or10v5	A	G	19: 11,805,556 (GRCm39)	V278A	probably benign	Het
Otog	A	G	7: 45,947,668 (GRCm39)	T2274A	probably damaging	Het
Pde4b	G	A	4: 102,459,848 (GRCm39)	R561Q	probably damaging	Het
Pitpnm2	A	G	5: 124,269,264 (GRCm39)	F453L	probably damaging	Het
Pms1	T	C	1: 53,235,972 (GRCm39)		probably null	Het
Pot1a	A	G	6: 25,771,540 (GRCm39)	V227A	possibly damaging	Het
Prdx6b	A	G	2: 80,123,659 (GRCm39)	N156S	probably damaging	Het
Ptpn9	A	G	9: 56,968,417 (GRCm39)	S586G	probably benign	Het
Serpina6	A	T	12: 103,618,053 (GRCm39)	N253K	probably damaging	Het
Slc12a2	T	A	18: 58,052,608 (GRCm39)	V809D	possibly damaging	Het
Slc2a8	C	T	2: 32,863,696 (GRCm39)	A449T	probably benign	Het
Slc6a6	A	G	6: 91,701,939 (GRCm39)	I116V	probably null	Het
Synj2	T	A	17: 6,058,380 (GRCm39)	S58R	possibly damaging	Het
Tafa3	T	C	3: 104,679,487 (GRCm39)		probably benign	Het
Tktl2	T	C	8: 66,965,831 (GRCm39)	V463A	probably damaging	Het
Uchl5	T	C	1: 143,670,082 (GRCm39)	V105A	possibly damaging	Het
Usp9y	T	C	Y: 1,333,600 (GRCm39)		probably benign	Het
Vmn1r200	T	C	13: 22,579,667 (GRCm39)	S148P	probably damaging	Het
Vmn2r50	A	T	7: 9,781,644 (GRCm39)	M367K	possibly damaging	Het
Vps13a	T	C	19: 16,632,570 (GRCm39)		probably benign	Het
Wdr26	A	T	1: 181,013,635 (GRCm39)		probably null	Het
Ythdc2	T	A	18: 44,983,465 (GRCm39)	M544K	probably damaging	Het
Zpld2	A	G	4: 133,930,221 (GRCm39)	I28T	probably benign	Het

Other mutations in Wdr87-ps

Allele	Source	Chr	Coord	Type	Predicted Effect
IGL00272:Wdr87-ps	APN	7	29,237,047 (GRCm39)	exon	noncoding transcript
IGL00505:Wdr87-ps	APN	7	29,233,608 (GRCm39)	exon	noncoding transcript
IGL00557:Wdr87-ps	APN	7	29,235,227 (GRCm39)	exon	noncoding transcript
IGL00569:Wdr87-ps	APN	7	29,233,565 (GRCm39)	exon	noncoding transcript
IGL00966:Wdr87-ps	APN	7	29,236,888 (GRCm39)	exon	noncoding transcript
IGL01668:Wdr87-ps	APN	7	29,236,855 (GRCm39)	exon	noncoding transcript
K7371:Wdr87-ps	UTSW	7	29,230,417 (GRCm39)	exon	noncoding transcript
P0037:Wdr87-ps	UTSW	7	29,233,039 (GRCm39)	exon	noncoding transcript
R0179:Wdr87-ps	UTSW	7	29,235,365 (GRCm39)	exon	noncoding transcript
R0357:Wdr87-ps	UTSW	7	29,235,007 (GRCm39)	exon	noncoding transcript
R0358:Wdr87-ps	UTSW	7	29,231,636 (GRCm39)	exon	noncoding transcript
R0412:Wdr87-ps	UTSW	7	29,229,995 (GRCm39)	exon	noncoding transcript
R0600:Wdr87-ps	UTSW	7	29,232,690 (GRCm39)	exon	noncoding transcript
R0675:Wdr87-ps	UTSW	7	29,231,942 (GRCm39)	exon	noncoding transcript
R1118:Wdr87-ps	UTSW	7	29,233,669 (GRCm39)	exon	noncoding transcript
R1395:Wdr87-ps	UTSW	7	29,230,812 (GRCm39)	exon	noncoding transcript
R1444:Wdr87-ps	UTSW	7	29,229,380 (GRCm39)	exon	noncoding transcript
R1476:Wdr87-ps	UTSW	7	29,234,315 (GRCm39)	exon	noncoding transcript
R1534:Wdr87-ps	UTSW	7	29,229,854 (GRCm39)	exon	noncoding transcript
R1535:Wdr87-ps	UTSW	7	29,229,004 (GRCm39)	exon	noncoding transcript
R2023:Wdr87-ps	UTSW	7	29,230,959 (GRCm39)	exon	noncoding transcript
R2127:Wdr87-ps	UTSW	7	29,236,565 (GRCm39)	exon	noncoding transcript
R2141:Wdr87-ps	UTSW	7	29,230,935 (GRCm39)	exon	noncoding transcript
R2198:Wdr87-ps	UTSW	7	29,226,697 (GRCm39)	exon	noncoding transcript
R2201:Wdr87-ps	UTSW	7	29,235,950 (GRCm39)	exon	noncoding transcript
R2262:Wdr87-ps	UTSW	7	29,231,987 (GRCm39)	exon	noncoding transcript
R2263:Wdr87-ps	UTSW	7	29,231,987 (GRCm39)	exon	noncoding transcript
R4874:Wdr87-ps	UTSW	7	29,235,608 (GRCm39)	exon	noncoding transcript
R5064:Wdr87-ps	UTSW	7	29,235,080 (GRCm39)	exon	noncoding transcript
R5130:Wdr87-ps	UTSW	7	29,228,699 (GRCm39)	exon	noncoding transcript
R5366:Wdr87-ps	UTSW	7	29,232,964 (GRCm39)	exon	noncoding transcript

Predicted Primers

PCR Primer
(F):5'- ACTGATAGCCATGCTGGACTCCTC -3'
(R):5'- TTCAATCCGTCCCAGGCAGTCAAC -3'

Sequencing Primer
(F):5'- GCTTGTGACTTTCAACCAGAG -3'
(R):5'- GCAGTCAACTGCAACTGG -3'

Posted On

2013-06-12